NiaCel 400

NiaCel 400

Thorne4.6 (1,306 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

62 out of 100

NiaCel 400 offers a simple combination of a niacin-related ingredient and betaine at a favorable serving cost. Unclear identification of the niacin form makes it harder to match the formula to a specific intended benefit.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality30

The niacin form is not clearly identified on the label. Betaine is named, but its comparative quality cannot be established from the available information.

Ingredient Transparency81

Both ingredient amounts are disclosed. The betaine form is identified, while the niacin form remains unclear.

Value For Money100

The full serving cost compares favorably with both ingredients. The price comparison does not resolve the uncertainty over which niacin form is supplied.

Customer Satisfaction80

Customer ratings are largely positive. Feedback from many buyers provides a broad picture of satisfaction.

Product Focus30

The formula is simple, but its cardiovascular purpose remains uncertain. Conflicting niacin identification and an unresolved relevant amount prevent a clear link to that intended benefit.

Format
Capsule
Container
60 Capsule(s)
Per serving
$1.23
Customer rating
4.6 · 1,306 ratings
Report analysis

Goals

Cardiovascular Support
Impact
Situational effect
D- Ingredient FitF PathwaysF EvidenceB Formulation Logic
Niacin · 415 mg
Study evidence
Niacin Supportive 136 studies
Skin Health
Impact
Situational effect
D- Ingredient FitF PathwaysF EvidenceB Formulation Logic
Study evidence
Niacin Supportive 61 studies
Heart Health
Impact
Situational effect
D- Ingredient FitF PathwaysF EvidenceB Formulation Logic
Study evidence
Niacin Supportive 105 studies

Ingredients

IngredientAmount per servingScore
Nicotinamide Riboside Hydrogen Malate
415 mg 85
Betaine Anhydrous (Trimethylglycine)
85 mg 100
Gluten Free Adults 18–50
Report overview
Niacin · 415 mg OverallScore85
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value
Each serving provides 415 mg of nicotinamide riboside hydrogen malate. The amount of niacin itself is unknown. The serving price is low for this form. It uses nicotinamide riboside hydrogen malate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability71

It uses nicotinamide riboside hydrogen malate.
Niacin Form & Goal Alignment
Nicotinamide Riboside Hydrogen Malate is the stated form.
Precursor Source Quality
The stated source is nicotinamide riboside hydrogen malate.

Dose, Safety & Label Transparency92

Each serving provides 415 mg of nicotinamide riboside hydrogen malate. The amount of niacin itself is unknown. No no-flush claim is recorded.
Clarity of Chemical Form
The form is disclosed as Nicotinamide Riboside Hydrogen Malate.
Form-Specific Dosage Efficacy
Each serving provides 415 mg of nicotinamide riboside hydrogen malate. The amount of niacin itself is unknown.
Flush Risk & Safety Labeling
No no-flush claim is recorded.

Value100

The serving price is low for this form.
Price Per Effective Serving
The serving price is low for this form.
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
A serving provides 85 mg of betaine anhydrous at a moderate cost. The amount is clearly stated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The declared form is betaine anhydrous.
Betaine Form (Anhydrous/TMG vs. HCl)
The declared form is betaine anhydrous.

Dose, Safety & Label Transparency100

The selected serving lists 85 mg of betaine anhydrous.
Label Transparency & Blend Disclosure
The selected serving lists 85 mg of betaine anhydrous.

Value100

The cost per selected serving is moderate.
Price per Active Dose Efficiency
The cost per selected serving is moderate.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  2. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  3. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  4. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  5. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  6. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  7. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  8. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  9. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  10. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  11. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  12. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  13. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  14. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin
  15. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin