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Ester-C With D3

4.9
★ ★ ★ ★ ★
(755 ratings)
Vitamin C 1000 mg
Product Image
Score81
Ester-C With D3 delivers a meaningful vitamin C amount for focused antioxidant and collagen support. The tablet format keeps use simple and the active amount is clearly stated
How scoring works
Tablet
Quantity:60 Tablet(s) • (60 servings)
Goals:
General Health
Immunity
Skin Health
Anti-Inflammatory Support
Vision Support

Score 81

Ester-C With D3 delivers a meaningful vitamin C amount for focused antioxidant and collagen support. The tablet format keeps use simple and the active amount is clearly stated
How scoring works
$13.78($0.22 per serving)
Vitacost
$ 13.79
iHerb
$ 14.82
Daily Vita
$ 13.78
Report prices

Analysis

Buffered calcium ascorbate supplies 1,000 mg, a meaningful amount for antioxidant defense, collagen formation, and normal immune function. Its strongest use is focused vitamin C support rather than broad daily nutrition.

The buffered calcium ascorbate form may be easier on the stomach than ordinary ascorbic acid. Vitamin D3 broadens immune and general nutrition support, while the remaining companion nutrients play smaller supporting roles.

The tablet format keeps use simple and the active amount is clearly stated. The long supply and simple formula offer good practical value for targeted vitamin C use, but people seeking comprehensive vision, skin, or inflammation support will need other relevant nutrients.

Who is it for
  • Adults seeking focused vitamin C supplementation
  • People comfortable with tablets or capsules
  • People who prefer a buffered vitamin C form
Best for
  • Antioxidant support
  • Collagen formation support
  • Filling a vitamin C intake gap

Pros

  • 1,000 mg vitamin C amount is clearly disclosed
  • Buffered Ester-C form may improve stomach comfort
  • Vitamin D3 adds a second relevant nutrition pathway
  • Good serving value for targeted use

Cons

  • Limited nutrient breadth beyond vitamin C
  • Does not provide broad vision or skin coverage
  • No dedicated hydration, macular-pigment, or omega-fat support
  • Single-pathway design may require complementary nutrients

Warnings

  • 125 mcg of vitamin D3 is a high daily amount; avoid stacking it with other high-dose vitamin D without professional guidance.

Nutrient quality

83 Highest impact

The ingredient form and serving amount provide solid nutritional support. One supporting nutrient is supplied aggressively enough to require closer attention.

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Ingredient transparency

88 Highest impact

Active amounts and ingredient names are mostly easy to assess. A complete inactive-ingredient list and full use directions are not included in the supplied facts.

.

Customer satisfaction

68 High impact

The aggregate rating is very strong with a moderate review base. No specific feedback is supplied to confirm recurring complaints or purpose-related experiences.

.

Value for money

84 Highest impact

The formula provides moderate value for its quality and format. Most of the cost appears directed toward the core active formula.

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Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Vitamin D · 125 mcgVitamin C · 1000 mg

Buffered calcium ascorbate supplies a substantial vitamin C amount with good digestive tolerability. The separate calcium contribution is disclosed clearly and does not obscure the main active.

Vitamin D3 broadens the formula, but its high amount makes total daily intake important. People already using vitamin D should avoid unplanned stacking of this high-dose source.

Study evidence
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Immunity
Immunity
Impact
Highest effect
A Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Vitamin C · 1000 mgVitamin D · 125 mcg

Buffered calcium ascorbate supplies a substantial vitamin C amount with good digestive tolerability. The separate calcium contribution is disclosed clearly and does not obscure the main active.

Vitamin D3 broadens the formula, but its high amount makes total daily intake important. People already using vitamin D should avoid unplanned stacking of this high-dose source.

Study evidence
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Skin Health
Skin Health
Impact
High effect
B Goal FitB+ Strength of SupportC CoverageB- Formula Quality
Vitamin C · 1000 mg

Vitamin C strongly supports collagen synthesis and antioxidant defense. The added vitamin D3 is not a primary skin active and is supplied at a high daily amount.

A 1000 mg Ester-C serving offers strong focused skin support, while 125 mcg of vitamin D3 may exceed routine needs. Long-term use is best guided by vitamin D and calcium status because excessive intake can raise blood calcium.

Study evidence
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B+ Goal FitC+ Strength of SupportC CoverageB+ Formula Quality
Vitamin D · 125 mcgVitamin C · 1000 mg

Buffered vitamin C and vitamin D3 combine antioxidant defense with immune-signaling support, giving the formula broader relevance than vitamin C alone. Both active amounts are fully disclosed and substantial.

The vitamin D3 serving is above the adult daily upper intake level, so routine use may provide more than many people need without laboratory-guided supervision. Taking additional vitamin D could raise the risk of high blood calcium, which may cause nausea, weakness, kidney stones, or heart rhythm problems.

Study evidence
Vitamin C Supportive 50 studies
Vitamin D Supportive 101 studies
Vision Support
Vision Support
Impact
High effect
D+ Goal FitA Strength of SupportD+ CoverageB- Formula Quality
Vitamin C · 1000 mg

A full serving supplies a clearly disclosed dose of buffered vitamin C, which may support antioxidant protection in ocular tissues. Vitamin D adds general nutritional support but does not replace core macular pigments or retinal lipids.

The formula provides useful depth for vitamin C while addressing only a limited part of vision support. It is better suited as supplemental antioxidant support than as a complete eye formula.

Study evidence
Vitamin C Disputed 24 studies
Vitamin D Disputed 35 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ester-C Calcium Ascorbate)
 1000 mg
Vitamin D (Vitamin D3)
 125 mcg
Calcium (Ester-C Calcium Ascorbate)
 111 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free Vegetarian
Report overview
Vitamin C (Ester-C Calcium Ascorbate) · 1000 mg OverallScore90
A- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Ester-C calcium ascorbate provides a buffered vitamin C form that should be easier on the stomach than plain ascorbic acid. The full-gram serving falls within the preferred dose range, and elemental calcium is clearly disclosed. Added vitamin D3 is substantial, so people already using vitamin D should account for their total daily intake.

View ingredientView products
Loading alternative details
89 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>The ingredient profile is a stronger fit for focused vitamin C support, supplying 1000 mg of vitamin C as Ester-C with calcium and citrus bioflavonoids. The added bioflavonoids broaden the formula beyond the original’s Ester-C Calcium Ascorbate-focused ingredient profile.</p>
89 Performance

Buffered Gold C

California Gold Nutrition
<p>The ingredient profile is a stronger fit for focused vitamin C support, supplying 1000 mg of vitamin C as Sodium Ascorbate. It provides at least as much vitamin C as the original while retaining a clearly disclosed active form.</p>
88 Performance

C

Swanson
<p>The ingredient profile is a stronger fit for focused vitamin C support, supplying 1000 mg of vitamin C as Calcium Ascorbate with calcium and citrus bioflavonoids. The added bioflavonoids broaden the formula beyond the original’s Ester-C Calcium Ascorbate-focused ingredient profile.</p>
89 Budget

Pure Buffered Calcium Ascorbate

NOW
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 890 mg of vitamin C as Calcium Ascorbate with calcium. The 890 mg amount is lower than the original's 1000 mg serving, so the trade-off is less vitamin C per serving.</p>
88 Budget

Sodium Ascorbate

NutriBiotic Immunity
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 1100 mg of vitamin C as Sodium Ascorbate. The vitamin C amount matches or exceeds the original's 1000 mg serving.</p>
87 Budget

100% Pure Vitamin C Powder

Swanson Premium Brand
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 1000 mg of vitamin C as Ascorbic Acid. The vitamin C amount matches or exceeds the original's 1000 mg serving.</p>
93 Value

Pure Buffered Magnesium Ascorbate

NOW
<p>Strong serving value is paired with 820 mg of vitamin C as Magnesium Ascorbate with magnesium. It uses a lower vitamin C amount than the original and keeps the active formula clearly disclosed, balancing cost-effectiveness with a useful ingredient profile.</p>
93 Value

Sodium Ascorbate Capsules

NutriBiotic Immunity
<p>Strong serving value is paired with 850 mg of vitamin C as Sodium Ascorbate. It uses a lower vitamin C amount than the original and keeps the active formula clearly disclosed, balancing cost-effectiveness with a useful ingredient profile.</p>
92 Value

Ester-C 500 mg With Citrus Bioflavoinds

American Health
<p>Strong serving value is paired with 1000 mg of vitamin C as Ester-C Calcium Ascorbate with calcium and citrus bioflavonoids. It matches or exceeds the original’s vitamin C amount and adds disclosed bioflavonoids, balancing cost-effectiveness with a useful ingredient profile.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forVitamin C
  2. Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials.
    Righi NC; Schuch FB; De Nardi AT; Pippi CM; de Almeida Righi G; Puntel GO; da Silva AMV; Signori LU · European journal of nutrition · 2021
    Meta-analysis313 participants18 studies pooledAnti-Inflammatory Support forVitamin C
  3. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  4. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin C
  5. Vitamin C and postoperative outcomes following mandibular third molar extraction: a randomized split-mouth study.
    Demirel M; Aktas A; Kizil M; Yalcin N · Oral surgery, oral medicine, oral pathology and oral radiology · 2026
    Randomized trial56 participantsSkin Health forVitamin C
  6. Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
    Singer RF · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011
    Randomized trial99 participantsGeneral Health forVitamin C
  7. Vitamin C for the management of COVID-19: a systematic review and meta-analysis of randomized controlled trials.
    Abid H; Mushtaq I; Munir ABI; Shakil J; Vinjamuri S; Tadasare N; Kiran F; Muhammad Wali Mirza A; Fatima Khidri F; Shahid A; Ayyan M; Ehsan M; Cheema HA; Alsubari AMA; Sahra S; Siddiqi NI · Annals of medicine and surgery (2012) · 2026
    Meta-analysis9 studies pooledGeneral Health Immunity forVitamin C
  8. A High Vitamin C Micronutrient Supplement Is Unable to Attenuate Inflammation in People with Metabolic Syndrome but May Improve Metabolic Health Indices: A Randomised Controlled Trial.
    Vlasiuk E; Zawari M; Whitehead R; Williman J; Carr AC · Antioxidants (Basel, Switzerland) · 2024
    Randomized trial72 participantsAnti-Inflammatory Support forVitamin C
  9. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledVision Support forVitamin C
  10. Association between hemoglobin A1c, Vitamin C, and microbiome in diabetic foot ulcers and intact skin: A cross-sectional study.
    Tong KPS; Green SJ; Ortiz J; Wu SC · Health science reports · 2024
    Cross-sectional study42 participantsSkin Health forVitamin C
  11. Serum vitamin C and spinal pain: a nationwide study.
    Dionne CE; Laurin D; Desrosiers T; Abdous B; Le Sage N; Frenette J; Mondor M; Pelletier S · Pain · 2017
    Cross-sectional study4,742 participantsGeneral Health forVitamin C
  12. Immunocompetence and oxidant defense during ascorbate depletion of healthy men.
    Jacob RA; Kelley DS; Pianalto FS; Swendseid ME; Henning SM; Zhang JZ; Ames BN; Fraga CG; Peters JH · The American journal of clinical nutrition · 1992
    Clinical trial8 participantsImmunity forVitamin C
  13. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  14. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  15. Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy.
    Christen WG; Ajani UA; Glynn RJ; Manson JE; Schaumberg DA; Chew EC; Buring JE; Hennekens CH · American journal of epidemiology · 1999
    Cohort study21,120 participantsVision Support forVitamin C
  16. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  17. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  18. Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses.
    Xu K; Peng R; Zou Y; Jiang X; Sun Q; Song C · International journal of food sciences and nutrition · 2022
    Meta-analysis76 studies pooledGeneral Health forVitamin C
  19. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  20. Age-related macular degeneration and antioxidant status in the POLA study. POLA Study Group. Pathologies Oculaires Liées à l'Age.
    Delcourt C; Cristol JP; Tessier F; Léger CL; Descomps B; Papoz L · Archives of ophthalmology (Chicago, Ill. : 1960) · 1999
    Observational study2,584 participantsVision Support forVitamin C
  21. Vitamin C Intravenous Treatment In the Setting of Atrial Fibrillation Ablation: Results From the Randomized, Double-Blinded, Placebo-Controlled CITRIS-AF Pilot Study.
    Trankle CR; Puckett L; Swift-Scanlan T; DeWilde C; Priday A; Sculthorpe R; Ellenbogen KA; Fowler A; Koneru JN · Journal of the American Heart Association · 2020
    Randomized trial20 participantsAnti-Inflammatory Support forVitamin C
  22. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  23. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  24. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22.
    Age-Related Eye Disease Study Research Group; SanGiovanni JP; Chew EY; Clemons TE; Ferris FL; Gensler G; Lindblad AS; Milton RC; Seddon JM; Sperduto RD · Archives of ophthalmology (Chicago, Ill. : 1960) · 2007
    Case-control study4,519 participantsVision Support forVitamin C
  25. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  26. Evaluating the effects of chlorhexidine and vitamin c mouthwash on oral health in non-surgical periodontal therapy: a randomized controlled clinical trial.
    Ozmeric N; Enver A; Isler SC; Gökmenoğlu C; Topaloğlu M; Selamet H; Altun G; Aykol Sayar S · Scientific reports · 2025
    Randomized trial60 participantsGeneral Health forVitamin C
  27. Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study.
    Raposo SE; Fondell E; Ström P; Bälter O; Bonn SE; Nyrén O; Plymoth A; Bälter K · European journal of clinical nutrition · 2018
    Cohort study1,533 participantsImmunity forVitamin C
  28. Comparison of the Efficacy of Intralesional Ascorbic Acid Mesotherapy and Intralesional Tranexamic Acid in Treating Melasma in the Skin of Colour Population.
    Aslam H; Muhammad A; Ullah A; Aziz N; Lakhiar JA; Ahmad B; Shahzadi A; Ahmad A; Chandni; Virdi G · Cureus · 2025
    Randomized trial110 participantsSkin Health forVitamin C
  29. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  30. Vitamin C supplementation and C-reactive protein levels: Findings from a systematic review and meta-analysis of clinical trials.
    Safabakhsh M; Emami MR; Zeinali Khosroshahi M; Asbaghi O; Khodayari S; Khorshidi M; Alizadeh S; Viri EH · Journal of complementary & integrative medicine · 2024
    Meta-analysis818 participants11 studies pooledAnti-Inflammatory Support forVitamin C
  31. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  32. Efficacy and Safety of tranexamic acid versus vitamin c after microneedling in treatment of melasma: Clinical and Dermoscopic study.
    El Attar Y; Doghaim N; El Far N; El Hedody S; Hawwam SA · Journal of cosmetic dermatology · 2022
    Randomized trial20 participantsSkin Health forVitamin C
  33. Dietary intake and supplement use of vitamins C and E and upper respiratory tract infection.
    Fondell E; Bälter O; Rothman KJ; Bälter K · Journal of the American College of Nutrition · 2012
    Cohort study1,509 participantsImmunity forVitamin C
  34. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C
  35. Ascorbate for Organ Dysfunction in Critically Ill Patients With Sepsis: The Phase 2b ASTER Trial.
    Files DC; Matthay MA; Ware LB; Brower RG; Aggarwal NR; Brown SM; Chang SY; Douglas IS; Duggal A; Gibbs KW; Fields S; Foulkes AS; Ginde A; Goodwin A; Harris ES; Hendey GW; Hibbert K; Hite RD; Hough CL; Huang W; Khan A; Lai P; Liu KD; Miller C; Moskowitz A; Riker R; Robinson BRH; Self WH; Tidswell MA; Yealy DM; Thompson BT; Fowler AA · CHEST critical care · 2026
    Randomized trial79 participantsGeneral Health forVitamin C
  36. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  37. Comparative Evaluation of Locally Injected Dexamethasone with and Without Vitamin C in Mandibular Fractures: A Randomized Controlled Trial.
    Chincholkar A; Rudagi BM; Setiya S; Sakhariya S · Journal of maxillofacial and oral surgery · 2025
    Randomized trial30 participantsSkin Health forVitamin C
  38. Vitamin C supplementation and salivary immune function following exercise-heat stress.
    Carrillo AE; Murphy RJ; Cheung SS · International journal of sports physiology and performance · 2009
    Randomized trial12 participantsImmunity forVitamin C
  39. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  40. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  41. Comparative Efficacy of Ulinastatin and Vitamin C in Burn-associated Sepsis: A Randomized Controlled Trial.
    Kumar N; Singh A; Kumar R; Kumar M; Chaudhary AK · Annals of African medicine · 2026
    Randomized trial70 participantsAnti-Inflammatory Support forVitamin C
  42. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage.
    Fitzpatrick RE; Rostan EF · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002
    Non-randomized trial10 participantsSkin Health forVitamin C
  43. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  44. Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract.
    Lim JC; Caballero Arredondo M; Braakhuis AJ; Donaldson PJ · Nutrients · 2021
    Narrative reviewVision Support forVitamin C
  45. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisGeneral Health forVitamin C
  46. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation.
    Block G; Jensen C; Dietrich M; Norkus EP; Hudes M; Packer L · Journal of the American College of Nutrition · 2005
    Randomized trial216 participantsAnti-Inflammatory Support forVitamin C
  47. Split-Face Comparative Analysis Of Micro-Needling With Tranexamic Acid Vs Vitamin C Serum In Melasma.
    Raza MH; Iftikhar N; Anwar A; Mashhood AA; Tariq S; Bin Hamid MA · Journal of Ayub Medical College, Abbottabad : JAMC · 2022
    Non-randomized trial30 participantsSkin Health forVitamin C
  48. The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review.
    SeyedAlinaghi S; Shahidi R; Mojdeganlou H; Akhtaran FK; Maroufi SF; Maroufi SP; Mirzapour P; Karimi A; Khodaei S; Pour MM; Mehraeen E; Dadras O · Journal of health, population, and nutrition · 2024
    Systematic review28 studies pooledImmunity forVitamin C
  49. Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age-sex-matched controls.
    Gopinath B; Liew G; Russell J; Cosatto V; Burlutsky G; Mitchell P · The British journal of ophthalmology · 2017
    Case-control studyVision Support forVitamin C
  50. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  51. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  52. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  53. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  54. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  55. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  56. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  57. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  58. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  59. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  60. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  61. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  62. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  63. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  64. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  65. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  66. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  67. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  68. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  69. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  70. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  71. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  72. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  73. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  74. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  75. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.
    Merle BMJ; Silver RE; Rosner B; Seddon JM · Investigative ophthalmology & visual science · 2017
    Cohort study2,146 participantsVision Support forVitamin D
  76. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis.
    Annweiler C; Drouet M; Duval GT; Paré PY; Leruez S; Dinomais M; Milea D · Maturitas · 2017
    Meta-analysis11 studies pooledVision Support forVitamin D
  77. Low serum vitamin D is associated with axial length and risk of myopia in young children.
    Tideman JW; Polling JR; Voortman T; Jaddoe VW; Uitterlinden AG; Hofman A; Vingerling JR; Franco OH; Klaver CC · European journal of epidemiology · 2017
    Cohort study2,666 participantsVision Support forVitamin D
  78. The effect of vitamin D supplementation on the outcome of treatment with bevacizumab in diabetic macular edema: a randomized clinical trial.
    Fekri S; Soheilian M; Roozdar S; Abtahi SH; Nouri H · International ophthalmology · 2022
    Randomized trial83 participantsVision Support forVitamin D
  79. Vitamin D Deficiency and Dry Eye Disease: A Retrospective Cohort Study.
    Shmushkevich SB; Bajrami S; Beauchamp B; Kane JS; Mutawe DL; Hollinger JC; Marks VA; Parekh PK; Rothman AL; Ansari ZA; Williams BK; Galor A · American journal of ophthalmology · 2026
    Cohort study12,095,004 participantsVision Support forVitamin D