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Methyl B12 3000 mcg Berry Flavor

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4.6
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(652 ratings)
Vitamin B12 3000 mcg
Product Image
Score76
A high-dose methylcobalamin and folate dissolvable with a coherent active profile. It is convenient but larger than most people need for routine maintenance.
How scoring works
Quantity:50 Liquid(s) • (50 servings)
Goals:
General Health
Energy
Productivity Boost
Hair Health

Score 76

A high-dose methylcobalamin and folate dissolvable with a coherent active profile. It is convenient but larger than most people need for routine maintenance.
How scoring works

Also available as

1 option
120 servings 1 Lozenge(s) • 120 Liquid(s) • 120 servings $21.47 ($0.17 per serving)
$16.99($0.33 per serving)
iHerb
$ 16.99
Amazon
$ 18.03
Vitacost
$ 16.99
iHerb
$ 16.99
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Analysis

Methylcobalamin provides active-form B12, while folate supports related methylation and blood-cell pathways. Vitamin C adds modest antioxidant support without distracting from the B-vitamin focus.

The 3,000 mcg B12 amount is substantial and may fit targeted repletion better than daily maintenance. A berry-flavored dissolvable format can improve adherence for people who dislike standard pills.

The active ingredients and amounts are clear, but flavoring and sweetener details are absent here. The product is strongest for someone who wants combined methyl-B12 and folate rather than a minimalist formula.

Who is it for
  • Adults seeking methylcobalamin with folate
  • People who prefer dissolvable supplements
  • Users following a high-dose B12 plan
Best for
  • Combined B12 and folate support
  • Supporting normal methylation
  • Pill-free use

Pros

  • Active methylcobalamin form
  • Meaningful folate contribution
  • Convenient dissolvable format

Cons

  • B12 amount far exceeds daily needs
  • Flavoring details are not supplied
  • Not a complete B-complex

Warnings

  • The 3,000 mcg B12 amount and 667 mcg DFE folate should be considered alongside other B-vitamin supplements to avoid unnecessary duplication.

Nutrient quality

82 Highest impact

The vitamin form provides only limited bioavailability confidence. An unusually large amount or mismatched additions reduce balance for general use.

Ingredient transparency

83 Highest impact

Active amounts are clearly disclosed and no proprietary blend is shown. Inactive ingredients and full daily-use directions are missing from the supplied data.

Customer satisfaction

67 High impact

The average rating is strong, with a moderate evidence base behind it. No specific feedback is supplied to judge repeated complaints or whether experience matches the intended use.

Value for money

69 High impact

The supply provides weak cost efficiency for the active amount. Secondary additions provide limited extra value.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA+ Strength of SupportC+ CoverageA Formula Quality
Folate · 667 mcg DFEVitamin B12 · 3000 mcgVitamin C · 50 mg

Methylcobalamin provides a high, clearly stated B12 amount that may support energy metabolism, red blood cell formation, and nerve function when B12 is low. Folate and vitamin C add related nutritional support.

The mouth-dissolving lozenge and bioactive B12 form strengthen delivery quality. The formula remains focused on a limited set of nutrient pathways rather than serving as comprehensive daily coverage.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Vitamin C Supportive 56 studies
Energy
Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Vitamin B12 · 3000 mcg

Methylcobalamin, folate, and vitamin C support nerve function, blood-cell formation, methylation, and antioxidant activity. The B12 form is favorable and all three amounts are clearly disclosed.

The B12 amount is very large for routine maintenance, while the folate chemical form is not identified. The combination offers meaningful depth in a few linked pathways but does not cover wider daily nutrition.

Study evidence
Vitamin B12 Disputed 14 studies
Productivity Boost
Productivity Boost
Impact
Highest effect
B- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin B12 · 3000 mcgVitamin B12 · 3000 mcg

Methylcobalamin with folate provides high-quality foundational support for neurological energy and methylation. Productivity benefits are most likely when B12 status is low rather than as an acute stimulant effect.

The 3,000 mcg mouth-dissolving dose is potent, fully disclosed, and uses a preferred bioactive form. Vitamin C and folate add relevant cofactor support without obscuring the main active.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Hair Health
Hair Health
Impact
High effect
C Goal FitA+ Strength of SupportD+ CoverageA- Formula Quality
Vitamin C · 50 mg

Methylcobalamin can help deficiency-related shedding, while folate supports red blood cell formation. The combination remains most useful for people with low B12 or folate status rather than as a general hair-growth product.

The high B12 amount uses a preferred bioactive form in a mouth-dissolving lozenge. Vitamin C and folate add nutritional support, but the formula lacks iron, zinc, biotin, or structural hair ingredients.

Study evidence
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies
Vitamin C Mixed 5 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 50 mg
Folate
667 mcg DFE
Vitamin B12 (Methylcobalamin)
 3000 mcg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Halal Vegetarian
Report overview
Vitamin B12 (Methylcobalamin) · 3000 mcg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Methylcobalamin provides a high, clearly disclosed dose in a mouth-dissolving lozenge. The form and delivery are well aligned with users seeking absorption-focused B12. Cost efficiency is strong after accounting for the premium bioactive form.

View ingredientView products
Loading alternative details
89 Performance

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>Methylcobalamin, folate, and active vitamin B6 support linked energy and methylation pathways with clearly stated amounts. Compared with the original 3,000 mcg serving, the lower 1,000 mcg amount is less aggressive while retaining methylcobalamin.</p>
87 Performance

Fully Active B12 1500 mcg

Doctor's Best
<p>1,500 mcg of bioactive methylcobalamin provides a focused, easy-to-assess vitamin B12 option. Compared with the original 3,000 mcg serving, the lower 1,500 mcg amount is less aggressive while retaining methylcobalamin.</p>
87 Performance

B12 Energizer+ Natural Cherry Flavor

Advanced Nutrition by Zahler
<p>5,000 mcg of bioactive methylcobalamin provides a focused, easy-to-assess vitamin B12 option. The 5,000 mcg amount exceeds the original 3,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
86 Budget

Vitamin B12 2000 mcg

Nutricost
<p>A lower serving cost provides 2,000 mcg of methylcobalamin in a clearly disclosed formula. Compared with the original 3,000 mcg serving, the lower 2,000 mcg amount is less aggressive while retaining methylcobalamin.</p>
86 Budget

Quick Dissolve B-12 Methylcobalamin 2500 mcg

Nature's Bounty
<p>A lower serving cost provides 2,500 mcg of methylcobalamin in a clearly disclosed formula. Compared with the original 3,000 mcg serving, the lower 2,500 mcg amount is less aggressive while retaining methylcobalamin.</p>
87 Budget

B12 Methylcobalamin 1000 mcg

Natural Factors
<p>A lower serving cost provides 1,000 mcg of methylcobalamin in a clearly disclosed formula. Compared with the original 3,000 mcg serving, the lower 1,000 mcg amount is less aggressive while retaining methylcobalamin.</p>
87 Value

Chewable Fully Active B12 Chocolate Mint Flavor 1000 mcg

Doctor's Best
<p>1,000 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and compared with the original 3,000 mcg serving, the lower 1,000 mcg amount is less aggressive while retaining methylcobalamin.</p>
85 Value

Vegan B12 2500 mcg

DEVA
<p>2,500 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and compared with the original 3,000 mcg serving, the lower 2,500 mcg amount is less aggressive while retaining methylcobalamin.</p>
83 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
<p>1,000 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and compared with the original 3,000 mcg serving, the lower 1,000 mcg amount is less aggressive while retaining methylcobalamin.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  4. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  5. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  6. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  7. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  8. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  9. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  10. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  11. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  12. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  13. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  14. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  15. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  16. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  17. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  18. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  19. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  20. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  21. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  22. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  23. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  24. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  25. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  26. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  27. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  28. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  29. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  30. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  31. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  32. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  33. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  34. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  35. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  36. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  37. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  38. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  39. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  40. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  41. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  42. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  43. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12