5-HTP

5-HTP

Integrative Therapeutics4.4 (14 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$24.00 $0.40 per serving

Product analysis

51 out of 100

5-HTP offers a single ingredient connected to the body’s production of serotonin, a chemical involved in mood. Everyday mood and stress benefits remain uncertain, and the serving is relatively expensive.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The plant source of 5-HTP is identified. That description does not establish an absorption advantage or settle its form-related quality.

Ingredient Transparency100

The 5-HTP amount and plant source are disclosed. That gives a straightforward description for comparing preparations.

Value For Money0

The 5-HTP is relatively expensive for the amount provided. The price does not strengthen the uncertain case for routine mood or sleep benefit.

Customer Satisfaction64

Customer feedback is generally favorable across a small number of ratings. The limited review base leaves uncertainty about how representative the feedback is.

Product Focus62

The possible uses center on mood-related chemical production, with more uncertain sleep and everyday stress effects. The modest serving amount does not establish a proven effective amount for those uses.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.40
Customer rating
4.4 · 14 ratings
Report analysis

Goals

Mood Support
Impact
High effect
B Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
5-HTP · 50 mg

5-HTP is a precursor used to make serotonin. That role gives it a connection to mood, but the supplied findings do not establish routine emotional benefit in generally healthy adults. The 50 mg serving is below the amount receiving the fullest allowance in the saved comparison; that comparison does not identify a proven effective mood dose.

How this product is rated for Mood Support

Ingredient fit76

5-HTP provide the relevant connections. Their amounts make uneven contributions to the comparison.
Goal fit
The relevant ingredients dominate this formula, although it is also linked to other health goals.
Dose adequacy
The included ingredients have known amounts, but several fall below their upper comparison references; this limits the amount-based contribution.

Pathways19

The main connection is neurotransmitter signalling, with the breadth determined by the additional ingredients and their amounts.
Depth
Monoamine signalling is the strongest connection in the saved findings; this describes ingredient roles rather than a demonstrated emotional effect.
Breadth
No route reaches the comparison’s meaningful-coverage threshold; the formula has a narrow serotonin-related connection.

Evidence94

5-HTP receives a strong saved evidence finding, but the supplied controlled mood results do not establish routine benefit in healthy adults.
Evidence strength
5-HTP leads the included evidence finding; its supplied population and outcome limitations still govern expectations.
Studied preparation
The included ingredients meet the saved preparation comparison; this alone does not establish benefit in healthy adults.

Formulation logic100

The included ingredients meet the partner and minimum amount conditions, with no listed conflict triggered. These findings do not demonstrate added benefit from the combination.
Partner coverage
The included ingredients have no unmet partner requirement; this does not imply extra benefit from combining them.
Conflicts
None of the listed ingredient-conflict conditions was triggered by the supplied product facts.
Effective doses
All ingredients retained in this finding meet its minimum amount threshold, which is not a proven effective mood dose.
Study evidence
5-HTP Supportive 9 studies
Impact
Moderate effect
B Ingredient FitD- PathwaysC- EvidenceA+ Formulation Logic

5-HTP may relate to the serotonin–melatonin precursor pathway, but its sleep contribution is uncertain outside particular circumstances. The 50 mg amount is modest and is the product’s only clear sleep-related role.

There is no melatonin for sleep timing or a separate calming ingredient. The formula’s possible contribution is therefore narrow and focused on the precursor pathway.

How this product is rated for Sleep Support

Ingredient fit76

5-HTP is the only sleep-related active; the modest amount gives the formula a narrow focus.
Goal fit
5-HTP is the only sleep-related active; no second ingredient broadens that role.
Dose adequacy
The 50 mg amount is a modest contribution, with no second sleep ingredient adding support.

Pathways40

5-HTP is the product’s only meaningful link to the precursor route.
Depth
5-HTP is the product’s only meaningful link to the precursor route.
Breadth
This one-ingredient formula does not provide separate support for timing or calming.

Evidence58

5-HTP has a limited, context-specific sleep link rather than a broad sleep-timing role.
Evidence strength
5-HTP has a limited, context-specific sleep link rather than a broad timing role.
Studied preparation
The product names the active 5-HTP form; no distinct extract is involved.

Formulation logic100

The single ingredient needs no companion, and no activating combination is identified.
Partner coverage
5-HTP does not require a companion ingredient for its possible contribution.
Conflicts
No bedtime stimulant or activating combination is identified alongside 5-HTP.
Effective doses
The 5-HTP amount contributes to the sleep context; no other ingredient adds a separate dose.
Study evidence
5-HTP Supportive 1 study
Stress Relief
Impact
Moderate effect
B Ingredient FitF PathwaysC- EvidenceA+ Formulation Logic

5-HTP may help with some anxiety and stress-related symptoms, but its usefulness for ordinary daily stress remains uncertain. Its connection is through mood-related chemical production. The declared amount doesn't resolve that uncertainty or tell you how much relief to expect.

How this product is rated for Stress Relief

Ingredient fit76

5-HTP is the main ingredient connecting this serving with stress-related functions.
Goal fit
5-HTP is the main ingredient connecting this serving with stress-related functions.
Dose adequacy
5-HTP: 50 mg. These are amounts per selected serving, not a guarantee of relief.

Pathways13

The main connection is making mood-related chemicals.
Depth
The main connection is making mood-related chemicals.
Breadth
The main connection is making mood-related chemicals. This describes ingredient roles, not how broadly you will feel relief.

Evidence56

5-HTP has conditional anxiety-related usefulness; everyday stress relief remains uncertain. The declared ingredient form is compatible with its context, without guaranteeing relief.
Evidence strength
5-HTP has conditional anxiety-related usefulness; everyday stress relief remains uncertain.
Studied preparation
The declared ingredient form is compatible with its context, without guaranteeing relief.

Formulation logic100

The relevant ingredients can act independently or have their listed partners. No particular ingredient conflict is identified.
Partner coverage
The relevant ingredients can act independently or have their listed partners.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The relevant amounts fall within the comparison ranges used here; those ranges do not guarantee an effective dose for each person.
Study evidence
5-HTP Supportive 18 studies

Ingredients

IngredientAmount per servingScore
L-5-Hydroxytryptophan (Griffonia simplicifolia)
50 mg 60
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
Each serving provides 50 mg of 5-HTP from Griffonia simplicifolia. The label warns about interactions with serotonin-modulating medications.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The saved facts identify Griffonia simplicifolia as the source, without a specified 5-HTP standardization percentage.
Botanical Source & Standardization
The saved facts identify Griffonia simplicifolia as the source, without a specified 5-HTP standardization percentage.

Dose, Safety & Label Transparency79

A serving provides 50 mg of 5-HTP. The label warns about interactions with serotonin-modulating medications.
Dosage Potency & Range
A serving provides 50 mg of 5-HTP.
Safety Warnings & Label Clarity
The label warns about interactions with serotonin-modulating medications.

Value0

Based on the whole-product price, 100 mg of 5-HTP corresponds to about $0.80.
Price per 100mg 5-HTP
Based on the whole-product price, 100 mg of 5-HTP corresponds to about $0.80.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  10. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  11. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP