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Niacin Inositol Hexanicotinate 500 mg

Nature's Bounty
4.8
★ ★ ★ ★ ★
(237 ratings)
Niacin 400 mg
Product Image
Score79
A transparent no-flush niacin complex with disclosed niacin and inositol components. It suits tolerance-focused B3 use more than lipid-focused heart support.
How scoring works
Quantity:120 Capsule(s) • (120 servings)
Goals:
Skin Health
Heart Health

Score 79

A transparent no-flush niacin complex with disclosed niacin and inositol components. It suits tolerance-focused B3 use more than lipid-focused heart support.
How scoring works
$16.53($0.13 per serving)
Vitacost
$ 22.04
Vitacost
$ 22.04
iHerb
$ 16.53
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Analysis

The formula clearly names inositol hexanicotinate rather than relying on vague no-flush wording. Component amounts are also shown, which improves label clarity.

This form generally favors tolerance by releasing niacin differently from nicotinic acid. It can support vitamin B3 intake but should not be assumed to provide the same lipid-related effects.

The long capsule supply is practical for users who already prefer no-flush niacin. The amount remains well beyond basic daily needs, so more is not automatically better for skin or general wellness.

Who is it for
  • Adults who want a clearly named no-flush form
  • People sensitive to nicotinic acid flushing
  • Users seeking a long capsule supply
Best for
  • No-flush niacin routines
  • General vitamin B3 supplementation
  • Tolerance-focused use

Pros

  • Clearly names inositol hexanicotinate
  • Component amounts are disclosed
  • Lower flushing potential

Cons

  • Less reliable for lipid-focused effects
  • High amount exceeds nutritional needs
  • Limited advantage for skin support

Warnings

  • Do not assume this form provides nicotinic acid's lipid effects.
  • Large no-flush niacin servings may still cause stomach upset or affect liver markers over time.
  • Avoid combining it with another high-dose niacin product without checking the total.

Nutrient quality

82 Highest impact

Inositol hexanicotinate is a clearly named no-flush niacin derivative. The amount is meaningful for this less direct niacin form.

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Ingredient transparency

81 Highest impact

All meaningful active amounts are clearly disclosed. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

67 High impact

The aggregate satisfaction measure is strong and supported by adequate volume. Missing feedback themes leave recurring complaints and purpose fit uncertain.

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Value for money

85 Highest impact

The price is reasonable for the formula quality and dose. Each serving provides good cost efficiency.

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Report analysis

Goals

Skin Health
Skin Health
Impact
Moderate effect
F Goal FitC Strength of SupportD- CoverageB- Formula Quality

Inositol hexanicotinate supplies a substantial no-flush niacin derivative, but it is not the niacinamide form most closely tied to skin barrier support. Its skin relevance is therefore indirect and less certain.

The simple formula may support general niacin status without directly covering collagen, hydration, or antioxidant defense. Clear amounts are a strength, while evidence for this specific oral form improving skin outcomes remains weak.

Study evidence
Niacin Supportive 61 studies
Heart Health
Heart Health
Impact
Moderate effect
D- Goal FitD+ Strength of SupportF CoverageA- Formula Quality

Inositol hexanicotinate is a no-flush niacin derivative with a plausible lipid-management role. It is not equivalent to well-studied nicotinic acid, and evidence for comparable cardiovascular effects is limited.

The 400 mg niacin amount is substantial and the chemical form is clearly disclosed. The focused formula is easy to assess, but it should not be treated as a substitute for clinician-managed lipid therapy.

Study evidence
Niacin Supportive 105 studies

Ingredients

IngredientAmount per serving
Niacin (Inositol Hexanicotinate)
 400 mg
Inositol (Inositol Hexanicotinate)
 100 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Niacin (Inositol Hexanicotinate) · 400 mg OverallScore88
B Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

Inositol hexanicotinate provides a substantial amount of a no-flush niacin derivative suited to cardiovascular-oriented use. It may require more material than nicotinic acid to achieve comparable effects, but the supplied amount is meaningful. The capsule is basic, while its serving cost is favorable for this form.

View ingredientView products
Loading alternative details
82 Performance

No Flush Niacin (Inositol Hexanicotinate) 800 mg

Life Extension
<p>Clearly named inositol hexanicotinate provides substantial flush-free niacin exposure with economical serving value. Compared with the original, it preserves the comfort-focused intent with a clearly identified and easier-to-assess vitamin B3 approach; however, its cardiovascular effects may be less direct and reliable than those of nicotinic acid.</p>
80 Performance

No Flush Niacin 500 mg

Natural Factors
<p>Transparent inositol hexaniacinate provides a substantial no-flush serving at practical cost. Compared with the original, it preserves the comfort-focused intent with a clearly identified and easier-to-assess vitamin B3 approach; however, the form may release niacin less directly than nicotinic acid and is not an equivalent lipid-focused option.</p>
80 Performance

No-Flush Niacin (Inositol Hexanicotinate) 500 mg

Solgar
<p>Clearly identified inositol hexanicotinate supports a comfort-focused no-flush approach with good serving value. Compared with the original, it preserves the comfort-focused intent with a clearly identified and easier-to-assess vitamin B3 approach; however, the form is less direct than nicotinic acid for cardiovascular purposes.</p>
86 Budget

Niacinamide B-3 100 mg

Source Naturals
<p>A clearly identified moderate niacinamide tablet offers simple non-flushing vitamin B3 support with excellent serving economics. Serving cost is lower than the original, but it does not provide nicotinic acid’s lipid-focused effects and complete excipient details are missing.</p>
82 Budget

Niacinamide 500 mg

NOW
<p>A simple niacinamide capsule provides clearly named non-flushing vitamin B3 with strong skin-goal alignment. Serving cost is lower than the original, but the amount remains high for routine nutrition and does not offer nicotinic acid’s lipid-related effects.</p>
80 Budget

Niacinamide 500 mg

Best Naturals
<p>Clearly identified niacinamide provides a non-flushing option with useful skin and NAD-metabolism alignment. Serving cost is lower than the original, but the amount is well above basic nutritional needs and is not equivalent to nicotinic acid for lipid-focused use.</p>
73 Value

No-Flush Niacin 500 mg

Source Naturals
<p>Inositol hexanicotinate offers a clearly identified flush-free vitamin B3 approach. Its lower serving cost and clearer active design support practical value compared with the original, although the released niacin amount and lipid-related benefit are less certain than with nicotinic acid.</p>
76 Value

Flush-Free Niacin 500 mg

Bluebonnet
<p>A named inositol hexanicotinate capsule provides a generally comfortable flush-free option. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although the form has less reliable lipid-related effects and weaker value than several simpler alternatives.</p>
80 Value

Niacinamide

Thorne
<p>Clearly identified niacinamide provides a simple non-flushing option with strong skin-purpose alignment. Its lower serving cost and clearer active design support practical value compared with the original, although the amount is well above basic nutritional needs and is not a direct cardiovascular niacin substitute.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  2. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health Cardiovascular Support forNiacin
  3. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  4. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledHeart Health Cardiovascular Support forNiacin
  5. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  6. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  7. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  8. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  9. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  10. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  11. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  12. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  13. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsHeart Health Cardiovascular Support forNiacin
  14. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  15. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  16. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  17. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  18. Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials.
    Xiang D; Zhang Q; Wang YT · Medicine · 2020
    Meta-analysis2,110 participants8 studies pooledCardiovascular Support forNiacin
  19. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  20. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  21. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy.
    Philpott AC; Hubacek J; Sun YC; Hillard D; Anderson TJ · Atherosclerosis · 2013
    Randomized trial66 participantsCardiovascular Support forNiacin
  22. Niacin intake and risk of skin cancer in US women and men.
    Park SM; Li T; Wu S; Li WQ; Weinstock M; Qureshi AA; Cho E · International journal of cancer · 2017
    Cohort study114,116 participantsSkin Health forNiacin
  23. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  24. Effects of HDL-modifiers on cardiovascular outcomes: a meta-analysis of randomized trials.
    Verdoia M; Schaffer A; Suryapranata H; De Luca G · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015
    Meta-analysis69,515 participants18 studies pooledCardiovascular Support forNiacin
  25. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  26. Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.
    Teo KK; Goldstein LB; Chaitman BR; Grant S; Weintraub WS; Anderson DC; Sila CA; Cruz-Flores S; Padley RJ; Kostuk WJ; Boden WE; AIM-HIGH Investigators · Stroke · 2013
    Randomized trial3,414 participantsHeart Health forNiacin
  27. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  28. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  29. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin