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Niacin 500 mg

4.6
★ ★ ★ ★ ★
(6961 ratings)
Niacin 500 mg
Product Image
Score73
A budget high-dose niacin tablet with a major form-disclosure gap. The exact form should be confirmed before use because it changes both effects and risks.
How scoring works
Tablet
Quantity:250 Tablet(s) • (250 servings)
Goals:
Heart Health
Cardiovascular Support

Score 73

A budget high-dose niacin tablet with a major form-disclosure gap. The exact form should be confirmed before use because it changes both effects and risks.
How scoring works
$15.10($0.06 per serving)
iHerb
$ 15.91
Vitacost
$ 15.91
Pure Formulas
$ 15.46
Daily Vita
$ 15.10
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Analysis

The high-potency tablet provides many times the basic daily requirement at very low cost. Its single-active design would otherwise be easy to assess.

The label only identifies vitamin B3, not nicotinic acid, niacinamide, or another form. Each has a different tolerance profile and different relevance to heart or skin goals.

Form verification is essential before taking a serving this large. Users seeking general nutrition would be better matched to a much smaller and clearly specified amount.

Who is it for
  • Adults with a specific high-dose vitamin B3 plan
  • Users willing to confirm the current label
  • People seeking a long, low-cost supply
Best for
  • High-dose niacin supplementation
  • Budget-conscious routines
  • Single-ingredient use

Pros

  • Large vitamin B3 amount
  • Long supply
  • Very low serving cost

Cons

  • Chemical form is unspecified
  • Potential effects cannot be predicted well
  • Excessive for ordinary daily nutrition

Warnings

  • If the form is nicotinic acid, flushing and dizziness may be substantial.
  • Prolonged high-dose niacin may affect liver enzymes, glucose, or uric acid.
  • Do not use it for cardiovascular management until the chemical form is confirmed.

Nutrient quality

58 Moderate impact

The generic vitamin B3 name does not identify the chemical form or expected absorption profile. The amount is substantial, but its practical effect depends heavily on the undisclosed form.

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Ingredient transparency

73 High impact

All meaningful active amounts are clearly disclosed. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

70 High impact

The aggregate satisfaction measure is strong and supported by adequate volume. Missing feedback themes leave recurring complaints and purpose fit uncertain.

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Value for money

95 Highest impact

The price is very well matched to the formula quality and dose. Each serving provides excellent cost efficiency.

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Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
B Goal FitB Strength of SupportC+ CoverageA+ Formula Quality

The 500 mg niacin amount can meaningfully alter lipid markers, but niacin is no longer a routine heart-health choice for most people because improved laboratory values have not consistently translated into added cardiovascular benefit on modern therapy. The unspecified chemical and release form makes the expected flush response and tolerability harder to predict.

This is a pharmacologic-level amount rather than basic vitamin coverage. It can cause intense flushing and may affect liver enzymes, blood sugar, or uric acid, so medical supervision is appropriate for lipid-focused use.

Study evidence
Niacin Supportive 105 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
B- Goal FitD- Strength of SupportF CoverageA- Formula Quality
Niacin · 500 mg

The high vitamin B3 amount could affect blood lipids if it is nicotinic acid, but the chemical form is not identified. That omission prevents reliable assessment of lipid efficacy, flushing risk, and release behavior.

The single-active design is focused but provides only one cardiovascular pathway. A high-dose niacin form can cause marked flushing and may affect liver function or glucose control, so the unspecified form and absent warning are important limitations.

Study evidence
Niacin Supportive 136 studies

Ingredients

IngredientAmount per serving
Niacin (Vitamin B3)
 500 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
Niacin (Vitamin B3) · 500 mg OverallScore53
D+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value

The formula supplies a substantial amount of vitamin B3 at a very low serving cost. The label does not identify the chemical form, so its goal fit and flush risk cannot be predicted confidently. No release technology or product-specific flush warning appears in the supplied information.

View ingredientView products
Loading alternative details
82 Performance

Sustained-Release Niacin with niaXtend 500 mg

Doctor's Best
<p>Sustained-release nicotinic acid provides a clearly identified cardiovascular-focused amount with controlled delivery. Compared with the original, it provides clearer form disclosure or a more purposeful match for cardiovascular-focused niacin use; however, high-dose niacin can still affect the liver and requires explicit safety guidance.</p>
80 Performance

Niacin (Vitamin B3) 500 mg

Solgar
<p>Clearly identified nicotinic acid provides direct high-dose vitamin B3 coverage with strong cardiovascular alignment. Compared with the original, it provides clearer form disclosure or a more purposeful match for cardiovascular-focused niacin use; however, the amount may cause flushing and can affect the liver, glucose, or blood pressure.</p>
79 Performance

Niacin-Time 500 mg

Carlson
<p>Timed-release nicotinic acid provides a transparent cardiovascular-focused dose in a long-supply format. Compared with the original, it provides clearer form disclosure or a more purposeful match for cardiovascular-focused niacin use; however, controlled delivery does not remove flushing or liver-related concerns from high-dose niacin.</p>
86 Budget

Niacinamide B-3 100 mg

Source Naturals
<p>A clearly identified moderate niacinamide tablet offers simple non-flushing vitamin B3 support with excellent serving economics. Serving cost is lower than the original, but it does not provide nicotinic acid’s lipid-focused effects and complete excipient details are missing.</p>
82 Budget

Niacin 100 mg

Nature's Way
<p>Clearly identified nicotinic acid supplies a modest, inexpensive vitamin B3 serving with direct form transparency. Serving cost is lower than the original, but immediate release can still cause temporary flushing and the dose is not intended for intensive cardiovascular use.</p>
82 Budget

Niacin 100 mg

Bluebonnet
<p>Clearly identified nicotinic acid provides a meaningful low-dose option in a simple long-supply capsule. It is among the lowest-cost supplied choices, although it does not undercut the already inexpensive original, but noticeable flushing remains possible and people sensitive to liver, glucose, or blood-pressure effects should choose carefully.</p>
80 Value

Niacin 50 mg

Carlson
<p>A clearly named low-dose nicotinic acid tablet provides economical and easy-to-assess vitamin B3 support. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although the amount is too low for focused cardiovascular use and can still cause flushing.</p>
85 Value

Niacin 100 mg

Source Naturals
<p>A moderate niacinamide tablet provides clearly identified vitamin B3 without typical nicotinic-acid flushing. Its lower serving cost and clearer active design support practical value compared with the original, although the form is intended for nutritional or skin support rather than lipid-focused effects.</p>
80 Value

No-Flush Niacin (Inositol Hexanicotinate) 500 mg

Solgar
<p>Clearly identified inositol hexanicotinate supports a comfort-focused no-flush approach with good serving value. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although the form is less direct than nicotinic acid for cardiovascular purposes.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  2. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  3. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health Cardiovascular Support forNiacin
  4. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledHeart Health forNiacin
  5. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  6. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  7. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  8. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  9. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  10. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  11. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  12. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  13. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  14. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  15. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  16. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  17. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy.
    Philpott AC; Hubacek J; Sun YC; Hillard D; Anderson TJ · Atherosclerosis · 2013
    Randomized trial66 participantsCardiovascular Support forNiacin
  18. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  19. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsCardiovascular Support forNiacin
  20. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  21. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  22. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  23. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  24. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  25. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin