D3 + K2

D3 + K2

Nature Made4.5 (206 ratings)
Format:Softgel Quantity: 30 Softgel(s) · 30 servings
Goals
$12.58 $0.41 per serving

Product analysis

72 out of 100

D3 + K2 offers a focused vitamin combination with clearly disclosed amounts and forms. Its identified K2 form is a particular quality strength.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality65

The all-trans MK-7 form of vitamin K is a clear quality strength. Vitamin D is identified as D3, though a firm comparison of its quality is unavailable.

Ingredient Transparency100

Both vitamin amounts and forms are clearly stated. That makes it straightforward to compare the contents with other D and K supplements.

Value For Money57

The vitamin K portion offers favorable value within the serving price. Vitamin D’s value remains uncertain, so the complete combination is harder to compare.

Customer Satisfaction69

Customer feedback is positive, based on a modest number of ratings. Those experiences support satisfaction but do not establish health benefits.

Product Focus75

The two-vitamin formula appears well aligned with its intended uses. It stays reasonably focused without ingredients identified as unnecessary.

Format
Softgel
Container
30 Softgel(s)
Per serving
$0.41
Customer rating
4.5 · 206 ratings
Report analysis

Goals

Heart Health
Impact
High effect
B+ Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin K · 100 mcgVitamin D · 125 mcg

Vitamin K as MK-7 has limited support for arterial-stiffness measures in studied postmenopausal populations. Its serving amount provides partial comparison-range coverage rather than establishing the effects of sustained trial exposure. Vitamin D supplementation has not demonstrated general prevention of major cardiovascular events, and combining it with MK-7 does not establish an additional preventive benefit.

How this product is rated for Heart Health

Ingredient fit82

Vitamin K, Vitamin D provide the included contribution, with partial coverage of the comparison amounts.
Goal fit
Vitamin K, Vitamin D provide the relevant focus, while the product is also linked to other goals.
Dose adequacy
The included amounts partly cover the saved comparison ranges, which describe exposure rather than proven treatment doses.

Pathways19

The strongest recorded connection is arterial calcification control, with partial coverage of the comparison range.
Depth
The strongest recorded connection is arterial calcification control, with partial coverage of the comparison range.
Breadth
No configured pathway reached the coverage threshold.

Evidence77

Vitamin K provides the strongest included evidence, within the limits of its studied outcomes and populations.
Evidence strength
Vitamin K provides the strongest included evidence, within the limits of its studied outcomes and populations.
Studied preparation
The included preparations were matched to studied material, within the limits of the outcomes and populations studied.

Formulation logic100

No configured ingredient conflict was identified. The included ingredients can stand alone or have their required partner present.
Partner coverage
The included ingredients can stand alone or have their required partner present.
Conflicts
No configured ingredient conflict was identified.
Effective doses
All included ingredients clear the saved minimum amount threshold; this does not guarantee a noticeable clinical benefit.
Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Everyday Health
Impact
Highest effect
B+ Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 125 mcgVitamin K · 100 mcg

Vitamin D and vitamin K contribute to bone and mineral nutrition, with practical value when dietary intake is low. Their combination does not establish an extra benefit, and K2 has no demonstrated superiority in the supplied context. The substantial vitamin D amount does not demonstrate broader health improvements above adequacy or establish safety.

How this product is rated for Everyday Health

Ingredient fit84

The selected serving makes a partial nutrient contribution relative to the comparison amounts.
Goal fit
The relevant ingredients give this formula a focused connection to the supplied general-health roles.
Dose adequacy
The selected serving makes a partial nutrient contribution relative to the comparison amounts.

Pathways60

The strongest contribution concerns bone and mineral nutrition. Other meaningful coverage is limited to the named nutrient roles.
Depth
The strongest finding concerns bone and mineral nutrition, based on the relevant ingredients and their supplied amounts.
Breadth
Meaningful coverage extends to bone and mineral nutrition.

Evidence82

Vitamin D provides the leading evidence contribution. Nutritional functions and the preparation findings do not establish broad health improvements above adequate intake.
Evidence strength
Vitamin D leads the evidence contribution; its nutrient role does not establish extra benefit above adequate intake.
Studied preparation
The included preparations meet the preparation criteria; this does not establish superiority of a particular form.

Formulation logic100

The included ingredients can contribute without a missing required partner, and no configured conflict was found. Their amounts pass the saved minimum contribution check.
Partner coverage
The included ingredients can contribute independently or have their required partners; no extra benefit from combining them is established.
Conflicts
No configured ingredient conflict was identified in the supplied facts.
Effective doses
The included amounts all meet the minimum amount used here; that threshold is not a proven clinical dose.
Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Bone Health
Impact
Highest effect
A- Ingredient FitC PathwaysB+ EvidenceA- Formulation Logic
Vitamin K · 100 mcgVitamin D · 125 mcg

Vitamin D helps calcium absorption and normal bone mineralization, particularly when vitamin D intake is inadequate. Vitamin K participates in bone-protein activation, but the saved result treated this preparation as unidentified despite the all-trans-MK-7 form description, so it did not receive the studied MK-7 preparation finding. The 125 mcg vitamin D serving does not imply extra fracture benefit. Calcium is absent, leaving mineral supply outside this formula’s contribution.

How this product is rated for Bone Health

Ingredient fit88

Vitamin D and vitamin K are relevant to bone-related functions, with a preparation uncertainty for vitamin K.
Goal fit
Vitamin D and vitamin K are relevant to bone-related functions, with a preparation uncertainty for vitamin K.
Dose adequacy
Vitamin D meets the saved amount reference, while vitamin K makes a smaller contribution under the unidentified-preparation finding.

Pathways60

Calcium absorption dominates; bone-protein activation contributes less and mineral supply is absent.
Depth
Calcium absorption and regulation are the best-covered aspect.
Breadth
Only calcium absorption meets the saved coverage criterion; bone-protein activation remains partial.

Evidence82

Vitamin D supplies the strongest saved evidence contribution; vitamin K preparation matching remains unresolved.
Evidence strength
Vitamin D supplies the strongest saved evidence contribution; this does not establish fracture prevention.
Studied preparation
Vitamin D matches the studied-preparation finding; vitamin K was treated as unidentified.

Formulation logic90

The saved findings identify no matched ingredient conflicts. Vitamin D lacks a qualifying calcium partner.
Partner coverage
Vitamin D lacks a qualifying calcium partner in the saved findings.
Conflicts
No evaluated ingredient conflict was found; this is not a general safety conclusion.
Effective doses
All ingredients included in this rule meet the saved amount threshold; that threshold is not a proven effective dose.
Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Longevity
Impact
High effect
A- Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Vitamin K · 100 mcgVitamin D · 125 mcg

Vitamin D helps preserve muscle function when deficiency causes weakness; supplementation has not shown the same benefit in vitamin D-replete adults. Vitamin K vascular findings apply to identified MenaQ7 in postmenopausal women; unspecified vitamin K does not establish the same benefit.

How this product is rated for Longevity

Ingredient fit88

The included ingredients are focused on the assessed aging-related roles, though these roles do not prove an anti-aging effect. Amount support is partial.
Goal fit
The included ingredients are focused on the assessed aging-related roles, though these roles do not prove an anti-aging effect.
Dose adequacy
Included amounts only partly meet the saved amount criteria; small or unknown quantities limit the findings without establishing ineffectiveness.

Pathways11

The main saved connection is arterial calcification control. No pathway reaches the saved coverage requirement.
Depth
The strongest saved connection is arterial calcification control; this describes an ingredient role rather than a demonstrated slowing of aging.
Breadth
No assessed pathway met the saved coverage requirement.

Evidence74

Vitamin D supplies the strongest included evidence in the saved findings; the supplied scientific context limits transfer to routine anti-aging use.
Evidence strength
Vitamin D supplies the strongest included evidence in the saved findings; the supplied scientific context limits transfer to routine anti-aging use.
Studied preparation
The study-preparation match is incomplete for Vitamin K. This limits direct transfer of research findings.

Formulation logic100

No required ingredient partner was missing in the saved findings; this does not establish a combined anti-aging benefit. No configured ingredient conflict was identified in the supplied findings.
Partner coverage
No required ingredient partner was missing in the saved findings; this does not establish a combined anti-aging benefit.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
All counted ingredients meet the saved minimum amount criterion; this is not a proven minimum effective anti-aging dose.
Study evidence
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
High effect
B+ Ingredient FitF PathwaysC+ EvidenceA+ Formulation Logic
Vitamin K · 100 mcgVitamin D · 125 mcg

MK-7 has limited support for selected arterial-stiffness measures in postmenopausal women, rather than established prevention of cardiovascular events. The 100 mcg per serving is below the 180 mcg daily exposure in the supplied long-term trial. Vitamin D does not establish routine cardiovascular prevention, and adding it to MK-7 does not establish a combined benefit.

How this product is rated for Cardiovascular Support

Ingredient fit83

Both nutrients receive credit within a formulation linked to several goals. MK-7's partial amount contribution limits the combined amount finding.
Goal fit
Both nutrients receive credit within a formulation linked to several goals.
Dose adequacy
MK-7's partial amount contribution limits the combined amount finding.

Pathways19

The saved arterial-calcification route has limited coverage; the clinical support concerns stiffness markers. No route reaches substantial coverage.
Depth
The saved arterial-calcification route has limited coverage; the clinical support concerns stiffness markers.
Breadth
No route reaches substantial coverage.

Evidence69

MK-7 supplies the strongest evidence, limited to selected arterial-stiffness findings. The explicitly identified MK-7 and vitamin D preparations are accepted.
Evidence strength
MK-7 supplies the strongest evidence, limited to selected arterial-stiffness findings.
Studied preparation
The explicitly identified MK-7 and vitamin D preparations are accepted.

Formulation logic100

The amount-eligible ingredients have no missing required partner or listed ingredient conflict.
Partner coverage
The credited ingredients can contribute alone or have their required partner.
Conflicts
No listed ingredient conflict was found.
Effective doses
Every amount-eligible ingredient meets the inclusion criterion, without establishing a clinically effective dose.
Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per servingScore
Vitamin D3 (Cholecalciferol)
125 mcg
Vitamin K2 (all-trans-Menaquinone-7)
100 mcg 96
Adults 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
The listed vitamin K amount is 100 mcg, with a moderate cost per serving. It uses all-trans-vitamin K2 as menaquinone-7 (MK-7). The MK-7 is specified as all-trans.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses all-trans-vitamin K2 as menaquinone-7 (MK-7). The MK-7 is specified as all-trans.
Vitamin K Form (MK-7 vs. MK-4 vs. K1)
It uses all-trans-vitamin K2 as menaquinone-7 (MK-7).
MK-7 Isomer Disclosure
The MK-7 is specified as all-trans.

Dose, Safety & Label Transparency100

The serving lists 100 mcg of MK-7. The amount and named form are stated.
Vitamin K2 (MK-7) Dosage Efficacy
The serving lists 100 mcg of MK-7.
Form and Subtype Transparency
The amount and named form are stated.

Value80

The cost per serving is moderate.
Price per Effective MK-7 Serving
The cost per serving is moderate.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  2. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  3. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  4. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  5. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  6. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  7. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  8. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  9. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  10. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  11. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forVitamin D
  12. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  13. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  14. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  15. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  16. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  17. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  18. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  19. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  20. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K