Product Image

Pre-Workout Blue Raz

Bucked Up
4.8
★ ★ ★ ★ ★
(55 ratings)
Caffeine 200 mg
Vitamin B12 100 mcg
Alpha-GPC 200 mg
Product Image
Score64
A solid stimulant pre-workout with meaningful citrulline, but several secondary ingredients are too light or uncertain to add much.
How scoring works
Quantity:11 Liquid(s) • (30 servings)
Goals:
Energy
Fitness
Weight Loss
Metabolism Boost
Mental Focus
Productivity Boost
Muscle Gain

Score 64

A solid stimulant pre-workout with meaningful citrulline, but several secondary ingredients are too light or uncertain to add much.
How scoring works
$42.95($1.43 per serving)
iHerb
$ 42.95
Nutrition Faktory
$ 49.95
Report prices

Analysis

The strongest feature is the exercise-performance core: citrulline malate supports blood flow, beta-alanine supports repeated high-intensity work, and caffeine provides acute alertness. The main amounts are easy to evaluate because they are fully disclosed.

Beta-alanine is below a typical full daily target, while Alpha-GPC likely supplies less active material than a dedicated focus product. Taurine, deer antler velvet, and the small botanical additions add label complexity without matching the importance of the core ingredients.

The formula fits training sessions that benefit from moderate stimulation and a meaningful citrulline serving. It is less suitable for evening workouts, stimulant-sensitive users, or anyone seeking hair, general-health, or appetite-focused support.

Who is it for
  • Adults wanting a moderately caffeinated pre-workout
  • Users prioritizing blood flow and training focus
  • People who tolerate beta-alanine tingling
Best for
  • Workout energy
  • Training focus
  • High-intensity exercise support
  • Pre-exercise blood-flow support

Pros

  • Meaningful citrulline malate amount
  • Moderate and clearly disclosed caffeine
  • Beta-alanine supports repeated efforts
  • No proprietary blend hides the main doses

Cons

  • Beta-alanine is below a full daily target
  • Alpha-GPC appears modest
  • Taurine is lightly dosed
  • Deer velvet and tiny botanicals add uncertain value

Warnings

  • The 200 mg caffeine amount may cause jitteriness, anxiety, a faster heartbeat, or sleep disruption, especially with other stimulants.
  • The 2 g beta-alanine amount can cause temporary skin tingling, which is harmless but may feel uncomfortable.

Nutrient quality

69 High impact

Citrulline malate and caffeine reach useful amounts for training support. Several secondary actives are underdosed, and deer antler velvet adds weakly supported complexity.

Ingredient transparency

78 High impact

All listed actives have specific amounts, including the stimulant. Several botanical and branded materials still lack standardization or active-yield detail.

Customer satisfaction

63 Moderate impact

The aggregate rating is very strong, but the evidence base is small. No detailed experience reports are supplied, so recurring complaints and purpose fit remain uncertain.

Value for money

42 Lower impact

Meaningful citrulline and caffeine provide some support for the premium cost. Underdosed support ingredients and weak extras make the expensive serving less competitive.

Report analysis

Goals

Impact
Highest effect
A+ Goal FitA Strength of SupportA- CoverageB- Formula Quality
Vitamin B12 · 100 mcgCaffeine · 200 mg

Caffeine provides predictable acute alertness, while citrulline malate and beta-alanine support workout performance through separate mechanisms. Alpha-GPC adds a focus-oriented pathway, making the formula broader than a stimulant alone.

The main performance amounts are fully disclosed and several are meaningful, though taurine and vitamin B12 are modest for their respective roles. No theanine or sustained-release caffeine is included, and deer velvet plus small botanical blends add uncertain value.

Study evidence
Caffeine Supportive 68 studies
Vitamin B12 Disputed 14 studies
Fitness
Impact
Highest effect
A Goal FitA- Strength of SupportA- CoverageB- Formula Quality
Beta-Alanine · 2000 mgCaffeine · 200 mg

Citrulline malate, beta-alanine, and caffeine directly support blood flow, high-intensity capacity, and training focus. The main doses are clearly disclosed and align reasonably well with common pre-workout use.

Beta-alanine is somewhat below a full daily target, while taurine, Alpha-GPC, and the botanical extras are lightly dosed. The moderate caffeine amount can still cause jitters, sleep disruption, or a faster heart rate in stimulant-sensitive users.

Study evidence
Caffeine Supportive 255 studies
Taurine Supportive 21 studies
Weight Loss
Impact
Highest effect
A- Goal FitA- Strength of SupportC+ CoverageB Formula Quality
Caffeine · 200 mg

Caffeine may modestly increase energy expenditure and supports training performance during a calorie deficit. Citrulline and beta-alanine support exercise rather than appetite, so the formula does not address satiety or dietary adherence.

Caffeine, citrulline malate, beta-alanine, methylcobalamin, and alpha-GPC have clear amounts and several branded sources. Deer velvet and multiple tiny botanical blends add weakly supported label complexity without improving the main weight-loss mechanisms. Caffeine at 200 mg may cause anxiety, rapid heartbeat, or sleep disruption in sensitive users, especially when combined with other stimulants.

Study evidence
Caffeine Disputed 14 studies
Metabolism Boost
Impact
High effect
A Goal FitA Strength of SupportC- CoverageD+ Formula Quality
Vitamin B12 · 100 mcgCaffeine · 200 mg

Caffeine provides a direct and predictable short-term increase in energy expenditure. The rest of the pre-workout is designed mainly for exercise performance rather than sustained metabolic support.

The clearly stated caffeine amount is well aligned with an effective stimulant serving. Deer antler, low-dose taurine, and several performance additions dilute focus without adding a meaningful metabolic pathway.

Study evidence
Caffeine Disputed 40 studies
Taurine Supportive 11 studies
Mental Focus
Impact
High effect
B+ Goal FitB Strength of SupportC+ CoverageD+ Formula Quality
Vitamin B12 · 100 mcgAlpha-GPC · 200 mgCaffeine · 200 mg

Caffeine provides a dependable 200 mg acute alertness effect, while AlphaSize Alpha-GPC may add cholinergic support. The listed 200 mg Alpha-GPC material likely provides less active Alpha-GPC than preferred cognitive amounts.

Most of the remaining formula serves exercise performance rather than mental focus. Caffeine can cause jitteriness, anxiety, a faster heartbeat, or sleep disruption, and the absence of L-theanine offers no built-in calming balance.

Study evidence
Alpha-GPC Supportive 1 study
Caffeine Supportive 128 studies
Productivity Boost
Impact
High effect
B+ Goal FitB Strength of SupportC CoverageC- Formula Quality
Vitamin B12 · 100 mcgVitamin B12 · 100 mcgAlpha-GPC · 200 mgCaffeine · 200 mg

Caffeine provides reliable acute alertness, while Alpha-GPC adds a relevant but underdosed cholinergic component. The pre-workout format favors exercise performance more than balanced, sustained productivity.

The 200 mg caffeine amount is clearly disclosed and predictable. Estimated active Alpha-GPC remains below the preferred range, and caffeine may cause jitteriness or disrupt sleep in sensitive users.

Study evidence
Alpha-GPC Supportive 2 studies
Caffeine Supportive 108 studies
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies

Ingredients

IngredientAmount per serving
Vitamin B12 (Methylcobalamin)
100 mcg
Citrulline Malate
6000 mg
CarnoSyn (Beta-Alanine)
2000 mg
Caffeine Anhydrous
200 mg
AlphaSize Alpha GPC
200 mg
Taurine
100 mg
Himalayan Rock Salt (Trace Minerals)
100 mg
Deer Antler Velvet extract
50 mg
AstraGin (Astragalus, Panax notoginseng)
25 mg
ActiGin (Panax notoginseng, Rosa roxburghii)
25 mg
Adults 18–50 Women
Report overview
Caffeine · 200 mg OverallScore72
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

A clearly disclosed 200 mg caffeine anhydrous dose provides a predictable, moderate stimulant effect. The formula lacks sustained-release caffeine, while its other performance ingredients do not add a high-potency stimulant. Very high serving cost weakens economic value despite the strong caffeine specification.

A- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Methylcobalamin provides a bioactive B12 form with clear label disclosure. The 100 mcg dose is better suited to basic maintenance than higher needs. Cost efficiency is weak, although the bioactive form adds some formulation value.

Alpha-GPC · 200 mg OverallScore50
C+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD- Value

AlphaSize provides a recognized branded form, but the listed 200 mg does not clarify active yield. Assuming 50% yield, the estimated 100 mg active amount falls below the preferred range. The included 200 mg caffeine may cause jitteriness or disrupt sleep in stimulant-sensitive users.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
    Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
    Randomized trial48 participantsEnergy forCaffeine
  2. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
    Juliano LM; Griffiths RR · Psychopharmacology · 2005
    Systematic review66 studies pooledEnergy forCaffeine
  3. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
    Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
    Randomized trial48 participantsEnergy forCaffeine
  4. Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
    Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial26 participantsEnergy forCaffeine
  5. Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
    Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
    Randomized trial20 participantsEnergy forCaffeine
  6. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
    Fuller DT; Smith ML; Boolani A · Nutrients · 2021
    Randomized trialEnergy forCaffeine
  7. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  8. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  9. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  10. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  11. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  12. Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis.
    Wu J; Xu K; Yin M; Ding X; Wang T; Zhang Q; Wu X; Xiao N · Frontiers in nutrition · 2026
    Meta-analysis226 participants20 studies pooledFitness forCaffeine
  13. Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis.
    Wang Z; Qiu B; Gao J; Del Coso J · Nutrients · 2023
    Meta-analysis254 participants21 studies pooledFitness forCaffeine
  14. Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis.
    Raya-González J; Rendo-Urteaga T; Domínguez R; Castillo D; Rodríguez-Fernández A; Grgic J · Sports medicine (Auckland, N.Z.) · 2021
    Meta-analysis12 studies pooledFitness forCaffeine
  15. Sex Differences in the Ergogenic Response of Acute Caffeine Intake on Muscular Strength, Power and Endurance Performance in Resistance-Trained Individuals: A Randomized Controlled Trial.
    Montalvo-Alonso JJ; Ferragut C; Del Val-Manzano M; Valadés D; Roberts J; Pérez-López A · Nutrients · 2024
    Randomized trial76 participantsFitness forCaffeine
  16. Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
    Carvalho A; Marticorena FM; Grecco BH; Barreto G; Saunders B · Sports medicine (Auckland, N.Z.) · 2022
    Meta-analysis60 studies pooledFitness forCaffeine
  17. Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study.
    Buzdağlı Y; Eyipınar CD; Öget F; Şıktar E; Forbes SC; Tekin A · Biology of sport · 2023
    Randomized trial30 participantsFitness forTaurine
  18. The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.
    Balshaw TG; Bampouras TM; Barry TJ; Sparks SA · Amino acids · 2013
    Randomized trial8 participantsFitness forTaurine
  19. Effects of different doses of taurine supplementation on repeated-sprint performance after exhaustive exercise in a high temperature and humidity environment.
    Cheng X; Lin Y; Li Z · Frontiers in nutrition · 2026
    Randomized trial16 participantsFitness forTaurine
  20. Oral taurine improves critical power and severe-intensity exercise tolerance.
    Waldron M; Patterson SD; Jeffries O · Amino acids · 2020
    Randomized trial12 participantsFitness forTaurine
  21. Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat.
    Page LK; Jeffries O; Waldron M · European journal of sport science · 2019
    Randomized trial11 participantsFitness forTaurine
  22. Cognitive Effects of Taurine and Related Sulphur-Containing Amino Acids: A Systematic Review of Human Trials and Considerations for Plant-Based Dietary Transitions.
    Moore JA; Cousins AL; Taylor RMJ; Griffiths AR; Young HA · Foods (Basel, Switzerland) · 2026
    Systematic review244 participants8 studies pooledGeneral Health forTaurine
  23. Association between habitual dietary taurine intake and the risk of metabolic dysfunction-associated steatotic liver disease: a prospective cohort study.
    Zhang S; Xu X; Wang D; Gu Y; Wu H; Meng G; Zhang Q; Liu L; Borné Y; Niu K; Bai L · Food & function · 2026
    Cohort study16,699 participantsGeneral Health forTaurine
  24. Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.
    Nie Z; Liu Y; Zhang M; Wu C; Cao Q; Xu J; Zheng Y; Min Z; Zhang W; Han S · Nutrition reviews · 2025
    Meta-analysis34 studies pooledGeneral Health forTaurine
  25. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  26. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  27. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  28. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  29. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  30. Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.
    Kerksick CM · Nutrients · 2024
    Randomized trial20 participantsMental Focus Productivity Boost forAlpha-GPC
  31. Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
    Randomized trial32 participantsMental Focus forCaffeine
  32. Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
    Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
    Randomized trial70 participantsMental Focus forCaffeine
  33. Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
    Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
    Randomized trial48 participantsMental Focus forCaffeine
  34. Effects of caffeine on mood and performance: a study of realistic consumption.
    Brice CF; Smith AP · Psychopharmacology · 2003
    Clinical trial24 participantsMental Focus forCaffeine
  35. Effects of caffeine or diphenhydramine on visual vigilance.
    Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
    Randomized trial24 participantsMental Focus forCaffeine
  36. A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
    Krieger J; Schrautemeier A; Hagele A; Gaige C; Mennemeyer O; Tolbert S; Iannotti J; Kerksick C; Noonan C; Mumford P · Nutrients · 2025
    Randomized trial60 participantsMetabolism Boost forCaffeine
  37. Oolong tea increases metabolic rate and fat oxidation in men.
    Rumpler W; Seale J; Clevidence B; Judd J; Wiley E; Yamamoto S; Komatsu T; Sawaki T; Ishikura Y; Hosoda K · The Journal of nutrition · 2001
    Randomized trial12 participantsMetabolism Boost forCaffeine
  38. Effect of caffeine intake on fat oxidation rate during exercise: is there a dose-response effect?
    Gutiérrez-Hellín J; Aguilar-Navarro M; Ruiz-Moreno C; Muñoz A; Varillas-Delgado D; Amaro-Gahete FJ; Del Coso J · European journal of nutrition · 2023
    Randomized trial18 participantsMetabolism Boost forCaffeine
  39. Comparison of changes in energy expenditure and body temperatures after caffeine consumption.
    Koot P; Deurenberg P · Annals of nutrition & metabolism · 1995
    Randomized trial12 participantsMetabolism Boost forCaffeine
  40. Caffeine Increases Work Done above Critical Power, but Not Anaerobic Work.
    Silveira R; Andrade-Souza VA; Arcoverde L; Tomazini F; Sansonio A; Bishop DJ; Bertuzzi R; Lima-Silva AE · Medicine and science in sports and exercise · 2018
    Randomized trial9 participantsMetabolism Boost forCaffeine
  41. Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis.
    Wang K; Ma CH; Khoramjoo M; Kung JY; Oudit GY · BMC infectious diseases · 2026
    Meta-analysis1,030 participants27 studies pooledMetabolism Boost forTaurine
  42. Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.
    Sun Q; Wang J; Wang H; Yu H; Wan K; Ma F; Wang R · Nutrients · 2025
    Meta-analysis9 studies pooledMetabolism Boost forTaurine
  43. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials.
    Guan L; Miao P · European journal of pharmacology · 2021
    Meta-analysis12 studies pooledMetabolism Boost forTaurine
  44. Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects.
    Zhang M; Bi LF; Fang JH; Su XL; Da GL; Kuwamori T; Kagamimori S · Amino acids · 2005
    Randomized trial30 participantsMetabolism Boost forTaurine
  45. Use of skeletal muscle fiber composition to assess relationship between amino acid metabolism and insulin sensitivity.
    Magnusson TE; Blackwood SJ; Tischer D; Strmeň T; Pontén M; Edman S; Horwath O; Apró W; Moberg M; Chorell E; Katz A · European journal of endocrinology · 2025
    Cross-sectional study36 participantsMetabolism Boost forTaurine
  46. The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength
    David Bellar, Nina R LeBlanc, Brian Campbell · Journal of the International Society of Sports Nutrition · 2015
    Randomized trial13 participantsMuscle Gain forAlpha-GPC
  47. Effects of Acute Ingestion of Caffeine Capsules on Muscle Strength and Muscle Endurance: A Systematic Review and Meta-Analysis.
    Wu W; Chen Z; Zhou H; Wang L; Li X; Lv Y; Sun T; Yu L · Nutrients · 2024
    Meta-analysis14 studies pooledMuscle Gain forCaffeine
  48. Acute caffeine intake improves muscular strength, power, and endurance performance, reversing the time-of-day effect regardless of muscle activation level in resistance-trained males: a randomized controlled trial.
    Montalvo-Alonso JJ; Del Val-Manzano M; Cerezo-Telléz E; Ferragut C; Valadés D; Rodríguez-Falces J; Pérez-López A · European journal of applied physiology · 2025
    Randomized trial13 participantsMuscle Gain forCaffeine
  49. Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses.
    Grgic J; Grgic I; Pickering C; Schoenfeld BJ; Bishop DJ; Pedisic Z · British journal of sports medicine · 2020
    Systematic review21 studies pooledMuscle Gain forCaffeine
  50. Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis.
    Grgic J; Trexler ET; Lazinica B; Pedisic Z · Journal of the International Society of Sports Nutrition · 2018
    Meta-analysis20 studies pooledMuscle Gain forCaffeine
  51. Caffeine increases strength and power performance in resistance-trained females during early follicular phase.
    Norum M; Risvang LC; Bjørnsen T; Dimitriou L; Rønning PO; Bjørgen M; Raastad T · Scandinavian journal of medicine & science in sports · 2021
    Randomized trial15 participantsMuscle Gain forCaffeine
  52. Treatment of dementia with neurotransmission modulation.
    Doggrell SA; Evans S · Expert opinion on investigational drugs · 2004
    Narrative reviewProductivity Boost forAlpha-GPC
  53. Effects of caffeine on alertness.
    Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
    Randomized trial24 participantsProductivity Boost forCaffeine
  54. Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
    Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
    Randomized trial22 participantsProductivity Boost forCaffeine
  55. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
    Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
    Randomized trial68 participantsProductivity Boost forCaffeine
  56. A review of caffeine's effects on cognitive, physical and occupational performance.
    McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
    Narrative reviewProductivity Boost forCaffeine
  57. Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
    Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
    Meta-analysis7 studies pooledProductivity Boost forCaffeine
  58. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  59. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  60. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  61. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  62. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  63. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  64. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  65. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  66. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12
  67. Changes in caffeine intake and long-term weight change in men and women.
    Lopez-Garcia E; van Dam RM; Rajpathak S; Willett WC; Manson JE; Hu FB · The American journal of clinical nutrition · 2006
    Cohort study58,157 participantsWeight Loss forCaffeine
  68. Does caffeine ingestion before a short-term sprint interval training promote body fat loss?
    Ferreira GA; Felippe LC; Bertuzzi R; Bishop DJ; Ramos IS; De-Oliveira FR; Lima-Silva AE · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2020
    Randomized trial20 participantsWeight Loss forCaffeine
  69. Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.
    Zhiang J; Song Q · Physiological research · 2026
    Randomized trial30 participantsWeight Loss forCaffeine
  70. Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss.
    Davoodi SH; Hajimiresmaiel SJ; Ajami M; Mohseni-Bandpei A; Ayatollahi SA; Dowlatshahi K; Javedan G; Pazoki-Toroudi H · Iranian journal of pharmaceutical research : IJPR · 2014
    Non-randomized trial60 participantsWeight Loss forCaffeine
  71. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.
    Tabrizi R; Saneei P; Lankarani KB; Akbari M; Kolahdooz F; Esmaillzadeh A; Nadi-Ravandi S; Mazoochi M; Asemi Z · Critical reviews in food science and nutrition · 2020
    Meta-analysis606 participants13 studies pooledWeight Loss forCaffeine