5-HTP 100 mg

5-HTP 100 mg

Solgar4.7 (1,934 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 90 servings
Goals

Product analysis

61 out of 100

5-HTP 100 mg is aimed at mood and sleep support, though the practical benefits remain uncertain. It may cause drowsiness, which matters when deciding when to take it.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality36

The named forms do not establish clear quality advantages, and the valerian preparation is unspecified. Undisclosed proportions of the vitamin B6 and magnesium forms add further uncertainty.

Ingredient Transparency73

All ingredient amounts and most forms are stated. Valerian lacks a specified preparation, while the proportions of the vitamin B6 and magnesium mixtures are missing.

Value For Money67

The 5-HTP amount and valerian serving compare favorably on price. Value for the vitamin B6 and magnesium contributions cannot be judged confidently.

Customer Satisfaction84

Customer feedback is favorable across a substantial review pool. The reviews do not establish mood or sleep effects.

Product Focus63

The formula centers on 5-HTP, with limited support from the smaller magnesium and valerian amounts. Everyday mood and sleep effects remain uncertain, and the as-needed directions do not establish consistent daily use.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.28
Customer rating
4.7 · 1,934 ratings
Report analysis

Goals

Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic
Magnesium · 50 mgVitamin B6 · 10 mg
Study evidence
5-HTP Supportive 18 studies
Magnesium Supportive 13 studies
Valerian Supportive 18 studies
Impact
Moderate effect
B+ Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic
Magnesium · 50 mg
Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Valerian Supportive 31 studies
Mood Support
Impact
Highest effect
B+ Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 10 mgMagnesium · 50 mg5-HTP · 100 mg
Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Valerian Supportive 17 studies
Vitamin B6 Supportive 19 studies
Impact
Moderate effect
D+ Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Magnesium · 50 mg
Study evidence
5-HTP Supportive 5 studies
Magnesium Supportive 17 studies

Ingredients

IngredientAmount per servingScore
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
10 mg
Magnesium (Magnesium Glycinate, Magnesium Oxide)
50 mg
5-HTP (Griffonia simplicifolia Seed Extract)
100 mg 85
Valerian extract
100 mg 88
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA- Value
A serving provides 100 mg of 5-HTP, at a relatively low cost per 100 mg. Griffonia simplicifolia is named, but its 5-HTP standardization percentage is not stated. A warning about serotonin-related medication interactions is included.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Griffonia simplicifolia is named, but its 5-HTP standardization percentage is not stated.
Botanical Source & Standardization
Griffonia simplicifolia is named, but its 5-HTP standardization percentage is not stated.

Dose, Safety & Label Transparency100

The serving provides 100 mg of 5-HTP. A warning about serotonin-related medication interactions is included.
Dosage Potency & Range
The serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
A warning about serotonin-related medication interactions is included.

Value85

The cost per 100 mg of 5-HTP is relatively low.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is relatively low.
Valerian · 100 mg OverallScore88
B- Composition And Label DisclosureA+ Composition And Label DisclosureA+ Commercial Price And Usability
The serving lists 100 mg of valerian and has a low product cost per serving. The preparation is Valeriana officinalis Root Extract. The label states a 4:1 extract ratio.
How this ingredient is rated

Composition and Label Disclosure70

The preparation is Valeriana officinalis Root Extract. The label states a 4:1 extract ratio.
Marker and Preparation Disclosure
The label states a 4:1 extract ratio.

Composition and Label Disclosure100

The label states 100 mg of valerian per serving.
Individual Preparation Amount Disclosure
The individual valerian amount is listed as 100 mg per serving.

Commercial Price and Usability100

The product cost per serving is low.
Commercial Price per Labeled Serving
The product cost per serving is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  7. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  8. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  9. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  10. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  11. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  12. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  13. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  14. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  15. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  16. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  17. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  18. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  19. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  20. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6