EstroPause

EstroPause

Irwin Naturals4.6 (1,094 ratings)
Format:Softgel Quantity: 80 Softgel(s) · 20 servings
Goals

Product analysis

47 out of 100

EstroPause supplies calcium and magnesium that may help fill dietary gaps related to bone health. Its St. John’s wort can weaken oral contraceptives, blood thinners and many other medicines, making a medication check important.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

Most preparations are unspecified, making meaningful quality comparisons difficult. Some mineral and source names are listed, but they do not clarify the quality of the wider formula.

Ingredient Transparency67

Most amounts and several composition details are disclosed. Preparation details remain largely unspecified, with one combined entry’s amount and composition unresolved.

Value For Money40

Value for money remains uncertain across the main ingredients.

Customer Satisfaction79

Customer ratings are positive. More than a thousand responses provide substantial satisfaction feedback, without establishing bone or mood benefits.

Product Focus51

Calcium and magnesium provide the clearest nutritional connection to bone support when intake is low. Mood-related expectations are more uncertain, and St. John’s wort requires checking for interactions with medicines.

Format
Softgel
Container
80 Softgel(s)
Per serving
$0.99
Customer rating
4.6 · 1,094 ratings
Report analysis

Goals

Mood Support
Impact
Moderate effect
D- Ingredient FitD- PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 200 mgOmega-3 · 647 mg

Magnesium may help when low levels contribute to apathy or depressed mood. St. John's wort has a different connection to depressive symptoms, but that doesn't imply routine mood improvement in healthy adults, and extracts aren't interchangeable. It can weaken oral contraceptives, anticoagulants and many other medicines. Fish oil doesn't provide a clear extra everyday mood benefit, and total oil mass isn't the amount of EPA and DHA.

How this product is rated for Mood Support

Ingredient fit44

The relevant nutrients may help when low levels contribute to mood symptoms. Other ingredients do not automatically add an emotional benefit.
Goal fit
The relevant nutrients may help when low levels contribute to mood symptoms.
Dose adequacy
Magnesium 200 mg; Omega-3 647 mg; St. John's Wort 300 mg per serving; these amounts describe exposure, not a guarantee of mood benefit.

Pathways40

Nutrient roles in the nervous system give a biological connection to mood, but that connection alone does not predict symptom relief.
Depth
Nutrient roles in the nervous system give a biological connection to mood, but that connection alone does not predict symptom relief.
Breadth
Several biological connections do not by themselves demonstrate several distinct emotional benefits.

Evidence88

Correcting low nutrient levels is different from improving mood in someone who already gets enough.
Evidence strength
Correcting low nutrient levels is different from improving mood in someone who already gets enough.
Studied preparation
The declared ingredients retain their preparation-specific limits; matching an ingredient name does not guarantee the same personal response.

Formulation logic100

No particular ingredient conflict or missing required partner is identified. Combining ingredients does not by itself demonstrate an added mood benefit.
Partner coverage
No additional partner ingredient is required by the available ingredient-specific information.
Conflicts
No particular conflict between the declared ingredients is identified.
Effective doses
Magnesium 200 mg; Omega-3 647 mg; St. John's Wort 300 mg per serving; these amounts describe exposure, not a guarantee of mood benefit.
Study evidence
Magnesium Supportive 60 studies
Omega-3 Supportive 141 studies
Bone Health
Impact
Moderate effect
D Ingredient FitD PathwaysA+ EvidenceA Formulation Logic
Magnesium · 200 mgCalcium · 500 mg

Calcium at 500 mg supplies mineral for normal bone structure, and 200 mg magnesium supports bone metabolism. These amounts may help fill dietary gaps. The supplied omega-3 evidence does not establish routine bone-density or fracture benefits.

How this product is rated for Bone Health

Ingredient fit47

Bone-related ingredients form one part of a broader formula aimed at other health needs. The included amounts provide partial support against the saved dose benchmarks.
Goal fit
Bone-related ingredients form one part of a broader formula aimed at other health needs.
Dose adequacy
The included amounts provide partial support against the saved dose benchmarks.

Pathways49

Bone mineral supply is the strongest mechanism in the saved findings. One of the three target mechanisms reaches the saved coverage threshold.
Depth
Bone mineral supply is the strongest mechanism in the saved findings.
Breadth
One of the three target mechanisms reaches the saved coverage threshold.

Evidence100

Calcium provides the strongest saved evidence rating here; the finding does not establish fracture prevention. The saved assessment recognizes the preparations of the ingredients included at qualifying amounts.
Evidence strength
Calcium provides the strongest saved evidence rating here; the finding does not establish fracture prevention.
Studied preparation
The saved assessment recognizes the preparations of the ingredients included at qualifying amounts.

Formulation logic93

The saved findings identify a missing partner for calcium, limiting its assessed contribution. No configured ingredient conflict was found in the saved assessment. All ingredients included in this finding reach the saved minimum dose threshold.
Partner coverage
The saved findings identify a missing partner for calcium, limiting its assessed contribution.
Conflicts
No configured ingredient conflict was found in the saved assessment.
Effective doses
All ingredients included in this finding reach the saved minimum dose threshold.
Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Omega-3 Supportive 32 studies

Ingredients

IngredientAmount per servingScore
Calories
35 Calorie(s)
Total Fat
2 Gram(s)
Saturated Fat
0.5 Gram(s)
Cholesterol
10 mg
Total Carbohydrates
2 Gram(s)
Protein
2 Gram(s)
Calcium (Calcium Carbonate, Calcium Citrate)
500 mg 56
Iron
0.6 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
200 mg
Sodium
15 mg
Fish Oil
2158 mg 6
Omega-3 Fatty Acids
647 mg 16
St. John's Wort Extract
300 mg 100
Hypericin
0.9 mg
Soy Isoflavones
100 mg
Total Isoflavones
5 mg
Black Cohosh root extract
80 mg
Triterpenoid Saponins
2 mg
Red Clover, Powder
40 mg
Asian Ginseng root extract
31 mg
Chasteberry Fruit Extract
20 mg
BioPerine Complex
6 mg
BioPerine (Black Pepper Fruit Extract)
0 NP
Ginger Rhizome Extract (Gingerols)
0 NP
Women Women 50+ Menopause
Report overview
C+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value
A serving provides 500 mg of calcium from calcium carbonate and calcium citrate. Their proportions are unknown, and the evaluation flags an artificial additive in Other Ingredients.
How this ingredient is rated

Active Ingredient Quality & Bioavailability69

The amount of calcium and its sources are disclosed: calcium carbonate and calcium citrate. The amounts from each source are unknown.
Calcium Form & Absorption Potential
The sources are calcium carbonate and calcium citrate; their individual proportions are unknown.
Elemental Calcium Transparency
The label declares 500 mg of calcium per serving.

Dose, Safety & Label Transparency60

The serving provides 500 mg of calcium. The evaluation flags an artificial additive in Other Ingredients.
Absorption-Optimized Serving Dose
The 500 mg of calcium per serving falls in the evaluation’s preferred serving band.
Formulation Purity & Additives
The evaluation flags an artificial additive in Other Ingredients; its identity is not specified in the saved facts.

Value20

The whole-product serving costs about $1.00, in the higher price range for this collection.
Price Per Serving Efficiency
The whole-product serving costs about $1.00, in the higher price range for this collection.
A+ Composition And Label Disclosure
The evaluation records an ingredient-specific warning for St. John's wort, but its wording is unavailable. Each serving lists 300 mg of St. John's wort extract.
How this ingredient is rated

Composition and Label Disclosure

Each serving lists 300 mg of St. John's wort extract; no composition rule was evaluated.

Composition and Label Disclosure100

An ingredient-specific warning is recorded in the saved evaluation, though its details are not supplied.
Explicit Label Detail
The saved facts indicate a specific warning, but do not provide its wording.

Commercial Price and Usability

A whole-product serving costs about $1.00; no price rule was evaluated.
Omega-3 · 647 mg OverallScore16
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  7. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  8. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  9. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  10. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  11. Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study.
    Mei Z; Chen GC; Hu J; Lin C; Sun Z; Liu C; Geng X; Yuan C; Qi Q; Zheng Y · The American journal of clinical nutrition · 2021
    Cohort study492,713 participantsBone Health forOmega-3
  12. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
    Matsuzaki K; Hossain S; Wakatsuki H; Tanabe Y; Ohno M; Kato S; Shido O; Hashimoto M · Phytotherapy research : PTR · 2023
    Randomized trial52 participantsBone Health forOmega-3
  13. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans.
    Griel AE; Kris-Etherton PM; Hilpert KF; Zhao G; West SG; Corwin RL · Nutrition journal · 2007
    Randomized trial23 participantsBone Health forOmega-3
  14. The Relationship Between Omega-3, Omega-6 and Total Polyunsaturated Fat and Musculoskeletal Health and Functional Status in Adults: A Systematic Review and Meta-analysis of RCTs.
    Abdelhamid A; Hooper L; Sivakaran R; Hayhoe RPG; Welch A; PUFAH Group · Calcified tissue international · 2020
    Meta-analysis7,288 participants28 studies pooledBone Health forOmega-3
  15. Dietary intake of fish, n-3 polyunsaturated fatty acids and risk of hip fracture: A systematic review and meta-analysis on observational studies.
    Sadeghi O; Djafarian K; Ghorabi S; Khodadost M; Nasiri M; Shab-Bidar S · Critical reviews in food science and nutrition · 2019
    Meta-analysis292,657 participants10 studies pooledBone Health forOmega-3
  16. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  17. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support forMagnesium
  18. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  19. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  20. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium