Pyridoxal 5'-Phosphate Caps 100 mg
Life Extension
Pyridoxal 5'-Phosphate Caps 100 mg
4.9
★ ★ ★ ★ ★
(2941 ratings)
Vitamin B6 100 mg
Score 80.0
A high-potency (100mg) P-5-P supplement from a premium brand, offering excellent bioavailability but at a higher price point.
Quantity: 60 Capsule(s)Servings size: 1 Vegetarian Capsules (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
leaderboard Score 80.0
A high-potency (100mg) P-5-P supplement from a premium brand, offering excellent bioavailability but at a higher price point.
insights Analysis
Life Extension's Pyridoxal 5'-Phosphate Caps provide a strong 100mg dose of P-5-P, which is the most metabolically active form of Vitamin B6. This makes it particularly effective for individuals with compromised liver function or genetic variations that hinder the conversion of standard pyridoxine HCl. Nutritionists often recommend P-5-P for its superior absorption and utilization. Online reviews frequently highlight its effectiveness for energy, mood, and nerve health. While the price per serving is on the higher side, it reflects the quality of the active ingredient and the brand's commitment to purity and potency, making it suitable for those who prioritize efficacy and strength.
- Contains a high 100mg dose of Pyridoxal 5-Phosphate (P-5-P), the active and most bioavailable form of Vitamin B6.
- From Life Extension, a highly respected brand known for science-backed formulations and quality control.
- High potency is ideal for individuals with significant B6 needs or absorption issues.
- The price per serving is relatively high compared to other P-5-P or standard B6 supplements.
- 100mg might be a higher dose than necessary for general maintenance for some individuals, potentially leading to unnecessary cost.
$16.50($0.27 per serving)
 Vitacost | $ 16.50 | |
 Pure Formulas | $ 16.50 | |
 iHerb | $ 16.50 |
bolt Effectiveness for goals
Yes, Vitamin B6 is a widely recognized and often recommended treatment for nausea and vomiting in pregnancy, commonly known as morning sickness. It is considered a first-line pharmacological therapy for mild to moderate symptoms. Pregnant individuals should consult their healthcare provider before taking any supplements.
Vitamin B6, or pyridoxine, is crucial for over 100 enzyme reactions, primarily involved in protein metabolism, red blood cell formation, and nervous system health. It plays a key role in metabolic processes that convert food into energy. Maintaining adequate B6 levels supports overall health and proper bodily functions.
Absolutely, Vitamin B6 is vital for brain development and function, and for maintaining a healthy nervous system. It is involved in the synthesis of several key neurotransmitters, such as serotonin, dopamine, and GABA, which regulate mood, sleep, and cognitive processes. Adequate B6 intake is essential for proper nerve signaling.
Some studies suggest that Vitamin B6 supplementation may help reduce certain PMS symptoms, particularly mood swings, irritability, and breast tenderness. The exact mechanism is not fully understood, but it may involve its role in neurotransmitter synthesis. However, evidence is mixed, and more robust research is needed.
Vitamin B6 is involved in the production of neurotransmitters like serotonin and norepinephrine, which are critical for mood regulation. Some research indicates that B6 supplementation may positively influence mood and reduce symptoms of depression, particularly in individuals with a deficiency. However, it should not replace prescribed treatments for mental health conditions.
schedule Dosage, timing & forms
The Recommended Dietary Allowance (RDA) for adult men and women (19-50 years) is 1.3 mg per day. For those over 50, it is 1.7 mg for men and 1.5 mg for women. These recommendations are for healthy individuals.
Yes, taking excessively high doses of Vitamin B6, particularly from supplements, can be harmful. The most well-known adverse effect is sensory neuropathy, which can cause numbness and tingling in the extremities. This risk increases with doses significantly above the Tolerable Upper Intake Level (UL) of 100 mg/day.
The Tolerable Upper Intake Level (UL) for Vitamin B6 in adults is 100 mg per day. Consuming amounts significantly above this UL, particularly from supplements, can lead to adverse effects like peripheral neuropathy. It is advisable not to exceed this limit without professional guidance.
There is no specific "best" time to take Vitamin B6; it can be taken at any time of day. Consistency in taking the supplement is generally more important than the exact timing. Some individuals may prefer to take it with a meal to avoid potential stomach upset.
Vitamin B6 supplements commonly contain pyridoxine hydrochloride (pyridoxine HCl). The active coenzyme form, pyridoxal 5'-phosphate (P5P), is also available in some supplements. Other forms like pyridoxal and pyridoxamine also exist in food.
health_and_safety Safety & interactions
Long-term intake of high doses, typically exceeding 200 mg per day, can lead to sensory peripheral neuropathy, characterized by numbness, tingling, and pain in the extremities. Other less common side effects might include skin lesions, photosensitivity, and gastrointestinal issues. These effects usually resolve after discontinuing supplementation.
For adults, the tolerable upper intake level (UL) for Vitamin B6 is set at 100 mg per day from supplements and fortified foods. Consuming amounts above this UL regularly increases the risk of adverse effects, primarily neurological damage. This limit is established to prevent potential harm.
The primary and most concerning symptom of Vitamin B6 toxicity, typically from chronic high doses, is sensory peripheral neuropathy. This involves symptoms like numbness, tingling, and burning pain, often starting in the hands and feet. Other less common signs might include skin lesions or gastrointestinal upset.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of levodopa (used for Parkinson's disease) and can interact with anti-seizure medications like phenytoin and phenobarbital. It is important to consult a healthcare provider when combining Vitamin B6 supplements with prescription drugs.
Vitamin B6 is generally considered safe during pregnancy and breastfeeding when taken within recommended dietary allowances. Higher doses might be used under medical supervision for specific conditions like severe morning sickness. Always discuss any supplementation with a healthcare provider to ensure appropriate dosing.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 100 mg |
Categories
Vitamin B6 90.0
This product stands out in the Vitamin B6 category due to its use of 100mg of the superior P-5-P form, ensuring maximum bioavailability and efficacy. While its price per serving is higher, the quality and potency justify its strong position for those prioritizing the active form and robust dosage.
Goals
Brain Health 90.0
As a precursor for key neurotransmitters like serotonin, dopamine, and GABA, P-5-P is fundamental for brain health. The high 100mg dose ensures robust support for cognitive function and neural communication, particularly beneficial for targeted interventions.
Mood Support 90.0
Given B6's critical role in serotonin and dopamine synthesis, the potent 100mg P-5-P dose offers strong support for mood regulation. This can be highly effective for individuals seeking to improve their emotional well-being and stability.
Energy 85.0
P-5-P is vital for energy production pathways, and the 100mg dose provides ample support for metabolic processes. This higher dose is more likely to noticeably contribute to improved energy levels, especially for those with a deficiency.
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