$5.08 $0.33 per serving
Product analysis
Serene Science 5-HTP 50 mg may help with appetite and fullness, with possible sleep support for some poor sleepers. Those benefits remain uncertain because the evidence is limited and does not apply equally to everyone.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality40
The plant source of 5-HTP is identified. Its quality cannot be judged further from the available information.
Ingredient Transparency100
The 5-HTP amount and plant source are disclosed. Those details help you check what is in the serving and compare it with alternatives.
Value For Money60
The serving price offers moderate value for the 5-HTP amount. It does not stand out as a particularly inexpensive option.
Customer Satisfaction64
Feedback is favorable, but it comes from a small group of buyers. The limited number of ratings makes the wider picture less certain.
Product Focus66
The formula centers on 5-HTP, with possible appetite and selected sleep benefits. Its role in making serotonin does not by itself establish a reliable everyday mood or stress benefit.
- Format
Capsule - Container
- 30 Capsule(s)
- Per serving
- $0.33
- Customer rating
- 4.4 · 13 ratings
Goals
Impact
Highest effect
5-HTP · 100 mg
5-HTP is a building block for serotonin, a messenger involved in mood. The supplied findings do not establish a mood improvement over a control in generally healthy adults, despite its clear biochemical role. The declared amount is fully recognized in the saved amount comparison, but that does not establish a reliable everyday emotional benefit.
How this product is rated for Mood Support
Ingredient fit95
The declared amounts fully meet the saved comparison references; this does not establish an effective dose for every user.
Goal fit
The relevant ingredients dominate the formula, although its wider uses also influence how specifically it addresses mood.
Dose adequacy
The declared amounts fully meet the saved comparison references; this does not establish an effective dose for every user.
Pathways59
The main recognized connection is monoamine signalling. This describes the supplied ingredient roles, without proving a mood effect.
Depth
The main recognized connection is monoamine signalling. This describes the supplied ingredient roles, without proving a mood effect.
Breadth
One route reaches the saved coverage reference, so the recognized connections to mood remain concentrated.
Evidence94
5-HTP provides the leading recognized evidence contribution; its population and outcome limitations still govern what emotional benefit can be expected.
Evidence strength
5-HTP provides the leading recognized evidence contribution; its population and outcome limitations still govern what emotional benefit can be expected.
Studied preparation
The qualifying ingredients are recognized as matching the saved preparation criteria; that does not make all preparations or populations interchangeable.
Formulation logic100
The recognized ingredients meet the partner requirements, and no evaluated ingredient conflict is triggered.
Partner coverage
The recognized ingredients do not depend on a missing partner under the supplied findings.
Conflicts
None of the evaluated ingredient combinations triggers a listed conflict; this finding does not establish medication compatibility.
Effective doses
All ingredients retained for this comparison meet its minimum amount threshold; this is not proof of clinical effectiveness.
Impact
Moderate effect
Whether 5-HTP eases everyday stress is uncertain. Its possible benefits concern selected anxiety and stress situations, with a connection to mood-related processes. Those narrower uses don’t mean you can expect reliable relief from ordinary psychological stress.
How this product is rated for Stress Relief
Ingredient fit95
5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Goal fit
5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Dose adequacy
5-HTP 100 mg per serving; comparison amounts describe quantity, not a guarantee of stress relief.
Pathways46
The main connection is to mood-related processes, with a smaller sleep-related connection.
Depth
The main connection is to mood-related processes, with a smaller sleep-related connection.
Breadth
5-HTP provides a concentrated connection rather than broad benefits across different stress processes.
Evidence56
5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Evidence strength
5-HTP has conditional anxiety and stress applicability; everyday relief is uncertain.
Studied preparation
5-HTP is an identified ingredient rather than an unknown preparation; the limits on its practical benefit still apply.
Formulation logic100
The relevant ingredients have no missing required partner or identified ingredient conflict.
Partner coverage
The relevant ingredients do not require a missing partner for their described role.
Conflicts
No particular ingredient conflict is identified.
Effective doses
5-HTP 100 mg per serving; comparison amounts describe quantity, not a guarantee of stress relief.
Impact
Moderate effect
5-HTP is the only sleep-focused ingredient and may contribute through the body’s melatonin-making process. Its possible sleep benefit is most relevant to some poor sleepers, so it doesn’t establish a general improvement for everyone.
There’s no separate ingredient here for calming or sleep timing. The possible contribution rests on 5-HTP alone.
How this product is rated for Sleep Support
Ingredient fit95
5-HTP is the sole sleep-related ingredient; its possible role through the body’s melatonin process is narrow and uncertain.
Goal fit
5-HTP is the only possible contributor, and its potential sleep benefit is limited to some poor sleepers.
Dose adequacy
The selected two-capsule serving lists 100 mg 5-HTP; the product name reflects 50 mg per capsule.
Pathways60
5-HTP may contribute through the body’s melatonin-making process, but no separate ingredient supports calming or sleep timing.
Depth
5-HTP contributes to the body’s melatonin-making process, with no separate calming role.
Breadth
No second sleep process contributes alongside the precursor role.
Evidence58
5-HTP contributes only to melatonin production, without separate calming or body-clock support.
Evidence strength
5-HTP is the only candidate, but its potential benefit is narrow and uncertain.
Studied preparation
The label identifies 5-HTP from Griffonia; the credited amount is not inferred from plant mass.
Formulation logic100
This formula offers one sleep angle, without a second route such as relaxation or timing.
Partner coverage
5-HTP is treated as a standalone precursor; no second ingredient is required.
Conflicts
No listed ingredient creates a bedtime sleep conflict.
Effective doses
The 100 mg serving may contribute to this limited role, but it doesn’t predict a sleep benefit.
Impact
Moderate effect
100 mg of 5-HTP relates mainly to appetite and fullness. Small trials suggest it may help reduce food intake, but the limited evidence leaves sustained weight-loss benefits uncertain.
How this product is rated for Weight Loss
Ingredient fit75
5-HTP gives the ingredient selection a clear appetite-related focus. 100 mg of 5-HTP provides partial amount support.
Goal fit
5-HTP gives the ingredient selection a clear appetite-related focus.
Dose adequacy
100 mg of 5-HTP provides partial amount support.
Pathways9
Appetite and fullness are the main connection, with limited overall depth. No pathway reaches the saved threshold for substantial coverage.
Depth
Appetite and fullness are the main connection, with limited overall depth.
Breadth
No pathway reaches the saved threshold for substantial coverage.
Evidence62
5-HTP provides the strongest evidence contribution in the saved findings, with small and limited appetite trials. The saved findings recognize the preparations of the reviewed contributors at qualifying amounts.
Evidence strength
5-HTP provides the strongest evidence contribution in the saved findings, with small and limited appetite trials.
Studied preparation
The saved findings recognize the preparations of the reviewed contributors at qualifying amounts.
Formulation logic100
No configured ingredient conflict was matched in the saved findings. All reviewed contributors meet the saved minimum amount threshold; that threshold is not a guarantee of weight loss.
Partner coverage
The reviewed contributors have no unmet partner requirement in the saved findings.
Conflicts
No configured ingredient conflict was matched in the saved findings.
Effective doses
All reviewed contributors meet the saved minimum amount threshold; that threshold is not a guarantee of weight loss.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
5-HTP (Griffonia simplicifolia) | 100 mg |
5-HTP (Griffonia simplicifolia) · 100 mg OverallScore80
Each two-capsule serving provides 100 mg of 5-HTP from Griffonia simplicifolia. The saved evaluation records a warning about serotonin-affecting medicines, and the whole-product price is about $0.34 per serving.
How this ingredient is rated
Active Ingredient Quality & Bioavailability70
The saved facts identify Griffonia simplicifolia as the source, but do not specify a 5-HTP standardization percentage.
Botanical Source & Standardization
The saved facts identify Griffonia simplicifolia as the source, but do not specify a 5-HTP standardization percentage.
Dose, Safety & Label Transparency100
A serving provides 100 mg of 5-HTP. The saved evaluation records a warning about serotonin-affecting medicines.
Dosage Potency & Range
A serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The saved evaluation records a warning about serotonin-affecting medicines.
Value60
At about $0.34 per 100 mg of 5-HTP, the whole-product price is in the middle in this comparison.
Price per 100mg 5-HTP
The whole-product price works out to about $0.34 per 100 mg of 5-HTP.
Alternative products
Report alternatives
Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
- Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
- Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
- Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
- Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
- An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
- The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
- Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
- The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
- Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
- Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.