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Leaky Gut Formula

Codeage
4.8
★ ★ ★ ★ ★
(4818 ratings)
Zinc 6 mg
Maitake Mushroom 50 mg
Glutamine 315 mg
N-Acetyl Glucosamine 210 mg
Ginger
Butyric acid 127 mg
Saccharomyces boulardii 112.5 mg
Product Image
Score59
A coherent but shallow gut-barrier blend led by zinc L-carnosine, with too many modest doses and missing probiotic potency for strong confidence.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Immunity
General Health

Score 59

A coherent but shallow gut-barrier blend led by zinc L-carnosine, with too many modest doses and missing probiotic potency for strong confidence.
How scoring works
$29.99($0.99 per serving)
Pure Formulas
$ 29.99
Vitacost
$ 31.73
BodyBuilding.com
$ 29.99
Amazon
$ 29.99
iHerb
$ 29.99
iHerb
$ 29.99
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Analysis

Zinc L-carnosine is the clearest quality feature and is well matched to a gastric-support formula. Glutamine, N-acetyl glucosamine, butyrate, probiotics, deglycyrrhizinated licorice, slippery elm, ginger, and marshmallow root broaden the digestive-barrier approach.

Most actives are present at amounts well below those used in dedicated single-ingredient products. The probiotic species are named without colony-forming-unit counts, while mushroom beta-glucans, ginger standardization, and part of the blend remain unclear.

The formula fits someone who wants many gut-oriented ingredients in a convenient capsule and accepts modest depth from each. It is poorly aligned with testosterone, hair, vision, or skin goals, and the specialized zinc form does not provide a large elemental zinc amount.

Who is it for
  • Adults seeking a broad digestive-barrier formula
  • People specifically interested in zinc L-carnosine
  • Users who prefer capsules over glutamine powder
Best for
  • Digestive lining support
  • Multi-pathway gut support
  • Low-dose probiotic and botanical coverage

Pros

  • Specialized zinc L-carnosine form
  • Maitake fruiting body is identified
  • Broad and coherent digestive ingredient mix
  • Main ingredient weights are disclosed

Cons

  • Glutamine and N-acetyl glucosamine are modestly dosed
  • Probiotic colony counts are missing
  • Several extracts lack standardization
  • Partially disclosed blend reduces clarity

Warnings

  • The source of N-acetyl glucosamine is not stated, leaving uncertainty for people with shellfish allergy
  • Black pepper extract can alter absorption of some medicines
  • Berberine can interact with glucose-lowering medicines even though its amount here is small
  • People with significant immune suppression should seek guidance before using products containing live probiotics

Nutrient quality

57 Moderate impact

Zinc L-carnosine and vitamin D provide useful form quality within the gut-focused concept. Most other actives are too lightly dosed or poorly characterized to provide strong dose depth.

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Ingredient transparency

60 Moderate impact

Many active weights are listed and the main specialized forms are identifiable. An unnamed blend, probiotic weights without viable counts, repeated zinc entries, and missing inactive ingredients limit transparency.

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Customer satisfaction

73 High impact

The supplied average rating is very strong and backed by a very large review pool. No review text is available to assess repeated complaints or digestive tolerance.

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Value for money

46 Lower impact

Specialized zinc and a broad digestive theme provide some practical value. Token doses, an opaque blend, and unquantified probiotic potency weaken cost efficiency.

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Goals

Immunity
Immunity
Impact
Moderate effect
C Goal FitD Strength of SupportC- CoverageC- Formula Quality
Zinc · 30 mgVitamin D · 10 mcgMaitake Mushroom · 50 mg

Zinc L-carnosine, butyrate, probiotics, glutamine, and soothing botanicals form a coherent gut-barrier concept with indirect immune relevance. Maitake adds an immune pathway through mushroom polysaccharides, but its beta-glucan content is not stated.

Glutamine, elemental zinc, vitamin D, ginger, and maitake all sit below stronger focused amounts. Probiotic strains are named without colony-forming-unit counts, so their live dose cannot be assessed.

Study evidence
Ginger Not classified

No linked studies yet.

Glutamine Supportive 36 studies
Maitake Mushroom Mixed 4 studies
Vitamin D Supportive 85 studies
Zinc Supportive 73 studies
General Health
General Health
Impact
Moderate effect
D Goal FitD+ Strength of SupportD CoverageB- Formula Quality
Vitamin D · 10 mcgZinc · 30 mg

Zinc L-carnosine, glutamine, butyrate, probiotics, and soothing botanicals form a coherent gut-focused combination. The specialized zinc form and clearly stated main amounts are useful formulation strengths.

Most actives are modest compared with commonly studied amounts, and several botanicals lack extract standardization. The narrow digestive focus and uneven dose depth make it a secondary general-wellness product rather than a foundational daily formula.

Study evidence
Zinc Supportive 60 studies

Ingredients

IngredientAmount per serving
Vitamin D (Vitamin D3)
 10 mcg
Zinc (Zinc L-Carnosine)
 6 mg
L-Glutamine
315 mg
N-Acetyl Glucosamine
210 mg
Butyric Acid
127 mg
Saccharomyces boulardii
112.5 mg
Bacillus coagulans
75 mg
Deglycyrrhizinated Licorice Root Extract
75 mg
Cinnamon, Powder (Cinnamomum burmannii, Powder)
 50 mg
Maitake mushroom fruiting body extract (Polysaccharides)
 50 mg
Blend
42.5 mg
Quercetin Dihydrate
42.5 mg
Slippery Elm
42.5 mg
Ginger extract
30 mg
Zinc L-Carnosine
30 mg
Grapefruit seed extract
20 mg
Chamomile
20 mg
Marshmallow root extract
10 mg
Berberine (Berberine Hydrochloride)
 10 mg
BioPerine (Black Pepper Fruit Extract)
 5 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Zinc (Zinc L-Carnosine) · 6 mg OverallScore74
A+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

Specialized zinc L-carnosine offers a high-quality form suited to gastric use. The elemental zinc amount is low and may contribute little to improving zinc status, while the low amount also makes copper depletion unlikely. The specialized form does not offset the high cost and low elemental amount.

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Maitake Mushroom (Polysaccharides) · 50 mg OverallScore62
C+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyC Value

The fruiting-body source is a clear quality strength. The unspecified extraction method and polysaccharide-only marker leave bioavailability and beta-glucan potency uncertain. The low amount and above-midpoint serving cost make it a secondary feature of the broader formula rather than a strong Maitake option.

View ingredientView products
Glutamine · 315 mg OverallScore56
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyB Value

Standard L-glutamine is clearly disclosed, but its amount is far below a stand-alone support dose. Capsules remove powder-mixing concerns, yet reaching a meaningful glutamine intake would require an impractical number of pills. The high glutamine cost is partly offset by a broad gut-focused formula with zinc carnosine, butyrate, probiotics, and soothing botanicals.

View ingredientView products
Loading alternative details
76 Performance

G.I. Integrity

Pure Encapsulations
<p>Clearly identified N-acetyl-D-glucosamine, glutamine, gamma oryzanol, and standardized aloe create a focused digestive formula. Glutamine and aloe remain modest, and the crab and shrimp sources make it unsuitable for people with shellfish allergy.</p>
71 Performance

IntestiNew

Renew Life
<p>A substantial glutamine serving with N-acetyl glucosamine provides much stronger gut-barrier ingredient depth than the original’s lightly dosed core. The herbal blend is undisclosed and glucosamine sourcing is missing, so people avoiding shellfish cannot confirm suitability.</p>
71 Performance

GI-Revive

Designs for Health
<p>Substantial N-acetyl glucosamine, glutamine, pectin, deglycyrrhizinated licorice, aloe, slippery elm, and zinc carnosine provide broad digestive support. Many extracts lack source or standardization details and the serving is costly, but the major actives are more meaningfully dosed than in the original.</p>
79 Budget

Gastro Relief

AOR Advanced Orthomolecular Research Advanced
<p>Zinc L-carnosine, mastic gum, alginate, and ginger provide a focused gastrointestinal formula at a lower serving cost. Ginger is lightly dosed and raw-material details are incomplete, but the core ingredients are more clearly quantified than the original’s crowded list.</p>
73 Budget

DefensePlus

NutriBiotic
<p>Vitamin C, zinc, grapefruit seed extract, mushrooms, astragalus, echinacea, and ginger provide broad immune and digestive-adjacent support at a much lower serving cost. Most botanicals are lightly dosed and unstandardized, and the formula lacks the original’s glutamine, butyrate, and N-acetyl glucosamine.</p>
57 Budget

GI Natural Total Digestive Wellness

NaturesPlus
<p>Glutamine, vitamin C, vitamin E, zinc, and selenium preserve a plausible digestive-support base at a lower serving cost. Opaque probiotic, prebiotic, food, and enzyme blends prevent potency assessment, but the glutamine amount is higher than in the original.</p>
67 Value

GI-Revive

Designs for Health
<p>Glutamine, N-acetyl glucosamine, pectin, deglycyrrhizinated licorice, aloe, slippery elm, and zinc carnosine offer broad disclosed digestive coverage. The large capsule burden and very high serving cost weaken value, despite stronger active amounts than the original.</p>
53 Value

GI Natural Total Digestive Wellness

NaturesPlus
<p>A substantial glutamine amount with antioxidant nutrients provides stronger gut-barrier support than the original’s modest glutamine dose. Serving-cost data are missing and several probiotic, enzyme, prebiotic, turmeric, and ginger additions are small or opaque, so value cannot be confirmed.</p>
73 Value

DefensePlus

NutriBiotic
<p>Vitamin C, zinc, ginger, maitake, and other immune botanicals come at a much lower serving cost. The blend is less directly aligned with gut-barrier support and most botanicals are lightly dosed, but the economical serving improves value for broad immune support.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  2. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  3. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  4. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  5. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  6. Meta-analysis of Glutamine on Immune Function and Post-Operative Complications of Patients With Colorectal Cancer.
    Yang T; Yan X; Cao Y; Bao T; Li G; Gu S; Xiong K; Xiao T · Frontiers in nutrition · 2021
    Meta-analysis2,201 participants31 studies pooledImmunity forGlutamine
  7. Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
    Dong S; Zhao Z; Li X; Chen Z; Jiang W; Zhou W · Frontiers in nutrition · 2023
    Meta-analysis1,201 participants30 studies pooledImmunity forGlutamine
  8. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial.
    Garrel D; Patenaude J; Nedelec B; Samson L; Dorais J; Champoux J; D'Elia M; Bernier J · Critical care medicine · 2003
    Randomized trial45 participantsImmunity forGlutamine
  9. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledImmunity forGlutamine
  10. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control.
    Wischmeyer PE; Lynch J; Liedel J; Wolfson R; Riehm J; Gottlieb L; Kahana M · Critical care medicine · 2001
    Randomized trial26 participantsImmunity forGlutamine
  11. Maitake mushroom supplementation modulates upper respiratory symptoms and immune responses in healthy adults: a randomized, double-blind, placebo-controlled trial.
    Masuda Y; Nakayama Y; Shimizu R; Jogi EM; Kato MC; Yamasaki K; Aoki R; Hashimoto M; Ohno M; Ohata S; Kato S; Konishi M · Food & function · 2026
    Randomized trialImmunity forMaitake Mushroom
  12. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.
    Deng G; Lin H; Seidman A; Fornier M; D'Andrea G; Wesa K; Yeung S; Cunningham-Rundles S; Vickers AJ; Cassileth B · Journal of cancer research and clinical oncology · 2009
    Single-arm trial34 participantsImmunity forMaitake Mushroom
  13. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.
    Wesa KM; Cunningham-Rundles S; Klimek VM; Vertosick E; Coleton MI; Yeung KS; Lin H; Nimer S; Cassileth BR · Cancer immunology, immunotherapy : CII · 2015
    Single-arm trial21 participantsImmunity forMaitake Mushroom
  14. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.
    Kodama N; Komuta K; Nanba H · Journal of medicinal food · 2004
    Single-arm trial10 participantsImmunity forMaitake Mushroom
  15. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  16. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  17. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  18. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  19. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  20. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  21. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  22. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  23. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  24. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc