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Isopure Zero Carb Creamy Vanilla

The Isopure Company
4.5
★ ★ ★ ★ ★
(30870 ratings)
Sodium 240 mg
Chloride 360 mg
Calcium 340 mg
Potassium 370 mg
Phosphorus 280 mg
Copper 0.6 mg
Protein (unspecified) 25 Gram(s)
Product Image
Score72
Lean zero-carb protein in a well-sized package, with useful minerals but no meaningful heart-specific formulation.
How scoring works
Quantity:4 lb(s) • (66 servings)
Goals:
Heart Health

Score 72

Lean zero-carb protein in a well-sized package, with useful minerals but no meaningful heart-specific formulation.
How scoring works
$114.97($1.74 per serving)
Vitacost
$ 114.97
Amazon
$ 134.99
iHerb
$ 139.73
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Analysis

The zero-carb vanilla serving supplies 25 g protein in 100 calories with no fat. Fortified calcium, potassium, magnesium, phosphorus, and vitamins make it more nutritionally complete than plain isolate.

Most micronutrient forms are not stated, and the 240 mg sodium amount is not especially low. No ingredient directly targets vascular function, lipids, or cardiac energy.

The four-pound package is practical for regular use and has a lower serving cost than several smaller sizes. It best fits users who value lean protein and convenience rather than heart-specific supplementation.

Who is it for
  • Regular zero-carb protein users
  • Adults wanting creamy vanilla whey
  • People seeking a large supply
Best for
  • Daily protein intake
  • Low-carb nutrition
  • Lean calorie control

Pros

  • Provides 25 g protein
  • Sixty-six servings
  • Zero fat and carbohydrate
  • Useful calcium and potassium

Cons

  • Most forms are unspecified
  • Contains 240 mg sodium
  • No direct cardiovascular ingredients
  • Large tub requires storage

Warnings

  • Whey protein is milk-derived and unsuitable for milk-protein allergy
  • People with kidney-related potassium or phosphorus restrictions should include the mineral content in their daily plan

Nutrient quality

71 High impact

The substantial protein serving and useful amounts of calcium, potassium, and phosphorus support general nutrition. Unspecified vitamin and mineral forms limit absorption confidence, and the profile is only indirectly aligned with heart health.

Ingredient transparency

73 High impact

Specific amounts are shown for the protein, vitamins, and minerals, with no hidden active blend. Most ingredient forms, daily-use directions, and inactive ingredients are not fully supplied.

Customer satisfaction

72 High impact

The aggregate rating is strong and supported by a meaningful review count. No specific review comments were supplied, so repeated complaints and purpose-related experiences cannot be verified.

Value for money

72 High impact

The meaningful protein dose supports practical value in each serving. Broad micronutrient coverage helps, though incomplete form details keep the formula from leading its category.

Report analysis

Goals

Heart Health
Impact
Moderate effect
C- Goal FitD Strength of SupportD+ CoverageC Formula Quality
Vitamin K · 20 mcgMagnesium · 100 mgVitamin B12 · 3.3 mcgVitamin B6 · 0.5 mgFolate · 160 mcg DFE

Potassium at 370 mg and magnesium at 100 mg give the fortified protein powder some cardiovascular relevance. The protein format is not designed as a focused heart supplement.

The potassium and magnesium forms are not identified, which limits assessment of absorption and functional quality. Low-dose B vitamins, vitamin K, and selenium add general fortification without meaningful cardiovascular depth.

Study evidence
Magnesium Supportive 158 studies
Potassium Supportive 182 studies
Selenium Mixed 89 studies
Vitamin K Mixed 62 studies

Ingredients

IngredientAmount per serving
Calories
100 Calorie(s)
Total Fat
0 Gram(s)
Cholesterol
10 mg
Sodium
240 mg
Total Carbohydrates
0 Gram(s)
Protein
25 Gram(s)
Calcium
340 mg
Potassium
370 mg
Vitamin A
380 mcg
Vitamin C
15 mg
Vitamin E
5 mg
Vitamin K
20 mcg
Thiamine
0.3 mg
Riboflavin
0.4 mg
Niacin
5 mg
Vitamin B6
0.5 mg
Folate
160 mcg DFE
Vitamin B12
3.3 mcg
Biotin
75 mcg
Pantothenic Acid
2.5 mg
Phosphorus
280 mg
Iodine
38 mcg
Magnesium
100 mg
Zinc
4.2 mg
Selenium
17 mcg
Copper
0.6 mg
Manganese
0.5 mg
Chromium
30 mcg
Molybdenum
18 mcg
Chloride
360 mg
Gluten Free Adults 18–50
Report overview
Sodium · 240 mg OverallScore67
D Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB- Value

The sodium source and supporting mineral forms are not fully identified, limiting confidence in ingredient quality. The sodium amount fits the lower replenishment band rather than the preferred range. The higher serving cost is partly explained by substantial non-electrolyte nutrition.

Chloride · 360 mg OverallScore54
D- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The chloride amount is meaningful for electrolyte support. The source salt is not identified, leaving a notable transparency gap. The dissolvable delivery is practical, but the serving cost is high.

Calcium · 340 mg OverallScore49
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The exact calcium amount is stated, but the chemical form is missing, so absorption quality cannot be assessed. The 340 mg serving provides a useful moderate amount but may require divided intake for higher needs. No artificial colors, sweeteners, titanium dioxide, or high sugar are disclosed in the supplied data, while the high serving cost is difficult to justify without calcium-form disclosure.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledHeart Health forMagnesium
  2. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  3. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  4. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  5. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forMagnesium
  6. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledHeart Health forPotassium
  7. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.
    Poorolajal J; Zeraati F; Soltanian AR; Sheikh V; Hooshmand E; Maleki A · PloS one · 2017
    Meta-analysis1,213 participants23 studies pooledHeart Health forPotassium
  8. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
    O'Donnell M; Mente A; Rangarajan S; McQueen MJ; O'Leary N; Yin L; Liu X; Swaminathan S; Khatib R; Rosengren A; Ferguson J; Smyth A; Lopez-Jaramillo P; Diaz R; Avezum A; Lanas F; Ismail N; Yusoff K; Dans A; Iqbal R; Szuba A; Mohammadifard N; Oguz A; Yusufali AH; Alhabib KF; Kruger IM; Yusuf R; Chifamba J; Yeates K; Dagenais G; Wielgosz A; Lear SA; Teo K; Yusuf S; PURE Investigators · BMJ (Clinical research ed.) · 2019
    Cohort study103,570 participantsHeart Health forPotassium
  9. Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Studies.
    D'Elia L; Cappuccio FP; Masulli M; La Fata E; Rendina D; Galletti F · Nutrients · 2023
    Meta-analysis332 participants5 studies pooledHeart Health forPotassium
  10. Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension.
    Kawano Y; Minami J; Takishita S; Omae T · American journal of hypertension · 1999
    Randomized trial55 participantsHeart Health forPotassium
  11. Selenium concentration is associated with occurrence and diagnosis of three cardiovascular diseases: A systematic review and meta-analysis.
    Yang L; Qi M; Du X; Xia Z; Fu G; Chen X; Liu Q; Sun N; Shi C; Zhang R · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
    Meta-analysis49 studies pooledHeart Health forSelenium
  12. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsHeart Health forSelenium
  13. Exploring the Impact of Selenium Supplementation on Nutritional, Inflammatory, and Cardiac Function in Chronic Heart Failure Patients: A Novel Approach to Managing Deficiency.
    Kou L; Meng F; Fu G; Zhang R · Cardiovascular toxicology · 2025
    Meta-analysis191 participantsHeart Health forSelenium
  14. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsHeart Health forSelenium
  15. Correlation between dietary selenium intake and stroke in the National Health and Nutrition Examination Survey 2003-2018.
    Shi W; Su L; Wang J; Wang F; Liu X; Dou J · Annals of medicine · 2022
    Cross-sectional study39,438 participantsHeart Health forSelenium
  16. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsHeart Health forVitamin K
  17. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsHeart Health forVitamin K
  18. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K
  19. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsHeart Health forVitamin K
  20. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsHeart Health forVitamin K