P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength
Swanson
P-5-P (Pyridoxal-5-Phosphate) 40 mg Double Strength
4.8
★ ★ ★ ★ ★
(1062 ratings)
Vitamin B6 40 mg
Score 95.0
A highly bioavailable and potent P-5-P form of Vitamin B6 from Swanson, ideal for those seeking maximum efficacy and direct absorption for energy, brain, and mood support.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
leaderboard Score 95.0
A highly bioavailable and potent P-5-P form of Vitamin B6 from Swanson, ideal for those seeking maximum efficacy and direct absorption for energy, brain, and mood support.
insights Analysis
This Swanson product uniquely offers Vitamin B6 in its active form, Pyridoxal-5-Phosphate (P-5-P), at a potent 40mg dose. P-5-P is widely considered by nutritionists and researchers to be superior to the more common pyridoxine hydrochloride (HCl) because it doesn't require conversion by the liver, making it immediately available for physiological functions. This can be particularly beneficial for individuals with genetic polymorphisms (e.g., MTHFR mutations) or liver issues that impair B6 conversion. Online reviews for P-5-P products often highlight noticeable improvements in energy, mood, and nerve function, supporting the claim of enhanced bioavailability. While the price per serving is higher than basic HCl forms, it is justified by its superior metabolic utility and potentially lower risk of certain side effects associated with high doses of unconverted pyridoxine HCl.
- Contains Pyridoxal-5-Phosphate (P-5-P), the active and most bioavailable form of B6.
- Bypasses liver conversion, potentially making it more effective for individuals with metabolic impairments.
- Potent 40mg dose of P-5-P offers significant physiological impact.
- Often associated with a lower risk of neuropathy compared to very high doses of pyridoxine HCl.
- Higher price per serving compared to basic pyridoxine HCl supplements.
- Smaller serving count means more frequent reordering compared to larger packs of HCl forms.
$5.99($0.09 per serving)
 iHerb | $ 5.99 |
bolt Effectiveness for goals
Yes, Vitamin B6 is a widely recognized and often recommended treatment for nausea and vomiting in pregnancy, commonly known as morning sickness. It is considered a first-line pharmacological therapy for mild to moderate symptoms. Pregnant individuals should consult their healthcare provider before taking any supplements.
Vitamin B6, or pyridoxine, is crucial for over 100 enzyme reactions, primarily involved in protein metabolism, red blood cell formation, and nervous system health. It plays a key role in metabolic processes that convert food into energy. Maintaining adequate B6 levels supports overall health and proper bodily functions.
Absolutely, Vitamin B6 is vital for brain development and function, and for maintaining a healthy nervous system. It is involved in the synthesis of several key neurotransmitters, such as serotonin, dopamine, and GABA, which regulate mood, sleep, and cognitive processes. Adequate B6 intake is essential for proper nerve signaling.
Some studies suggest that Vitamin B6 supplementation may help reduce certain PMS symptoms, particularly mood swings, irritability, and breast tenderness. The exact mechanism is not fully understood, but it may involve its role in neurotransmitter synthesis. However, evidence is mixed, and more robust research is needed.
Vitamin B6 is involved in the production of neurotransmitters like serotonin and norepinephrine, which are critical for mood regulation. Some research indicates that B6 supplementation may positively influence mood and reduce symptoms of depression, particularly in individuals with a deficiency. However, it should not replace prescribed treatments for mental health conditions.
schedule Dosage, timing & forms
The Recommended Dietary Allowance (RDA) for adult men and women (19-50 years) is 1.3 mg per day. For those over 50, it is 1.7 mg for men and 1.5 mg for women. These recommendations are for healthy individuals.
Yes, taking excessively high doses of Vitamin B6, particularly from supplements, can be harmful. The most well-known adverse effect is sensory neuropathy, which can cause numbness and tingling in the extremities. This risk increases with doses significantly above the Tolerable Upper Intake Level (UL) of 100 mg/day.
The Tolerable Upper Intake Level (UL) for Vitamin B6 in adults is 100 mg per day. Consuming amounts significantly above this UL, particularly from supplements, can lead to adverse effects like peripheral neuropathy. It is advisable not to exceed this limit without professional guidance.
There is no specific "best" time to take Vitamin B6; it can be taken at any time of day. Consistency in taking the supplement is generally more important than the exact timing. Some individuals may prefer to take it with a meal to avoid potential stomach upset.
Vitamin B6 supplements commonly contain pyridoxine hydrochloride (pyridoxine HCl). The active coenzyme form, pyridoxal 5'-phosphate (P5P), is also available in some supplements. Other forms like pyridoxal and pyridoxamine also exist in food.
health_and_safety Safety & interactions
Long-term intake of high doses, typically exceeding 200 mg per day, can lead to sensory peripheral neuropathy, characterized by numbness, tingling, and pain in the extremities. Other less common side effects might include skin lesions, photosensitivity, and gastrointestinal issues. These effects usually resolve after discontinuing supplementation.
For adults, the tolerable upper intake level (UL) for Vitamin B6 is set at 100 mg per day from supplements and fortified foods. Consuming amounts above this UL regularly increases the risk of adverse effects, primarily neurological damage. This limit is established to prevent potential harm.
The primary and most concerning symptom of Vitamin B6 toxicity, typically from chronic high doses, is sensory peripheral neuropathy. This involves symptoms like numbness, tingling, and burning pain, often starting in the hands and feet. Other less common signs might include skin lesions or gastrointestinal upset.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of levodopa (used for Parkinson's disease) and can interact with anti-seizure medications like phenytoin and phenobarbital. It is important to consult a healthcare provider when combining Vitamin B6 supplements with prescription drugs.
Vitamin B6 is generally considered safe during pregnancy and breastfeeding when taken within recommended dietary allowances. Higher doses might be used under medical supervision for specific conditions like severe morning sickness. Always discuss any supplementation with a healthcare provider to ensure appropriate dosing.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Vitamin B-6 (Pyridoxal 5-Phosphate) | 40 mg |
Categories
Vitamin B6 95.0
As a Vitamin B6 supplement, this P-5-P form stands out due to its superior bioavailability and direct physiological activity. It represents the highest quality option for individuals seeking optimal B6 absorption and utilization.
Goals
Brain Health 95.0
P-5-P is directly involved in the synthesis of critical neurotransmitters like serotonin, dopamine, and GABA, which are vital for optimal brain function, mood, and nerve transmission. Its superior bioavailability makes it particularly effective for neurological support and cognitive well-being.
Mood Support 95.0
The direct bioavailability of P-5-P makes it highly effective in supporting neurotransmitter balance, which is crucial for mood stability and emotional well-being. It is often the preferred form by health professionals for individuals specifically targeting mood regulation.
Energy 90.0
As the active coenzyme, P-5-P is directly utilized in metabolic pathways to convert food into energy, offering a more immediate and efficient boost for cellular energy production. This direct action often leads to more noticeable effects on energy levels compared to less active forms.
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