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Only One Liquid-Gel Multi

Irwin Naturals
4.3
★ ★ ★ ★ ★
(39 ratings)
Vitamin A 5000 IU
Vitamin E 30 IU
Fish Oil 500 mg
Product Image
Score66
Best suited to skin health, with the clearest benefits coming from the disclosed active ingredients. The softgel improves delivery of fat-soluble nutrients, though zinc oxide is a weakly absorbed form and fish oil potency is not detailed.
How scoring works
Quantity:60 Softgel(s) • (60 servings)
Goals:
Skin Health
Cardiovascular Support
Vision Support

Score 66

Best suited to skin health, with the clearest benefits coming from the disclosed active ingredients. The softgel improves delivery of fat-soluble nutrients, though zinc oxide is a weakly absorbed form and fish oil potency is not detailed.
How scoring works
$21.99($0.36 per serving)
Vitacost
$ 21.99
Vitacost
$ 21.99
Pure Formulas
$ 21.99
iHerb
$ 21.99
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Analysis

Vitamins A, C, and E combine with zinc, selenium, copper, and fish oil to cover several skin needs. The softgel improves delivery of fat-soluble nutrients, though zinc oxide is a weakly absorbed form and fish oil potency is not detailed. Clearly listed amounts make the core micronutrients easy to evaluate.

Vitamin A, 250 mg of vitamin C, vitamin E, zinc, selenium, copper, and fish oil provide several ocular-support inputs. The softgel aids fat-soluble absorption, but zinc is oxide and the fish oil lacks EPA and DHA amounts. The formula covers antioxidants, night-vision nutrition, and a nominal lipid pathway without lutein or zeaxanthin.

The vitamin A form provides only moderate quality assurance. A disclosed lipid matrix supports absorption of this fat-soluble nutrient. The dose is well aligned and cost efficiency is favorable.

Who is it for
  • People seeking skin health support
  • People seeking cardiovascular support support
  • People seeking vision support support
Best for
  • Skin Health
  • Cardiovascular Support
  • Vision Support

Pros

  • Vitamins A, C, and E combine with zinc, selenium, copper, and fish oil to cover several skin needs.
  • Clearly listed amounts make the core micronutrients easy to evaluate.
  • B vitamins, selenium, vitamin E, vitamin D, and fish oil touch homocysteine, antioxidant, and lipid pathways.
  • The fish oil is a minor, uncharacterized addition, so the formula remains a general multivitamin rather than focused heart support.
  • Vitamin A, 250 mg of vitamin C, vitamin E, zinc, selenium, copper, and fish oil provide several ocular-support inputs.

Cons

  • The softgel improves delivery of fat-soluble nutrients, though zinc oxide is a weakly absorbed form and fish oil potency is not detailed.
  • A broad multivitamin design and small green blend reduce skin-specific depth.
  • Natural vitamin E and methylcobalamin are favorable, while magnesium oxide, zinc oxide, and folic acid reduce form quality.
  • The 500 mg fish-oil total lacks EPA and DHA disclosure and cannot establish cardiovascular potency.
  • The softgel aids fat-soluble absorption, but zinc is oxide and the fish oil lacks EPA and DHA amounts.

Nutrient quality

70 High impact

Several nutrients use favorable forms, but oxide minerals and an unquantified fish-oil portion lower quality. Broad coverage is useful, though iron and small add-on blends reduce universal fit.

Ingredient transparency

63 Moderate impact

Most nutrients have specific amounts, but EPA and DHA are absent and small blends are not broken down. Daily directions and complete excipient details are not supplied.

Customer satisfaction

61 Moderate impact

The supplied aggregate satisfaction metric is strong and supported by the available feedback volume. No feedback excerpts or complaint themes are supplied, so specific experience patterns cannot be verified.

Value for money

72 High impact

Meaningful active dosing supports favorable serving value. Some additions provide limited value relative to the core formula.

Report analysis

Goals

Skin Health
Clear and Even Tone
Skin Health
Impact
High effect
B- Goal FitC+ Strength of SupportB CoverageC+ Formula Quality
Zinc · 15 mgVitamin C · 250 mgCopper · 2 mgSelenium · 70 mcgVitamin E · 30 IU

Vitamins A, C, and E combine with zinc, selenium, copper, and fish oil to cover several skin needs. The softgel improves delivery of fat-soluble nutrients, though zinc oxide is a weakly absorbed form and fish oil potency is not detailed.

Clearly listed amounts make the core micronutrients easy to evaluate. A broad multivitamin design and small green blend reduce skin-specific depth.

Study evidence
Copper Supportive 16 studies
Selenium Supportive 22 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies
Cardiovascular Support
Arterial Integrity and Protection
Cardiovascular Support
Impact
Moderate effect
C+ Goal FitD Strength of SupportC+ CoverageC Formula Quality
Magnesium · 10 mgVitamin D · 1000 IUFish Oil · 500 mgSelenium · 70 mcgVitamin B12 · 50 mcgVitamin B6 · 20 mgVitamin E · 30 IUFolate · 400 mcgNiacin · 20 mgVitamin C · 250 mg

B vitamins, selenium, vitamin E, vitamin D, and fish oil touch homocysteine, antioxidant, and lipid pathways. The fish oil is a minor, uncharacterized addition, so the formula remains a general multivitamin rather than focused heart support.

Natural vitamin E and methylcobalamin are favorable, while magnesium oxide, zinc oxide, and folic acid reduce form quality. The 500 mg fish-oil total lacks EPA and DHA disclosure and cannot establish cardiovascular potency.

Study evidence
Fish Oil Supportive 185 studies
Magnesium Supportive 123 studies
Selenium Supportive 107 studies
Vitamin D Mixed 170 studies
Vitamin E Mixed 79 studies
Vision Support
Macular and Blue Light DefenseRetinal Health and Eye Moisture +1
Vision Support
Impact
Moderate effect
C Goal FitC- Strength of SupportC- CoverageC+ Formula Quality
Zinc · 15 mgVitamin E · 30 IUVitamin C · 250 mgCopper · 2 mgVitamin A · 5000 IU

Vitamin A, 250 mg of vitamin C, vitamin E, zinc, selenium, copper, and fish oil provide several ocular-support inputs. The softgel aids fat-soluble absorption, but zinc is oxide and the fish oil lacks EPA and DHA amounts.

The formula covers antioxidants, night-vision nutrition, and a nominal lipid pathway without lutein or zeaxanthin. Broad multivitamin ingredients add convenience but not the depth of a dedicated vision formula.

Study evidence
Copper Supportive 7 studies
Selenium Supportive 15 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Vitamin E Disputed 35 studies
Zinc Supportive 39 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 5000 IU
Vitamin C (Ascorbic Acid)
 250 mg
Vitamin D (Vitamin D3)
 1000 IU
Vitamin E (D-Alpha-Tocopherol)
 30 IU
Thiamine (Thiamine Hydrochloride)
 20 mg
Riboflavin
20 mg
Niacin (Niacinamide)
 20 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 20 mg
Folic Acid
400 mcg
Vitamin B12 (Methylcobalamin)
 50 mcg
Biotin
500 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 20 mg
Iron (Iron Amino Acid Chelate)
 18 mg
Magnesium (Magnesium Oxide)
 10 mg
Zinc (Zinc Oxide)
 15 mg
Selenium (L-Selenomethionine)
 70 mcg
Copper (Copper Citrate)
 2 mg
Manganese (Manganese Citrate)
 2 mg
Chromium (Chromium Picolinate)
 120 mcg
Molybdenum (Molybdenum Citrate)
 75 mcg
Fish Oil
500 mg
Green Super Food Blend
25 mg
BioPerine Complex
6 mg
Adults 18–50
Report overview
Vitamin A (Beta-Carotene) · 5000 IU OverallScore84
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The vitamin A form provides only moderate quality assurance. A disclosed lipid matrix supports absorption of this fat-soluble nutrient. The dose is well aligned and cost efficiency is favorable.

View ingredientView products
Vitamin E (D-Alpha-Tocopherol) · 30 IU OverallScore68
D Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA+ Value

Natural d-alpha-tocopherol reaches the start of the maintenance range in a convenient liquid softgel. The formula lacks mixed tocopherols and tocotrienols, so the vitamin E profile remains narrow. Its low serving cost offers strong value for a natural form.

View ingredientView products
Fish Oil · 500 mg OverallScore7
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The fish oil is a minor part of a multivitamin and lacks form, species, and purification details. EPA and DHA are not broken out, leaving its active omega-3 contribution unknown. Vitamin E adds oxidation protection, but active-dose value cannot be determined.

View ingredientView products
Loading alternative details
68 Performance

Twice Daily Multi

Designs for Health
Ingredient forms or goal focus are stronger because the original has mixed mineral forms and does not quantify EPA or DHA in its fish oil. Chelated trace minerals, methylcobalamin, natural vitamin E, mixed carotenoids, and named boron provide strong form quality. High pyridoxine, repeated nutrient entries, and modest vitamin D reduce balance.
69 Performance

The Total EFA

Health From The Sun
Ingredient forms or goal focus are stronger because the original has mixed mineral forms and does not quantify EPA or DHA in its fish oil. Fish, borage, and flax oils provide broad fatty-acid sources with mixed tocopherols. EPA, DHA, GLA, and ALA amounts are not disclosed, so effective potency remains uncertain.
67 Performance

Multivitamin with Omega-3

Nature Made Kids First
Ingredient forms or goal focus are stronger because the original has mixed mineral forms and does not quantify EPA or DHA in its fish oil. Vitamin D3 and a basic vitamin panel accompany fish oil in a child-focused gummy. Synthetic vitamin E, folic acid, cyanocobalamin, and an unquantified fish-oil contribution limit ingredient quality.
59 Budget

Daily Total One

Country Life
A lower serving cost improves everyday affordability. Active B-vitamin forms, methylcobalamin, natural vitamin E, and several citrate or chelated minerals add useful form quality at low routine cost. Many nutrients are repeated with potentially very high combined amounts, making the supplied label hard to interpret and poorly balanced.
71 Budget

Norwegian Cod Liver Oil 1000 mg Fresh Orange Flavor

AN Amazing Nutrition Amazing Omega
A lower serving cost improves everyday affordability. Cod liver oil provides natural vitamin E, vitamin D3, and preformed vitamin A in an inexpensive serving. EPA and DHA are not quantified, and the preformed vitamin A amount warrants care when combined with other vitamin A sources.
73 Budget

Flintstones Gummies + Immunity Support

Bayer
A lower serving cost improves everyday affordability. Vitamin C, vitamin D, zinc, and basic vitamins provide inexpensive child-focused nutritional coverage. Most chemical forms and the complete inactive ingredients are not supplied, limiting quality assessment.
65 Value

Omega-3 Fish Body Oils 1000 mg

Country Life
The balance of ingredient coverage and routine cost improves practical value because the original has mixed mineral forms and does not quantify EPA or DHA in its fish oil. A clearly stated fish-oil amount is paired with natural vitamin E at a low routine cost. EPA and DHA are not quantified, so cardiovascular potency and the value of the oil itself cannot be judged.
65 Value

Ultra Omega 3-6-9

KAL
The balance of ingredient coverage and routine cost improves practical value because the original has mixed mineral forms and does not quantify EPA or DHA in its fish oil. Flax, fish, and borage oils provide broad fatty-acid sources with mixed tocopherols. EPA, DHA, GLA, and the main omega-9 fatty acid are not quantified, leaving the practical dose uncertain.
51 Value

Lil'Ollys Kids' Multi + Probiotic Yum Berry Punch

OLLY
The balance of ingredient coverage and routine cost improves practical value because the original has mixed mineral forms and does not quantify EPA or DHA in its fish oil. Vitamin D3, natural vitamin E, zinc citrate, and a basic vitamin panel offer convenient child-focused coverage. The supplied folic-acid and biotin units appear implausible and probiotic potency is missing, so the package label should be checked before use.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  2. The effects of topical vitamin E on the cosmetic appearance of scars.
    Baumann LS; Spencer J · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2000
    Randomized trial15 participantsSkin Health forVitamin E
  3. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
    Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
    Randomized trial121 participantsSkin Health forVitamin E Skin Health forSelenium
  4. Topical application of a cream containing nanoparticles with vitamin E for radiodermatitis prevention in women with breast cancer: A randomized, triple-blind, controlled pilot trial.
    Queiroz Schmidt FM; Serna González CV; Mattar RC; Lopes LB; Santos MF; Santos VLCG · European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2022
    Randomized trial40 participantsSkin Health forVitamin E
  5. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  6. Photodecomposition of vitamin A and photobiological implications for the skin.
    Fu PP; Xia Q; Yin JJ; Cherng SH; Yan J; Mei N; Chen T; Boudreau MD; Howard PC; Wamer WG · Photochemistry and photobiology · 2007
    Narrative reviewSkin Health forVitamin A
  7. Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial.
    Chien AL; Kim DJ; Cheng N; Shin J; Leung SG; Nelson AM; Zang J; Suh H; Rainer B; Wallis L; Okoye GA; Loss M; Kang S · JAMA dermatology · 2022
    Randomized trial24 participantsSkin Health forVitamin A
  8. Evidence for the Efficacy of Over-the-counter Vitamin A Cosmetic Products in the Improvement of Facial Skin Aging: A Systematic Review.
    Spierings NMK · The Journal of clinical and aesthetic dermatology · 2022
    Systematic review9 studies pooledSkin Health forVitamin A
  9. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin E Vision Support forVitamin C
  10. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin A Vision Support forVitamin E
  11. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract.
    Mathew MC; Ervin AM; Tao J; Davis RM · The Cochrane database of systematic reviews · 2012
    Meta-analysis117,272 participants9 studies pooledVision Support forVitamin E
  12. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin E
  13. Long-term effects of fenretinide on retinal function.
    Decensi A; Fontana V; Fioretto M; Rondanina G; Torrisi R; Orengo MA; Costa A · European journal of cancer (Oxford, England : 1990) · 1997
    Clinical trial42 participantsVision Support forVitamin A
  14. Vitamin A and fish oils for retinitis pigmentosa.
    Rayapudi S; Schwartz SG; Wang X; Chavis P · The Cochrane database of systematic reviews · 2014
    Systematic review866 participants3 studies pooledVision Support forVitamin A
  15. Gildeuretinol Acetate versus Placebo for Geographic Atrophy Secondary to Age-Related Macular Degeneration: The Study of ALK-001 in Geographic Atrophy Randomized Clinical Trial.
    Boyer DS; Saad L; Washington I; Melamud A; Graham KB; O'Malley AE; DeBartolomeo GM; Jiang H; Harris LD; Kay CN; Ferrone PJ; Khan S; SAGA Study Team · Ophthalmology. Retina · 2026
    Randomized trial198 participantsVision Support forVitamin A
  16. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  17. Fish oil, enriched with polyunsaturated fatty acids of the omega-3-type accelerates the nucleation time in healthy subjects.
    Janowitz P; Swobodnik W; Wechsler JG; Janowitz A; Saal D; Ditschuneit H · Klinische Wochenschrift · 1991
    Non-randomized trial24 participantsCardiovascular Support forFish Oil
  18. Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
    Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
    Randomized trial415 participantsCardiovascular Support forFish Oil
  19. Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
    Manson JE; Bassuk SS; Cook NR; Lee IM; Mora S; Albert CM; Buring JE; VITAL Research Group · Circulation research · 2020
    Randomized trial25,871 participantsCardiovascular Support forFish Oil
  20. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  21. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  22. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  23. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  24. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  25. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  26. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support forMagnesium
  27. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support forMagnesium Cardiovascular Support forVitamin D
  28. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  29. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsCardiovascular Support forSelenium
  30. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey.
    Xing X; Xu M; Yang L; Shao C; Wang Y; Qi M; Niu X; Gao D · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
    Cohort study15,689 participantsCardiovascular Support forSelenium
  31. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsCardiovascular Support forSelenium
  32. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
    Kuria A; Tian H; Li M; Wang Y; Aaseth JO; Zang J; Cao Y · Critical reviews in food science and nutrition · 2021
    Meta-analysis13 studies pooledCardiovascular Support forSelenium
  33. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledCardiovascular Support forSelenium
  34. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  35. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  36. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  37. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support forVitamin D
  38. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  39. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  40. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  41. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  42. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  43. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialSkin Health forCopper
  44. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsSkin Health forCopper
  45. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentSkin Health forCopper
  46. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentSkin Health forCopper
  47. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialSkin Health forCopper
  48. Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
    Chu AC · Dermatologica · 1985
    Randomized trial38 participantsSkin Health forSelenium
  49. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
    Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
    Randomized trial1,312 participantsSkin Health forSelenium
  50. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forSelenium Skin Health forVitamin E Skin Health forZinc
  51. The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
    Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
    Clinical trial31 participantsSkin Health forSelenium
  52. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  53. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  54. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  55. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  56. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  57. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  58. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  59. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  60. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  61. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  62. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  63. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  64. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  65. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  66. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  67. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  68. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledVision Support forCopper
  69. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
    Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
    Cohort study8,242 participantsVision Support forCopper
  70. Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
    Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
    Observational study4,996 participantsVision Support forCopper
  71. Associations between dietary nutrient intake and the risk of multiple age-related ocular diseases: evidence from longitudinal analysis.
    Yang Y; Zou H · The journal of nutrition, health & aging · 2026
    Cohort study103,192 participantsVision Support forCopper
  72. Dietary habits and dietary nutrient intake in patients with age-related macular degeneration: A case-control study.
    Šalková Kráľová J; Kolář P; Kapounová Z; Veselý P; Derflerová Brázdová Z · Central European journal of public health · 2023
    Case-control study151 participantsVision Support forCopper
  73. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
    Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
    Randomized trial245 participantsVision Support forSelenium
  74. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledVision Support forSelenium
  75. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
    Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial245 participantsVision Support forSelenium
  76. AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
    Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial67 participantsVision Support forSelenium
  77. The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
    Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
    Randomized trial14 participantsVision Support forSelenium
  78. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsVision Support forVitamin A
  79. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledVision Support forVitamin A
  80. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsVision Support forVitamin A
  81. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsVision Support forVitamin A
  82. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  83. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  84. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  85. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C
  86. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVision Support forVitamin E
  87. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVision Support forVitamin E
  88. Dietary intake of antioxidants and risk of age-related macular degeneration.
    van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
    Cohort study4,765 participantsVision Support forVitamin E
  89. Antioxidant vitamin and mineral supplements for age-related macular degeneration.
    Evans JR · The Cochrane database of systematic reviews · 2002
    Systematic review170 participants7 studies pooledVision Support forZinc
  90. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
    Meta-analysis3,790 participants5 studies pooledVision Support forZinc
  91. Oral zinc in macular degeneration.
    Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
    Randomized trial151 participantsVision Support forZinc
  92. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
    Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
    Randomized trial3,640 participantsVision Support forZinc
  93. Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
    Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
    Randomized trial133 participantsVision Support forZinc