No Flush Niacin 500 mg
Natural Factors
No Flush Niacin 500 mg
4.6
★ ★ ★ ★ ★
(901 ratings)
Niacin 500 mg
Score 78.0
A well-priced no-flush niacin (inositol hexanicotinate) from a trusted brand, good for general B3 benefits, but less effective for specific cholesterol management.
Quantity: 90 Capsule(s)Servings size: 1 Capsule(s) (90 servings)
Selected goals:
Other goals:
Mood Support
Stress Relief
Brain Health
Heart Health
Skin Health
leaderboard Score 78.0
A well-priced no-flush niacin (inositol hexanicotinate) from a trusted brand, good for general B3 benefits, but less effective for specific cholesterol management.
insights Analysis
This Natural Factors supplement offers niacin in its inositol hexanicotinate form, specifically chosen to bypass the typical skin flushing associated with conventional niacin. It serves as an excellent source of Vitamin B3, supporting essential bodily functions such as energy production, metabolic processes, and maintaining healthy skin. However, like other no-flush niacins, it generally doesn't deliver the same potent cholesterol-lowering effects as nicotinic acid, a distinction important for those specifically seeking lipid management. Despite this, its favorable price per serving and substantial positive reviews make it a commendable option for daily B3 supplementation without discomfort.
- Effectively prevents the uncomfortable 'niacin flush' experienced with other forms.
- Offers good value within the no-flush niacin category with a competitive price per serving.
- Benefits from a high volume of positive online reviews, indicating user satisfaction and efficacy.
- Less potent for significant cholesterol lowering compared to traditional nicotinic acid.
- While 'no-flush', its form means a portion of the dosage is inositol, not active niacin.
- Some users may find the 500mg dose high for their individual needs if not specifically targeting higher intake.
$16.07($0.17 per serving)
 iHerb | $ 16.07 | |
 Vitacost | $ 16.07 |
bolt Effectiveness for goals
Niacin is known as one of the most effective agents for increasing high-density lipoprotein (HDL) cholesterol levels. It can significantly raise HDL, which is often considered beneficial for cardiovascular health. However, studies have shown that this increase in HDL does not always translate to a reduction in cardiovascular events.
While Niacin can contribute to lowering LDL cholesterol, its primary effect on lipids is typically a more significant reduction in triglycerides and an increase in HDL cholesterol. For LDL reduction, it is generally considered less potent than statins and often used in conjunction with other lipid-lowering therapies if prescribed.
Yes, Niacin is highly effective at reducing elevated triglyceride levels. It achieves this by decreasing the liver's production of very low-density lipoprotein (VLDL), which is a precursor to triglycerides and LDL cholesterol. This makes it a common consideration for individuals with hypertriglyceridemia.
Niacin, also known as vitamin B3, is primarily recognized for its role in preventing and treating pellagra, a deficiency disease. In supplement form, it has been extensively studied for its effects on cholesterol and triglyceride levels. Its physiological functions include energy metabolism and DNA repair.
Niacin can be used in combination with statins to further improve lipid profiles, particularly to increase HDL and lower triglycerides. However, some studies have shown that adding Niacin to statin therapy does not consistently provide additional cardiovascular benefits and may increase the risk of side effects such as myopathy (muscle pain) when taken with certain statins. Medical supervision is essential for this combination.
schedule Dosage, timing & forms
Nicotinic acid is the form most commonly associated with the 'niacin flush' and is often used at higher doses for specific health support under medical supervision. Niacinamide (nicotinamide) generally does not cause flushing and is often preferred for general vitamin B3 supplementation, though it has different metabolic effects compared to nicotinic acid. Their applications can differ significantly.
'Flush-free' niacin, often inositol hexanicotinate, is a form where niacin is chemically bound to inositol, a sugar-like compound. This bond leads to a slow, gradual release of niacin in the body, significantly reducing or eliminating the rapid vasodilation that causes the common flushing sensation. It's often chosen by individuals sensitive to the flush.
To minimize the niacin flush from immediate-release nicotinic acid, individuals can start with a very low dose and gradually increase it over time. Taking it with a non-fatty meal, avoiding hot beverages or alcohol around the time of dosing, and potentially taking aspirin 30 minutes beforehand (if medically appropriate and advised) can also help. Slow and steady increases in dosage are key.
Immediate-release niacin (nicotinic acid) is absorbed quickly, leading to a rapid peak effect and often a pronounced, but temporary, flush. Extended-release forms are designed to release niacin slowly over several hours, which can help reduce the intensity and duration of the flush and may allow for less frequent dosing. The slower release aims to improve tolerance.
Niacin is available in several forms, including nicotinic acid (immediate-release and extended-release), niacinamide (nicotinamide), and inositol hexanicotinate (often marketed as 'no-flush' niacin). Each form has distinct properties and effects within the body. The choice of form can influence how it is absorbed and its potential side effects.
health_and_safety Safety & interactions
The niacin flush is a common side effect characterized by redness, itching, warmth, and tingling, primarily on the face, neck, and chest. It is caused by the release of prostaglandins, which dilate blood vessels. Taking niacin with food, starting with a low dose and gradually increasing it, or taking a low-dose aspirin before niacin may help reduce the flush.
High doses of niacin, particularly sustained-release forms, have been associated with elevated liver enzymes and, in rare cases, liver toxicity. Regular monitoring of liver function by a healthcare professional is often recommended when taking high-dose niacin. Individuals with pre-existing liver conditions should avoid niacin unless specifically advised by a doctor.
Yes, niacin can interact with several medications. It may enhance the effects of blood pressure-lowering drugs, potentially causing hypotension, and can increase the risk of myopathy when taken with statins. Niacin might also interact with blood thinners, antidiabetic medications, and gout medications. Consulting a healthcare provider about all current medications before starting niacin is important.
Individuals with active liver disease, severe hypotension, active peptic ulcer disease, or active bleeding should generally avoid niacin supplements. Those with a history of gout, diabetes, or gallbladder disease should also use niacin with caution and under medical supervision. Consultation with a healthcare provider is essential to determine suitability.
High doses of niacin, particularly nicotinic acid, can sometimes increase blood glucose levels. This effect is more pronounced in individuals with diabetes or prediabetes. People managing their blood sugar should monitor their levels closely if taking niacin and discuss its use with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Niacin | 500 mg |
Inositol | 120 mg |
Categories
Niacin 78.0
This Niacin product offers a popular 'no-flush' option that is well-received by users for comfort and general B3 benefits. Its competitive pricing within this specific Niacin form (inositol hexanicotinate) makes it a strong contender, though pure nicotinic acid forms may offer more targeted cholesterol benefits.
Goals
Skin Health 85.0
Niacin is crucial for maintaining healthy skin by promoting cellular regeneration, reducing inflammation, and strengthening the skin barrier. The 'no-flush' nature of this form makes it particularly suitable for skin support, as it avoids the temporary redness and tingling that could deter consistent use.
Energy 80.0
Niacin is a key component in the body's energy production cycle, acting as a precursor to vital coenzymes (NAD+ and NADH) involved in converting food into cellular energy. Supplementing with this no-flush niacin provides the necessary B3 to support these fundamental processes, contributing to sustained energy levels throughout the day.
Metabolism Boost 80.0
By participating in numerous metabolic reactions, including the breakdown of carbohydrates, fats, and proteins, niacin plays an indispensable role in maintaining efficient metabolism. This product provides an effective dose of niacin to ensure these critical metabolic pathways function optimally, aiding in nutrient processing and overall metabolic health.
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