Product Image

Ultimate Iron

Nature's Way
4.7
★ ★ ★ ★ ★
(1524 ratings)
Iron 50 mg
Vitamin B12 200 mcg
Product Image
Score71
Includes vitamin C with iron is a useful strength, but very high iron amount is the main trade-off.
How scoring works
Quantity:90 Softgel(s) • (45 servings)
Goals:
Hair Health
Energy
Productivity Boost
General Health
Fitness

Score 71

Includes vitamin C with iron is a useful strength, but very high iron amount is the main trade-off.
How scoring works
$20.81($0.46 per serving)
Vitacost
$ 24.49
Vitacost
$ 24.49
Amazon
$ 20.81
iHerb
$ 24.49
Pure Formulas
$ 23.13
Report prices

Analysis

Iron, vitamin C, folate, and B12 form a coherent blood-support blend, and liver fractions provide an additional animal-derived component. The named forms and amounts show where the formula provides its clearest nutritional value.

Ferrous succinate at 50 mg is unusually high for general use, while cyanocobalamin and unspecified folate are basic or incompletely described forms. Those limitations matter when comparing it with simpler or more transparent alternatives.

It may suit an adult with a confirmed substantial iron need who prefers softgels and is being monitored. Casual use for energy or hair is not appropriate because the safety cost of unnecessary iron outweighs the broad claims.

Who is it for
  • Adults with a confirmed high iron requirement
  • Softgel users receiving iron monitoring
Best for
  • Supervised iron repletion
  • Iron with vitamin C, folate, and B12

Pros

  • Includes vitamin C with iron
  • Provides folate and B12
  • Softgel format
  • Clearly lists the iron amount

Cons

  • Very high iron amount
  • Uses cyanocobalamin
  • Folate form is unspecified
  • Contains animal-derived liver fractions

Warnings

  • Iron at 50 mg can cause nausea, constipation, abdominal pain, or harmful accumulation and should be used only for a confirmed need. Keep it securely away from children because accidental ingestion can be dangerous.
  • Contains liver-derived ingredients and is not suitable for vegetarian or vegan users.

Nutrient quality

70 High impact

Ferrous succinate is a usable iron form, while cyanocobalamin and unspecified folate are conventional. The iron amount is high and requires a clear clinical need.

Ingredient transparency

73 High impact

Core active amounts are stated without a proprietary blend. Liver-fraction composition, folate form, full directions, and non-active ingredients remain unclear.

Customer satisfaction

70 High impact

The supplied average rating is strong and the review base is large. No review text is available to assess recurring complaints or experiences tied to the intended use.

Value for money

69 High impact

Focused iron dosing and a moderate serving cost provide fair value for a confirmed need. Conventional B12, vague liver fractions, and the aggressive iron amount limit broader competitiveness.

Report analysis

Goals

Hair Health
Hair Health
Impact
Highest effect
A+ Goal FitB Strength of SupportB CoverageA- Formula Quality
Iron · 50 mgVitamin C · 120 mg

Iron, vitamin C, folate, and B12 form a strong combination for shedding caused by iron-deficiency anemia. The formula is not appropriate as general hair support when iron stores are already adequate.

Ferrous succinate is clearly disclosed and vitamin C supports absorption, but the 50 mg iron amount exceeds the usual adult upper intake level. That amount can cause gastrointestinal effects or harmful iron accumulation and should be used only for a confirmed need under clinical guidance.

Study evidence
Folate Mixed 15 studies
Iron Disputed 25 studies
Vitamin B12 Disputed 17 studies
Vitamin C Mixed 5 studies
Energy
Energy
Impact
High effect
A+ Goal FitC Strength of SupportB+ CoverageB Formula Quality
Vitamin B12 · 200 mcgIron · 50 mg

Iron, folate, vitamin B12, and vitamin C address red blood cell formation, oxygen transport, and related energy metabolism. Liver fractions fit the blood-building concept but add less transparent animal-derived material.

The iron amount exceeds the usual adult daily upper limit and cyanocobalamin is a less preferred B12 form. Unsupervised use may cause constipation, nausea, or iron overload, so this formula is best reserved for a confirmed need and kept away from children.

Study evidence
Iron Supportive 74 studies
Vitamin B12 Disputed 14 studies
Productivity Boost
Productivity Boost
Impact
High effect
C+ Goal FitB Strength of SupportC CoverageA- Formula Quality
Iron · 50 mgVitamin B12 · 200 mcgVitamin B12 · 200 mcg

Iron can reduce fatigue and brain fog when deficiency is present, while folate and B12 support blood formation. The formula does not act as a general nootropic in iron-replete users.

The 50 mg iron amount is high and uses ferrous succinate rather than a preferred chelate. It may cause nausea or constipation and should not be used with iron-overload conditions unless specifically directed.

Study evidence
Iron Supportive 69 studies
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
General Health
General Health
Impact
High effect
B+ Goal FitD+ Strength of SupportC- CoverageB+ Formula Quality
Folate · 666 mcg DFEVitamin B12 · 200 mcgVitamin C · 120 mg

Iron, folate, vitamin B12, and vitamin C form a logical blood-building combination for people with a confirmed iron need. Ferrous succinate is clearly disclosed, and vitamin C can support iron absorption.

The iron amount exceeds the adult upper intake level, so routine use without an identified need carries avoidable digestive and overload risk. Cyanocobalamin and the swallowed softgel also make the B12 component less compelling.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Vitamin C Supportive 56 studies
Fitness
Fitness
Impact
High effect
C+ Goal FitB- Strength of SupportD+ CoverageB Formula Quality

A high iron amount with vitamin C, folate, and vitamin B12 may support oxygen transport and stamina when deficiency is present. The formula is poorly suited to routine performance use without a confirmed need.

Ferrous succinate is disclosed, and the supporting nutrients fit red blood cell production, but liquid liver fractions are less transparent. The 50 mg iron amount is high enough to increase digestive and excess-iron risks, so iron-status testing and professional guidance are important before use.

Study evidence
Iron Supportive 81 studies
Vitamin C No effect 17 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Fat
1 Gram(s)
Vitamin C (Ascorbic Acid)
 120 mg
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
 200 mcg
Iron (Ferrous Succinate)
 50 mg
Liquid Liver Fractions
500 mg
Gluten Free Adults 18–50 Dairy Free Women
Report overview
Iron (Ferrous Succinate) · 50 mg OverallScore70
C+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

Ferrous succinate is a standard iron salt without the gentleness advantage of a chelate, and the softgel should be easier to swallow than a hard tablet but is not a slow-release format. The iron amount is high potency and suited mainly to confirmed deficiency needs; vitamin C meets the absorption threshold and red-blood-cell support includes vitamin B12 or folate. The high dose and complete cofactors support reasonable value despite the standard form; the serving cost is in the collection’s average band.

View ingredientView products
Vitamin B12 (Cyanocobalamin) · 200 mcg OverallScore27
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The low B12 amount and cyanocobalamin form make this a weak B12-focused option. The swallowed softgel does not enhance absorption for people with uptake issues. A substantial iron dose also makes it inappropriate for anyone seeking B12 without added iron.

View ingredientView products
Loading alternative details
88 Performance

Gentle Iron 28 mg

Nature's Bounty
<p>Ferrous bisglycinate is paired with vitamin C, folate, and vitamin B12 in a more moderate and coherent formula. The lower iron amount may be easier to justify, though any supplemental iron should match a confirmed need.</p>
83 Performance

Iron Complex

NOW
<p>Ferrochel iron, vitamin C, folate, and vitamin B12 preserve the original nutritional strategy with a lower iron dose. Dong quai adds little and may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
85 Performance

Iron Ferrochel Ferrous Bisglycinate Chelate 36 mg

California Gold Nutrition
<p>A single 36 mg ferrous bisglycinate ingredient offers clearer form disclosure and less iron than the original. It lacks vitamin C, folate, and vitamin B12, so it is a better choice only when a focused iron product is preferred.</p>
89 Budget

Iron 18 mg

NOW
<p>A simple 18 mg Ferrochel dose lowers both recurring cost and iron exposure compared with the original 50 mg formula. It omits vitamin C, folate, vitamin B12, and liver fractions, so it fits a narrower iron-only need.</p>
86 Budget

Albion Chelated Ferrochel Iron 18 mg

Swanson Ultra
<p>A clearly defined 18 mg chelated iron dose offers economical use and avoids undisclosed liver components. Supporting vitamin C, folate, and vitamin B12 are absent, but the lower amount may be more practical for a moderate need.</p>
89 Budget

Chelated Iron 27 mg

Carlson
<p>Iron bisglycinate provides a clear 27 mg amount at a lower recurring cost and with less exposure than the original. The focused formula omits B vitamins and vitamin C, so those must be considered separately.</p>
89 Value

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>Methylcobalamin, methylfolate, and active vitamin B6 provide strong value when B-vitamin support is the main goal. No iron is included, so it is not an alternative for a confirmed iron requirement.</p>
86 Value

Chelated Iron 18 mg

Bluebonnet
<p>A simple 18 mg ferrous bisglycinate dose offers economical support with substantially less iron exposure. Vitamin C, folate, and vitamin B12 are absent, but the focused label avoids liver fractions of uncertain composition.</p>
86 Value

High Absorption Iron with Ferrochel 27 mg

Doctor's Best
<p>A 27 mg Ferrochel dose combines low recurring cost with clear active disclosure. The lower amount and lack of cofactors are trade-offs, while unnecessary iron can still cause digestive effects or harmful accumulation.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. Association between serum vitamin B12 level and frailty in older adults.
    Dokuzlar O; Soysal P; Isik AT · Northern clinics of Istanbul · 2022
    Cross-sectional study335 participantsEnergy forVitamin B12
  4. Megaloblastic anaemia: prevalence and causative factors.
    Khanduri U; Sharma A · The National medical journal of India · 2008
    Observational study175 participantsEnergy forVitamin B12
  5. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
    Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
    Randomized trial477 participantsEnergy forIron
  6. Intravenous iron versus blood transfusion for postpartum anemia: a systematic review and meta-analysis.
    Caljé E; Groom KM; Dixon L; Marriott J; Foon R; Oyston C; Bloomfield FH; Jordan V · Systematic reviews · 2024
    Meta-analysis4,196 participantsEnergy forIron
  7. Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial.
    Waldvogel S; Pedrazzini B; Vaucher P; Bize R; Cornuz J; Tissot JD; Favrat B · BMC medicine · 2012
    Randomized trial154 participantsEnergy forIron
  8. Iron deficiency, general health and fatigue: results from the Australian Longitudinal Study on Women's Health.
    Patterson AJ; Brown WJ; Powers JR; Roberts DC · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2001
    Cohort studyEnergy forIron
  9. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  10. A Hospital-based Study to Determine Causes of Diffuse Hair Loss in Women.
    Malkud S · Journal of clinical and diagnostic research : JCDR · 2015
    Observational study180 participantsHair Health forIron
  11. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forIron Hair Health forFolate
  12. Iron status in diffuse telogen hair loss among women.
    Moeinvaziri M; Mansoori P; Holakooee K; Safaee Naraghi Z; Abbasi A · Acta dermatovenerologica Croatica : ADC · 2010
    Case-control study60 participantsHair Health forIron
  13. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
    Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
    Randomized trial176 participantsEnergy forIron
  14. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
    Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
    Randomized trial252 participantsEnergy forIron
  15. Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
    Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
    Randomized trial164 participantsEnergy forIron
  16. Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
    Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Randomized trial85 participantsEnergy forIron
  17. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  18. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  19. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  20. Ferric carboxymaltose in patients with heart failure and iron deficiency.
    Anker SD; Comin Colet J; Filippatos G; Willenheimer R; Dickstein K; Drexler H; Lüscher TF; Bart B; Banasiak W; Niegowska J; Kirwan BA; Mori C; von Eisenhart Rothe B; Pocock SJ; Poole-Wilson PA; Ponikowski P; FAIR-HF Trial Investigators · The New England journal of medicine · 2010
    Randomized trial459 participantsFitness forIron
  21. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women.
    Brownlie T; Utermohlen V; Hinton PS; Giordano C; Haas JD · The American journal of clinical nutrition · 2002
    Randomized trial41 participantsFitness forIron
  22. Ferric Carboxymaltose Versus Ferrous Fumarate in Anemic Children with Inflammatory Bowel Disease: The POPEYE Randomized Controlled Clinical Trial.
    Bevers N; Van de Vijver E; Aliu A; Rezazadeh Ardabili A; Rosias P; Stapelbroek J; Bertrams Maartens IA; van de Feen C; Escher H; Oudshoorn A; Teklenburg S; Vande Velde S; Winkens B; Raijmakers M; Vreugdenhil A; Pierik MJ; van Rheenen PF · The Journal of pediatrics · 2023
    Randomized trial64 participantsFitness forIron
  23. Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
    Low MS; Speedy J; Styles CE; De-Regil LM; Pasricha SR · The Cochrane database of systematic reviews · 2016
    Meta-analysis8,506 participants67 studies pooledFitness Productivity Boost forIron
  24. Altered metabolic response of iron-depleted nonanemic women during a 15-km time trial.
    Zhu YI; Haas JD · Journal of applied physiology (Bethesda, Md. : 1985) · 1998
    Randomized trial37 participantsFitness forIron
  25. Inter-individual variability in redox and performance responses after antioxidant supplementation: A randomized double blind crossover study.
    Margaritelis NV; Nastos GG; Vasileiadou O; Chatzinikolaou PN; Theodorou AA; Paschalis V; Vrabas IS; Kyparos A; Fatouros IG; Nikolaidis MG · Acta physiologica (Oxford, England) · 2023
    Randomized trial44 participantsFitness forVitamin C
  26. Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
    Margaritelis NV; Paschalis V; Theodorou AA; Kyparos A; Nikolaidis MG · Free radical biology & medicine · 2021
    Randomized trial73 participantsFitness forVitamin C
  27. A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women.
    Saito K; Yokoyama T; Yoshida H; Kim H; Shimada H; Yoshida Y; Iwasa H; Shimizu Y; Kondo Y; Handa S; Maruyama N; Ishigami A; Suzuki T · The journals of gerontology. Series A, Biological sciences and medical sciences · 2012
    Cross-sectional study655 participantsFitness forVitamin C
  28. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation.
    Paschalis V; Theodorou AA; Kyparos A; Dipla K; Zafeiridis A; Panayiotou G; Vrabas IS; Nikolaidis MG · European journal of nutrition · 2016
    Clinical trial20 participantsFitness forVitamin C
  29. Low dietary vitamin C intake is associated with low muscle strength among elderly Korean women.
    Park CY; Shin S · Nutrition research (New York, N.Y.) · 2024
    Cross-sectional study14,844 participantsFitness forVitamin C
  30. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  31. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  32. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  33. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  34. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  35. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  36. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  37. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  38. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  39. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  40. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  41. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  42. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  43. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  44. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  45. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  46. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  47. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  48. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  49. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  50. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  51. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  52. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  53. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  54. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  55. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  56. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  57. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  58. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  59. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  60. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  61. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  62. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials.
    Low M; Farrell A; Biggs BA; Pasricha SR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
    Meta-analysis7,089 participants32 studies pooledProductivity Boost forIron
  63. Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial.
    Murray-Kolb LE; Wenger MJ; Scott SP; Rhoten SE; Lung'aho MG; Haas JD · The Journal of nutrition · 2017
    Randomized trial150 participantsProductivity Boost forIron
  64. Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China.
    Li R; Chen X; Yan H; Deurenberg P; Garby L; Hautvast JG · The American journal of clinical nutrition · 1994
    Randomized trial80 participantsProductivity Boost forIron
  65. The Effect of Iron-Fortified Lentils on Blood and Cognitive Status among Adolescent Girls in Bangladesh.
    Barnett AL; Wenger MJ; Yunus FM; Jalal C; DellaValle DM · Nutrients · 2023
    Randomized trial359 participantsProductivity Boost forIron
  66. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  67. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  68. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  69. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  70. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  71. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  72. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  73. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  74. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12