Product Image

OptiFerin-C

4.8
★ ★ ★ ★ ★
(121 ratings)
Iron 28 mg
Product Image
Score84

A strong bisglycinate-and-vitamin C capsule is well suited to a confirmed iron need, with safety depending on appropriate use.

How scoring works
Capsule
Quantity:60 Capsule(s) • (60 servings)
Goals:
Energy
Hair Health
Fitness
Productivity Boost
Immunity
Mental Focus

Score 84

A strong bisglycinate-and-vitamin C capsule is well suited to a confirmed iron need, with safety depending on appropriate use.

How scoring works
$16.00($0.26 per serving)
Vitacost
$ 16.00
Pure Formulas
$ 16.00
Report prices

Analysis

One capsule provides 28 mg iron as bisglycinate, a clearly identified chelated form. The dose is substantial enough for focused supplementation rather than casual wellness use.

One hundred milligrams of vitamin C from calcium ascorbate supports absorption while offering a buffered form. Folate and B12 are absent, so broader blood-cell support must come from food or other supplements.

The pairing is especially relevant to deficiency-related fatigue or low-iron hair shedding. Fitness, focus, productivity, and immunity benefits remain conditional on low iron rather than acting as general enhancement.

Who is it for
  • Adults with confirmed low iron
  • Users wanting vitamin C with bisglycinate
  • People who prefer a one-capsule serving
Best for
  • Targeted iron correction
  • Deficiency-related fatigue
  • Low-iron-related hair shedding

Pros

  • Uses iron bisglycinate
  • Provides 28 mg iron
  • Includes 100 mg buffered vitamin C
  • Focused one-capsule formula

Cons

  • No folate or B12
  • Dose is too high for casual use
  • Does not address non-iron causes of fatigue
  • Only situationally useful for immunity or focus

Warnings

  • The 28 mg iron dose should be guided by testing or a defined need
  • Iron can cause constipation, nausea, or excess accumulation
  • Keep capsules away from children because accidental iron overdose is dangerous

Nutrient quality

92 Highest impact

Iron bisglycinate and calcium ascorbate are favorable forms for absorption and tolerance. The focused formula provides an effective targeted iron amount with useful vitamin C support without unrelated active padding.

Ingredient transparency

85 Highest impact

The active amount and form are disclosed without a hidden blend. Full intake directions and non-active ingredients are not available in the supplied facts.

Customer satisfaction

64 Moderate impact

The aggregate satisfaction metric is strong and supported by a useful volume of ratings. Specific firsthand feedback is absent, so recurring complaints and purpose fit cannot be assessed.

Value for money

93 Highest impact

The focused formula and a reasonable serving cost support practical value. Vitamin C improves absorption support, although folate and vitamin B12 are absent.

Report analysis

Goals

Energy
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB- CoverageA+ Formula Quality
Iron · 28 mg

Iron bisglycinate directly supports hemoglobin and oxygen transport, while buffered vitamin C aids iron absorption. The combination is highly relevant when low iron status contributes to fatigue.

The chelated form is generally well tolerated, but iron is not an appropriate general energy aid when iron stores are already adequate. Unnecessary iron can cause constipation, nausea, or iron overload, so the amount is best used for a confirmed need.

Study evidence
Iron Supportive 74 studies
Hair Health
Impact
Highest effect
A Goal FitA Strength of SupportB CoverageA+ Formula Quality
Iron · 28 mgVitamin C · 100 mg

Iron bisglycinate directly addresses low-iron shedding, and vitamin C supports iron absorption. Benefit is most likely when low ferritin or iron-deficiency anemia has been confirmed.

The 28 mg iron amount and chelated form provide strong targeted contribution with full label clarity. Unneeded iron can cause constipation and harmful accumulation, so ongoing use is inappropriate for people without a demonstrated need.

Study evidence
Iron Disputed 25 studies
Vitamin C Mixed 5 studies
Fitness
Impact
High effect
B- Goal FitA Strength of SupportC- CoverageA Formula Quality

Iron bisglycinate with vitamin C can support oxygen transport and endurance when iron deficiency is confirmed. It is not a general performance enhancer for people with adequate iron stores.

The 28 mg iron amount is substantial, while bisglycinate and vitamin C support absorption and make the focused formula easy to assess. Because unnecessary iron can cause digestive effects and excess accumulation, use is best guided by iron-status testing rather than routine fitness goals.

Study evidence
Iron Supportive 81 studies
Vitamin C No effect 17 studies
Productivity Boost
Impact
High effect
C Goal FitA- Strength of SupportD+ CoverageA+ Formula Quality
Iron · 28 mg

Iron can improve energy and mental clarity when iron deficiency is present. It is not a general productivity enhancer for people with adequate iron status.

Iron bisglycinate and vitamin C support absorption and tolerability. The 28 mg dose may cause nausea or constipation and is unsuitable for iron-overload conditions without medical direction.

Study evidence
Iron Supportive 69 studies
Immunity
Impact
High effect
C Goal FitB+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin C · 100 mg

Iron bisglycinate may support immunity when iron deficiency is confirmed, and vitamin C assists iron absorption. The chelated iron form and buffered vitamin C are both clearly disclosed.

Iron is only situationally useful for immunity, while the vitamin C amount is below the targeted immune threshold. The iron amount should be tied to documented need because unnecessary iron can accumulate and impair immune balance.

Study evidence
Iron Supportive 23 studies
Vitamin C Supportive 53 studies
Mental Focus
Impact
High effect
D Goal FitA- Strength of SupportD- CoverageA Formula Quality

Iron may improve concentration when low iron status is contributing to fatigue or poor oxygen delivery. Iron bisglycinate and vitamin C provide a well-constructed combination for absorption.

People with adequate iron are unlikely to gain a direct focus benefit from routine use. The 28 mg amount is best reserved for a defined need because unnecessary iron can cause digestive effects and excess accumulation.

Study evidence
Iron Adverse 33 studies

Ingredients

IngredientAmount per serving
Vitamin C (Calcium Ascorbate)
100 mg
Calcium (Calcium Ascorbate)
11 mg
Iron (Iron Bisglycinate)
28 mg
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Iron bisglycinate is a premium chelated form with favorable absorption potential, and the capsule format should be gentler than a hard-compressed tablet. The iron amount is within the effective supplemental range; vitamin C meets the absorption-support threshold, but folate and vitamin B12 are not both supplied. The favorable form, useful dose, and vitamin C justify its still-reasonable serving cost; the serving cost is favorable for the collection.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The role of iron homeostasis in remodeling immune function and regulating inflammatory disease.
    Mu Q; Chen L; Gao X; Shen S; Sheng W; Min J; Wang F · Science bulletin · 2023
    Narrative reviewImmunity forIron
  2. Lack of Evidence on Association between Iron Deficiency and COVID-19 Vaccine-Induced Neutralizing Humoral Immunity.
    Faizo AA; Bawazir AA; Almashjary MN; Hassan AM; Qashqari FS; Barefah AS; El-Kafrawy SA; Alandijany TA; Azhar EI · Vaccines · 2023
    Case-control study130 participantsImmunity forIron
  3. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
    Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
    Randomized trial176 participantsEnergy forIron
  4. Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial.
    Waldvogel S; Pedrazzini B; Vaucher P; Bize R; Cornuz J; Tissot JD; Favrat B · BMC medicine · 2012
    Randomized trial154 participantsEnergy forIron
  5. Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration.
    Krayenbuehl PA; Battegay E; Breymann C; Furrer J; Schulthess G · Blood · 2011
    Randomized trial90 participantsEnergy forIron
  6. Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.
    Šmid AN; Golja P; Hadžić V; Abazović E; Drole K; Paravlic AH · Sports medicine (Auckland, N.Z.) · 2024
    Meta-analysis449 participants13 studies pooledFitness forIron
  7. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women.
    Brownlie T; Utermohlen V; Hinton PS; Giordano C; Haas JD · The American journal of clinical nutrition · 2002
    Randomized trial41 participantsFitness forIron
  8. Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes.
    Burden RJ; Pollock N; Whyte GP; Richards T; Moore B; Busbridge M; Srai SK; Otto J; Pedlar CR · Medicine and science in sports and exercise · 2016
    Randomized trial15 participantsFitness forIron
  9. The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis.
    Falkingham M; Abdelhamid A; Curtis P; Fairweather-Tait S; Dye L; Hooper L · Nutrition journal · 2010
    Meta-analysisMental Focus forIron
  10. Iron Status, Anemia, and Iron Interventions and Their Associations with Cognitive and Academic Performance in Adolescents: A Systematic Review.
    Samson KLI; Fischer JAJ; Roche ML · Nutrients · 2022
    Systematic review50 studies pooledMental Focus forIron
  11. Iron-deficiency anaemia and its effect on worker productivity and activity patterns.
    Edgerton VR; Gardner GW; Ohira Y; Gunawardena KA; Senewiratne B · British medical journal · 1980
    Non-randomized trialProductivity Boost forIron
  12. Iron status in diffuse telogen hair loss among women.
    Moeinvaziri M; Mansoori P; Holakooee K; Safaee Naraghi Z; Abbasi A · Acta dermatovenerologica Croatica : ADC · 2010
    Case-control study60 participantsHair Health forIron
  13. Scientific Opinion on the substantiation of a health claim related to iron and maintenance of normal hair growth pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusHair Health forIron
  14. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
    Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
    Randomized trial477 participantsEnergy forIron
  15. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
    Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
    Randomized trial252 participantsEnergy forIron
  16. Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
    Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
    Randomized trial164 participantsEnergy forIron
  17. Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
    Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Randomized trial85 participantsEnergy forIron
  18. Ferric carboxymaltose in patients with heart failure and iron deficiency.
    Anker SD; Comin Colet J; Filippatos G; Willenheimer R; Dickstein K; Drexler H; Lüscher TF; Bart B; Banasiak W; Niegowska J; Kirwan BA; Mori C; von Eisenhart Rothe B; Pocock SJ; Poole-Wilson PA; Ponikowski P; FAIR-HF Trial Investigators · The New England journal of medicine · 2010
    Randomized trial459 participantsFitness forIron
  19. Ferric Carboxymaltose Versus Ferrous Fumarate in Anemic Children with Inflammatory Bowel Disease: The POPEYE Randomized Controlled Clinical Trial.
    Bevers N; Van de Vijver E; Aliu A; Rezazadeh Ardabili A; Rosias P; Stapelbroek J; Bertrams Maartens IA; van de Feen C; Escher H; Oudshoorn A; Teklenburg S; Vande Velde S; Winkens B; Raijmakers M; Vreugdenhil A; Pierik MJ; van Rheenen PF · The Journal of pediatrics · 2023
    Randomized trial64 participantsFitness forIron
  20. Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
    Low MS; Speedy J; Styles CE; De-Regil LM; Pasricha SR · The Cochrane database of systematic reviews · 2016
    Meta-analysis8,506 participants67 studies pooledFitness Productivity Boost forIron
  21. Altered metabolic response of iron-depleted nonanemic women during a 15-km time trial.
    Zhu YI; Haas JD · Journal of applied physiology (Bethesda, Md. : 1985) · 1998
    Randomized trial37 participantsFitness forIron
  22. Inter-individual variability in redox and performance responses after antioxidant supplementation: A randomized double blind crossover study.
    Margaritelis NV; Nastos GG; Vasileiadou O; Chatzinikolaou PN; Theodorou AA; Paschalis V; Vrabas IS; Kyparos A; Fatouros IG; Nikolaidis MG · Acta physiologica (Oxford, England) · 2023
    Randomized trial44 participantsFitness forVitamin C
  23. Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
    Margaritelis NV; Paschalis V; Theodorou AA; Kyparos A; Nikolaidis MG · Free radical biology & medicine · 2021
    Randomized trial73 participantsFitness forVitamin C
  24. A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women.
    Saito K; Yokoyama T; Yoshida H; Kim H; Shimada H; Yoshida Y; Iwasa H; Shimizu Y; Kondo Y; Handa S; Maruyama N; Ishigami A; Suzuki T · The journals of gerontology. Series A, Biological sciences and medical sciences · 2012
    Cross-sectional study655 participantsFitness forVitamin C
  25. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation.
    Paschalis V; Theodorou AA; Kyparos A; Dipla K; Zafeiridis A; Panayiotou G; Vrabas IS; Nikolaidis MG · European journal of nutrition · 2016
    Clinical trial20 participantsFitness forVitamin C
  26. Low dietary vitamin C intake is associated with low muscle strength among elderly Korean women.
    Park CY; Shin S · Nutrition research (New York, N.Y.) · 2024
    Cross-sectional study14,844 participantsFitness forVitamin C
  27. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  28. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  29. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  30. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  31. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  32. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  33. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  34. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  35. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  36. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  37. The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components.
    Macdougall LG; Anderson R; McNab GM; Katz J · The Journal of pediatrics · 1975
    Single-arm trial27 participantsImmunity forIron
  38. Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism.
    Ganz T · Current topics in microbiology and immunology · 2006
    Narrative reviewImmunity forIron
  39. Adaptive immunity and vaccination - iron in the spotlight.
    Preston AE; Drakesmith H; Frost JN · Immunotherapy advances · 2025
    Narrative reviewImmunity forIron
  40. Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy.
    Barber MF; Elde NC · Trends in genetics : TIG · 2016
    Narrative reviewImmunity forIron
  41. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  42. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  43. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  44. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  45. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  46. The Effect of Iron-Fortified Lentils on Blood and Cognitive Status among Adolescent Girls in Bangladesh.
    Barnett AL; Wenger MJ; Yunus FM; Jalal C; DellaValle DM · Nutrients · 2023
    Randomized trial359 participantsMental Focus Productivity Boost forIron
  47. Cognitive Performance in Indian School-Going Adolescents Is Positively Affected by Consumption of Iron-Biofortified Pearl Millet: A 6-Month Randomized Controlled Efficacy Trial.
    Scott SP; Murray-Kolb LE; Wenger MJ; Udipi SA; Ghugre PS; Boy E; Haas JD · The Journal of nutrition · 2019
    Randomized trial140 participantsMental Focus forIron
  48. Effects of iron supplementation twice a week on attention score and haematologic measures in female high school students.
    Rezaeian A; Ghayour-Mobarhan M; Mazloum SR; Yavari M; Jafari SA · Singapore medical journal · 2015
    Randomized trial200 participantsMental Focus forIron
  49. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls.
    Bruner AB; Joffe A; Duggan AK; Casella JF; Brandt J · Lancet (London, England) · 1996
    Randomized trial81 participantsMental Focus forIron
  50. Effect of iron supplementation on cognition in Greek preschoolers.
    Metallinos-Katsaras E; Valassi-Adam E; Dewey KG; Lönnerdal B; Stamoulakatou A; Pollitt E · European journal of clinical nutrition · 2005
    Randomized trial49 participantsMental Focus forIron
  51. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials.
    Low M; Farrell A; Biggs BA; Pasricha SR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
    Meta-analysis7,089 participants32 studies pooledProductivity Boost forIron
  52. Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial.
    Murray-Kolb LE; Wenger MJ; Scott SP; Rhoten SE; Lung'aho MG; Haas JD · The Journal of nutrition · 2017
    Randomized trial150 participantsProductivity Boost forIron
  53. Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China.
    Li R; Chen X; Yan H; Deurenberg P; Garby L; Hautvast JG · The American journal of clinical nutrition · 1994
    Randomized trial80 participantsProductivity Boost forIron