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Methyl B12 3000 mcg Berry Flavor

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4.6
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(562 ratings)
Vitamin B12 3000 mcg
Product Image
Score79
A coherent methyl-B12 and folate dissolvable with a generous supply. Strong active forms are balanced by an unnecessarily high B12 amount for many users.
How scoring works
Quantity:120 Liquid(s) • (120 servings)
Goals:
General Health
Energy
Productivity Boost
Hair Health

Score 79

A coherent methyl-B12 and folate dissolvable with a generous supply. Strong active forms are balanced by an unnecessarily high B12 amount for many users.
How scoring works
$21.47($0.17 per serving)
Amazon
$ 21.47
Pure Formulas
$ 32.99
Vitacost
$ 32.99
iHerb
$ 32.99
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Analysis

A 3,000 mcg methylcobalamin amount supplies active-form B12 for normal nerve function and blood-cell formation. Folate complements B12 in methylation pathways, while 50 mg vitamin C adds a small antioxidant contribution.

The berry-flavored dissolvable format can be useful for people who avoid conventional tablets. Active amounts are transparent, although no inactive ingredient list is provided in the supplied data.

The high B12 amount is best suited to a targeted plan rather than assumed necessary for energy. A larger serving count makes this version more practical for regular users than smaller packages of the same formula.

Who is it for
  • Adults wanting active B12 with folate
  • People who prefer dissolvable tablets
  • Users with a defined higher-dose need
Best for
  • Combined B12-folate support
  • Supporting normal nerve and blood-cell function
  • Convenient long-term use

Pros

  • Active methylcobalamin
  • Complementary folate amount
  • Large serving count

Cons

  • Very high B12 amount
  • Flavoring details are unavailable
  • Limited broader B-vitamin coverage

Warnings

  • Consider the 667 mcg DFE folate when combining the product with multivitamins or other folate supplements.

Nutrient quality

82 Highest impact

The vitamin form provides only limited bioavailability confidence. An unusually large amount or mismatched additions reduce balance for general use.

Ingredient transparency

83 Highest impact

Active amounts are clearly disclosed and no proprietary blend is shown. Inactive ingredients and full daily-use directions are missing from the supplied data.

Customer satisfaction

68 High impact

The average rating is strong, with a moderate evidence base behind it. No specific feedback is supplied to judge repeated complaints or whether experience matches the intended use.

Value for money

82 Highest impact

The supply provides reasonable cost efficiency for the active amount. Secondary additions provide limited extra value.

Report analysis

Goals

General Health
Impact
Highest effect
A Goal FitA+ Strength of SupportC+ CoverageA Formula Quality
Folate · 667 mcg DFEVitamin B12 · 3000 mcgVitamin C · 50 mg

Methylcobalamin provides a high, clearly stated B12 amount that may support energy metabolism, red blood cell formation, and nerve function when B12 is low. Folate and vitamin C add related nutritional support.

The mouth-dissolving lozenge and bioactive B12 form strengthen delivery quality. The formula remains focused on a limited set of nutrient pathways rather than serving as comprehensive daily coverage.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Vitamin C Supportive 56 studies
Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Vitamin B12 · 3000 mcg

Methylcobalamin, folate, and vitamin C support nerve function, blood-cell formation, methylation, and antioxidant activity. The B12 form is favorable and all three amounts are clearly disclosed.

The B12 amount is very large for routine maintenance, while the folate chemical form is not identified. The combination offers meaningful depth in a few linked pathways but does not cover wider daily nutrition.

Study evidence
Vitamin B12 Disputed 14 studies
Productivity Boost
Impact
Highest effect
B- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin B12 · 3000 mcgVitamin B12 · 3000 mcg

Methylcobalamin with folate provides high-quality foundational support for neurological energy and methylation. Productivity benefits are most likely when B12 status is low rather than as an acute stimulant effect.

The 3,000 mcg mouth-dissolving dose is potent, fully disclosed, and uses a preferred bioactive form. Vitamin C and folate add relevant cofactor support without obscuring the main active.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Hair Health
Impact
High effect
C Goal FitA+ Strength of SupportD+ CoverageA- Formula Quality
Vitamin C · 50 mg

Methylcobalamin can help deficiency-related shedding, while folate supports red blood cell formation. The combination remains most useful for people with low B12 or folate status rather than as a general hair-growth product.

The high B12 amount uses a preferred bioactive form in a mouth-dissolving lozenge. Vitamin C and folate add nutritional support, but the formula lacks iron, zinc, biotin, or structural hair ingredients.

Study evidence
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies
Vitamin C Mixed 5 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
50 mg
Folate
667 mcg DFE
Vitamin B12 (Methylcobalamin)
3000 mcg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Halal Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A high methylcobalamin dose combines preferred form quality with clear disclosure. Mouth-dissolving lozenges provide an absorption-focused alternative to swallowed tablets. The larger package delivers excellent cost efficiency for the active amount.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  2. Holo-transcobalamin is not associated with the risk of all-cause mortality in the general population.
    Stürmer P; Strathmann EA; Rimbach G; Weber KS; Lieb W · Clinical nutrition ESPEN · 2024
    Cohort study862 participantsGeneral Health forVitamin B12
  3. The origin of vitamin B12 levels and risk of all-cause, cardiovascular and cancer specific mortality: A systematic review and dose-response meta-analysis.
    Liu K; Yang Z; Lu X; Zheng B; Wu S; Kang J; Sun S; Zhao J · Archives of gerontology and geriatrics · 2024
    Meta-analysis92,346 participants22 studies pooledGeneral Health forVitamin B12
  4. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  5. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  6. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  7. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  8. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  9. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  10. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  11. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  12. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  13. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  14. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  15. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  16. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  17. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  18. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  19. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  20. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  21. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  22. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  23. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  24. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  25. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  26. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  27. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  28. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  29. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  30. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  31. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  32. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  33. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  34. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  35. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  36. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  37. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  38. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  39. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  40. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  41. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  42. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  43. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  44. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  45. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  46. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12