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Choline 500 mg

Nature's Way
4.7
★ ★ ★ ★ ★
(6028 ratings)
Choline 500 mg
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Score83
Choline supports the export of fat from the liver and helps preserve normal hepatic function. The amount is useful, but the bitartrate form is less brain-targeted than some alternatives.
How scoring works
Quantity:100 Tablet(s) • (100 servings)
Goals:
Detoxification
Cognitive Support
Mental Focus

Score 83

Choline supports the export of fat from the liver and helps preserve normal hepatic function. The amount is useful, but the bitartrate form is less brain-targeted than some alternatives.
How scoring works
$9.72($0.09 per serving)
Vitacost
$ 10.75
iHerb
$ 9.77
Vitacost
$ 10.75
Pure Formulas
$ 9.72
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Analysis

Choline supports the export of fat from the liver and helps preserve normal hepatic function. That role supports detoxification capacity indirectly rather than neutralizing toxins itself.

Choline bitartrate at 500 mg provides meaningful choline support. The amount is useful, but the bitartrate form is less brain-targeted than some alternatives.

Choline supplies a precursor for acetylcholine, giving it a clear foundational role in attention and memory. The 500 mg amount is meaningful, but bitartrate is less brain-targeted than Alpha-GPC or citicoline.

Who is it for
  • Adults seeking Detoxification support
  • People comfortable with a focused tablet formula
  • Users who can review the ingredient list against medicines and existing supplements
Best for
  • Detoxification
  • Cognitive Support
  • Mental Focus

Pros

  • Choline supports the export of fat from the liver and helps preserve normal hepatic function
  • Strongest formulation fit is Detoxification
  • Main label amounts are disclosed for Choline
  • Choline amount and form can be assessed from the supplied label

Cons

  • useful, but the bitartrate form is less brain-targeted than some alternatives
  • Weak fit for Mental Focus
  • Several secondary ingredients add breadth without equally strong dose or form support

Warnings

  • High choline intake may cause nausea, sweating, or a fishy body odor in sensitive users.

Nutrient quality

86 Highest impact

The choline bitartrate amount is meaningful for systemic support. The form is less suited to focused cognitive use, while the compact formula avoids major dose concerns.

Ingredient transparency

85 Highest impact

Active amounts are clearly stated and no proprietary blend is shown. Full use directions and non-active ingredients are not supplied.

Customer satisfaction

70 High impact

The supplied average rating is good and the review base is very large. No review text is available to assess recurring complaints or experiences tied to the intended use.

Value for money

91 Highest impact

The robust dose and straightforward formula support good quality value. The very low serving cost makes it highly competitive for systemic choline use.

Report analysis

Goals

Detoxification
Impact
Highest effect
B Goal FitA+ Strength of SupportD+ CoverageA Formula Quality
Choline · 500 mg

Choline supports the export of fat from the liver and helps preserve normal hepatic function. That role supports detoxification capacity indirectly rather than neutralizing toxins itself.

The 500 mg amount is robust and fully disclosed as choline from choline bitartrate. The focused tablet provides strong depth in one liver-support pathway without antioxidant or gut-binding coverage.

Study evidence
Choline Supportive 6 studies
Cognitive Support
Impact
High effect
C+ Goal FitA+ Strength of SupportD+ CoverageA- Formula Quality
Choline · 500 mg

Choline is a precursor for acetylcholine, a neurotransmitter involved in memory and attention. The 500 mg amount is substantial and clearly disclosed.

Choline bitartrate is a dependable systemic form but has less direct brain-delivery advantage than Alpha-GPC or citicoline. The single-ingredient formula provides good depth without broader pathway coverage.

Study evidence
Choline Supportive 76 studies
Mental Focus
Impact
High effect
B- Goal FitB- Strength of SupportD+ CoverageA+ Formula Quality
Choline · 500 mg

Choline supplies a precursor for acetylcholine, giving it a clear foundational role in attention and memory. The 500 mg amount is meaningful, but bitartrate is less brain-targeted than Alpha-GPC or citicoline.

The single nutrient offers good depth for one neurotransmitter pathway without addressing alertness or stress resilience. High choline intake may cause nausea, sweating, or a fishy body odor in sensitive users.

Study evidence
Choline Supportive 22 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s)
Choline (Choline Bitartrate)
500 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Choline bitartrate is a standard systemic form rather than a premium option for focused cognitive use. A single tablet clearly supplies a robust 500 mg dose. The large dose and low serving cost create excellent choline-specific value.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
    Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
    Cohort study1,391 participantsMental Focus forCholine
  2. Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers.
    Knott V; de la Salle S; Choueiry J; Impey D; Smith D; Smith M; Beaudry E; Saghir S; Ilivitsky V; Labelle A · Pharmacology, biochemistry, and behavior · 2016
    Randomized trial24 participantsMental Focus forCholine
  3. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  4. Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.
    Long C; Li Z; Feng H; Jiang Y; Pu Y; Tao J; Yue R · Frontiers in aging neuroscience · 2024
    Meta-analysis82,246 participants9 studies pooledCognitive Support forCholine
  5. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsDetoxification forCholine
  6. Relationship of Choline Intake with Biomarkers of Liver Health by Genotype-A Cross-Sectional Analysis.
    Wallace TC; Cowan-Pyle AE; Klatt KC; Bailey RL · The Journal of nutrition · 2025
    Cross-sectional study1,438 participantsDetoxification forCholine
  7. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  8. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  9. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  10. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  11. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusDetoxification forCholine
  12. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsDetoxification forCholine
  13. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsDetoxification forCholine
  14. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsDetoxification forCholine
  15. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
    Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
    Randomized trial31 participantsMental Focus forCholine
  16. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
    Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis30 studies pooledMental Focus forCholine
  17. Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
    Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
    Systematic reviewMental Focus forCholine
  18. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
    Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
    Randomized trialMental Focus forCholine