5-HTP 5-Hydroxytryptophan 50 mg

5-HTP 5-Hydroxytryptophan 50 mg

Natural Factors Stress-Relax4.6 (359 ratings)
Format:Tablet Quantity: 60 Tablet(s) · 60 servings
Goals
$13.97 $0.23 per serving
iHerbLowest$13.97Vitacost$19.95

Product analysis

63 out of 100

5-HTP 5-Hydroxytryptophan 50 mg offers a focused supplement for people interested in mood, sleep or stress support, though dependable benefits remain uncertain.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The calcium and 5-HTP sources are identified. Their absorption and quality cannot be confirmed from the available information.

Ingredient Transparency100

Both ingredients have their amounts and sources disclosed. That makes it easier to see what a serving contains.

Value For Money56

The cost for the amount of 5-HTP is moderate. Calcium adds no confirmed value advantage.

Customer Satisfaction73

Customer ratings are positive across several hundred reviews. That gives a useful picture of satisfaction without showing whether mood or sleep improves.

Product Focus60

The formula stays focused on mood, sleep and stress through 5-HTP. Benefits across these related uses remain uncertain.

Format
Tablet
Container
60 Tablet(s)
Per serving
$0.23
Customer rating
4.6 · 359 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
C Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
5-HTP · 50 mg
Study evidence
5-HTP Supportive 9 studies
Sleep Support
Sleep Rhythm
Sleep Support
Impact
Moderate effect
C Ingredient FitD- PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study
Stress Relief
Stress Relief
Impact
Moderate effect
C Ingredient FitF PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 18 studies

Ingredients

IngredientAmount per servingScore
Calcium (Dicalcium Phosphate)
 35 mg
5-Hydroxytryptophan (Griffonia simplicifolia)
 50 mg 72
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
5-HTP (Griffonia simplicifolia) · 50 mg OverallScore72
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyC Value
A serving provides 50 mg of 5-HTP, at a moderate cost per 100 mg. The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated. The label includes a warning about serotonin-related medication interactions.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.

Dose, Safety & Label Transparency79

The serving contains 50 mg of 5-HTP. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
The serving provides 50 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value60

The cost per 100 mg of 5-HTP is moderate.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is moderate.
View ingredientView products
85 Performance

5-HTP 100 mg

NOW
Clearer botanical sourcing makes this a stronger quality alternative. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  10. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  11. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP