Product Image

Seventh Gear Your Mom's Lemonade

Axe & Sledge Supplements
4.9
★ ★ ★ ★ ★
(16 ratings)
Caffeine 175 mg
Betaine Anhydrous 1000 mg
Alpha-GPC 100 mg
Product Image
Score72
A broad, layered stimulant pre-workout with useful betaine and beta-alanine, but complex caffeine and modest focus doses make it harder to tailor.
How scoring works
Quantity:318 Gram(s) • (60 servings)
Goals:
Energy
Metabolism Boost
Weight Loss
Fitness
Mental Focus
Productivity Boost
Weight Gain

Score 72

A broad, layered stimulant pre-workout with useful betaine and beta-alanine, but complex caffeine and modest focus doses make it harder to tailor.
How scoring works
$34.99($0.58 per serving)
Nutrition Faktory
$ 34.99
Report prices

Analysis

Caffeine anhydrous, dicaffeine malate, and theacrine provide layered stimulation, supported by beta-alanine and betaine for training. Choline sources and huperzine A extend the formula toward focus, though the performance side is more convincing.

Most amounts are disclosed, but the actual caffeine contribution from dicaffeine malate is not separated from its compound weight. Betaine is meaningful but below common full daily amounts, while Alpha-GPC and magnesium creatine chelate make relatively small contributions.

Experienced stimulant users may value the option of a partial serving because the container offers many servings. Beginners, late-day trainers, and people using other cholinergic products should favor a simpler formula.

Who is it for
  • Experienced stimulant users wanting combined training and focus support
  • Adults who prefer adjustable powder servings
Best for
  • High-energy workouts
  • Combined stimulant and cholinergic focus

Pros

  • Layered stimulant profile
  • Meaningful beta-alanine and betaine amounts
  • Includes two choline sources
  • Long serving count improves flexibility

Cons

  • Total caffeine exposure is not fully explicit
  • Alpha-GPC amount is low
  • Creatine contribution is modest
  • Complex formula increases interaction and tolerance concerns

Warnings

  • Multiple stimulants may cause jitteriness, rapid heartbeat, or sleep disruption
  • Huperzine A may cause nausea, vivid dreams, or cholinergic side effects
  • Niacin can cause warmth or flushing
  • Avoid stacking with other stimulant or huperzine-containing products

Nutrient quality

70 High impact

The staged stimulant profile and several useful forms provide broad pre-workout support. Underdosed performance actives and an assertive stimulant combination reduce balance.

.

Ingredient transparency

83 Highest impact

Every active dose is disclosed without a hidden blend. Combined stimulant exposure, complete directions, and inactive ingredients are not presented as clearly as they could be.

.

Customer satisfaction

57 Moderate impact

The supplied average is very strong and based on a small sample. No review themes were provided, so consistency and purpose-specific experience cannot be assessed.

.

Value for money

71 High impact

Broad active coverage and a reasonable serving cost support fair value. Several underdosed performance ingredients reduce quality-adjusted competitiveness.

.
Report analysis

Goals

Energy
Energy
Impact
Highest effect
A+ Goal FitA Strength of SupportA CoverageA- Formula Quality
Magnesium · 60 mgVitamin B12 · 150 mcgCaffeine · 25 mg

Immediate and slower caffeine sources provide acute alertness, while theacrine and choline add focus-oriented support. Beta-alanine, betaine, and a creatine-magnesium ingredient extend the formula toward workout performance.

Most active amounts are disclosed and the stimulant total is moderate to high. Caffeine, theacrine, and huperzine may be too stimulating for sensitive users and can disrupt sleep when taken late.

Study evidence
Caffeine Supportive 68 studies
Magnesium Supportive 4 studies
Metabolism Boost
Metabolism Boost
Impact
Highest effect
A- Goal FitA- Strength of SupportB CoverageB- Formula Quality
Niacin · 12.5 mg NEVitamin B12 · 150 mcgVitamin B6 · 12.5 mgMagnesium · 60 mgCaffeine · 25 mg

Caffeine provides a direct and well-supported increase in alertness, energy expenditure, and short-term fat oxidation. The total stimulant load is substantial, while B vitamins and magnesium add only secondary support.

Caffeine amounts and theacrine are clearly disclosed, providing good dosing confidence. Multiple caffeine sources plus theacrine may increase jitteriness, sleep disruption, or cardiovascular strain in sensitive users.

Study evidence
Caffeine Disputed 40 studies
Magnesium Supportive 61 studies
Weight Loss
Weight Loss
Impact
Highest effect
B+ Goal FitA- Strength of SupportC+ CoverageA- Formula Quality
Magnesium · 60 mgCaffeine · 25 mg

Caffeine and theacrine may increase alertness and modestly support thermogenesis, while creatine-related and beta-alanine ingredients support training. The formula does not address appetite or fiber-based satiety.

Immediate and slower caffeine sources plus theacrine have disclosed amounts, and methylcobalamin is clearly identified. Several performance compounds are below full standalone doses, but the stimulant pathway retains practical depth. Caffeine from two sources plus theacrine may cause rapid heartbeat, anxiety, elevated blood pressure, or sleep disruption in stimulant-sensitive users.

Study evidence
Caffeine Disputed 14 studies
Fitness
Fitness
Impact
High effect
A- Goal FitB- Strength of SupportB- CoverageB Formula Quality
Magnesium · 60 mgBetaine Anhydrous · 1000 mgBeta-Alanine · 1600 mgCaffeine · 25 mg

Caffeine, beta-alanine, betaine, creatine chelate, and focus ingredients provide several relevant pre-workout mechanisms. The staged stimulant system and active B12 can support training drive and concentration.

Beta-alanine, betaine, and creatine are below common full performance amounts, so the formula leans more on stimulation than physical-performance dosing. Combined caffeine sources plus theacrine may prolong stimulation and disrupt sleep in sensitive users.

Study evidence
Betaine Anhydrous Mixed 16 studies
Caffeine Supportive 255 studies
Mental Focus
Mental Focus
Impact
High effect
A- Goal FitB- Strength of SupportB CoverageC+ Formula Quality
Choline · 125 mgVitamin B6 · 12.5 mgVitamin B12 · 150 mcgMagnesium · 60 mgAlpha-GPC · 100 mgCaffeine · 25 mg

Caffeine, theacrine, choline compounds, and huperzine create strong short-term alertness and cholinergic support. The caffeine amount is effective, while the Alpha-GPC serving appears too low to provide a robust active yield.

Every active is quantified, but consumers must combine two caffeine entries and the Alpha-GPC yield is not stated. The combined caffeine and theacrine load may cause jitteriness, a faster heart rate, or sleep disruption in stimulant-sensitive users.

Study evidence
Alpha-GPC Supportive 1 study
Caffeine Supportive 128 studies
Choline Supportive 22 studies
Productivity Boost
Productivity Boost
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageC+ Formula Quality
Vitamin B12 · 150 mcgVitamin B12 · 150 mcgVitamin B6 · 12.5 mgMagnesium · 60 mgAlpha-GPC · 100 mgCaffeine · 25 mg

Immediate caffeine, di-caffeine malate, theacrine, Alpha-GPC, choline, and huperzine create a direct multi-pathway productivity stack. The roughly 200 mg combined caffeine materials provide substantial alertness, while Alpha-GPC is too small for strong cholinergic depth.

The label lists each active separately, though consumers must add the two caffeine entries and Alpha-GPC yield is not stated. Combined caffeine and theacrine may cause jitteriness, insomnia, palpitations, or blood-pressure increases in sensitive users.

Study evidence
Alpha-GPC Supportive 2 studies
Caffeine Supportive 108 studies

Ingredients

IngredientAmount per serving
Vitamin B3 (Niacin)
 12.5 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
 12.5 mg
Vitamin B12 (Methylcobalamin)
 150 mcg
Choline (Choline Bitartrate)
 50 mg
Magnesium (Magnesium Creatine Chelate)
 60 mg
Beta-Alanine
1600 mg
Betaine Anhydrous
1000 mg
Magnesium Creatine Chelate
750 mg
Caffeine Anhydrous
175 mg
Choline Bitartrate
125 mg
Alpha-Glyceryl Phosphoryl Choline
100 mg
Theacrine
50 mg
Dicaffeine Malate
25 mg
Black Pepper extract
2.5 mg
Toothed Clubmoss (Huperzine A)
 50 mcg
Adults 18–50 Women
Report overview
Caffeine · 175 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value

Immediate caffeine and di-caffeine malate provide a staged stimulant profile with a moderate combined amount. The consumer must add the two caffeine entries to understand the total, while theacrine supplies another clearly measured stimulant. The serving cost is fair, but stimulant-sensitive users should account for the combined caffeine and theacrine load.

View ingredientView products
Betaine Anhydrous · 1000 mg OverallScore75
A+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyC Value

Betaine anhydrous is clearly identified, which confirms the form suited to performance and methylation support. The 1,000 mg serving is below the commonly used full performance amount, although every active dose is disclosed. Low serving cost partly offsets the modest betaine dose, while the stimulant blend makes this better suited to caffeine-tolerant adults.

View ingredientView products
Alpha-GPC · 100 mg OverallScore30
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Generic Alpha-GPC is listed at 100 mg without source or active-yield clarification. Assuming 50% yield, the estimated 50 mg active amount falls below the preferred range. The caffeine and theacrine combination may increase jitteriness or interfere with sleep in stimulant-sensitive users.

View ingredientView products
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<p>Full pre-workout amounts of citrulline malate, beta-alanine, betaine, theanine, Alpha-GPC, and caffeine create excellent performance depth. Compared with Seventh Gear Your Mom's Lemonade, the disclosed delivery approach and ingredient profile provide a useful quality-focused alternative, although the noted limitations prevent a definitive advantage for every user.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of caffeine ingestion on time trial performance in cyclists: a systematic review and meta-analysis.
    Chen B; Ding L; Qin Q; Lei TH; Girard O; Cao Y · Journal of the International Society of Sports Nutrition · 2024
    Meta-analysis15 studies pooledFitness forCaffeine
  2. Betaine supplementation improves CrossFit performance and increases testosterone levels, but has no influence on Wingate power: randomized crossover trial.
    Zawieja E; Durkalec-Michalski K; Sadowski M; Główka N; Chmurzynska A · Journal of the International Society of Sports Nutrition · 2023
    Randomized trial43 participantsFitness forBetaine Anhydrous
  3. Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness.
    Paech GM; Banks S; Pajcin M; Grant C; Johnson K; Kamimori GH; Vedova CB · Pharmacology, biochemistry, and behavior · 2017
    Randomized trial24 participantsEnergy forCaffeine
  4. No effects of caffeine on cycling to exhaustion and perceptual responses in non-caffeine-restricted subjects.
    Weippert M; Behrens M; Schlegel M; Schröder T; Tillmann M; Rühe N; Römer R; Mau-Möller A; Bruhn S · Journal of the International Society of Sports Nutrition · 2025
    Randomized trial56 participantsEnergy Fitness forCaffeine
  5. Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance.
    del Favero S; Roschel H; Artioli G; Ugrinowitsch C; Tricoli V; Costa A; Barroso R; Negrelli AL; Otaduy MC; da Costa Leite C; Lancha-Junior AH; Gualano B · Amino acids · 2012
    Randomized trialFitness forBetaine Anhydrous
  6. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
    Juliano LM; Griffiths RR · Psychopharmacology · 2005
    Systematic review66 studies pooledEnergy forCaffeine
  7. Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis.
    Wu J; Xu K; Yin M; Ding X; Wang T; Zhang Q; Wu X; Xiao N · Frontiers in nutrition · 2026
    Meta-analysis226 participants20 studies pooledFitness forCaffeine
  8. Betaine Supplementation Does Not Improve Muscle Hypertrophy or Strength Following 6 Weeks of Cross-Fit Training.
    Moro T; Badiali F; Fabbri I; Paoli A · Nutrients · 2021
    Randomized trial29 participantsFitness forBetaine Anhydrous
  9. Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis.
    Wang Z; Qiu B; Gao J; Del Coso J · Nutrients · 2023
    Meta-analysis254 participants21 studies pooledFitness forCaffeine
  10. Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
    Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
    Randomized trial48 participantsEnergy forCaffeine
  11. Effects of Betaine Supplementation on Muscle Strength and Power: A Systematic Review.
    Ismaeel A · Journal of strength and conditioning research · 2018
    Systematic review7 studies pooledFitness forBetaine Anhydrous
  12. Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes.
    Guest N; Corey P; Vescovi J; El-Sohemy A · Medicine and science in sports and exercise · 2019
    Randomized trial101 participantsFitness forCaffeine
  13. Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
    Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
    Randomized trial20 participantsEnergy forCaffeine
  14. Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.
    Arazi H; Aboutalebi S; Taati B; Cholewa JM; Candow DG · Journal of the International Society of Sports Nutrition · 2022
    Randomized trial10 participantsFitness forBetaine Anhydrous
  15. Placebo in sports nutrition: a proof-of-principle study involving caffeine supplementation.
    Saunders B; de Oliveira LF; da Silva RP; de Salles Painelli V; Gonçalves LS; Yamaguchi G; Mutti T; Maciel E; Roschel H; Artioli GG; Gualano B · Scandinavian journal of medicine & science in sports · 2018
    Randomized trial42 participantsFitness forCaffeine
  16. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
    Fuller DT; Smith ML; Boolani A · Nutrients · 2021
    Randomized trialEnergy forCaffeine
  17. Effect of betaine supplementation on power performance and fatigue.
    Hoffman JR; Ratamess NA; Kang J; Rashti SL; Faigenbaum AD · Journal of the International Society of Sports Nutrition · 2011
    Randomized trial24 participantsFitness forBetaine Anhydrous
  18. Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis.
    Raya-González J; Rendo-Urteaga T; Domínguez R; Castillo D; Rodríguez-Fernández A; Grgic J · Sports medicine (Auckland, N.Z.) · 2021
    Meta-analysis12 studies pooledFitness forCaffeine
  19. Effect of Caffeine on Golf Performance and Fatigue during a Competitive Tournament.
    Mumford PW; Tribby AC; Poole CN; Dalbo VJ; Scanlan AT; Moon JR; Roberts MD; Young KC · Medicine and science in sports and exercise · 2016
    Randomized trial12 participantsEnergy forCaffeine
  20. The Impacts of Combined Blood Flow Restriction Training and Betaine Supplementation on One-Leg Press Muscular Endurance, Exercise-Associated Lactate Concentrations, Serum Metabolic Biomarkers, and Hypoxia-Inducible Factor-1α Gene Expression.
    Machek SB; Harris DR; Zawieja EE; Heileson JL; Wilburn DT; Radziejewska A; Chmurzynska A; Cholewa JM; Willoughby DS · Nutrients · 2023
    Randomized trial18 participantsFitness forBetaine Anhydrous
  21. Acute Effects of Caffeine Supplementation on Physical Performance, Physiological Responses, Perceived Exertion, and Technical-Tactical Skills in Combat Sports: A Systematic Review and Meta-Analysis.
    Delleli S; Ouergui I; Messaoudi H; Trabelsi K; Ammar A; Glenn JM; Chtourou H · Nutrients · 2022
    Meta-analysis26 studies pooledFitness forCaffeine
  22. Effects of Caffeine Intake on Cognitive Performance Related to Total Sleep Deprivation and Time on Task: A Randomized Cross-Over Double-Blind Study.
    Quiquempoix M; Sauvet F; Erblang M; Van Beers P; Guillard M; Drogou C; Trignol A; Vergez A; Léger D; Chennaoui M; Gomez-Merino D; Rabat A · Nature and science of sleep · 2022
    Randomized trial24 participantsEnergy forCaffeine
  23. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial.
    Nobari H; Cholewa JM; Castillo-Rodríguez A; Kargarfard M; Pérez-Gómez J · Journal of the International Society of Sports Nutrition · 2021
    Randomized trial29 participantsFitness forBetaine Anhydrous
  24. Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
    Carvalho A; Marticorena FM; Grecco BH; Barreto G; Saunders B · Sports medicine (Auckland, N.Z.) · 2022
    Meta-analysis60 studies pooledFitness forCaffeine
  25. Caffeine Supplementation and Physical Performance, Muscle Damage and Perception of Fatigue in Soccer Players: A Systematic Review.
    Mielgo-Ayuso J; Calleja-Gonzalez J; Del Coso J; Urdampilleta A; León-Guereño P; Fernández-Lázaro D · Nutrients · 2019
    Systematic review17 participants17 studies pooledEnergy forCaffeine
  26. Effects of Two-Week Betaine Supplementation on Apoptosis, Oxidative Stress, and Aerobic Capacity after Exhaustive Endurance Exercise.
    Yang MT; Lee XX; Huang BH; Chien LH; Wang CC; Chan KH · Antioxidants (Basel, Switzerland) · 2024
    Randomized trial10 participantsFitness forBetaine Anhydrous
  27. Sex Differences in the Ergogenic Response of Acute Caffeine Intake on Muscular Strength, Power and Endurance Performance in Resistance-Trained Individuals: A Randomized Controlled Trial.
    Montalvo-Alonso JJ; Ferragut C; Del Val-Manzano M; Valadés D; Roberts J; Pérez-López A · Nutrients · 2024
    Randomized trial76 participantsFitness forCaffeine
  28. Effect of caffeine intake on fat oxidation rate during exercise: is there a dose-response effect?
    Gutiérrez-Hellín J; Aguilar-Navarro M; Ruiz-Moreno C; Muñoz A; Varillas-Delgado D; Amaro-Gahete FJ; Del Coso J · European journal of nutrition · 2023
    Randomized trial18 participantsEnergy Metabolism Boost forCaffeine
  29. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men.
    Trepanowski JF; Farney TM; McCarthy CG; Schilling BK; Craig SA; Bloomer RJ · Journal of strength and conditioning research · 2012
    Randomized trialFitness forBetaine Anhydrous
  30. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusDetoxification forCholine
  31. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsDetoxification forCholine
  32. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsDetoxification forCholine
  33. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsDetoxification forCholine
  34. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsDetoxification forCholine
  35. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
    Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
    Randomized trial48 participantsEnergy forCaffeine
  36. Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
    Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial26 participantsEnergy forCaffeine
  37. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  38. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  39. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  40. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  41. Effects of Nutrition Interventions on Athletic Performance in Soccer Players: A Systematic Review.
    Aguinaga-Ontoso I; Guillen-Aguinaga S; Guillen-Aguinaga L; Alas-Brun R; Guillen-Grima F · Life (Basel, Switzerland) · 2023
    Systematic review310 participants16 studies pooledFitness forBetaine Anhydrous
  42. Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.
    Kerksick CM · Nutrients · 2024
    Randomized trial20 participantsMental Focus Productivity Boost forAlpha-GPC
  43. Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
    Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
    Randomized trial32 participantsMental Focus forCaffeine
  44. Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
    Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
    Randomized trial70 participantsMental Focus forCaffeine
  45. Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
    Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
    Randomized trial48 participantsMental Focus forCaffeine
  46. Effects of caffeine on mood and performance: a study of realistic consumption.
    Brice CF; Smith AP · Psychopharmacology · 2003
    Clinical trial24 participantsMental Focus forCaffeine
  47. Effects of caffeine or diphenhydramine on visual vigilance.
    Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
    Randomized trial24 participantsMental Focus forCaffeine
  48. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
    Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
    Randomized trial31 participantsMental Focus forCholine
  49. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
    Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
    Cohort study1,391 participantsMental Focus forCholine
  50. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
    Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis30 studies pooledMental Focus forCholine
  51. Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
    Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
    Systematic reviewMental Focus forCholine
  52. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
    Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
    Randomized trialMental Focus forCholine
  53. A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
    Krieger J; Schrautemeier A; Hagele A; Gaige C; Mennemeyer O; Tolbert S; Iannotti J; Kerksick C; Noonan C; Mumford P · Nutrients · 2025
    Randomized trial60 participantsMetabolism Boost forCaffeine
  54. Oolong tea increases metabolic rate and fat oxidation in men.
    Rumpler W; Seale J; Clevidence B; Judd J; Wiley E; Yamamoto S; Komatsu T; Sawaki T; Ishikura Y; Hosoda K · The Journal of nutrition · 2001
    Randomized trial12 participantsMetabolism Boost forCaffeine
  55. Comparison of changes in energy expenditure and body temperatures after caffeine consumption.
    Koot P; Deurenberg P · Annals of nutrition & metabolism · 1995
    Randomized trial12 participantsMetabolism Boost forCaffeine
  56. Caffeine Increases Work Done above Critical Power, but Not Anaerobic Work.
    Silveira R; Andrade-Souza VA; Arcoverde L; Tomazini F; Sansonio A; Bishop DJ; Bertuzzi R; Lima-Silva AE · Medicine and science in sports and exercise · 2018
    Randomized trial9 participantsMetabolism Boost forCaffeine
  57. Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis.
    Zhao B; Deng H; Li B; Chen L; Zou F; Hu L; Wei Y; Zhang W · Diabetes/metabolism research and reviews · 2021
    Meta-analysis1,168 participants26 studies pooledMetabolism Boost forMagnesium
  58. Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.
    Tan X; Huang Y · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Meta-analysis4 studies pooledMetabolism Boost forMagnesium
  59. Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
    Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
    Meta-analysis384 participants5 studies pooledMetabolism Boost forMagnesium
  60. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial.
    Rodríguez-Morán M; Guerrero-Romero F · Diabetes care · 2003
    Randomized trial63 participantsMetabolism Boost forMagnesium
  61. Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
    Randomized trial70 participantsMetabolism Boost forMagnesium
  62. The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength
    David Bellar, Nina R LeBlanc, Brian Campbell · Journal of the International Society of Sports Nutrition · 2015
    Randomized trial13 participantsMuscle Gain forAlpha-GPC
  63. Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population.
    Huang BX; Zhu YY; Tan XY; Lan QY; Li CL; Chen YM; Zhu HL · The British journal of nutrition · 2017
    Cohort study1,996 participantsMuscle Gain Weight Gain forBetaine Anhydrous
  64. Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study.
    Long JA; Zhong RH; Chen S; Wang F; Luo Y; Lu XT; Yishake D; Chen YM; Fang AP; Zhu HL · The British journal of nutrition · 2021
    Cohort study1,242 participantsMuscle Gain Weight Gain forBetaine Anhydrous
  65. Higher serum choline and betaine levels are associated with better body composition in male but not female population.
    Gao X; Randell E; Zhou H; Sun G · PloS one · 2018
    Cross-sectional study1,081 participantsMuscle Gain forBetaine Anhydrous
  66. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise.
    Apicella JM; Lee EC; Bailey BL; Saenz C; Anderson JM; Craig SA; Kraemer WJ; Volek JS; Maresh CM · European journal of applied physiology · 2013
    Randomized trial12 participantsMuscle Gain forBetaine Anhydrous
  67. Ergogenic effects of betaine supplementation on strength and power performance.
    Lee EC; Maresh CM; Kraemer WJ; Yamamoto LM; Hatfield DL; Bailey BL; Armstrong LE; Volek JS; McDermott BP; Craig SA · Journal of the International Society of Sports Nutrition · 2011
    Randomized trial12 participantsMuscle Gain forBetaine Anhydrous
  68. Treatment of dementia with neurotransmission modulation.
    Doggrell SA; Evans S · Expert opinion on investigational drugs · 2004
    Narrative reviewProductivity Boost forAlpha-GPC
  69. Effects of caffeine on alertness.
    Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
    Randomized trial24 participantsProductivity Boost forCaffeine
  70. Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
    Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
    Randomized trial22 participantsProductivity Boost forCaffeine
  71. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
    Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
    Randomized trial68 participantsProductivity Boost forCaffeine
  72. A review of caffeine's effects on cognitive, physical and occupational performance.
    McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
    Narrative reviewProductivity Boost forCaffeine
  73. Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
    Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
    Meta-analysis7 studies pooledProductivity Boost forCaffeine
  74. Effects of betaine on body composition, performance, and homocysteine thiolactone.
    Cholewa JM; Wyszczelska-Rokiel M; Glowacki R; Jakubowski H; Matthews T; Wood R; Craig SA; Paolone V · Journal of the International Society of Sports Nutrition · 2013
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  75. Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II.
    Trujillo-González I; Barisione G; Bottiglieri T; Reyes M; Garmendia ML; Mujica-Coopman MF · The Journal of nutrition · 2026
    Cohort study150 participantsWeight Gain forBetaine Anhydrous
  76. Effects of Betaine Supplementation on Markers of Metabolic Flexibility, Body Composition, and Anaerobic Performance in Active College-Age Females.
    Waldman HS; Bryant AR; McAllister MJ · Journal of dietary supplements · 2023
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  77. Association between coffee intake and skeletal muscle mass among U.S. adults: a population-based study.
    Yin H; Zhu W; Guo L; Li W; Liang M · Frontiers in nutrition · 2024
    Cross-sectional study8,333 participantsWeight Gain forCaffeine
  78. Use of caffeine in 19,660 randomly selected U.S. adults: the role of overweight and obesity.
    Tucker LA; Beltran F · Frontiers in nutrition · 2025
    Cross-sectional study19,660 participantsWeight Gain forCaffeine
  79. Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals.
    Alshahrani SH; Atia YA; Badir RA; Almalki SG; Tayyib NA; Shahab S; Romero-Parra RM; Abid MK; Hussien BM; Ramaiah P · BMC endocrine disorders · 2023
    Cross-sectional study488 participantsWeight Gain forCaffeine
  80. Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool.
    Sharp GC; Lawlor DA; Easey KE; Kundu S; Elhakeem A; Hone E; McEachan RRC; Magnus MC; Havdahl A; Relton CL · PLoS medicine · 2026
    Cohort study232,139 participantsWeight Gain forCaffeine
  81. Weight gain in older adolescent females: the internet, sleep, coffee, and alcohol.
    Berkey CS; Rockett HR; Colditz GA · The Journal of pediatrics · 2008
    Cohort study5,000 participantsWeight Gain forCaffeine
  82. Magnesium supplementation alleviates premenstrual symptoms of fluid retention.
    Walker AF; De Souza MC; Vickers MF; Abeyasekera S; Collins ML; Trinca LA · Journal of women's health · 1999
    Randomized trial38 participantsWeight Gain forMagnesium
  83. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials.
    Askari M; Mozaffari H; Jafari A; Ghanbari M; Darooghegi Mofrad M · Critical reviews in food science and nutrition · 2021
    Meta-analysis32 studies pooledWeight Gain forMagnesium
  84. Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects.
    Guerrero-Romero F; Rodriguez-Moran M · European journal of internal medicine · 2014
    Cross-sectional study427 participantsWeight Gain forMagnesium
  85. No association between dietary magnesium intake and body composition among Iranian adults: a cross-sectional study.
    Mirrafiei A; Jabbarzadeh B; Hosseini Y; Djafarian K; Shab-Bidar S · BMC nutrition · 2022
    Cross-sectional study778 participantsWeight Gain forMagnesium
  86. Serum magnesium in overweight children.
    Jose B; Jain V; Vikram NK; Agarwala A; Saini S · Indian pediatrics · 2012
    Cross-sectional study108 participantsWeight Gain forMagnesium
  87. Changes in caffeine intake and long-term weight change in men and women.
    Lopez-Garcia E; van Dam RM; Rajpathak S; Willett WC; Manson JE; Hu FB · The American journal of clinical nutrition · 2006
    Cohort study58,157 participantsWeight Loss forCaffeine
  88. Does caffeine ingestion before a short-term sprint interval training promote body fat loss?
    Ferreira GA; Felippe LC; Bertuzzi R; Bishop DJ; Ramos IS; De-Oliveira FR; Lima-Silva AE · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2020
    Randomized trial20 participantsWeight Loss forCaffeine
  89. Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.
    Zhiang J; Song Q · Physiological research · 2026
    Randomized trial30 participantsWeight Loss forCaffeine
  90. Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss.
    Davoodi SH; Hajimiresmaiel SJ; Ajami M; Mohseni-Bandpei A; Ayatollahi SA; Dowlatshahi K; Javedan G; Pazoki-Toroudi H · Iranian journal of pharmaceutical research : IJPR · 2014
    Non-randomized trial60 participantsWeight Loss forCaffeine
  91. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.
    Tabrizi R; Saneei P; Lankarani KB; Akbari M; Kolahdooz F; Esmaillzadeh A; Nadi-Ravandi S; Mazoochi M; Asemi Z · Critical reviews in food science and nutrition · 2020
    Meta-analysis606 participants13 studies pooledWeight Loss forCaffeine