Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis.
Trexler ET; Persky AM; Ryan ED; Schwartz TA; Stoner L; Smith-Ryan AE · Sports medicine (Auckland, N.Z.) · 2020
Meta-analysis198 participants12 studies pooledflagFitness forscienceCitrulline
- The effect of l-citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance.
Cutrufello PT; Gadomski SJ; Zavorsky GS · Journal of sports sciences · 2016
Randomized trial22 participantsflagFitness forscienceCitrulline
- Does One Shot Work? The Acute Impact of a Single Taurine Dose on Exercise Performance: A Meta-Analytic Review.
Deng H; Song T; Yin M; Xu K; Zhong Y; Liu P; Sun S; Bin Naharudin MN; Yusof A; Fan X · Scandinavian journal of medicine & science in sports · 2025
Meta-analysis308 participants23 studies pooledflagFitness forscienceTaurine
- Combined but Not Isolated Ingestion of Caffeine and Taurine Improves Wingate Sprint Performance in Female Team-Sport Athletes Habituated to Caffeine.
Karayigit R; Naderi A; Saunders B; Forbes SC; Coso JD; Berjisian E; Yildirim UC; Suzuki K · Sports (Basel, Switzerland) · 2021
Randomized trial17 participantsflagFitness forscienceTaurine
- Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.
Ghazzagh A; Naderi A; Agha-Alinejad H; Livani A; Sarlak M; Aghamohammadi S; Saunders B · International journal of sport nutrition and exercise metabolism · 2024
Randomized trial11 participantsflagFitness forscienceTaurine
- Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
De Jesus Moreno Moreno M · Clinical therapeutics · 2003
Randomized trial261 participantsflagBrain Health forscienceAlpha-GPC
- Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis.
Sagaro GG; Traini E; Amenta F · Journal of Alzheimer's disease : JAD · 2023
Meta-analysis8 studies pooledflagBrain Health flagCognitive Support forscienceAlpha-GPC
- Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial.
Lee W; Kim M · Medicine · 2024
Randomized trial119 participantsflagCognitive Support flagBrain Health forscienceAlpha-GPC
- Effect of Choline Alfoscerate on the Progression From Mild Cognitive Impairment to Dementia: Distributed Network Analysis of a Multicenter Korean Database Using a Common Data Model.
Pyun JM; Lee I; Lee K; Kim MH; Park C; Yang HJ · Dementia and neurocognitive disorders · 2024
Cohort study3,062 participantsflagCognitive Support forscienceAlpha-GPC
- Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women.
Chupel MU; Minuzzi LG; Furtado GE; Santos ML; Ferreira JP; Filaire E; Teixeira AM · Amino acids · 2021
Randomized trial48 participantsflagAnti-Aging forscienceTaurine
- Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70.
Abud GF; De Carvalho FG; Batitucci G; Travieso SG; Bueno Junior CR; Barbosa Junior F; Marchini JS; de Freitas EC · Nutrition (Burbank, Los Angeles County, Calif.) · 2022
Randomized trial24 participantsflagAnti-Aging forscienceTaurine
- Association of taurine intake with changes in physical fitness among community-dwelling middle-aged and older Japanese adults: an 8-year longitudinal study.
Domoto T; Kise K; Oyama Y; Furuya K; Kato Y; Nishita Y; Kozakai R; Otsuka R · Frontiers in nutrition · 2024
Cohort studyflagAnti-Aging forscienceTaurine
- Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study.
Rosa FT; Freitas EC; Deminice R; Jordão AA; Marchini JS · European journal of nutrition · 2015
Randomized trial24 participantsflagAnti-Inflammatory Support flagWeight Gain forscienceTaurine
- Effect of taurine supplementation on preventing ventilator-associated pneumonia in pediatrics under mechanical ventilation, a randomized controlled double-blind clinical trial.
Shirzad-Yazdi N; Shorafa E; Abootalebi SN; Heidari R; Hojabri K; Doostfatemeh M; Masjedi F; Vazin A; Shafiekhani M · Frontiers in pediatrics · 2025
Randomized trial77 participantsflagAnti-Inflammatory Support forscienceTaurine
- Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise.
Wang Y; Xu T; Zhao H; Gu C; Li Z · Frontiers in physiology · 2022
Non-randomized trial10 participantsflagAnti-Inflammatory Support forscienceTaurine
- Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women.
Chupel MU; Minuzzi LG; Furtado G; Santos ML; Hogervorst E; Filaire E; Teixeira AM · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2018
Randomized trial48 participantsflagAnti-Inflammatory Support forscienceTaurine
- Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure.
Ahmadian M; Roshan VD; Aslani E; Stannard SR · Therapeutic advances in cardiovascular disease · 2017
Randomized trialflagAnti-Inflammatory Support forscienceTaurine
- Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
Randomized trial36 participantsflagBrain Health flagCognitive Support forscienceAlpha-GPC
- Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.
Kerksick CM · Nutrients · 2024
Randomized trial20 participantsflagBrain Health flagMental Focus flagProductivity Boost forscienceAlpha-GPC
- Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis.
Xing SH; Zhu CX; Zhang R; An L · Evidence-based complementary and alternative medicine : eCAM · 2014
Meta-analysis825 participants10 studies pooledflagBrain Health flagCognitive Support forscienceHuperzine
- [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial].
Zhang Z; Wang X; Chen Q; Shu L; Wang J; Shan G · Zhonghua yi xue za zhi · 2002
Randomized trial202 participantsflagBrain Health flagCognitive Support forscienceHuperzine
- Huperzine A associated with improved early postoperative cognitive function after neurosurgery under general anesthesia: a randomized clinical trial.
Zhang Z; Shen Y; Li J; Tang Y; Zhou P; Ying T; Mo R; Ru Z; Zhao G; Zhu J; Li S; Zhao H · International journal of surgery (London, England) · 2026
Randomized trial123 participantsflagBrain Health flagCognitive Support forscienceHuperzine
- Treatment with Huperzine A improves cognition in vascular dementia patients.
Xu ZQ; Liang XM; Juan-Wu; Zhang YF; Zhu CX; Jiang XJ · Cell biochemistry and biophysics · 2012
Randomized trial78 participantsflagBrain Health forscienceHuperzine
- Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease.
Gul A; Bakht J; Mehmood F · Journal of the Chinese Medical Association : JCMA · 2019
Randomized trial100 participantsflagBrain Health forscienceHuperzine
- Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
Meta-analysis415 participants15 studies pooledflagCardiovascular Support forscienceCitrulline
- Micronutrient Supplementation to Reduce Cardiovascular Risk.
An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
Meta-analysis883,627 participants884 studies pooledflagCardiovascular Support forscienceCitrulline
- l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
Randomized trial10 participantsflagCardiovascular Support forscienceCitrulline
- Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
Randomized trial25 participantsflagCardiovascular Support flagHeart Health forscienceCitrulline
- Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
Randomized trial15 participantsflagCardiovascular Support forscienceCitrulline
- Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.
Sun Q; Wang B; Li Y; Sun F; Li P; Xia W; Zhou X; Li Q; Wang X; Chen J; Zeng X; Zhao Z; He H; Liu D; Zhu Z · Hypertension (Dallas, Tex. : 1979) · 2016
Randomized trial120 participantsflagCardiovascular Support flagHeart Health forscienceTaurine
- Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial.
Li Y; Wang Q; Liu Y; Li Q; Xia W; Lin S; Yang Q; Scholze A; Zhao Z; He H; Zhang H; Yan Z; Tepel M; Mu H; Zhu Z; Liu D · iScience · 2025
Randomized trial165 participantsflagCardiovascular Support flagHeart Health forscienceTaurine
- Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
Tzang CC; Chi LY; Lin LH; Lin TY; Chang KV; Wu WT; Özçakar L · Nutrition & diabetes · 2024
Meta-analysis1,024 participants25 studies pooledflagCardiovascular Support forscienceTaurine
- Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.
Nie Z; Liu Y; Zhang M; Wu C; Cao Q; Xu J; Zheng Y; Min Z; Zhang W; Han S · Nutrition reviews · 2025
Meta-analysis34 studies pooledflagCardiovascular Support forscienceTaurine
- The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
Maleki V; Alizadeh M; Esmaeili F; Mahdavi R · Amino acids · 2021
Randomized trial45 participantsflagCardiovascular Support forscienceTaurine
- Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial.
Neufingerl N; Zebregs YE; Schuring EA; Trautwein EA · The American journal of clinical nutrition · 2013
Randomized trial152 participantsflagCardiovascular Support forscienceTheobromine
- The Effect of Theobromine Supplementation on HDL-c Subclasses (HDL-c2, HDL-c3), HDL-c2/HDL-c3 Ratio, and Gene Expression of PPAR-α and Sirt1 in Subjects With Metabolic Syndrome: A Randomized Controlled Clinical Trial.
Sharifi-Zahabi E; Dastafkan Z; Asadi A; Hosseini-Baharanchi FS; Rezvani N; Yari S; Shidfar F · Food science & nutrition · 2025
Randomized trial80 participantsflagCardiovascular Support forscienceTheobromine
- Relationships between consumption of theobromine in cocoa products and cardiovascular risk factors in 2015-2020 National health and nutrition examination survey.
Ponsuporn W; Naumovski N; McKune AJ; Khemacheewakul J; Leksawasdi N; Rachtanapun P; Taesuwan S · European journal of nutrition · 2026
Cross-sectional study8,531 participantsflagCardiovascular Support forscienceTheobromine
- The acute effects on duodenal gene expression in healthy men following consumption of a low-fat meal enriched with theobromine or fat.
Smolders L; Mensink RP; Boekschoten MV; de Ridder RJJ; Plat J · Scientific reports · 2018
Randomized trial8 participantsflagCardiovascular Support forscienceTheobromine
- Theobromine supplementation in combination with a low-calorie diet improves cardiovascular risk factors in overweight and obese subjects with metabolic syndrome: a randomized controlled trial.
Sharifi-Zahabi E; Rezvani N; Hajizadeh-Sharafabad F; Hosseini-Baharanchi FS; Shidfar F; Rahimi M · Food & function · 2023
Randomized trial80 participantsflagCardiovascular Support forscienceTheobromine
- [Gliatilin in the Treatment of Cognitive Impairments Not Reaching the Level of Dementia: Meta-Analysis and Systematic Review].
Voznyuk IA; Nepomnyashchiy IS; Kutkova AK; Tokareva DV; Prokhorova MV; Ovdiienko OA; Shusharina NN · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2025
Meta-analysis10 studies pooledflagCognitive Support forscienceAlpha-GPC
- Vertical Association Between Dietary Total Choline and L-alpha-glycerylphosphorylcholine and the Cognitive Function in Chinese Adults Aged over 55, Result from China Health and Nutrition Survey 1997-2018.
Guan F; Jia X; Huang F; Zhang J; Wei Y; Li L; Bai J; Wang H · Nutrients · 2024
Cohort study7,659 participantsflagCognitive Support forscienceAlpha-GPC
- Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.
Zheng W; Xiang YQ; Li XB; Ungvari GS; Chiu HF; Sun F; D'Arcy C; Meng X; Xiang YT · Human psychopharmacology · 2017
Meta-analysis1,117 participants12 studies pooledflagCognitive Support forscienceHuperzine
- [Drug evaluation of huperzine A in the treatment of senile memory disorders].
Zhang RW; Tang XC; Han YY; Sang GW; Zhang YD; Ma YX; Zhang CL; Yang RM · Zhongguo yao li xue bao = Acta pharmacologica Sinica · 1992
Randomized trial56 participantsflagCognitive Support forscienceHuperzine
- Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
Randomized trial48 participantsflagEnergy forscienceCaffeine
- Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
Randomized trial26 participantsflagEnergy forscienceCaffeine
- Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
Randomized trial48 participantsflagEnergy forscienceCaffeine
- Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
Randomized trial20 participantsflagEnergy forscienceCaffeine
- Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
Fuller DT; Smith ML; Boolani A · Nutrients · 2021
Randomized trialflagEnergy forscienceCaffeine
- Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
Meta-analysis137 participants8 studies pooledflagEnergy forscienceCitrulline
- Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
Randomized trial22 participantsflagEnergy forscienceCitrulline
- Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
Randomized trial41 participantsflagEnergy forscienceCitrulline
- Citrulline/malate promotes aerobic energy production in human exercising muscle.
Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
Single-arm trial18 participantsflagEnergy forscienceCitrulline
- The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
Randomized trial12 participantsflagEnergy forscienceCitrulline
- Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis.
Wu J; Xu K; Yin M; Ding X; Wang T; Zhang Q; Wu X; Xiao N · Frontiers in nutrition · 2026
Meta-analysis226 participants20 studies pooledflagFitness forscienceCaffeine
- Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis.
Wang Z; Qiu B; Gao J; Del Coso J · Nutrients · 2023
Meta-analysis254 participants21 studies pooledflagFitness forscienceCaffeine
- Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis.
Raya-González J; Rendo-Urteaga T; Domínguez R; Castillo D; Rodríguez-Fernández A; Grgic J · Sports medicine (Auckland, N.Z.) · 2021
Meta-analysis12 studies pooledflagFitness forscienceCaffeine
- Sex Differences in the Ergogenic Response of Acute Caffeine Intake on Muscular Strength, Power and Endurance Performance in Resistance-Trained Individuals: A Randomized Controlled Trial.
Montalvo-Alonso JJ; Ferragut C; Del Val-Manzano M; Valadés D; Roberts J; Pérez-López A · Nutrients · 2024
Randomized trial76 participantsflagFitness forscienceCaffeine
- Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
Carvalho A; Marticorena FM; Grecco BH; Barreto G; Saunders B · Sports medicine (Auckland, N.Z.) · 2022
Meta-analysis60 studies pooledflagFitness forscienceCaffeine
- The Effects of Combined Exercise with Citrulline Supplementation on Body Composition and Lower Limb Function of Overweight Older Adults: A Systematic Review and Meta-Analysis.
Xie S; Li S; Shaharudin S · Journal of sports science & medicine · 2023
Meta-analysis303 participants7 studies pooledflagFitness forscienceCitrulline
- Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults.
Buckinx F; Gouspillou G; Carvalho LP; Marcangeli V; El Hajj Boutros G; Dulac M; Noirez P; Morais JA; Gaudreau P; Aubertin-Leheudre M · Journal of clinical medicine · 2020
Randomized trial56 participantsflagFitness flagMuscle Gain forscienceCitrulline
- Initial Dietary Protein Intake Influence Muscle Function Adaptations in Older Men and Women Following High-Intensity Interval Training Combined with Citrulline.
Buckinx F; Marcangeli V; Pinheiro Carvalho L; Dulac M; Hajj Boutros G; Gouspillou G; Gaudreau P; Morais J; Noirez P; Aubertin-Leheudre M · Nutrients · 2020
Randomized trial73 participantsflagFitness forscienceCitrulline
- Effects of Citrulline alone or combined with exercise on muscle mass, muscle strength, and physical performance among older adults: a systematic review.
Aubertin-Leheudre M; Buckinx F · Current opinion in clinical nutrition and metabolic care · 2021
Systematic review250 participants6 studies pooledflagFitness flagMuscle Gain forscienceCitrulline
- Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.
Wang Y; Wang Y; Qian K · Journal of sports science & medicine · 2025
Randomized trial40 participantsflagFitness forscienceCitrulline
- Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study.
Buzdağlı Y; Eyipınar CD; Öget F; Şıktar E; Forbes SC; Tekin A · Biology of sport · 2023
Randomized trial30 participantsflagFitness forscienceTaurine
- The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.
Balshaw TG; Bampouras TM; Barry TJ; Sparks SA · Amino acids · 2013
Randomized trial8 participantsflagFitness forscienceTaurine
- Effects of different doses of taurine supplementation on repeated-sprint performance after exhaustive exercise in a high temperature and humidity environment.
Cheng X; Lin Y; Li Z · Frontiers in nutrition · 2026
Randomized trial16 participantsflagFitness forscienceTaurine
- Oral taurine improves critical power and severe-intensity exercise tolerance.
Waldron M; Patterson SD; Jeffries O · Amino acids · 2020
Randomized trial12 participantsflagFitness forscienceTaurine
- Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat.
Page LK; Jeffries O; Waldron M · European journal of sport science · 2019
Randomized trial11 participantsflagFitness forscienceTaurine
- Effect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials.
Yang HH; Li XL; Zhang WG; Figueroa A; Chen LH; Qin LQ · Nutrition & metabolism · 2022
Meta-analysis8 studies pooledflagHeart Health forscienceCitrulline
- Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.
Rodríguez-Carrillo AA; Espinoza-Vargas MR; Vargas-Ortiz K; Ibarra-Reynoso LDR; Olvera-Juárez M; Gómez-Ojeda A; Garay-Sevilla ME; Figueroa A · Nutrients · 2025
Randomized trial44 participantsflagHeart Health forscienceCitrulline
- Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.
Nogimura D; Nagaoka K; Ogino K; Ogino N; Moriyasu K; Morita M · Nutrition research (New York, N.Y.) · 2026
Randomized trial66 participantsflagHeart Health forscienceCitrulline
- The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727).
Safi M; Mahjoob MP; Nateghi S; Khaheshi I; Akbarzadeh MA; Naderian M · Romanian journal of internal medicine = Revue roumaine de medecine interne · 2017
Randomized trial30 participantsflagHeart Health forscienceCitrulline
- Seafood diets: hypolipidemic and antiatherogenic effects of taurine and n-3 fatty acids.
Elvevoll EO; Eilertsen KE; Brox J; Dragnes BT; Falkenberg P; Olsen JO; Kirkhus B; Lamglait A; Østerud B · Atherosclerosis · 2009
Randomized trial80 participantsflagHeart Health forscienceTaurine
- The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials.
Guan L; Miao P · European journal of pharmacology · 2021
Meta-analysis12 studies pooledflagHeart Health forscienceTaurine
- The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis.
Waldron M; Patterson SD; Tallent J; Jeffries O · Current hypertension reports · 2019
Meta-analysis103 participants7 studies pooledflagHeart Health forscienceTaurine
- Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
Randomized trial32 participantsflagMental Focus forscienceCaffeine
- Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
Randomized trial70 participantsflagMental Focus forscienceCaffeine
- Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
Randomized trial48 participantsflagMental Focus forscienceCaffeine
- Effects of caffeine on mood and performance: a study of realistic consumption.
Brice CF; Smith AP · Psychopharmacology · 2003
Clinical trial24 participantsflagMental Focus forscienceCaffeine
- Effects of caffeine or diphenhydramine on visual vigilance.
Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
Randomized trial24 participantsflagMental Focus forscienceCaffeine
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
Meta-analysis50 studies pooledflagMental Focus forscienceTheanine
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
Randomized trialflagMental Focus flagProductivity Boost forscienceTheanine
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
Clinical trial20 participantsflagMental Focus forscienceTheanine
- Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
Randomized trial30 participantsflagMental Focus flagProductivity Boost forscienceTheanine
- Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
Randomized trial24 participantsflagMental Focus forscienceTheanine
- A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
Krieger J; Schrautemeier A; Hagele A; Gaige C; Mennemeyer O; Tolbert S; Iannotti J; Kerksick C; Noonan C; Mumford P · Nutrients · 2025
Randomized trial60 participantsflagMetabolism Boost forscienceCaffeine
- Oolong tea increases metabolic rate and fat oxidation in men.
Rumpler W; Seale J; Clevidence B; Judd J; Wiley E; Yamamoto S; Komatsu T; Sawaki T; Ishikura Y; Hosoda K · The Journal of nutrition · 2001
Randomized trial12 participantsflagMetabolism Boost forscienceCaffeine
- Effect of caffeine intake on fat oxidation rate during exercise: is there a dose-response effect?
Gutiérrez-Hellín J; Aguilar-Navarro M; Ruiz-Moreno C; Muñoz A; Varillas-Delgado D; Amaro-Gahete FJ; Del Coso J · European journal of nutrition · 2023
Randomized trial18 participantsflagMetabolism Boost forscienceCaffeine
- Comparison of changes in energy expenditure and body temperatures after caffeine consumption.
Koot P; Deurenberg P · Annals of nutrition & metabolism · 1995
Randomized trial12 participantsflagMetabolism Boost forscienceCaffeine
- Caffeine Increases Work Done above Critical Power, but Not Anaerobic Work.
Silveira R; Andrade-Souza VA; Arcoverde L; Tomazini F; Sansonio A; Bishop DJ; Bertuzzi R; Lima-Silva AE · Medicine and science in sports and exercise · 2018
Randomized trial9 participantsflagMetabolism Boost forscienceCaffeine
- The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength
David Bellar, Nina R LeBlanc, Brian Campbell · Journal of the International Society of Sports Nutrition · 2015
Randomized trial13 participantsflagMuscle Gain forscienceAlpha-GPC
- Effects of Acute Ingestion of Caffeine Capsules on Muscle Strength and Muscle Endurance: A Systematic Review and Meta-Analysis.
Wu W; Chen Z; Zhou H; Wang L; Li X; Lv Y; Sun T; Yu L · Nutrients · 2024
Meta-analysis14 studies pooledflagMuscle Gain forscienceCaffeine
- Acute caffeine intake improves muscular strength, power, and endurance performance, reversing the time-of-day effect regardless of muscle activation level in resistance-trained males: a randomized controlled trial.
Montalvo-Alonso JJ; Del Val-Manzano M; Cerezo-Telléz E; Ferragut C; Valadés D; Rodríguez-Falces J; Pérez-López A · European journal of applied physiology · 2025
Randomized trial13 participantsflagMuscle Gain forscienceCaffeine
- Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses.
Grgic J; Grgic I; Pickering C; Schoenfeld BJ; Bishop DJ; Pedisic Z · British journal of sports medicine · 2020
Systematic review21 studies pooledflagMuscle Gain forscienceCaffeine
- Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis.
Grgic J; Trexler ET; Lazinica B; Pedisic Z · Journal of the International Society of Sports Nutrition · 2018
Meta-analysis20 studies pooledflagMuscle Gain forscienceCaffeine
- Caffeine increases strength and power performance in resistance-trained females during early follicular phase.
Norum M; Risvang LC; Bjørnsen T; Dimitriou L; Rønning PO; Bjørgen M; Raastad T · Scandinavian journal of medicine & science in sports · 2021
Randomized trial15 participantsflagMuscle Gain forscienceCaffeine
- Impact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressure.
Figueroa A; Alvarez-Alvarado S; Ormsbee MJ; Madzima TA; Campbell JC; Wong A · Experimental gerontology · 2015
Randomized trial41 participantsflagMuscle Gain forscienceCitrulline
- Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes.
Figueroa A; Dillon KN; Levitt DE; Kang Y · Nutrients · 2025
Randomized trial16 participantsflagMuscle Gain forscienceCitrulline
- Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet - A pilot study.
Jourdan M; Nair KS; Carter RE; Schimke J; Ford GC; Marc J; Aussel C; Cynober L · Clinical nutrition (Edinburgh, Scotland) · 2016
Randomized trial8 participantsflagMuscle Gain forscienceCitrulline
- Treatment of dementia with neurotransmission modulation.
Doggrell SA; Evans S · Expert opinion on investigational drugs · 2004
Narrative reviewflagProductivity Boost forscienceAlpha-GPC
- Effects of caffeine on alertness.
Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
Randomized trial24 participantsflagProductivity Boost forscienceCaffeine
- Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
Randomized trial22 participantsflagProductivity Boost forscienceCaffeine
- Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
Randomized trial68 participantsflagProductivity Boost forscienceCaffeine
- A review of caffeine's effects on cognitive, physical and occupational performance.
McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
Narrative reviewflagProductivity Boost forscienceCaffeine
- Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
Meta-analysis7 studies pooledflagProductivity Boost forscienceCaffeine
- Effect of Huperzine A on Cognitive Function and Perception of Effort during Exercise: A Randomized Double-Blind Crossover Trial.
Wessinger CM; Inman CL; Weinstock J; Weiss EP · International journal of exercise science · 2025
Randomized trial15 participantsflagProductivity Boost forscienceHuperzine
- Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
Meta-analysis1,168 participants31 studies pooledflagProductivity Boost forscienceTheanine
- Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
Narrative reviewflagProductivity Boost forscienceTheanine
- Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
Randomized trial48 participantsflagProductivity Boost forscienceTheanine
- Association between coffee intake and skeletal muscle mass among U.S. adults: a population-based study.
Yin H; Zhu W; Guo L; Li W; Liang M · Frontiers in nutrition · 2024
Cross-sectional study8,333 participantsflagWeight Gain forscienceCaffeine
- Use of caffeine in 19,660 randomly selected U.S. adults: the role of overweight and obesity.
Tucker LA; Beltran F · Frontiers in nutrition · 2025
Cross-sectional study19,660 participantsflagWeight Gain forscienceCaffeine
- Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals.
Alshahrani SH; Atia YA; Badir RA; Almalki SG; Tayyib NA; Shahab S; Romero-Parra RM; Abid MK; Hussien BM; Ramaiah P · BMC endocrine disorders · 2023
Cross-sectional study488 participantsflagWeight Gain forscienceCaffeine
- Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool.
Sharp GC; Lawlor DA; Easey KE; Kundu S; Elhakeem A; Hone E; McEachan RRC; Magnus MC; Havdahl A; Relton CL · PLoS medicine · 2026
Cohort study232,139 participantsflagWeight Gain forscienceCaffeine
- Weight gain in older adolescent females: the internet, sleep, coffee, and alcohol.
Berkey CS; Rockett HR; Colditz GA · The Journal of pediatrics · 2008
Cohort study5,000 participantsflagWeight Gain forscienceCaffeine
- Effects of Citrulline Supplementation on Body Weight in Patients With Hepatobiliary Pancreatic Surgery.
Yang JA; Lee KE; Park JH; Yee J; Kim JY; Gwak HS · Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020
Cohort study138 participantsflagWeight Gain forscienceCitrulline
- Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults.
Marcangeli V; Youssef L; Dulac M; Carvalho LP; Hajj-Boutros G; Reynaud O; Guegan B; Buckinx F; Gaudreau P; Morais JA; Mauriège P; Noirez P; Aubertin-Leheudre M; Gouspillou G · Journal of cachexia, sarcopenia and muscle · 2022
Clinical trial81 participantsflagWeight Gain forscienceCitrulline
- Synergistic effect of long-term L-citruline supplementation combined with exercise on body composition in adults: A systematic review and meta-analysis of randomized controlled trials.
Wang W; Cai S; Liu K; Luo P · Complementary therapies in medicine · 2026
Meta-analysis9 studies pooledflagWeight Gain forscienceCitrulline
- Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis.
Ashtary-Larky D; Mohammadi S; Mousavi SAH; Hajizadeh L; Candow DG; Forbes SC; Afrisham R; Farrokhi V; Antonio J; Suzuki K · Nutrients · 2025
Meta-analysis21 studies pooledflagWeight Gain forscienceCitrulline
- Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial.
Bouillanne O; Melchior JC; Faure C; Paul M; Canouï-Poitrine F; Boirie Y; Chevenne D; Forasassi C; Guery E; Herbaud S; Le Corvoisier P; Neveux N; Nivet-Antoine V; Astier A; Raynaud-Simon A; Walrand S; Cynober L; Aussel C · Clinical nutrition (Edinburgh, Scotland) · 2020
Randomized trial24 participantsflagWeight Gain forscienceCitrulline
- Effect of taurine supplementation on growth and development in preterm or low birth weight infants.
Verner A; Craig S; McGuire W · The Cochrane database of systematic reviews · 2008
Meta-analysis189 participants9 studies pooledflagWeight Gain forscienceTaurine
- Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis.
Cao SL; Jiang H; Niu SP; Wang XH; Du S · Indian journal of pediatrics · 2018
Meta-analysis216 participants9 studies pooledflagWeight Gain forscienceTaurine
- Taurine and cholesterol supplementation in the term infant: responses of growth and metabolism.
Rassin DK; Räihä NC; Minoli I; Moro G · JPEN. Journal of parenteral and enteral nutrition · 1990
Non-randomized trialflagWeight Gain forscienceTaurine
- Taurine supplementation prevents hyperaminoacidemia in growing term infants fed high-protein cow's milk formula.
Räihä NC; Fazzolari-Nesci A; Boehm G · Acta paediatrica (Oslo, Norway : 1992) · 1997
Randomized trialflagWeight Gain forscienceTaurine
- Changes in caffeine intake and long-term weight change in men and women.
Lopez-Garcia E; van Dam RM; Rajpathak S; Willett WC; Manson JE; Hu FB · The American journal of clinical nutrition · 2006
Cohort study58,157 participantsflagWeight Loss forscienceCaffeine
- Does caffeine ingestion before a short-term sprint interval training promote body fat loss?
Ferreira GA; Felippe LC; Bertuzzi R; Bishop DJ; Ramos IS; De-Oliveira FR; Lima-Silva AE · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2020
Randomized trial20 participantsflagWeight Loss forscienceCaffeine
- Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.
Zhiang J; Song Q · Physiological research · 2026
Randomized trial30 participantsflagWeight Loss forscienceCaffeine
- Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss.
Davoodi SH; Hajimiresmaiel SJ; Ajami M; Mohseni-Bandpei A; Ayatollahi SA; Dowlatshahi K; Javedan G; Pazoki-Toroudi H · Iranian journal of pharmaceutical research : IJPR · 2014
Non-randomized trial60 participantsflagWeight Loss forscienceCaffeine
- The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.
Tabrizi R; Saneei P; Lankarani KB; Akbari M; Kolahdooz F; Esmaillzadeh A; Nadi-Ravandi S; Mazoochi M; Asemi Z · Critical reviews in food science and nutrition · 2020
Meta-analysis606 participants13 studies pooledflagWeight Loss forscienceCaffeine