St. John's Wort Extended Release

St. John's Wort Extended Release

NaturesPlus Herbal Actives4.6 (421 ratings)
Format:Tablet Quantity: 60 Tablet(s) · 60 servings
Goals
$23.76 $0.39 per serving
iHerbLowest$23.76Amazon$23.76Walmart$23.76Pure Formulas$23.76Vitacost$24.15

Product analysis

59 out of 100

St. John’s Wort Extended Release centers on an extract with mood-related evidence in specific clinical circumstances. Its important interactions with many medicines and other mood-related ingredients can make it unsuitable for some people.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The extract description is identified, but its quality remains uncertain. Extended release alone does not establish equivalence to preparations linked to mood benefits.

Ingredient Transparency100

The extract amount and form are identified. That makes the serving easier to check and compare with other St. John’s wort supplements.

Value For Money40

There is not enough information to judge the cost for a comparable amount of this extract. Its value therefore remains uncertain.

Customer Satisfaction75

Customer ratings are positive across hundreds of reviews. The review base provides a useful picture of satisfaction without establishing effectiveness.

Product Focus53

The mood-related evidence depends on the extract and clinical circumstances, rather than routine use in healthy adults. The serving is below the described daily trial exposures, and extended release does not establish an equivalent effect.

Format
Tablet
Container
60 Tablet(s)
Per serving
$0.39
Customer rating
4.6 · 421 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic

St. John's wort has evidence for mood symptoms in diagnosed mild-to-moderate depression, with results depending on the extract and trial. That does not establish routine benefit in healthy adults. The 450 mg serving is below the daily extract exposure used in the cited trials, and extended release alone does not establish equivalence. It also has important interactions with many medicines and serotonergic ingredients.

How this product is rated for Mood Support

Ingredient fit77

The recognized ingredients relate to mood support, although the product may also serve other goals. The serving amounts fall short of several saved comparisons, limiting the amount-based findings without proving ineffectiveness.
Goal fit
The recognized ingredients relate to mood support, although the product may also serve other goals.
Dose adequacy
The serving amounts fall short of several saved comparisons, limiting the amount-based findings without proving ineffectiveness.

Pathways16

The strongest represented aspect is monoamine signalling, with limited representation from the recognized ingredients. No aspect reaches the saved coverage comparison; the ingredient roles remain limited rather than broadly established.
Depth
The strongest represented aspect is monoamine signalling, with limited representation from the recognized ingredients.
Breadth
No aspect reaches the saved coverage comparison; the ingredient roles remain limited rather than broadly established.

Evidence84

St. John's Wort provides the strongest recognized evidence here, subject to its population and preparation limitations. The saved result recognizes the qualifying preparations as studied; this does not establish benefit for every user.
Evidence strength
St. John's Wort provides the strongest recognized evidence here, subject to its population and preparation limitations.
Studied preparation
The saved result recognizes the qualifying preparations as studied; this does not establish benefit for every user.

Formulation logic100

The recognized ingredients have their required partners or can stand alone, and no listed conflict was matched. Their amounts meet the saved minimum comparisons.
Partner coverage
The recognized ingredients do not lack a required partner under the supplied checks; this does not demonstrate synergy.
Conflicts
No listed ingredient conflict was matched. This check does not establish medication compatibility.
Effective doses
All recognized ingredients meet the saved minimum amount comparison, which is not a proven clinical effect threshold.
Study evidence
Stress Relief
Stress Relief
Impact
Lower effect
A+ Ingredient FitF PathwaysF EvidenceA+ Formulation Logic
Study evidence

Ingredients

IngredientAmount per servingScore
St. John's Wort (Hypericin)
 450 mg 50
Gluten Free Adults 18–50
Report overview
St. John's Wort (Hypericin) · 450 mg OverallScore50
D+ Composition And Label Disclosure
A serving lists 450 mg of St. John's wort. The evaluation records a general warning, but its wording is not available in the saved facts.
How this ingredient is rated

Composition and Label Disclosure

No separate source or delivery criteria were evaluated.

Composition and Label Disclosure50

A general warning is recorded; the saved facts do not provide its wording or an ingredient-specific warning.
Explicit Label Detail
The evaluation records a general warning, but its wording is not available in the saved facts.

Commercial Price and Usability

No price criterion was evaluated.
View ingredientView products
88 Performance

Full Spectrum St. John's Wort Extract 600 mg

Planetary Herbals
A standardized, substantial Saint John’s wort blend offers focused mood support with stronger potency clarity than nonstandardized options; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  6. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  7. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  8. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  9. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  10. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort