Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors4.8 (3,381 ratings)
Format:Softgel Quantity: 60 Softgel(s) · 60 servings
Goals
$20.97 $0.34 per serving

Product analysis

76 out of 100

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg may help fill nutrient gaps relevant to normal bone and mineral health.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality72

The K2 is identified as MK-7, a favorable vitamin K form. D3 is also named, but its quality remains uncertain.

Ingredient Transparency80

The vitamin amounts and forms are stated, making the main ingredients easy to compare. The relative contributions of the declared vitamin K sources are undisclosed.

Value For Money72

The serving price is favorable when considered as a source of MK-7 vitamin K. Vitamin D value remains uncertain, so the favorable comparison does not establish value for both nutrients.

Customer Satisfaction90

Customer ratings are very positive. Thousands of responses give the favorable feedback a broad base.

Product Focus74

The clearest purpose is nutritional support for normal bone and mineral functions. The K2 serving is below one arterial-stiffness comparison, and taking D3 with K2 does not establish extra benefits from the combination.

Format
Softgel
Container
60 Softgel(s)
Per serving
$0.34
Customer rating
4.8 · 3,381 ratings
Report analysis

Goals

Bone Health
Impact
Highest effect
B Ingredient FitC+ PathwaysA+ EvidenceA Formulation Logic
Vitamin K · 120 mcgVitamin D · 25 mcg

Vitamin D helps calcium absorption and supports mineralization when intake or vitamin D status is low. MK-7 supports bone-protein activation, with limited and mixed bone-density findings in postmenopausal women. The saved nutrient contributions do not establish routine fracture prevention.

How this product is rated for Bone Health

Ingredient fit79

The formula supplies several bone-related nutrients, with much of its support tied to normal nutrition. The included nutrients provide mixed amount comparisons; several reach their saved references while others provide partial contributions.
Goal fit
The formula supplies several bone-related nutrients, with much of its support tied to normal nutrition.
Dose adequacy
The included nutrients provide mixed amount comparisons; several reach their saved references while others provide partial contributions.

Pathways67

The saved findings concentrate on calcium absorption, bone-protein activation.
Depth
The saved findings concentrate on calcium absorption, bone-protein activation.
Breadth
These areas reach the saved coverage threshold.

Evidence98

Vitamin K supplies the strongest saved evidence. Normal nutrient roles and limited bone-density findings do not establish routine fracture prevention.
Evidence strength
Vitamin K supplies the strongest saved evidence; its retained contribution does not establish fracture prevention.
Studied preparation
The included preparations meet the saved preparation criterion; this does not prove superior absorption or fracture outcomes.

Formulation logic92

Vitamin D retains an individual contribution, but calcium is absent or below the required partner amount. No configured conflict was identified.
Partner coverage
Vitamin D retains an individual contribution, but calcium is absent or below the required partner amount.
Conflicts
No configured conflict was identified in the supplied findings.
Effective doses
All included ingredients reach the saved minimum amount criterion; that criterion is not a proven clinical dose.
Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Heart Health
Impact
High effect
B Ingredient FitD- PathwaysB EvidenceA+ Formulation Logic
Vitamin K · 120 mcgVitamin D · 25 mcg

MK-7 vitamin K has limited support for arterial stiffness, chiefly from selected postmenopausal populations; this does not establish prevention of heart events.

How this product is rated for Heart Health

Ingredient fit76

The relevant nutrients contribute to distinct nutritional or vascular roles, with preparation and amount limits shaping their contribution.
Goal fit
The relevant ingredients give this formula a clear focus on the supported heart-health roles.
Dose adequacy
The credited amounts provide partial coverage of the saved comparison anchors, rather than establishing a complete daily regimen.

Pathways44

The strongest finding concerns MK-7 and arterial stiffness; the pathway label does not establish reversal of arterial calcification.
Depth
The strongest finding concerns MK-7 and arterial stiffness; the pathway label does not establish reversal of arterial calcification.
Breadth
Only one area reaches the saved coverage benchmark, so support is concentrated rather than broad.

Evidence77

MK-7 leads the evidence finding, with limited arterial-stiffness support in selected populations.
Evidence strength
MK-7 leads the evidence finding, with limited arterial-stiffness support in selected populations.
Studied preparation
The saved finding recognizes the credited preparations; this does not make different forms interchangeable or establish a daily study regimen.

Formulation logic100

The counted ingredients have their required partners, and no configured conflict was identified.
Partner coverage
No required partner is missing among the credited ingredients; this does not establish added benefit from combining them.
Conflicts
No configured ingredient conflict was matched in the supplied facts.
Effective doses
The counted ingredients meet the saved amount benchmark, which is a comparison convention rather than a proven minimum effective dose.
Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Longevity
Impact
High effect
B Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Vitamin K · 120 mcgVitamin D · 25 mcg

Vitamin D helps preserve muscle function when deficiency is corrected. Vitamin K’s arterial-flexibility findings concern identified MenaQ7 in postmenopausal women; generic MK-7 is not automatically equivalent.

How this product is rated for Longevity

Ingredient fit76

The saved findings count a range of ingredients and compare their amounts with reference amounts. Ingredient presence and amount alone do not establish anti-aging effects.
Goal fit
The counted ingredients form a focused mixture, although the product is linked to several health purposes.
Dose adequacy
The counted amounts provide partial coverage of the saved references; that comparison does not establish a clinically effective anti-aging dose.

Pathways13

The strongest saved coverage is arterial calcification control. Mechanistic coverage does not demonstrate lifespan extension.
Depth
The strongest saved coverage concerns arterial calcification control, a mechanistic finding rather than evidence of slower human aging.
Breadth
No pathway reaches the saved coverage threshold.

Evidence74

Vitamin D leads this finding; functional benefit is most relevant to deficiency correction, not additional benefit in replete adults.
Evidence strength
Vitamin D leads this finding; functional benefit is most relevant to deficiency correction, not additional benefit in replete adults.
Studied preparation
The saved preparation check remains incomplete for Vitamin K. Clinical preparation equivalence cannot be assumed.

Formulation logic100

The saved findings show partner coverage and no matched ingredient conflicts. Some amount or preparation limits may still restrict practical relevance.
Partner coverage
The counted ingredients have their required partners or work independently under the saved findings; this does not demonstrate added benefit from combining them.
Conflicts
No ingredient conflict was matched in the supplied findings.
Effective doses
All counted ingredients pass the saved minimum amount threshold, which does not establish a proven anti-aging dose.
Study evidence
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
Everyday Health
Impact
Highest effect
B+ Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 25 mcgVitamin K · 120 mcg

Vitamin D contributes to bone and mineral nutrition, and vitamin K supplies a nutrient involved in normal bone metabolism. Their usefulness is primarily in filling dietary gaps. The saved comparison gives a larger relative amount contribution to vitamin K, without establishing extra benefit from taking the two together or superiority of a particular vitamin K form.

How this product is rated for Everyday Health

Ingredient fit83

Vitamin D and vitamin K align with the supported nutritional roles for general health. Vitamin K reaches the comparison range; vitamin D supplies a partial contribution.
Goal fit
Vitamin D and vitamin K align with the supported nutritional roles for general health.
Dose adequacy
Vitamin K reaches the comparison range; vitamin D supplies a partial contribution.

Pathways60

The supported coverage includes bone and mineral metabolism.
Depth
The strongest contribution centres on bone and mineral metabolism.
Breadth
The supported coverage includes bone and mineral metabolism.

Evidence82

Vitamin D provides the strongest supported contribution at the supplied amount. The relevant preparations were accepted, without establishing superiority of a particular form.
Evidence strength
Vitamin D provides the strongest supported contribution at the supplied amount, within the limits of its nutritional role.
Studied preparation
The relevant preparations were accepted in the supplied findings; this does not establish a special benefit from their forms.

Formulation logic100

The included nutrient contributions meet the saved amount criterion; this is not proof of additional health benefit.
Partner coverage
The included contributions do not have an unmet required ingredient partner.
Conflicts
No listed ingredient conflict was identified in the supplied findings.
Effective doses
The included nutrient contributions meet the saved amount criterion; this is not proof of additional health benefit.
Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Cardiovascular Support
Impact
High effect
B Ingredient FitD- PathwaysC+ EvidenceA+ Formulation Logic
Vitamin K · 120 mcgVitamin D · 25 mcg

Vitamin K as MK-7 has limited support for selected arterial-stiffness measures, mainly from a long trial in postmenopausal women. The 120 mcg serving is below the 180 mcg daily exposure highlighted in that trial, and receives a partial saved amount contribution. This does not establish prevention or reversal of arterial calcification or fewer cardiovascular events. Vitamin D is also present, but routine cardiovascular prevention and additional D3–K2 benefit are not established.

How this product is rated for Cardiovascular Support

Ingredient fit76

The explicitly identified MK-7 form supplies the main cardiovascular connection; both declared nutrients receive partial amount contributions.
Goal fit
The two nutrients are closely aligned with the saved findings, although the product serves several goals.
Dose adequacy
The 120 mcg MK-7 serving and declared vitamin D receive partial amount contributions.

Pathways44

The saved findings emphasize the arterial-calcification category, while the supporting clinical evidence concerns selected arterial-stiffness measures.
Depth
The arterial-calcification category is strongest in the saved findings; that label does not prove prevention or reversal of calcification.
Breadth
Only the arterial-calcification category reaches substantial saved coverage.

Evidence69

MK-7 leads the evidence findings, with limited population-specific arterial-stiffness results.
Evidence strength
MK-7 leads the saved finding; selected stiffness measures do not establish fewer cardiovascular events.
Studied preparation
The explicitly declared MK-7 and vitamin D preparations are recognized in the saved findings.

Formulation logic100

No missing partner or assessed ingredient conflict was identified among the included ingredients.
Partner coverage
No required partner is missing among the included ingredients.
Conflicts
No assessed ingredient conflict was identified.
Effective doses
Both included ingredients meet the saved amount criterion; this does not establish extra benefit from combining them.
Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per servingScore
Vitamin D3 (Cholecalciferol)
25 mcg
Vitamin K2 (Menaquinone-7, Natto)
120 mcg 93
Gluten Free Adults 18–50 Dairy Free
Report overview
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Each serving provides 120 mcg of vitamin K2 as MK-7 at a low cost. The label does not specify whether the MK-7 is trans or all-trans.
How this ingredient is rated

Active Ingredient Quality & Bioavailability82

It uses vitamin K2 as MK-7, a form that stays in the bloodstream longer than other forms. The MK-7 is not specified as trans or all-trans.
Vitamin K Form (MK-7 vs. MK-4 vs. K1)
It uses vitamin K2 as MK-7, a form that stays in the bloodstream longer than other forms.
MK-7 Isomer Disclosure
The MK-7 is not specified as trans or all-trans.

Dose, Safety & Label Transparency100

Each serving provides 120 mcg of MK-7. The amount and MK-7 subtype are stated.
Vitamin K2 (MK-7) Dosage Efficacy
Each serving provides 120 mcg of MK-7.
Form and Subtype Transparency
The amount and MK-7 subtype are stated.

Value100

The cost per serving is low.
Price per Effective MK-7 Serving
The cost per serving is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  2. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  3. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  4. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  5. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  6. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  7. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  8. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  9. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  10. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  11. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forVitamin D
  12. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  13. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  14. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  15. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  16. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  17. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  18. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  19. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  20. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K