Product Image

Vitamin C with Flavonoids

Thorne
4.8
★ ★ ★ ★ ★
(9116 ratings)
Flavonoid 75 mg
Vitamin C 500 mg
Product Image
Score82
A clean, practical vitamin C and bioflavonoid combination is easy to use, with incomplete bioflavonoid characterization as its main trade-off.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Immunity
General Health
Skin Health
Anti-Inflammatory Support

Score 82

A clean, practical vitamin C and bioflavonoid combination is easy to use, with incomplete bioflavonoid characterization as its main trade-off.
How scoring works
$23.00($0.25 per serving)
Amazon
$ 23.00
Vitacost
$ 23.00
iHerb
$ 23.00
Pure Formulas
$ 23.00
Vitacost
$ 23.00
Report prices

Analysis

A 500 mg vitamin C dose provides a practical middle ground for people who want more than a multivitamin typically supplies. Citrus bioflavonoids complement the formula without adding unnecessary complexity.

The ingredient list is easy to understand, but the bioflavonoid portion is not broken down into named compounds or standardized constituents. That omission limits comparison with more precisely characterized flavonoid products.

One capsule per serving keeps use simple, and the focused formula should fit buyers who do not want a broad antioxidant blend. It offers good utility, though shoppers prioritizing fuller plant-compound disclosure may prefer another option.

Who is it for
  • Adults seeking a straightforward vitamin C supplement
  • People who want citrus bioflavonoids without a large blend
Best for
  • Everyday vitamin C intake
  • Focused antioxidant support

Pros

  • Practical 500 mg vitamin C dose
  • Includes citrus bioflavonoids
  • Simple two-ingredient formula
  • One capsule per serving

Cons

  • Bioflavonoids are not individually identified
  • No bioflavonoid standardization is stated
  • Provides a shorter supply than some alternatives

Warnings

  • Vitamin C at 500 mg may cause stomach upset or loose stools in sensitive users.

Nutrient quality

90 Highest impact

Meaningful vitamin C and bioflavonoid amounts make the formula focused and useful. Standard ascorbic acid is reliable but offers no special bioavailability advantage.

Ingredient transparency

83 Highest impact

Both active amounts are clearly stated and no hidden blend appears. Excipients and complete daily-use directions are absent from the supplied data.

Customer satisfaction

72 High impact

The average rating is strong and the large evidence base makes it more dependable. No specific feedback is supplied to judge repeated complaints or alignment with the intended use.

Value for money

81 Highest impact

The focused composition avoids low-value extras and supports reasonable value. Standard vitamin C form and moderate serving cost keep competitiveness good rather than exceptional.

Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Vitamin C · 500 mg

Vitamin C provides direct support for immune-cell activity, barrier integrity, and antioxidant defenses. The amount meets a practical focused immune level.

Citrus bioflavonoids add a logical companion, but generic ascorbic acid lacks buffering or enhanced delivery. The compact formula offers strong depth for one immune pathway without unnecessary additions.

Study evidence
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportC CoverageA+ Formula Quality
Vitamin C · 500 mg

Vitamin C supports antioxidant defenses, immune function, and collagen production. The disclosed amount is substantial for routine supplementation.

Citrus bioflavonoids provide a logical companion, but generic ascorbic acid lacks buffering or advanced delivery. The focused formula delivers good depth for one nutrient pathway without unnecessary additions.

Study evidence
Vitamin C Supportive 56 studies
Skin Health
Skin Health
Impact
High effect
B Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin C · 500 mg

Vitamin C directly supports collagen production and helps protect skin from oxidative stress. The serving provides a substantial amount with a useful citrus bioflavonoid companion.

Generic ascorbic acid lacks buffering or enhanced delivery. The streamlined formula still provides good depth for one important skin pathway.

Study evidence
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Cellular Defense
Anti-Inflammatory Support
Impact
High effect
C- Goal FitB- Strength of SupportD+ CoverageA Formula Quality
Vitamin C · 500 mg

Vitamin C provides antioxidant support that may help limit oxidative amplification of inflammation, but it is not a direct COX or NF-kB inhibitor. Human evidence supports antioxidant and immune roles more strongly than broad anti-inflammatory effects from vitamin C alone.

The vitamin C amount is useful and the citrus bioflavonoids add a meaningful companion serving. The concise blend offers moderate antioxidant breadth without a direct, high-impact inflammatory-pathway active.

Study evidence
Vitamin C Supportive 50 studies
Vision Support
Macular and Blue Light Defense
Vision Support
Impact
Moderate effect
D- Goal FitC+ Strength of SupportD- CoverageA- Formula Quality
Vitamin C · 500 mg

Vitamin C with citrus bioflavonoids supports general antioxidant defense but not macular pigment or retinal structure. The amount is useful, though the formula cannot reproduce the evidence for a complete eye-health combination.

Both actives are clearly disclosed, while plain ascorbic acid and nonstandardized flavonoids offer basic form quality. The focused capsule avoids unrelated ingredients but covers only a narrow pathway.

Study evidence
Flavonoid Supportive 5 studies
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 500 mg
Citrus Bioflavonoids
75 mg
Gluten Free Adults 18–50
Report overview
Flavonoid · 75 mg OverallScore74
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 75 mg citrus bioflavonoid dose fits the useful range and is clearly disclosed. Its non-standardized form and basic capsule provide limited evidence for active-marker consistency or enhanced absorption. Low cost per active amount makes it an efficient simple option.

View ingredientView products
Vitamin C (Ascorbic Acid) · 500 mg OverallScore58
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value

The 500 mg serving is well targeted and pairs vitamin C with a disclosed citrus bioflavonoid amount. Generic ascorbic acid provides no buffering or advanced delivery benefit. Cost per gram falls in a moderate range.

View ingredientView products
Loading alternative details
89 Performance

C-500 Calcium Ascorbate-C

NOW
<p>Buffered calcium ascorbate provides a practical vitamin C amount with clear calcium disclosure and a small citrus bioflavonoid addition. The buffered form may suit sensitive users better than the original’s plain ascorbic acid, though its bioflavonoid addition is smaller.</p>
88 Performance

Sodium Ascorbate Capsules

NutriBiotic Immunity
<p>Buffered sodium ascorbate supplies a useful vitamin C amount with its sodium contribution clearly disclosed. Buffered sodium ascorbate offers a gentler form and clear disclosure, but it gives up the original’s flavonoid coverage.</p>
88 Performance

Buffered Gold C

California Gold Nutrition
<p>Buffered sodium ascorbate provides a substantial vitamin C serving in a simple, fully quantified active profile. The buffered form and simple disclosure improve form clarity, although sodium and the lack of bioflavonoids require consideration.</p>
85 Budget

C-500 With Rose Hips

NOW
<p>A focused ascorbic acid serving with rose hips covers core vitamin C needs without an elaborate blend. Its serving cost is much lower while retaining a meaningful vitamin C amount, though rose hips do not match the original’s citrus bioflavonoid amount.</p>
85 Budget

Gold C Vitamin C 1000 mg

California Gold Nutrition
<p>A simple ascorbic acid serving provides substantial vitamin C without active padding. Its lower serving cost and larger vitamin C amount favor budget use, but it removes the original’s flavonoid component.</p>
83 Budget

C 500 mg

21st Century
<p>A straightforward ascorbic acid serving with a small calcium addition provides focused vitamin C support. Its much lower serving cost improves economy while matching the vitamin C amount, though the formula omits bioflavonoids.</p>
82 Value

Metabolic C 500 mg

Source Naturals
<p>Vitamin C and citrus bioflavonoids preserve the original collection match in a focused antioxidant formula. It retains both vitamin C and citrus bioflavonoids at a lower serving cost, with only the branded form’s incomplete explanation limiting confidence.</p>
84 Value

Ester-C 500 mg With Citrus Bioflavoinds

American Health
<p>Buffered calcium ascorbate combines a substantial vitamin C serving with a sizeable citrus bioflavonoid complex. Its buffered form and much larger citrus bioflavonoid complex provide more ingredient depth at a lower serving cost.</p>
84 Value

Ester-C 24 Hour Immune Support 1000 mg

NatureSmart
<p>Buffered calcium ascorbate supplies substantial vitamin C with a compatible citrus bioflavonoid complex. The buffered form and compatible bioflavonoids retain the formula’s purpose at a lower serving cost.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses.
    Xu K; Peng R; Zou Y; Jiang X; Sun Q; Song C · International journal of food sciences and nutrition · 2022
    Meta-analysis76 studies pooledGeneral Health forVitamin C
  2. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  3. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forVitamin C
  4. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisGeneral Health forVitamin C
  5. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  6. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  7. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  8. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  9. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  10. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  11. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  12. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  13. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  14. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  15. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  16. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  17. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  18. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  19. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  20. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  21. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  22. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  23. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  24. Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration.
    Gopinath B; Liew G; Kifley A; Flood VM; Joachim N; Lewis JR; Hodgson JM; Mitchell P · The American journal of clinical nutrition · 2019
    Cohort study2,856 participantsVision Support forFlavonoid
  25. The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis.
    Patel S; Mathan JJ; Vaghefi E; Braakhuis AJ · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016
    Meta-analysisVision Support forFlavonoid
  26. Dietary flavonoids are associated with longitudinal treatment outcomes in neovascular age-related macular degeneration.
    Detaram HD; Liew G; Lewis JR; Bondonno NP; Bondonno CP; Van Vu K; Burlutsky G; Hodgson JM; Mitchell P; Gopinath B · European journal of nutrition · 2021
    Cohort study547 participantsVision Support forFlavonoid
  27. Dietary Flavonoid Intake and Chronic Sensory Conditions: A Scoping Review.
    Tang D; Tran Y; Shekhawat GS; Gopinath B · Antioxidants (Basel, Switzerland) · 2025
    Scoping review10 studies pooledVision Support forFlavonoid
  28. Effects of Flavonoid Supplementation on Common Eye Disorders: A Systematic Review and Meta-Analysis of Clinical Trials
    Sergio Davinelli, Sawan Ali, Giovanni Scapagnini, Ciro Costagliola · Frontiers in Nutrition · 2021
    Meta-analysis724 participants11 studies pooledVision Support forFlavonoid
  29. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  30. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  31. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  32. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  33. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C