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Glutathione Booster

Carlson
4.7
★ ★ ★ ★ ★
(1259 ratings)
Selenium 200 mcg
Glycine 50 mg
Milk Thistle 140 mg
Product Image
Score73
A lower-commitment antioxidant blend with NAC, selenium, vitamin C, and several supporting ingredients. Its modest precursor doses and limited standardization make it supportive rather than intensive.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Immunity
General Health

Score 73

A lower-commitment antioxidant blend with NAC, selenium, vitamin C, and several supporting ingredients. Its modest precursor doses and limited standardization make it supportive rather than intensive.
How scoring works
$16.90($0.56 per serving)
Walmart
$ 18.25
iHerb
$ 16.90
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Analysis

NAC, glycine, and glutamine contribute building blocks linked with glutathione metabolism. Vitamin C, selenomethionine, alpha-lipoic acid, milk thistle, and garlic widen antioxidant coverage, while direct glutathione is present only in a small amount.

Two capsules are practical and the active amounts are clearly listed. The core amino acids are much lower than dedicated powders, and the supplied milk thistle and garlic details do not establish standardized actives.

The smaller bottle makes sense for users who want to test tolerance before committing to a longer supply. Value and potency remain ordinary when compared with focused NAC or glycine products.

Who is it for
  • Adults trying a glutathione-support formula
  • Users wanting a shorter supply
  • People seeking NAC with selenium
Best for
  • Trying a multi-pathway antioxidant blend
  • General glutathione support
  • Shorter-term supplementation

Pros

  • Includes NAC and selenomethionine
  • Adds vitamin C and alpha-lipoic acid
  • Two-capsule serving
  • Smaller bottle reduces commitment

Cons

  • NAC and amino-acid amounts are moderate
  • Direct glutathione amount is small
  • Botanical standardization is unclear
  • Value is not exceptional

Warnings

  • The 200 mcg selenium amount needs to be counted with all other selenium sources.
  • Garlic may increase bleeding tendency with anticoagulant or antiplatelet medicines.
  • Alpha-lipoic acid can lower blood glucose and may interact with diabetes treatment.
  • NAC can worsen headache or low blood pressure with nitroglycerin.

Nutrient quality

71 High impact

Selenomethionine and N-acetyl cysteine are useful forms, while milk thistle, garlic, and glutathione forms are not specified. Vitamin C and selenium are meaningful, but N-acetyl cysteine, glycine, glutamine, glutathione, and alpha lipoic acid are modest.

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Ingredient transparency

81 Highest impact

Every listed active has a specific amount. Serving count is available, but complete daily use directions are not supplied.

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Customer satisfaction

72 High impact

The aggregate rating is strong and supported by large rating volume. No specific feedback was supplied to judge repeated complaints or fit with the intended use.

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Value for money

67 High impact

The broad formula partly supports the asking price, though dose depth is uneven. Each serving provides several antioxidant pathways at reasonable cost efficiency.

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Goals

Immunity
Impact
High effect
B Goal FitC Strength of SupportB- CoverageC Formula Quality
Vitamin C · 200 mgSelenium · 200 mcg

Selenium, vitamin C, and N-acetyl cysteine support antioxidant defenses that help normal immune function. The broad formula touches several related pathways, but many supporting ingredients are too small to carry much weight.

Selenomethionine is supplied at a useful amount, while vitamin C falls below the stronger immune-support target used here. Low glutathione, amino acid, and botanical amounts make the formula less convincing than its long ingredient list suggests.

Study evidence
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
General Health
Impact
Moderate effect
C+ Goal FitC- Strength of SupportC CoverageC Formula Quality
Glycine · 50 mgSelenium · 200 mcgVitamin C · 200 mg

The blend targets antioxidant support through vitamin C, selenium, N-acetyl cysteine, and several complementary compounds. Its strongest contributions come from the clearly disclosed selenium and vitamin C rather than the long ingredient list.

Many supporting actives are present in modest or token amounts, including the small glutathione amount and limited N-acetyl cysteine. The substantial selenium amount can accumulate when combined with other selenium products, and garlic may increase bleeding tendency with anticoagulants.

Study evidence
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin C (Ascorbic Acid)
200 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
67 mcg
Riboflavin (Vitamin B2)
5 mg
Selenium (Selenomethionine)
200 mcg
N-Acetyl Cysteine
200 mg
Milk Thistle extract
140 mg
Garlic
100 mg
Alpha Lipoic Acid
50 mg
L-Glutamine
50 mg
L-Glycine
50 mg
Asparagus concentrate
25 mg
Glutathione
20 mg
Gluten Free Adults 18–50
Report overview
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Selenomethionine supplies a well-targeted amount in an organic form, but the label does not identify its active isomer. The dose leaves a practical margin below the upper intake limit. Value is limited when judged on selenium alone, although the formula is designed as a broader combination.

Glycine · 50 mg OverallScore59
C+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

The formula supplies only 50 mg of L-glycine, making it poorly suited to a glycine-focused sleep goal. The capsule and clear amount disclosure are useful, but source purity and excipient quality are not verified. Multiple antioxidant-related ingredients add context, yet glycine cost efficiency remains weak.

Milk Thistle · 140 mg OverallScore15
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The extract amount is listed, but the missing silymarin percentage prevents confirmation of active potency. Standard capsules and an unidentified plant part add further uncertainty. Its serving cost is above the collection norm without premium delivery or clear standardization.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium supplementation for the primary prevention of cardiovascular disease.
    Rees K; Hartley L; Day C; Flowers N; Clarke A; Stranges S · The Cochrane database of systematic reviews · 2013
    Meta-analysis19,715 participants12 studies pooledGeneral Health forSelenium
  2. Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial.
    Rayman MP; Winther KH; Pastor-Barriuso R; Cold F; Thvilum M; Stranges S; Guallar E; Cold S · Free radical biology & medicine · 2019
    Randomized trial491 participantsGeneral Health forSelenium
  3. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  4. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  5. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  6. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  7. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  8. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  9. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  10. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  11. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  12. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  13. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  14. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  15. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  16. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  17. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  18. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  19. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  20. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  21. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  22. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C