5-HTP 100 mg

5-HTP 100 mg

Protocol For Life Balance4.8 (110 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 90 servings
Goals
$30.00 $0.33 per serving

Product analysis

65 out of 100

5-HTP 100 mg offers a simple way to take an ingredient that the body uses to make serotonin. Possible appetite benefits are supported by limited evidence, while reliable improvements in mood, sleep or everyday stress remain uncertain.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The Griffonia seed source is clearly named. Its relative quality is still uncertain, so the source description alone does not establish an advantage.

Ingredient Transparency100

The amount and source are both clear. That makes it straightforward to compare with other single-ingredient 5-HTP supplements.

Value For Money60

The 5-HTP offers reasonable value for its amount. That cost advantage does not resolve the uncertainty about noticeable benefits.

Customer Satisfaction73

Customer feedback is very positive. The modest number of reviews gives some reassurance about satisfaction, rather than proof of benefits.

Product Focus66

The single ingredient has possible roles in appetite, mood, sleep and stress. Support for lasting benefits is limited, so the range of uses should not imply reliable results.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.33
Customer rating
4.8 · 110 ratings
Report analysis

Goals

Impact
Moderate effect
A Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic

5-HTP may contribute along a sleep-related precursor pathway, but a direct benefit for sleep timing or onset has not been established. It is the only active, so that narrow route defines the product's sleep focus.

The 100 mg serving is not the limiting part of its potential role, but amount alone does not establish a sleep benefit. The product contains no melatonin for a separate timing contribution.

How this product is rated for Sleep Support

Ingredient fit95

5-HTP is the sole sleep-related active, keeping the product focused on a precursor pathway.
Goal fit
One sleep-related ingredient is present, with no off-goal actives.
Dose adequacy
The 100 mg 5-HTP serving provides the full amount considered for its potential precursor role.

Pathways60

5-HTP fully covers the precursor route, while other sleep pathways are not represented.
Depth
The precursor route is the strongest and only substantial pathway.
Breadth
Meaningful coverage is limited to one of the three target routes.

Evidence58

5-HTP has a limited potential sleep role compared with melatonin's timing contribution.
Evidence strength
5-HTP's potential contribution is below melatonin's highest sleep role.
Studied preparation
The label identifies 5-HTP as the product's only active, without a special preparation distinction.

Formulation logic100

5-HTP can contribute without a partner, and no bedtime conflict is identified.
Partner coverage
No second ingredient is needed for 5-HTP's listed role.
Conflicts
No listed ingredient triggers a bedtime conflict.
Effective doses
The 100 mg serving provides the full amount considered for 5-HTP's potential role.
Study evidence
5-HTP Supportive 1 study
Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic

Whether 5-HTP eases everyday stress is uncertain. Its possible benefits concern selected anxiety and stress situations, with a connection to mood-related processes. Those narrower uses don’t mean you can expect reliable relief from ordinary psychological stress.

How this product is rated for Stress Relief

Ingredient fit95

5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Goal fit
5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Dose adequacy
5-HTP 100 mg per serving; comparison amounts describe quantity, not a guarantee of stress relief.

Pathways46

The main connection is to mood-related processes, with a smaller sleep-related connection.
Depth
The main connection is to mood-related processes, with a smaller sleep-related connection.
Breadth
5-HTP provides a concentrated connection rather than broad benefits across different stress processes.

Evidence56

5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Evidence strength
5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Studied preparation
5-HTP is an identified ingredient rather than an unknown preparation; the limits on its practical benefit still apply.

Formulation logic100

The relevant ingredients have no missing required partner or identified ingredient conflict.
Partner coverage
The relevant ingredients do not require a missing partner for their described role.
Conflicts
No particular ingredient conflict is identified.
Effective doses
5-HTP 100 mg per serving; comparison amounts describe quantity, not a guarantee of stress relief.
Study evidence
5-HTP Supportive 18 studies
Mood Support
Impact
Highest effect
A Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 100 mg

5-HTP supplies a precursor used to make serotonin. Although the saved findings credit its declared amount, the supplied scientific context does not establish routine mood improvement: a small older-adult study did not show a significant mood advantage over control. Its Griffonia source does not change that limitation.

How this product is rated for Mood Support

Ingredient fit95

5-HTP provides the included contributions, with declared amounts reaching the saved comparison ranges.
Goal fit
The declared active ingredients are concentrated on the mood-related roles considered here.
Dose adequacy
The declared amount reaches the saved comparison range; this does not establish an individual mood response.

Pathways59

Monoamine signalling is the leading route in the saved findings. The represented routes describe ingredient roles rather than demonstrated additional mood improvement.
Depth
Monoamine signalling is the strongest represented route in the saved findings; this does not establish a measured mood effect.
Breadth
The saved findings cover one route to the required extent, with no established additional benefit from combining routes.

Evidence94

5-HTP provides the strongest included evidence finding. Population, preparation and direct mood-outcome limitations still constrain what can be expected.
Evidence strength
5-HTP anchors this finding, subject to the population and outcome limits described for its mood role.
Studied preparation
The saved findings accept the included preparations; this does not remove the ingredient-specific limits on mood evidence.

Formulation logic100

The included ingredients meet the amount and partner checks, and none of the specified conflicts was found.
Partner coverage
No required supporting partner is missing for the included ingredients.
Conflicts
None of the specified ingredient conflict checks was triggered.
Effective doses
The included ingredients meet the saved minimum amount threshold; this is not a proven effective dose for mood.
Study evidence
5-HTP Supportive 9 studies
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic

100 mg of 5-HTP relates mainly to appetite and fullness. Small trials suggest it may help reduce food intake, but the limited evidence leaves sustained weight-loss benefits uncertain.

How this product is rated for Weight Loss

Ingredient fit75

5-HTP gives the ingredient selection a clear appetite-related focus. 100 mg of 5-HTP provides partial amount support.
Goal fit
5-HTP gives the ingredient selection a clear appetite-related focus.
Dose adequacy
100 mg of 5-HTP provides partial amount support.

Pathways9

Appetite and fullness are the main connection, with limited overall depth. No pathway reaches the saved threshold for substantial coverage.
Depth
Appetite and fullness are the main connection, with limited overall depth.
Breadth
No pathway reaches the saved threshold for substantial coverage.

Evidence62

5-HTP provides the strongest evidence contribution in the saved findings, with small and limited appetite trials. The saved findings recognize the preparations of the reviewed contributors at qualifying amounts.
Evidence strength
5-HTP provides the strongest evidence contribution in the saved findings, with small and limited appetite trials.
Studied preparation
The saved findings recognize the preparations of the reviewed contributors at qualifying amounts.

Formulation logic100

No configured ingredient conflict was matched in the saved findings. All reviewed contributors meet the saved minimum amount threshold; that threshold is not a guarantee of weight loss.
Partner coverage
The reviewed contributors have no unmet partner requirement in the saved findings.
Conflicts
No configured ingredient conflict was matched in the saved findings.
Effective doses
All reviewed contributors meet the saved minimum amount threshold; that threshold is not a guarantee of weight loss.
Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per servingScore
5-HTP (Griffonia simplicifolia Seed Extract)
100 mg 80
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value
Each serving provides 100 mg of 5-HTP from Griffonia simplicifolia. The recorded warning mentions antidepressants or other serotonin-affecting medications.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Griffonia simplicifolia is identified as the source, but the saved information does not specify a 5-HTP standardization percentage.
Botanical Source & Standardization
Griffonia simplicifolia is named; a percentage specifying 5-HTP standardization is not recorded.

Dose, Safety & Label Transparency100

The serving provides 100 mg of 5-HTP. The recorded warning mentions antidepressants or other serotonin-affecting medications.
Dosage Potency & Range
The serving contains 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The recorded warning mentions antidepressants or other serotonin-affecting medications.

Value60

The whole-product serving costs about $0.33; its cost relative to the 5-HTP provided is moderate in the evaluation.
Price per 100mg 5-HTP
The whole-product price corresponds to about $0.33 per 100 mg of 5-HTP.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  10. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  11. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  12. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  13. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  14. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  15. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  16. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP