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Clincally Advanced Hair Skin & Nails

NOW Solutions
4.7
★ ★ ★ ★ ★
(5108 ratings)
Keratin 500 mg
Copper 2 mg
Proline 100 mg
Thiamin 10 mg
Biotin 300 mcg
Choline 25 mg
Riboflavin 10 mg
Product Image
Score82
A purposeful keratin-and-MSM core with chelated zinc and copper makes this a strong hair and nail formula. Horsetail disclosure and several minor extras are less convincing.
How scoring works
Quantity:90 Capsule(s) • (30 servings)
Goals:
Hair Health
Nail Health
Energy

Score 82

A purposeful keratin-and-MSM core with chelated zinc and copper makes this a strong hair and nail formula. Horsetail disclosure and several minor extras are less convincing.
How scoring works
$16.00($0.53 per serving)
iHerb
$ 20.20
Pure Formulas
$ 18.19
Vitacost
$ 21.07
Daily Vita
$ 19.10
iHerb
$ 20.20
Amazon
$ 16.00
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Analysis

The strongest feature is 500 mg Cynatine HNS solubilized keratin, paired with 500 mg MSM, 100 mg proline, and 200 mg gelatin. These ingredients directly support the structural focus rather than relying only on a high biotin amount.

Zinc and copper use bisglycinate forms, while vitamin C, vitamin E, folate, B vitamins, and biotin provide useful nutritional cofactors. Hyaluronic acid adds a skin-oriented element, although choline and inositol are too small for focused use.

The formula is best matched to hair and nail goals, where its keratin-centered design is most relevant. Three capsules per serving and missing silica-yield information for horsetail are the main practical and disclosure drawbacks.

Who is it for
  • Adults seeking targeted hair and nail support
  • Users who want keratin rather than biotin alone
  • People comfortable with a three-capsule serving
Best for
  • Hair structure support
  • Brittle or weak nails
  • Combining keratin with MSM and mineral cofactors

Pros

  • Provides 500 mg solubilized keratin
  • Includes 500 mg MSM and 100 mg proline
  • Uses chelated zinc and copper
  • Biotin amount is moderate rather than excessive
  • Methylcobalamin is included

Cons

  • Horsetail silica yield is not stated
  • Requires three capsules per serving
  • Choline and inositol amounts are too small for focused support
  • Gelatin makes the formula unsuitable for vegetarians

Warnings

  • Beef gelatin makes the capsules unsuitable for vegetarian or vegan diets
  • Biotin can interfere with some laboratory tests, so the 300 mcg amount should be disclosed before testing
  • Zinc may cause nausea if the capsules are taken without food

Nutrient quality

90 Highest impact

Full-dose solubilized keratin and complementary structural nutrients provide a strong, focused formula. Chelated minerals add quality, while the lightly characterized horsetail is the main weakness.

Ingredient transparency

78 High impact

All listed active ingredients have specific amounts and no proprietary blend hides the formula. Horsetail specifications, complete directions, and non-active capsule ingredients remain incomplete.

Customer satisfaction

73 High impact

The supplied satisfaction metric is strong and response volume is very large. Specific firsthand feedback was not supplied, so recurring complaints and purpose alignment remain uncertain.

Value for money

84 Highest impact

A full-dose branded keratin core and favorable serving cost support strong value. The focused formula compares well with similar beauty supplements despite requiring three capsules.

Report analysis

Goals

Hair Health
Hair Health
Impact
Highest effect
A Goal FitA Strength of SupportA CoverageA Formula Quality
Biotin · 300 mcgZinc · 15 mgVitamin C · 60 mgKeratin · 500 mg

Full-dose solubilized keratin gives the formula strong structural relevance, while MSM, proline, vitamin C, zinc, copper, and biotin support keratin and connective-tissue pathways. The branded keratin has unusually strong product-specific form and dose evidence.

The formula also covers mineral cofactors and antioxidant support without relying on a large proprietary blend. Horsetail lacks silica-yield details, but that limitation is minor beside the well-characterized keratin and chelated minerals.

Study evidence
Biotin Supportive 4 studies
Copper Adverse 4 studies
Horsetail Not classified

No linked studies yet.

Keratin Disputed 14 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Nail Health
Nail Health
Impact
Highest effect
A Goal FitA Strength of SupportA CoverageA Formula Quality
Biotin · 300 mcgHorsetail · 100 mgKeratin · 500 mg

Solubilized keratin, MSM, biotin, zinc, gelatin, proline, vitamin C, and horsetail create a highly targeted nail formula. Branded Cynatine HNS supplies a direct nail structural protein at its full reference amount.

Horsetail does not disclose silica standardization, and the three-capsule serving is the main practical trade-off. The strong structural core still makes the product well suited to brittle or weak nails.

Study evidence
Biotin Supportive 8 studies
Horsetail Not classified

No linked studies yet.

Keratin Adverse 7 studies
Vitamin C Supportive 1 study
Zinc No effect 1 study
Energy
Essential Energy Nutrients
Energy
Impact
Moderate effect
C Goal FitC Strength of SupportD- CoverageF Formula Quality
Vitamin B5 · 14 mgRiboflavin · 10 mgThiamin · 10 mgVitamin B12 · 100 mcg

B vitamins support normal metabolism, but the formula is primarily designed for hair, skin, and nails. Methylcobalamin and several moderate B-vitamin amounts provide basic nutritional energy support.

B12 remains below the stated focused target, and the keratin, MSM, gelatin, and beauty ingredients do not add energy pathways. The large hair-focused component therefore dilutes the formula’s usefulness for fatigue or stamina.

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 1500 mcg
Vitamin C (Ascorbic Acid)
 60 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 20 mg
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 10 mg
Riboflavin (Vitamin B2)
 10 mg
Niacin (Niacinamide, Vitamin B3)
 18 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
Folate
680 mcg DFE
Vitamin B12 (Methylcobalamin)
 100 mcg
Biotin
300 mcg
Pantothenic Acid (Calcium Pantothenate)
 14 mg
Choline (Choline Bitartrate)
 25 mg
Zinc (Zinc Bisglycinate)
 15 mg
Copper (Copper Bisglycinate)
 2 mg
Cynatine HNS
500 mg
MSM
500 mg
Beef Gelatin
200 mg
L-Proline
100 mg
Horsetail
100 mg
Hyaluronic Acid (Sodium Hyaluronate)
 50 mg
Inositol
25 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Keratin · 500 mg OverallScore100
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Branded Cynatine HNS provides a solubilized keratin form at the full reference dose. The exact amount is easy to verify, and the serving cost is favorable for the active quality delivered. The three-capsule serving is the main practical trade-off.

View ingredientView products
Copper (Copper Bisglycinate) · 2 mg OverallScore88
A+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value

copper bisglycinate is a premium amino acid chelate with strong absorption potential, and the 2 mg dose exactly matches the collection median. The zinc-to-copper ratio sits just below the preferred range. The serving cost is moderately high, which leaves value mixed.

View ingredientView products
Proline · 100 mg OverallScore68
A+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

Isolated L-proline provides a clearly identified, readily usable form for structural support. The moderate dose fits a broad hair, skin, and nail formula but remains below a targeted high-dose product. Vegetable capsules preserve ingredient integrity, while the cost per equivalent proline amount is high.

View ingredientView products
Loading alternative details
87 Performance

Keratin Hair Booster

Reserveage Nutrition
<p>A meaningful keratin amount and high biotin align directly with hair and nail structure. Basic zinc and copper forms plus a small hidden blend make it less complete than the original’s keratin, MSM, proline, and chelated-mineral combination.</p>
85 Performance

Tres Beauty 3

Reserveage Beauty
<p>Meaningful collagen and soluble keratin provide a strong structural focus for hair and nails. Basic mineral forms, partially described branded blends, and a high serving cost limit transparency and value.</p>
79 Performance

Liquid Collagen

Applied Nutrition
<p>Hydrolyzed collagen, silica, and biotin create a useful liquid beauty core that broadens structural support beyond keratin alone. Missing collagen source details and an opaque antioxidant blend make the formula less transparent.</p>
82 Budget

Heavenly Hair Tropical Citrus

OLLY
<p>D-biotin, zinc citrate, silica, horsetail, keratin, and amla closely match the hair and nail goal at similar serving cost. Keratin and botanicals are light, and high biotin can interfere with laboratory tests.</p>
76 Budget

Longer Stronger Hair and Nails

Irwin Naturals
<p>Buffered vitamin C, useful mineral forms, biotin, horsetail, amino acids, and flax oil offer a close hair-focused comparison. No eligible option is truly cheaper than the original, and this formula uses more modest structural amino acids.</p>
61 Budget

Mega-Liposomal B-Complex+ Organic Fruit Flavor

Aurora NutraScience
<p>Activated riboflavin and methylcobalamin provide a liquid nutrient option near the original’s serving cost. It lacks keratin, MSM, proline, and the original’s structural focus, so it is not a direct beauty replacement.</p>
78 Value

Longer Stronger Hair and Nails

Irwin Naturals
<p>Buffered vitamin C, useful mineral forms, biotin, horsetail, amino acids, and flax oil provide a practical hair-focused alternative. It costs more per serving and uses modest lysine and proline, but keeps active amounts largely visible.</p>
75 Value

Keratin Hair Booster

Reserveage Nutrition
<p>Meaningful keratin and high biotin directly support hair and nail goals in a simpler formula. Basic mineral forms and premium serving cost weaken the quality-to-cost trade-off compared with the original.</p>
63 Value

Liquid Morning Multivitamin Raspberry

Mary Ruth's
<p>Methylfolate, methylcobalamin, vitamin D3, natural vitamin E, and zinc citrate provide broad liquid nutrition. The formula lacks the original’s keratin, MSM, and proline, while carbohydrate and duplicate label values reduce value.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health forBiotin
  2. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper
  5. Trace element levels in alopecia areata.
    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
  6. UV damage to hair and the effect of antioxidants and metal chelators.
    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  7. The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Clinical Study in Healthy Women.
    Tursi F; Nobile V; Cestone E; De Ponti I; Lepoudere A; Sergheraert R; Soulard JP · Journal of cosmetic dermatology · 2025
    Randomized trialHair Health Nail Health forKeratin
  8. Halloysite/Keratin Nanocomposite for Human Hair Photoprotection Coating.
    Cavallaro G; Milioto S; Konnova S; Fakhrullina G; Akhatova F; Lazzara G; Fakhrullin R; Lvov Y · ACS applied materials & interfaces · 2021
    In vitro / ex vivo studyHair Health forKeratin
  9. A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.
    Winter H; Labrèze C; Chapalain V; Surlève-Bazeille JE; Mercier M; Rogers MA; Taieb A; Schweizer J · The Journal of investigative dermatology · 1998
    Case series3 participantsHair Health forKeratin
  10. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  11. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  12. Brittle nails: response to daily biotin supplementation.
    Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
    Case series35 participantsNail Health forBiotin
  13. Comparative Analysis of Type I Keratin Expression By Nail Consistency: An Immunohistochemistry Study.
    Mingorance Álvarez E; Rodríguez-León J; Pérez Pico AM; Mayordomo R · Applied immunohistochemistry & molecular morphology : AIMM · 2022
    Cross-sectional study32 participantsNail Health forKeratin
  14. Exposure to toxic agents alters organic elemental composition in human fingernails.
    Schumacher E; Dindorf W; Dittmar M · The Science of the total environment · 2009
    Cross-sectional study120 participantsNail Health forKeratin
  15. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  16. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  17. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial.
    Tenore GC; Caruso D; Buonomo G; D'Avino M; Santamaria R; Irace C; Piccolo M; Maisto M; Novellino E · Journal of medicinal food · 2018
    Randomized trialHair Health forKeratin
  18. Keratin/alginate hybrid hydrogels filled with halloysite clay nanotubes for protective treatment of human hair.
    Cavallaro G; Caruso MR; Milioto S; Fakhrullin R; Lazzara G · International journal of biological macromolecules · 2022
    In vitro / ex vivo studyHair Health forKeratin
  19. Patient Satisfaction and Adverse Effects Following the use of Topical Hair Fiber Fillers.
    Babadjouni A; Juhasz M; Pham C; Csuka E; Hedayati B; Evron E; Mesinkovska NA · International journal of trichology · 2024
    Cross-sectional study40 participantsHair Health forKeratin
  20. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  21. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  22. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  23. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  24. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  25. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  26. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  27. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  28. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  29. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  30. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  31. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin Nail Health forZinc
  32. Human keratin diseases: hereditary fragility of specific epithelial tissues.
    Corden LD; McLean WH · Experimental dermatology · 1997
    Narrative reviewNail Health forKeratin
  33. Phenotype and genotype features of Vietnamese children with pachyonychia congenita.
    Chu HT; Dinh Duong TA; Le DH; Le TV; Nguyen BB; Dang CV; Vu QV · Pediatrics and neonatology · 2023
    Case series7 participantsNail Health forKeratin
  34. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C