Acetyl L-Carnitine 500 mg

Acetyl L-Carnitine 500 mg

Swanson4.7 (1,308 ratings)
Format:Capsule Quantity: 100 Capsule(s) · 100 servings
Goals
$16.09 $0.16 per serving

Product analysis

59 out of 100

Acetyl L-Carnitine 500 mg provides a single ingredient involved in cellular energy processes, with limited evidence for fatigue-related benefits in selected older adults.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The exact ingredient form is not disclosed. Its quality cannot be confidently distinguished from other acetyl L-carnitine products.

Ingredient Transparency63

The amount per serving is stated. The missing form detail leaves less information for comparing ingredient quality.

Value For Money100

The serving offers very good value for its acetyl L-carnitine amount. A low cost does not establish better results for energy or concentration.

Customer Satisfaction82

Customer feedback is very positive across more than a thousand ratings. The review volume gives a useful picture of satisfaction, without establishing effectiveness.

Product Focus57

One ingredient is linked to several energy and brain-related uses. The evidence comes mainly from selected older or clinical populations, so everyday focus and productivity benefits remain uncertain.

Format
Capsule
Container
100 Capsule(s)
Per serving
$0.16
Customer rating
4.7 · 1,308 ratings
Report analysis

Goals

Energy
Impact
High effect
B- Ingredient FitD- PathwaysA+ EvidenceA+ Formulation Logic
Acetyl L-Carnitine · 500 mg

Acetyl L-carnitine has a connection to cellular energy metabolism, but the supplied fatigue evidence concerns adults over 70 with clinical fatigue. The 500 mg serving receives a contribution in the saved findings, yet it does not establish routine adult energy improvement. Results for other carnitine forms cannot be transferred to this ingredient.

How this product is rated for Energy

Ingredient fit72

Acetyl L-Carnitine anchors this product’s saved energy connection. The serving only partly reaches the saved amount comparisons; this does not measure how much energy it provides.
Goal fit
Acetyl L-Carnitine is the focused ingredient in the saved energy findings.
Dose adequacy
The serving only partly reaches the saved amount comparisons; this does not measure how much energy it provides.

Pathways40

The saved findings concentrate on mitochondrial energy production, without establishing the size of a clinical benefit. That is a narrow connection rather than broad energy coverage.
Depth
The saved findings concentrate on mitochondrial energy production, without establishing the size of a clinical benefit.
Breadth
Coverage is concentrated in mitochondrial energy production, rather than extending across several distinct energy functions.

Evidence95

Acetyl L-Carnitine appears in the saved findings, but the supplied population or preparation limits prevent a routine adult energy claim.
Evidence strength
Acetyl L-Carnitine appears in the saved findings, but the supplied population or preparation limits prevent a routine adult energy claim.
Studied preparation
The preparation qualifies in the saved findings, although population and treatment limits still govern how its effects can be described.

Formulation logic100

No missing partner or specified conflict was identified. The included amounts meet the saved minimum comparisons, without establishing a routine energy benefit.
Partner coverage
The included ingredients do not require a missing partner for the roles described.
Conflicts
No specified ingredient conflict was identified in the supplied findings.
Effective doses
The included ingredients meet the saved minimum amount comparisons; these are not proven fatigue-treatment thresholds.
Study evidence
Metabolism Support
Impact
Lower effect
B- Ingredient FitF PathwaysF EvidenceA+ Formulation Logic
Acetyl L-Carnitine · 500 mg
Study evidence
Brain Health
Impact
High effect
B- Ingredient FitF PathwaysB EvidenceA+ Formulation Logic

Acetyl L-carnitine is linked to brain energy processes, but that mechanism and findings in disease populations do not establish improved cognition in healthy adults. The 500 mg serving receives a partial amount contribution in the saved comparison. The supplied evidence does not support dependable memory or attention benefits for general use.

How this product is rated for Brain Health

Ingredient fit72

The serving amounts provide partial contributions; unknown individual quantities cannot establish an amount-based contribution.
Goal fit
The relevant ingredients are concentrated on this goal, although the product may also be linked to other uses.
Dose adequacy
The serving amounts provide partial contributions; unknown individual quantities cannot establish an amount-based contribution.

Pathways19

The strongest saved finding concerns cerebral energy metabolism; that connection does not by itself establish a noticeable cognitive benefit.
Depth
The strongest saved finding concerns cerebral energy metabolism; that connection does not by itself establish a noticeable cognitive benefit.
Breadth
No listed function reaches the saved comparison's coverage threshold at these serving amounts.

Evidence76

The saved comparison recognizes the included forms, without establishing that the entire product or its serving schedule was tested.
Evidence strength
Acetyl L-Carnitine provides the strongest saved evidence contribution among the included ingredients; its specific population and benefit limitations still apply.
Studied preparation
The saved comparison recognizes the included forms, without establishing that the entire product or its serving schedule was tested.

Formulation logic100

The supplied comparison finds no missing required partners or matched conflicts. Amount limitations are reflected separately.
Partner coverage
The included contributions have no missing required partner in the supplied comparison; this does not establish added benefit from combining them.
Conflicts
No configured conflict was matched in the supplied facts.
Effective doses
All counted ingredients clear the saved minimum amount threshold; that threshold is not a proven effective dose for an individual.
Study evidence
Productivity Boost
Impact
Moderate effect
B- Ingredient FitF PathwaysC+ EvidenceA+ Formulation Logic
Acetyl L-Carnitine · 500 mgAcetyl L-Carnitine · 500 mg

Acetyl L-carnitine at 500 mg relates to brain energy processes. The supplied assessment offers a limited connection to productivity, rather than evidence of a reliable improvement in everyday work.

How this product is rated for Productivity Boost

Ingredient fit72

The saved assessment finds a reasonably focused contribution to the goal, while accounting for other ingredients and uses. The assessed amounts provide partial support against the saved dose references (50 out of 100).
Goal fit
The saved assessment finds a reasonably focused contribution to the goal, while accounting for other ingredients and uses.
Dose adequacy
The assessed amounts provide partial support against the saved dose references (50 out of 100).

Pathways14

The strongest saved coverage concerns brain energy buffering, with partial coverage. No mechanism reaches the saved threshold for broad coverage.
Depth
The strongest saved coverage concerns brain energy buffering, with partial coverage.
Breadth
No mechanism reaches the saved threshold for broad coverage.

Evidence67

Acetyl L-Carnitine leads the saved evidence comparison at an assessed amount; this is not a prediction of improved work output. The saved assessment identifies the qualifying ingredients as matching its studied-preparation category.
Evidence strength
Acetyl L-Carnitine leads the saved evidence comparison at an assessed amount; this is not a prediction of improved work output.
Studied preparation
The saved assessment identifies the qualifying ingredients as matching its studied-preparation category.

Formulation logic100

The assessed ingredients work independently or have their listed partner. No ingredient conflict is recorded in the saved assessment.
Partner coverage
The assessed ingredients work independently or have their listed partner.
Conflicts
No ingredient conflict is recorded in the saved assessment.
Effective doses
All assessed ingredients reach the saved minimum dose threshold.
Study evidence
Cognitive Support
Impact
High effect
B- Ingredient FitD- PathwaysB EvidenceA+ Formulation Logic
Acetyl L-Carnitine · 500 mg

Acetyl L-carnitine has a role in energy metabolism and acetyl donation, but these mechanisms do not establish improved everyday cognition. The supplied clinical evidence comes from a disease population and cannot be transferred to healthy adults. Its 500 mg per serving receives partial amount recognition in the saved findings, without establishing a proven cognitive dose.

How this product is rated for Cognitive Support

Ingredient fit72

Acetyl L-carnitine supplies the relevant connection to cognition. The amount findings are mixed, with some ingredients receiving only partial recognition.
Goal fit
Acetyl L-carnitine provides the relevant ingredient focus, although the product is associated with several goals.
Dose adequacy
The 500 mg serving receives partial amount recognition, without establishing an effective dose for healthy-adult cognition.

Pathways40

The recorded connection concerns cerebral energy buffering; metabolic mechanisms do not establish an everyday cognitive benefit. Coverage is concentrated in this one area.
Depth
The recorded connection concerns cerebral energy buffering; metabolic mechanisms do not establish an everyday cognitive benefit.
Breadth
Only cerebral energy buffering reaches the saved coverage threshold, leaving the other named pathways uncovered.

Evidence79

Acetyl L-carnitine evidence from a disease cohort cannot establish routine cognitive enhancement in healthy adults.
Evidence strength
Acetyl L-carnitine evidence from a disease cohort cannot establish routine cognitive enhancement in healthy adults.
Studied preparation
The saved preparation finding recognizes the counted ingredients; form naming does not establish superior cognitive effects.

Formulation logic100

No configured conflict was identified in the supplied findings. The counted ingredients have no unmet partner requirement.
Partner coverage
The counted ingredients have no unmet partner requirement in the supplied findings; that does not establish an added benefit from combining them.
Conflicts
No configured conflict was identified in the supplied findings.
Effective doses
All counted ingredients meet the saved minimum amount threshold; this threshold is not a demonstrated effective dose.
Study evidence
Mental Focus
Impact
High effect
B- Ingredient FitD- PathwaysB+ EvidenceA+ Formulation Logic
Acetyl L-Carnitine · 500 mg

Acetyl L-carnitine contributes to processes involved in cellular energy and acetylcholine, but those roles do not establish better attention after a serving. The supplied clinical context concerns disease populations and longer use, rather than routine focus in healthy adults. Its declared amount receives credit in the saved calculation, while the supplied scientific context remains insufficient for an acute focus claim.

How this product is rated for Mental Focus

Ingredient fit72

The serving has focus-related ingredients, with amount suitability and broader-purpose ingredients assessed separately.
Goal fit
The ingredients are concentrated on the assessed focus-related role, though the product is also linked to other goals.
Dose adequacy
The declared serving receives partial amount credit; matching an amount reference does not establish an effective dose for acute focus.

Pathways40

The saved mechanism finding is concentrated in the roles described below. Mechanism coverage does not establish clinical improvement.
Depth
The strongest mapped role is cerebral energy supply; this describes the saved mechanism finding rather than a demonstrated clinical effect.
Breadth
Only one assessed route reaches the saved coverage threshold, so the mapped contribution remains narrow.

Evidence83

The strongest saved evidence finding and preparation matches are described separately. Scientific limitations still determine which focus benefits can be claimed.
Evidence strength
Acetyl L-carnitine leads the saved finding, while the supplied scientific context does not establish routine acute focus enhancement.
Studied preparation
The saved preparation check is satisfied for qualifying ingredients; this does not make every ingredient clinically effective for immediate focus.

Formulation logic100

Partner requirements, recorded conflicts and minimum amounts shape the saved formulation finding.
Partner coverage
The saved partner check finds no missing required partner among the credited ingredients.
Conflicts
No configured conflict was recorded in the supplied facts; this is not a general safety assessment.
Effective doses
All credited ingredients meet the saved minimum amount threshold; that threshold does not prove a clinically effective focus dose.
Study evidence

Ingredients

IngredientAmount per servingScore
Acetyl L-Carnitine HCl
500 mg 95
Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
A serving provides 500 mg of acetyl L-carnitine, with the hydrochloride form and individual amount identified. The whole-product price works out to about $0.16 per 500 mg of ALCAR, giving a clear basis for comparing cost.
How this ingredient is rated

Active Ingredient Quality & Bioavailability88

The hydrochloride form is identified. The supplied evidence does not establish a manufacturing or purity claim.
ALCAR vs. Standard Carnitine Form
Acetyl L-carnitine is identified, with no other carnitine forms recorded alongside it.
Advanced Sourcing and Salt Specificity
The hydrochloride form is identified, but no manufacturing or purity claim is recorded in the supplied evidence.

Dose, Safety & Label Transparency100

The 500 mg ALCAR amount is disclosed individually, so it can be compared without guessing its share of a blend.
Clinical Dosage Efficacy
A serving provides 500 mg of acetyl L-carnitine.
Label Transparency and Proprietary Blends
The individual ALCAR amount is explicitly stated, rather than hidden within a combined blend weight.

Value100

About $0.16 per 500 mg of ALCAR is a low ingredient-normalized cost in the saved evaluation. The calculation uses the complete product price.
Price per 500mg Acetyl L-Carnitine
The whole-product price works out to about $0.16 per 500 mg of declared ALCAR; this is not a price for isolated ALCAR.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
    Malaguarnera M; Gargante MP; Cristaldi E; Vacante M; Risino C; Cammalleri L; Pennisi G; Rampello L · Digestive diseases and sciences · 2008
    Randomized trial125 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  2. Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
    Spagnoli A; Lucca U; Menasce G; Bandera L; Cizza G; Forloni G; Tettamanti M; Frattura L; Tiraboschi P; Comelli M · Neurology · 1991
    Randomized trial130 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  3. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome.
    Herrmann WM; Dietrich B; Hiersemenzel R · International journal of clinical pharmacology research · 1990
    Randomized trialBrain Health forAcetyl L-Carnitine
  4. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
    Malaguarnera M; Vacante M; Motta M; Giordano M; Malaguarnera G; Bella R; Nunnari G; Rampello L; Pennisi G · Metabolic brain disease · 2012
    Randomized trial61 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  5. Acetyl-L-carnitine in the treatment of mildly demented elderly patients.
    Passeri M; Cucinotta D; Bonati PA; Iannuccelli M; Parnetti L; Senin U · International journal of clinical pharmacology research · 1990
    Randomized trial60 participantsBrain Health Mental Focus forAcetyl L-Carnitine
  6. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
    Torrioli MG; Vernacotola S; Peruzzi L; Tabolacci E; Mila M; Militerni R; Musumeci S; Ramos FJ; Frontera M; Sorge G; Marzullo E; Romeo G; Vallee L; Veneselli E; Cocchi E; Garbarino E; Moscato U; Chiurazzi P; D'Iddio S; Calvani M; Neri G · American journal of medical genetics. Part A · 2008
    Randomized trial63 participantsCognitive Support forAcetyl L-Carnitine
  7. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.
    Malaguarnera M; Gargante MP; Cristaldi E; Colonna V; Messano M; Koverech A; Neri S; Vacante M; Cammalleri L; Motta M · Archives of gerontology and geriatrics · 2008
    Randomized trial96 participantsCognitive Support forAcetyl L-Carnitine
  8. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
    Malaguarnera M; Vacante M; Giordano M; Pennisi G; Bella R; Rampello L; Malaguarnera M; Li Volti G; Galvano F · The American journal of clinical nutrition · 2011
    Randomized trial121 participantsEnergy forAcetyl L-Carnitine
  9. The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.
    Malaguarnera M; Vacante M; Bertino G; Neri S; Malaguarnera M; Gargante MP; Motta M; Lupo L; Chisari G; Bruno CM; Pennisi G; Bella R · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012
    Randomized trial60 participantsEnergy forAcetyl L-Carnitine
  10. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
    Malaguarnera M; Bella R; Vacante M; Giordano M; Malaguarnera G; Gargante MP; Motta M; Mistretta A; Rampello L; Pennisi G · Scandinavian journal of gastroenterology · 2011
    Randomized trial67 participantsEnergy forAcetyl L-Carnitine
  11. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy.
    Sun Y; Shu Y; Liu B; Liu P; Wu C; Zheng R; Zhang X; Zhuang Z; Deng Y; Zheng L; Xu Q; Jiang B; Ouyang X; Gao J; Xu N; Li X; Jiang S; Liang C; Yao Y · Experimental and therapeutic medicine · 2020
    Randomized trial239 participantsEnergy forAcetyl L-Carnitine
  12. Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.
    Kumar R; Nuñez NA; Joshi N; Joseph B; Verde A; Seshadri A; Cuellar Barboza AB; Prokop LJ; Medeiros GC; Singh B · Bipolar disorders · 2024
    Systematic reviewEnergy forAcetyl L-Carnitine
  13. Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
    Malaguarnera G; Catania VE; Bertino G; Chisari LM; Castorina M; Bonfiglio C; Cauli O; Malaguarnera M · Current pharmaceutical design · 2022
    Randomized trial92 participantsLongevity forAcetyl L-Carnitine
  14. Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial.
    Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
    Randomized trial62 participantsMental Focus Productivity Boost forAcetyl L-Carnitine
  15. [Psycho-functional changes in attention and learning under the action of L-acetylcarnitine in 17 young subjects. A pilot study of its use in mental deterioration].
    Lino A; Boccia MM; Rusconi AC; Bellomonte L; Cocuroccia B · La Clinica terapeutica · 1992
    Non-randomized trial17 participantsMental Focus forAcetyl L-Carnitine
  16. Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial.
    Arnold LE; Amato A; Bozzolo H; Hollway J; Cook A; Ramadan Y; Crowl L; Zhang D; Thompson S; Testa G; Kliewer V; Wigal T; McBurnett K; Manos M · Journal of child and adolescent psychopharmacology · 2008
    Randomized trial112 participantsMental Focus forAcetyl L-Carnitine
  17. Acetyl-L-carnitine for patients with hepatic encephalopathy.
    Martí-Carvajal AJ; Gluud C; Arevalo-Rodriguez I; Martí-Amarista CE · The Cochrane database of systematic reviews · 2019
    Meta-analysis398 participants5 studies pooledMental Focus forAcetyl L-Carnitine
  18. Low Bioavailability and High TMAO Production: Novel Insights Into Acetylcarnitine and Carnitine Metabolism.
    Krims-Davis K; Ozola M; Razzivina V; Gukalova B; Konrade I; Dambrova M; Liepinsh E · Molecular nutrition & food research · 2025
    Randomized trialMetabolism Support forAcetyl L-Carnitine