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Vitamin D3 125 mcg (5000 IU) with Sea-Iodine

Life Extension
4.9
★ ★ ★ ★ ★
(3866 ratings)
Iodine 1000 mcg
Product Image
Score73
Two clearly dosed nutrients offer convenience, but high vitamin D3 and near-upper-limit iodine require individualized use.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Energy
Metabolism Boost

Score 73

Two clearly dosed nutrients offer convenience, but high vitamin D3 and near-upper-limit iodine require individualized use.
How scoring works
$10.50($0.17 per serving)
Vitacost
$ 10.53
Amazon
$ 10.50
Vitacost
$ 10.50
Pure Formulas
$ 10.50
iHerb
$ 10.50
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Analysis

Vitamin D3 and iodine combine two nutrients involved in endocrine and general nutritional function. Both amounts are clearly stated, so users can calculate their total exposure.

The 125 mcg vitamin D3 amount is high for unsupervised daily use, while 1,000 mcg iodine sits close to the adult upper limit. The iodine source is also not identified.

People with lab-guided needs for both nutrients may value the compact capsule. Routine users should prefer lower doses and adjust vitamin D based on measured status.

Who is it for
  • Adults with measured vitamin D needs and guided iodine use
  • People following a clinician-directed dual-nutrient plan
  • Users wanting one capsule for both actives
Best for
  • Targeted vitamin D3 supplementation
  • Professionally guided iodine use
  • Compact dual-nutrient dosing

Pros

  • Uses cholecalciferol for vitamin D
  • Clearly discloses both amounts
  • Combines two actives in one capsule

Cons

  • Iodine source is unspecified
  • Both amounts are high for routine use
  • Not easily adjusted ingredient by ingredient

Warnings

  • The 1,000 mcg iodine amount may alter thyroid function, especially in people with autoimmune thyroid disease, nodules, or thyroid medication use.
  • The 125 mcg vitamin D3 serving can raise calcium excessively during prolonged use, particularly when combined with other vitamin D products.
  • People using thiazide diuretics or managing high calcium should obtain guidance before taking this vitamin D amount.

Nutrient quality

62 Moderate impact

Cholecalciferol is a useful vitamin D form, while the marine iodine source lacks chemical-form and origin details. Both nutrients are supplied at amounts better suited to a defined need than routine stacking, while high vitamin D and iodine together require care with other fortified products and thyroid conditions.

Ingredient transparency

75 High impact

Both active amounts are clear, though the iodine form and marine purity details are incomplete. Serving totals are apparent, but full directions and inactive ingredients are not supplied.

Customer satisfaction

72 High impact

The supplied average rating is exceptionally strong. The very large rating base makes the average unusually stable, while complaint and firsthand experience details are unavailable.

Value for money

84 Highest impact

Formula quality provides partial support for the asking position. The serving value is reasonably competitive within the category.

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Goals

Energy
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageA- Formula Quality
Iodine · 1000 mcgVitamin D · 125 mcg

Iodine supports thyroid-driven metabolism and provides the main connection to energy. Vitamin D3 broadens nutritional support but is not a direct energy-producing ingredient.

Both nutrients are supplied at substantial amounts that are better suited to a defined need than casual stacking. Thyroid conditions and other sources of iodine or vitamin D should be considered before regular use.

Study evidence
Iodine Adverse 3 studies
Vitamin D Supportive 32 studies
Metabolism Boost
Impact
High effect
B Goal FitC Strength of SupportC- CoverageA Formula Quality
Vitamin D · 125 mcg

Iodine supports thyroid-hormone production and vitamin D3 adds broader endocrine support. The combination may help when either nutrient is low but does not directly boost metabolism in replete users.

Both active amounts are clearly disclosed in useful forms. The high iodine amount may worsen thyroid dysfunction in susceptible users.

Study evidence
Iodine Mixed 17 studies
Vitamin D Supportive 65 studies

Ingredients

IngredientAmount per serving
Vitamin D (Cholecalciferol)
125 mcg
Iodine
1000 mcg
Gluten Free Adults 18–50
Report overview
Iodine · 1000 mcg OverallScore80
C+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

The named Sea-Iodine pairing provides a high but still tolerable iodine dose alongside vitamin D. No organic status or geographic origin is stated, so marine purity remains uncertain. A single capsule and very low serving cost support efficient use for people who specifically need the higher dose.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  2. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  3. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  4. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  5. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  6. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  7. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  8. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  9. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.
    Herter-Aeberli I; Cherkaoui M; El Ansari N; Rohner R; Stinca S; Chabaa L; von Eckardstein A; Aboussad A; Zimmermann MB · The Journal of nutrition · 2015
    Randomized trial163 participantsMetabolism Boost forIodine
  10. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.
    Zimmermann MB; Adou P; Torresani T; Zeder C; Hurrell RF · European journal of clinical nutrition · 2000
    Single-arm trial51 participantsMetabolism Boost forIodine
  11. Serum Iodine Concentration as a Biomarker for Individual Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study in Hubei Province.
    Xu M; Dai X; Wang Z; Guo C; Zhang B; Guo H · Public health nutrition · 2026
    Cross-sectional study1,197 participantsMetabolism Boost forIodine
  12. Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire.
    Zimmermann MB · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2002
    OtherMetabolism Boost forIodine
  13. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire.
    Zimmermann M; Adou P; Torresani T; Zeder C; Hurrell R · The American journal of clinical nutrition · 2000
    Non-randomized trial109 participantsMetabolism Boost forIodine
  14. Effects of vitamin D supplementation on insulin resistance and lipid metabolic profiles in women with gestational diabetes mellitus: A randomized controlled trial.
    Duan Y; Zhang S; Ma X; Li L; Jia K · African journal of reproductive health · 2026
    Randomized trial120 participantsMetabolism Boost forVitamin D
  15. Vitamin D3 improves glucose metabolism and attenuates inflammation in prediabetic human and mice.
    Zhang Y; Ni P; Miao Y; Chen H; Tang L; Song H; Li W; Li X · The Journal of nutritional biochemistry · 2024
    Randomized trialMetabolism Boost forVitamin D
  16. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial.
    Mitri J; Dawson-Hughes B; Hu FB; Pittas AG · The American journal of clinical nutrition · 2011
    Randomized trial92 participantsMetabolism Boost forVitamin D
  17. The Effects of Vitamin D Supplementation on Glycemic Control, Lipid Profiles and C-Reactive Protein Among Patients with Cardiovascular Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Ostadmohammadi V; Milajerdi A; Ghayour-Mobarhan M; Ferns G; Taghizadeh M; Badehnoosh B; Mirzaei H; Asemi Z · Current pharmaceutical design · 2020
    Meta-analysis630 participants8 studies pooledMetabolism Boost forVitamin D
  18. The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis.
    Mirhosseini N; Vatanparast H; Mazidi M; Kimball SM · The Journal of clinical endocrinology and metabolism · 2017
    Meta-analysis1,528 participants24 studies pooledMetabolism Boost forVitamin D