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Mild-C 1600 mg

4.6
★ ★ ★ ★ ★
(205 ratings)
Vitamin C 1600 mg
Product Image
Score84
A high-dose buffered vitamin C powder with clear calcium disclosure and good value. The full serving is larger than many users need at one time.
How scoring works
Powder
Quantity:6 Liquid(s) • (85 servings)
Goals:
Immunity
General Health
Skin Health
Anti-Inflammatory Support
Vision Support

Score 84

A high-dose buffered vitamin C powder with clear calcium disclosure and good value. The full serving is larger than many users need at one time.
How scoring works
$16.92($0.19 per serving)
Pure Formulas
$ 16.92
iHerb
$ 16.92
iHerb
$ 16.92
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Analysis

The powder supplies 1,600 mg of vitamin C as calcium ascorbate, plus 180 mg of calcium. Full buffering may improve stomach comfort compared with ordinary ascorbic acid.

The concentrated format supports flexible dosing and favorable value. The listed serving is large, so taking the full amount at once may provide diminishing absorption efficiency and more digestive burden than a smaller divided dose.

It fits users who want high-dose buffered vitamin C and are comfortable measuring powder. People seeking broad immune, vision, or skin support should note that no complementary nutrients are included.

Who is it for
  • People sensitive to acidic vitamin C
  • Adults who prefer powder dosing
  • Users wanting concentrated calcium ascorbate
Best for
  • High-dose buffered vitamin C
  • Flexible serving sizes
  • Antioxidant and immune support

Pros

  • Fully buffered calcium ascorbate
  • Clear vitamin C and calcium amounts
  • Flexible powder format
  • Favorable value

Cons

  • Very large listed serving
  • Narrow nutrient coverage
  • Requires careful measuring
  • Single-dose absorption may be inefficient

Warnings

  • A 1,600 mg serving may cause loose stools even in buffered form
  • The serving adds 180 mg of calcium for users limiting supplemental calcium
  • Measure the powder carefully and consider whether a divided serving better suits tolerance

Nutrient quality

85 Highest impact

Calcium ascorbate supplies a well-regarded buffered form with a substantial amount. The concentrated serving may be more aggressive than needed for routine use.

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Ingredient transparency

84 Highest impact

Active names and amounts are clearly stated, with no hidden proprietary dose. Complete intake directions and a full inactive-ingredient list are not included in the supplied data.

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Customer satisfaction

68 High impact

Supplied satisfaction metrics indicate a strong result with a meaningful response pool. Detailed experience themes are absent, so recurring complaints and real-world purpose fit remain uncertain.

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Value for money

98 Highest impact

Serving value appears favorable relative to the disclosed form and amount. The focused formula avoids low-value extras.

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Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A+ Goal FitA- Strength of SupportC- CoverageA+ Formula Quality
Vitamin C · 1600 mg

Buffered calcium ascorbate supplies a substantial vitamin C amount for antioxidant protection and immune-cell function. The gentle mineral form is useful for people who find plain ascorbic acid irritating.

The 1,600 mg serving is somewhat above the most efficient range but remains clearly disclosed. The simple powder avoids a large excipient load and allows measured use.

Study evidence
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin C · 1600 mg

Buffered calcium ascorbate supplies vitamin C for antioxidant defense, immune function, and collagen production. The powder also clearly identifies the accompanying calcium and avoids the acidity of standard ascorbic acid.

The serving is larger than the most efficient single-dose range, so dividing the amount may improve tolerance and use. Its streamlined design supports one important nutrient well but does not provide broad coverage of general-health needs.

Study evidence
Vitamin C Supportive 56 studies
Skin Health
Skin Health
Impact
High effect
B Goal FitB+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin C · 1600 mg

Vitamin C directly supports collagen synthesis and antioxidant defense, and calcium ascorbate offers a buffered form. The substantial amount provides focused support for the skin structural pathway.

The single-active design does not add collagen peptides, hydration support, or lipid-barrier nutrients. The high vitamin C amount may cause diarrhea or abdominal cramping in sensitive users.

Study evidence
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitA Strength of SupportC CoverageA- Formula Quality
Vitamin C · 1600 mg

A substantial calcium ascorbate dose provides focused antioxidant support that may help limit oxidative stress linked with inflammatory signaling. The buffered form is clearly disclosed and may be easier for some people to tolerate.

Support is concentrated on antioxidant protection rather than direct control of several inflammatory pathways. The lean formula is well dosed, but it does not provide complementary fats, botanicals, or other major anti-inflammatory actives.

Study evidence
Vitamin C Supportive 50 studies
Vision Support
Vision Support
Impact
High effect
C+ Goal FitA Strength of SupportD CoverageA+ Formula Quality
Vitamin C · 1600 mg

Vitamin C provides relevant antioxidant support for the lens and retina. Its strongest vision evidence comes from multi-nutrient frameworks rather than use as a stand-alone eye supplement.

Buffered calcium ascorbate is clearly disclosed and may be gentler than plain ascorbic acid. The high amount creates strong antioxidant depth but does not provide carotenoids, retinal lipids, or zinc.

Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Vitamin C (Calcium Ascorbate)
 1600 mg
Calcium (Calcium Ascorbate)
 180 mg
Gluten Free Adults 18–50
Report overview
Vitamin C (Calcium Ascorbate) · 1600 mg OverallScore87
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

The fully buffered calcium ascorbate form supports good stomach comfort and clearly identifies the accompanying calcium. The Vitamin C amount is somewhat above the most efficient target range, which may reduce absorption efficiency for some people. Its concentrated powder format delivers strong value with few disclosed extras.

View ingredientView products
Loading alternative details
89 Performance

C-500 Calcium Ascorbate-C

NOW
The clearly disclosed vitamin C form provides a more focused alternative to the original buffered vitamin C formula. Its 500 mg of calcium ascorbate is buffered and includes 55 mg of calcium; the 10 mg bioflavonoid addition is modest.
88 Performance

Buffered Gold C

California Gold Nutrition
The clearly disclosed vitamin C form provides a more focused alternative to the original buffered vitamin C formula. Its 1,000 mg of sodium ascorbate is buffered and simply formulated, with 130 mg of sodium clearly disclosed.
88 Performance

Sodium Ascorbate Capsules

NutriBiotic Immunity
The clearly disclosed vitamin C form provides a more focused alternative to the original buffered vitamin C formula. Its capsules provide 850 mg of buffered sodium ascorbate with a clearly disclosed 100 mg sodium contribution.
85 Budget

C-500 With Rose Hips

NOW
The supplied serving-cost data indicates a less expensive way to obtain a comparable vitamin C serving. Compared with the original buffered vitamin C formula, it supplies 500 mg of ascorbic acid with 40 mg of rose hips, although the vitamin C remains unbuffered.
83 Budget

C 500 mg

21st Century
The supplied serving-cost data indicates a less expensive way to obtain a comparable vitamin C serving. Compared with the original buffered vitamin C formula, it supplies 500 mg of ascorbic acid with 30 mg of calcium in a basic, clearly dosed formula.
85 Budget

Gold C Vitamin C 1000 mg

California Gold Nutrition
The supplied serving-cost data indicates a less expensive way to obtain a comparable vitamin C serving. Compared with the original buffered vitamin C formula, it supplies 1,000 mg of plain ascorbic acid without extra actives, favoring simplicity rather than buffering.
87 Value

100% Pure Vitamin C Powder

Swanson Premium Brand
The combination of a focused ingredient list and efficient supply makes it a stronger value candidate than the original buffered vitamin C formula. Its powder provides 1,000 mg of ascorbic acid with flexible measuring, though the acidic form may not suit every user.
87 Value

C 500 mg

Mason Natural
The combination of a focused ingredient list and efficient supply makes it a stronger value candidate than the original buffered vitamin C formula. Its single active is 500 mg of ascorbic acid, making the label easy to assess despite the lack of buffering.
88 Value

Sodium Ascorbate

NutriBiotic Immunity
The combination of a focused ingredient list and efficient supply makes it a stronger value candidate than the original buffered vitamin C formula. Its 1,100 mg of sodium ascorbate is fully buffered, but the disclosed 120 mg of sodium matters for sodium-restricted users.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  2. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  3. The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review.
    SeyedAlinaghi S; Shahidi R; Mojdeganlou H; Akhtaran FK; Maroufi SF; Maroufi SP; Mirzapour P; Karimi A; Khodaei S; Pour MM; Mehraeen E; Dadras O · Journal of health, population, and nutrition · 2024
    Systematic review28 studies pooledImmunity forVitamin C
  4. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  5. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage.
    Fitzpatrick RE; Rostan EF · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002
    Non-randomized trial10 participantsSkin Health forVitamin C
  6. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledVision Support forVitamin C
  7. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin C
  8. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  9. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  10. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  11. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  12. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  13. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  14. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  15. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  16. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  17. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  18. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  19. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  20. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  21. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  22. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  23. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  24. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  25. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  26. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  27. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  28. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  29. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  30. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C