St. John's Wort

St. John's Wort

Herb Pharm4.7 (196 ratings)
Format:Liquid Quantity: 1 Fluid Ounce · 42 servings
Goals
$15.18 $0.36 per serving

Product analysis

44 out of 100

St. John's Wort is aimed at mood support, but its unspecified extract makes the likely benefit difficult to judge. It can weaken medicines including oral contraceptives and anticoagulants, so medication interactions materially affect its suitability.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The herbal preparation is unspecified, leaving its quality uncertain. A named extract with defined contents would be easier to compare with other options.

Ingredient Transparency63

The amount of St. John’s wort is given, but the preparation is not identified. The amount alone does not show whether it matches a well-defined extract.

Value For Money40

Value cannot be judged confidently from the available price and ingredient information. The declared amount alone does not settle whether the supplement is a worthwhile buy.

Customer Satisfaction73

Customer ratings are generally positive across hundreds of ratings. The feedback describes satisfaction without establishing effectiveness or safety.

Product Focus47

The single-herb formula has a clear mood-support purpose. Everyday mood benefits remain uncertain for this preparation, and its medication interactions are a major suitability consideration.

Format
Liquid
Container
1 Fluid Ounce
Per serving
$0.36
Customer rating
4.7 · 196 ratings
Report analysis

Goals

Mood Support
Impact
Moderate effect
A- Ingredient FitF PathwaysF EvidenceA+ Formulation Logic

Whether this St. John's wort extract improves everyday mood in otherwise healthy adults is unclear. Benefits associated with defined extracts in diagnosed depression don't transfer automatically to this unspecified preparation. St. John's wort can also weaken oral contraceptives, anticoagulants and many other medicines, so medication interactions materially affect its suitability.

How this product is rated for Mood Support

Ingredient fit85

The relevance of St. John's wort to routine mood in healthy adults is uncertain and depends on the extract.
Goal fit
The relevance of St. John's wort to routine mood in healthy adults is uncertain and depends on the extract.
Dose adequacy
St. John's wort provides 633 mg per serving; this amount alone doesn't predict mood improvement.

Pathways11

The main connection concerns brain chemical signalling, without confirming a benefit from this extract.
Depth
The main connection concerns brain chemical signalling, without confirming a benefit from this extract.
Breadth
The mood connection is narrow; additional emotional effects cannot be assumed from ingredient mechanisms.

Evidence27

St. John's wort's declaration does not securely match a defined preparation associated with the benefit.
Evidence strength
The relevance of St. John's wort to routine mood in healthy adults is uncertain and depends on the extract.
Studied preparation
St. John's wort's declaration does not securely match a defined preparation associated with the benefit.

Formulation logic100

St. John's wort does not depend on a companion ingredient here. No particular conflict among the listed ingredients is identified.
Partner coverage
St. John's wort does not require another listed ingredient for its potential contribution.
Conflicts
No particular conflict among the listed ingredients is identified.
Effective doses
St. John's wort provides 633 mg per serving; this amount alone doesn't predict mood improvement.
Study evidence
Stress Relief
Impact
Lower effect
A+ Ingredient FitF PathwaysF EvidenceA+ Formulation Logic
Study evidence

Ingredients

IngredientAmount per servingScore
St. John's Wort flowering top (Hypericum perforatum) extract
633 mg 0
Gluten Free Adults 18–50
Report overview
F Composition And Label Disclosure
The saved evaluation does not record a warning for St. John's wort, which does not establish what the label says. Each serving lists 633 mg of St. John's wort.
How this ingredient is rated

Composition and Label Disclosure

Each serving lists 633 mg of St. John's wort; no composition rule was evaluated.

Composition and Label Disclosure0

The saved evaluation does not record a general or ingredient-specific warning; the package wording is not available here.
Explicit Label Detail
Neither a general nor an ingredient-specific warning is recorded in the available facts; this does not establish whether the label has one.

Commercial Price and Usability

A whole-product serving costs about $0.35; no price rule was evaluated.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  6. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  7. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  8. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  9. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  10. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort