Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
Meta-analysis1,998 participants34 studies pooledflagSleep Support forscienceMelatonin
- Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials.
Fernández-San-Martín MI; Masa-Font R; Palacios-Soler L; Sancho-Gómez P; Calbó-Caldentey C; Flores-Mateo G · Sleep medicine · 2010
Meta-analysis18 studies pooledflagSleep Support forscienceValerian
- Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
Meta-analysis516 participants8 studies pooledflagSleep Support forscienceMelatonin
- Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Ell J; Schmid SR; Benz F; Spille L · Journal of sleep research · 2024
Systematic review15 studies pooledflagSleep Support forscienceValerian
- Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
Peltz JS; Rogge R · Sleep and biological rhythms · 2025
Cohort study331 participantsflagSleep Support forscienceMelatonin
- Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
Randomized trial40 participantsflagSleep Support forscienceValerian
- Meta-analysis: melatonin for the treatment of primary sleep disorders.
Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
Meta-analysis1,683 participants19 studies pooledflagSleep Support forscienceMelatonin
- Valerian for sleep: a systematic review and meta-analysis.
Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
Meta-analysis1,093 participants16 studies pooledflagSleep Support forscienceValerian
- Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
Meta-analysis205 participants7 studies pooledflagSleep Support forscienceMelatonin
- Does valerian work for insomnia? An umbrella review of the evidence.
Valente V; Machado D; Jorge S; Drake CL; Marques DR · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
Systematic review8 studies pooledflagSleep Support forscienceValerian
- Melatonin Treatment for Sleep Disorders in Parkinson's Disease: A Meta-Analysis and Systematic Review.
Ma H; Yan J; Sun W; Jiang M; Zhang Y · Frontiers in aging neuroscience · 2022
Meta-analysis7 studies pooledflagSleep Support forscienceMelatonin
- Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
Sateia MJ; Buysse DJ; Krystal AD; Neubauer DN; Heald JL · Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
Guideline / consensusflagSleep Support forscienceValerian
- Effects of Melatonin Treatment on Perioperative Sleep Quality: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials.
Gao Y; Chen X; Zhou Q; Song J; Zhang X; Sun Y; Yu M; Li Y · Nature and science of sleep · 2022
Meta-analysis725 participants10 studies pooledflagSleep Support forscienceMelatonin
- Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
Randomized trial202 participantsflagSleep Support forscienceValerian
- Melatonin treatment for age-related insomnia.
Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
Randomized trial30 participantsflagSleep Support forscienceMelatonin
- Herbal medicine for insomnia: A systematic review and meta-analysis.
Leach MJ; Page AT · Sleep medicine reviews · 2016
Meta-analysis1,602 participants14 studies pooledflagSleep Support forscienceValerian
- Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
Randomized trial116 participantsflagSleep Support forscienceMelatonin
- Valerian for insomnia: a systematic review of randomized clinical trials.
Stevinson C; Ernst E · Sleep medicine · 2019
Systematic review9 studies pooledflagSleep Support forscienceValerian
- The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
Meta-analysis409 participants8 studies pooledflagSleep Support forscienceMelatonin
- A systematic review of insomnia and complementary medicine.
Sarris J; Byrne GJ · Sleep medicine reviews · 2011
Systematic review20 studies pooledflagSleep Support forscienceValerian
- Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
Randomized trial320 participantsflagSleep Support forscienceMagnesium
- Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
Cohort study3,964 participantsflagSleep Support forscienceMagnesium
- Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
Randomized trial120 participantsflagSleep Support forscienceMagnesium
- The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
Randomized trial46 participantsflagSleep Support forscienceMagnesium
- A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
Randomized trial175 participantsflagSleep Support forscienceMagnesium
- Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
Randomized trial791 participantsflagSleep Support forscienceMelatonin
- Effects of exogenous melatonin on sleep: a meta-analysis.
Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
Meta-analysis284 participants8 studies pooledflagSleep Support forscienceMelatonin
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
Randomized trial80 participantsflagSleep Support forscienceValerian
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
Randomized trial40 participantsflagSleep Support forscienceValerian
- Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
Randomized trial63 participantsflagStress Relief forscienceGABA
- GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
Randomized trial30 participantsflagStress Relief forscienceGABA
- Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
Clinical trial30 participantsflagStress Relief forscienceGABA
- Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
Case-control study45 participantsflagStress Relief forscienceGABA
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagStress Relief forscienceGABA
- Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
Randomized trial126 participantsflagStress Relief forscienceMagnesium
- Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
Randomized trial137 participantsflagStress Relief forscienceMagnesium
- Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
Non-randomized trial60 participantsflagStress Relief forscienceMagnesium
- Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
Randomized trial45 participantsflagStress Relief forscienceMagnesium
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
Randomized trialflagStress Relief forscienceMagnesium
- The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
Randomized trial202 participantsflagStress Relief forscienceMelatonin
- Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
Randomized trial90 participantsflagStress Relief forscienceMelatonin
- Melatonin for pre- and postoperative anxiety in adults.
Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
Meta-analysis774 participants12 studies pooledflagStress Relief forscienceMelatonin
- Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
Meta-analysis441 participants5 studies pooledflagStress Relief forscienceMelatonin
- Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
Randomized trial88 participantsflagStress Relief forscienceMelatonin
- Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
Moludi J; Qaisar SA; Kadhim MM; Ahmadi Y; Davari M · Nutrition & metabolism · 2022
Randomized trial120 participantsflagStress Relief forscienceTaurine
- Effects of taurine supplementation on VDT work induced visual stress.
Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
Randomized trial25 participantsflagStress Relief forscienceTaurine
- Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.
Ra SG; Choi Y; Akazawa N; Ohmori H; Maeda S · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017
Randomized trial29 participantsflagStress Relief forscienceTaurine
- Correlations between dietary taurine intake and life stress in Korean college students.
Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
Observational studyflagStress Relief forscienceTaurine
- Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.
Faghfouri AH; Seyyed Shoura SM; Fathollahi P; Shadbad MA; Papi S; Ostadrahimi A; Faghfuri E · European journal of clinical nutrition · 2022
Meta-analysisflagStress Relief forscienceTaurine