Hair Skin & Nails

Hair Skin & Nails

Nature Made4.7 (159 ratings)
Format:Softgel Quantity: 120 Softgel(s) · 120 servings
Goals
$13.18 $0.10 per serving

Product analysis

61 out of 100

Hair Skin & Nails centers on biotin and zinc for normal nail and hair maintenance, with benefits most relevant when intake is low. Copper oxide is a poorly absorbed choice, weakening that part of the formula.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality25

Copper oxide is the clearest quality weakness because it has poor absorption. Biotin’s form is unspecified, while the quality of the other named nutrient forms remains uncertain.

Ingredient Transparency93

All listed ingredient amounts and most forms are disclosed. Biotin’s missing form limits how closely that ingredient can be compared.

Value For Money68

Biotin and the vitamin A contribution offer favorable value at the whole-product cost. Copper is inexpensive by serving, but its poor absorption weakens the practical appeal.

Customer Satisfaction73

Customer feedback is very positive, though the review base is modest. The ratings do not establish better hair, skin or nail outcomes.

Product Focus69

Nail maintenance is the clearest fit, with more conditional relevance to hair and skin. Benefits depend on nutritional need, and routine improvements from extra biotin are uncertain.

Format
Softgel
Container
120 Softgel(s)
Per serving
$0.10
Customer rating
4.7 · 159 ratings
Report analysis

Goals

Nail Health
Impact
Highest effect
B+ Ingredient FitB- PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 2500 mcg
Study evidence
Biotin Supportive 8 studies
Vitamin C Supportive 1 study
Zinc No effect 1 study
Impact
High effect
B Ingredient FitF PathwaysA+ EvidenceA Formulation Logic
Biotin · 2500 mcgZinc · 11 mgVitamin C · 100 mg
Study evidence
Biotin Supportive 4 studies
Copper Adverse 4 studies
Vitamin A Disputed 13 studies
Zinc Supportive 22 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Beta-Carotene)
2500 IU 69
Vitamin C (Ascorbic Acid)
100 mg
Biotin
2500 mcg 82
Zinc (Zinc Oxide)
11 mg
Copper (Copper Oxide)
0.9 mg 66
Gluten Free Adults 18–50
Report overview
D+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB+ Value
A serving supplies 2,500 IU of vitamin A at a moderate cost per 5,000 IU. The beta-carotene origin is unspecified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability50

Vitamin A comes from beta-carotene, whose origin is unspecified.
Vitamin A Chemical Form & Source
Vitamin A comes from beta-carotene, whose origin is unspecified.

Dose, Safety & Label Transparency82

A serving supplies 2,500 IU of vitamin A. The label names beta-carotene as the form.
Dosage Efficacy & Safety Thresholds
A serving supplies 2,500 IU of vitamin A.
Label Transparency of Specific Forms
The label names beta-carotene as the form.

Value80

The cost per 5,000 IU is moderate.
Price per 5,000 IU Dose
The cost per 5,000 IU is moderate.
Biotin · 2500 mcg OverallScore82
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB+ Value
Each serving provides 2500 mcg of biotin at a moderate cost per amount of biotin. The label says biotin but does not specify its isomer.
How this ingredient is rated

Active Ingredient Quality & Bioavailability82

The label says biotin but does not specify its isomer. The listed Other Ingredients show no artificial colors or sweeteners.
Biologically Active d-Biotin Isomer
The label says biotin but does not specify its isomer.
Excipient Purity
The listed Other Ingredients show no artificial colors or sweeteners.

Dose, Safety & Label Transparency84

Each serving contains 2500 mcg of biotin. The amount is stated on the label.
Biotin Potency for Health Goals
Each serving contains 2500 mcg of biotin.
Label Transparency & Exact Disclosure
The label states the biotin amount.

Value80

The cost per amount of biotin is moderate.
Price per 5,000 mcg Biotin
The cost per amount of biotin is moderate.
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value
Each serving provides 0.9 mg of copper at a low cost per serving. The copper comes from copper oxide. The amount is stated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability30

The copper comes from copper oxide. The elemental copper amount and source are stated.
Copper Form Bioavailability
The copper comes from copper oxide.
Elemental Copper Labeling Clarity
The elemental copper amount and source are stated.

Dose, Safety & Label Transparency86

The serving supplies 0.9 mg of copper. The serving also provides 11 mg of zinc alongside 0.9 mg of copper.
Copper Dosage Safety & Efficacy
The serving supplies 0.9 mg of copper.
Zinc-to-Copper Balance
The serving also provides 11 mg of zinc alongside 0.9 mg of copper.

Value100

The cost per serving is low.
Price Per Serving Efficiency
The cost per serving is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health forBiotin
  2. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper
  6. Trace element levels in alopecia areata.
    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
  7. UV damage to hair and the effect of antioxidants and metal chelators.
    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  8. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  9. Topical tretinoin for hair growth promotion.
    Bazzano GS; Terezakis N; Galen W · Journal of the American Academy of Dermatology · 1986
    Non-randomized trial56 participantsHair Health forVitamin A
  10. A review of isotretinoin in the treatment of frontal fibrosing alopecia.
    Shahpar A; Nezhad NZ; Sahaf AS; Ahramiyanpour N · Journal of cosmetic dermatology · 2024
    Systematic review232 participants15 studies pooledHair Health forVitamin A
  11. Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases.
    Rakowska A; Gradzińska A; Olszewska M; Rudnicka L · Journal of drugs in dermatology : JDD · 2018
    Cohort study54 participantsHair Health forVitamin A
  12. Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients.
    Willaert M; Van Dongen T; Dikrama P; Nijsten T; Hijnen D; Waalboer-Spuij R · Acta dermato-venereologica · 2025
    Cohort study315 participantsHair Health forVitamin A
  13. Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.
    Sharma A; Goren A; Dhurat R; Agrawal S; Sinclair R; Trüeb RM; Vañó-Galván S; Chen G; Tan Y; Kovacevic M; Situm M; McCoy J · Dermatologic therapy · 2020
    Single-arm trialHair Health forVitamin A
  14. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  15. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  16. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  17. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  18. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  19. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  20. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc