$43.49 $0.48 per serving
Product analysis
5-HTP Synergy pairs 5-HTP with B6 for someone seeking a focused combination. The high cost for the 5-HTP supplied weakens its value.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality30
The B6 preparation is identified, while the 5-HTP preparation is less clear. Their relative quality cannot be judged confidently from those details alone.
Ingredient Transparency81
Both amounts are stated, making the serving easier to track. Only B6 has a named form, which leaves the 5-HTP preparation harder to compare.
Value For Money19
The 5-HTP is expensive for the amount supplied. B6's value is uncertain, so it does not provide a clear offset to that cost.
Customer Satisfaction73
The small number of ratings is very positive. Such limited feedback leaves the broader customer experience uncertain.
Product Focus64
The short pairing keeps the formula directed toward a small range of uses. That focus does not establish that both ingredients provide added benefit together.
- Format
Capsule - Container
- 90 Capsule(s)
- Per serving
- $0.48
- Customer rating
- 4.9 · 11 ratings
Goals
Impact
High effect
Vitamin B6 · 10 mg5-HTP · 50 mg
Impact
Moderate effect
Impact
Moderate effect
Vitamin B6 · 10 mg
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin B-6 (Pyridoxal 5-Phosphate) | 10 mg | |
5-HTP | 50 mg |
5-HTP · 50 mg OverallScore48
Each serving supplies 50 mg of 5-HTP, with a high estimated cost for the amount supplied. 5-HTP is named, but its botanical source is unclear. The label includes a warning about serotonin-related medicines.
How this ingredient is rated
Active Ingredient Quality & Bioavailability40
5-HTP is named, but its botanical source is unclear.
Botanical Source & Standardization
5-HTP is named, but its botanical source is unclear.
Dose, Safety & Label Transparency79
The serving provides 50 mg. The label includes a warning about serotonin-related medicines.
Dosage Potency & Range
50 mg per serving is a standard starting amount.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medicines.
Value0
The estimated cost per 100 mg of 5-HTP is high; the full serving price is attributed to 5-HTP.
Price per 100mg 5-HTP
The estimated cost per 100 mg of 5-HTP is high; the full serving price is attributed to 5-HTP.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- High Dose Vitamin B6 Reduces Depression Symptoms.
- Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
- Associations of dietary B vitamins intakes with depression in adults.
- Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
- Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
- Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
- The effect of pyridoxine administration on melatonin secretion in normal men.
- Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
- Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
- Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
- Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.