Advanced Sleep Melatonin + 5-HTP Time Release
Goals
$12.99 $0.21 per serving
Product analysis
Advanced Sleep Melatonin + 5-HTP Time Release includes 5-HTP, which may offer limited support for people who already sleep poorly. Conflicting melatonin descriptions leave its presence, amount and release type unconfirmed.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality40
Vitamin B6 and the plant source of 5-HTP are named. Their form quality cannot be confirmed confidently from those names alone.
Ingredient Transparency100
The listed B6 and 5-HTP amounts and forms are disclosed, making those ingredients straightforward to compare. Conflicting melatonin descriptions still leave a central part of the sleep positioning unresolved.
Value For Money50
The 5-HTP contribution offers moderate value for the price. Uncertain value for B6 limits a confident judgement of the whole combination.
Customer Satisfaction84
Customer feedback is positive across a large number of ratings. That gives an established picture of satisfaction without proving a sleep effect.
Product Focus64
The 5-HTP provides a possible but limited sleep-related contribution. Mood and stress benefits remain uncertain, and melatonin cannot be relied on while its declaration is unresolved.
- Format
Tablet - Container
- 60 Tablet(s)
- Per serving
- $0.21
- Customer rating
- 4.5 · 8,639 ratings
Goals
Impact
Moderate effect
5-HTP offers a possible but limited sleep-related contribution through a precursor route, with the supplied context most relevant to people who already sleep poorly. Vitamin B6 is also present, but its ordinary metabolic role does not establish an added sleep benefit.
The title mentions time-release melatonin and the stored label facts mention quick-release melatonin, but the ingredient inventory contains no melatonin declaration. Its presence and amount therefore remain unconfirmed.
How this product is rated for Sleep Support
Ingredient fit76
5-HTP and B6 are present, but the melatonin named in the product title and label is not confirmed in the ingredient inventory.
Goal fit
The confirmed ingredients are sleep-linked, but the product’s melatonin claim cannot be confirmed from the listed ingredients.
Dose adequacy
The label declares 50 mg 5-HTP and 10 mg B6, while melatonin has no confirmed amount.
Pathways50
5-HTP contributes through precursor-related support; sleep timing is not confirmed because melatonin is not confirmed in the ingredient list.
Depth
The clearest confirmed route is 5-HTP’s serotonin–melatonin precursor role.
Breadth
The confirmed sleep support is concentrated in one precursor-related route.
Evidence58
5-HTP has a more limited sleep role than melatonin, whose presence is unconfirmed here.
Evidence strength
5-HTP's sleep role is more limited than melatonin's, which is not confirmed here.
Studied preparation
The confirmed 5-HTP and B6 forms fit their ingredient contexts; melatonin’s form cannot be checked.
Formulation logic100
The confirmed ingredients have separate roles, while the unverified melatonin claim adds no clear sleep role.
Partner coverage
The confirmed ingredients have separate roles; no added effect from combining them is established.
Conflicts
No confirmed ingredient is identified as working against sleep.
Effective doses
The declared 5-HTP and B6 amounts are clear; no amount is available for melatonin.
Impact
High effect
Vitamin B6 · 10 mg5-HTP · 50 mg
B6 supports mood when deficiency contributes to symptoms, but extra benefit with adequate intake is not established. 5-HTP supplies a serotonin precursor, although the supplied controlled mood findings do not establish general mood efficacy. The 50 mg per serving contributes to the saved comparison without establishing a proven daily mood dose or sustained benefit.
How this product is rated for Mood Support
Ingredient fit76
5-HTP, Vitamin B6 provide the main counted contributions. Several counted amounts only partly match the supplied references, limiting the expected contribution.
Goal fit
The relevant ingredients dominate the active formula, although the product is linked to other goals.
Dose adequacy
Several counted amounts only partly match the supplied references, limiting the expected contribution.
Pathways50
The supplied findings are strongest for monoamine signalling. One route reaches the supplied coverage threshold, leaving support concentrated rather than broad.
Depth
Monoamine signalling is the strongest represented route in the saved findings; a mechanism alone does not prove improved mood.
Breadth
One route reaches the supplied coverage threshold, leaving support concentrated rather than broad.
Evidence96
Vitamin B6 contributes the strongest evidence finding. The counted preparations match those accepted by the supplied evidence findings; this does not establish a mood benefit for every ingredient.
Evidence strength
Vitamin B6 drives the strongest evidence contribution among the counted ingredients; the population and outcome limitations still matter.
Studied preparation
The counted preparations match those accepted by the supplied evidence findings; this does not establish a mood benefit for every ingredient.
Formulation logic100
The counted ingredients have no unmet partner requirement or listed conflict. All counted ingredients meet the minimum amount threshold used here; that threshold is not a proven effective mood dose.
Partner coverage
The counted ingredients do not have an unmet partner requirement in the supplied findings; this does not establish an added combination benefit.
Conflicts
No listed ingredient conflict was identified in the supplied checks.
Effective doses
All counted ingredients meet the minimum amount threshold used here; that threshold is not a proven effective mood dose.
Impact
Moderate effect
Vitamin B6 · 10 mg
Whether 5-HTP helps with everyday stress remains uncertain. It has a conditional connection to anxiety and stress-related symptoms, rather than a reliable broad calming effect. The declared ingredient comes from Griffonia simplicifolia. The separate quick-release melatonin claim conflicts with the ingredient inventory, so its presence and amount remain unresolved; a sleep-related contribution can't be assumed from that claim.
How this product is rated for Stress Relief
Ingredient fit76
5-HTP has a conditional stress connection; melatonin's presence and amount remain unresolved.
Goal fit
5-HTP has a conditional stress connection; melatonin's presence and amount remain unresolved.
Dose adequacy
The serving declares 50 mg 5-HTP and 10 mg vitamin B6; the melatonin amount remains unknown.
Pathways13
5-HTP has a limited mood-related connection; a melatonin contribution cannot be assumed.
Depth
5-HTP has a limited mood-related connection; a melatonin contribution cannot be assumed.
Breadth
The known ingredients provide limited breadth for everyday stress relief.
Evidence56
5-HTP's applicability to everyday stress is conditional, rather than a reliable general effect.
Evidence strength
5-HTP's applicability to everyday stress is conditional, rather than a reliable general effect.
Studied preparation
The relevant declared ingredients have identified preparations; this does not guarantee a personal stress benefit.
Formulation logic100
No particular ingredient conflict is identified. The relevant ingredients do not require an additional partner for their individual roles.
Partner coverage
The relevant ingredients can have their individual roles without an additional partner.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The serving declares 50 mg 5-HTP and 10 mg vitamin B6; the melatonin amount remains unknown.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin B6 (Pyridoxine Hydrochloride) | 10 mg | |
5-HTP (Griffonia simplicifolia) | 50 mg |
5-HTP (Griffonia simplicifolia) · 50 mg OverallScore72
Each serving provides 50 mg of 5-HTP from Griffonia simplicifolia. The label warns about interactions with serotonin-modulating medications.
How this ingredient is rated
Active Ingredient Quality & Bioavailability70
The saved facts identify Griffonia simplicifolia as the source, without a specified 5-HTP standardization percentage.
Botanical Source & Standardization
The saved facts identify Griffonia simplicifolia as the source, without a specified 5-HTP standardization percentage.
Dose, Safety & Label Transparency79
A serving provides 50 mg of 5-HTP. The label warns about interactions with serotonin-modulating medications.
Dosage Potency & Range
A serving provides 50 mg of 5-HTP.
Safety Warnings & Label Clarity
The label warns about interactions with serotonin-modulating medications.
Value60
Based on the whole-product price, 100 mg of 5-HTP corresponds to about $0.43.
Price per 100mg 5-HTP
Based on the whole-product price, 100 mg of 5-HTP corresponds to about $0.43.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- High Dose Vitamin B6 Reduces Depression Symptoms.
- Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
- Associations of dietary B vitamins intakes with depression in adults.
- Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
- Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
- Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
- The effect of pyridoxine administration on melatonin secretion in normal men.
- Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
- Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
- Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
- Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.