SAMe 200 mg

SAMe 200 mg

Metabolic Maintenance4.5 (31 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$70.00 $1.16 per serving
Pure FormulasLowest$70.00iHerb$70.00

About this product

The capsule lists 200 mg of SAMe, a common starting amount for a focused methyl-donor supplement. Small amounts of calcium and magnesium do not materially broaden the formula's detoxification role.

SAMe can support methylation used in Phase II conjugation, but this product covers only one part of liver and antioxidant metabolism. The label does not identify a stabilized salt or clarify whether the stated amount represents net active SAMe.

A standard capsule with no stated acid protection or moisture-protective packaging raises concern about delivery and stability. The high cost relative to the disclosed active amount further weakens the case for routine use.

Who is it for
  • Adults specifically directed toward a low SAMe starting amount
  • People focused on methylation support
  • Users able to verify storage and formulation details
Best for
  • Low starting amounts of SAMe
  • Narrow methyl-donor support
  • Clinician-guided use when formulation details are acceptable

Pros

  • Common 200 mg starting amount
  • One capsule per serving
  • Includes clearly named mineral forms
  • Focused methyl-donor role

Cons

  • Stabilized SAMe salt is not identified
  • No stated acid protection
  • Net active SAMe amount is unclear
  • No stated moisture-protective packaging
  • Weak value for the disclosed amount

Warnings

  • SAMe may trigger agitation or mania in people with bipolar disorder.
  • SAMe can compound serotonergic effects from antidepressants and other serotonergic medicines; clinician-guided use is important.

Product analysis

60 out of 100
A 200 mg starting amount offers narrow methylation support, but the SAMe form, net active yield, and protection from acid or moisture are unclear. Those gaps combine with weak value.

AI assessment of the formula, label and price. How scoring works

Nutrient quality70

The SAMe amount is a practical starting serving and directly fits detoxification support. Missing salt stabilization and acid protection limit likely delivery.

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Ingredient transparency72

All listed amounts are disclosed without a hidden blend. Salt form, net active SAMe, intake directions, excipients, and protective packaging are unclear.

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Customer satisfaction56

The supplied average rating is strong and comes from a very small rating pool. No firsthand experiences or recurring complaint details were provided, so consistency remains uncertain.

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Value for money35

The starting amount offers poor value because the serving cost is high. Uncertain stability and delivery further weaken competitiveness.

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Format
Capsule
Container
60 Capsule(s)
Per serving
$1.16
Customer rating
4.5 · 31 ratings
Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
C+ Ingredient FitF PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 20 mgSAMe · 200 mg

SAMe supplies methyl groups used in normal body processes, which gives it a biochemical connection to this goal. That role doesn't show that taking it improves routine removal of toxins. The declared 200 mg serving also doesn't by itself identify a toxin-clearance benefit you can expect.

How this product is rated for Detoxification

Ingredient fit66

SAMe provides 200 mg per serving; the amount alone does not demonstrate a routine toxin-clearance benefit.
Goal fit
SAMe supplies the main relevant ingredient, alongside calcium and a small amount of magnesium.
Dose adequacy
SAMe provides 200 mg per serving; the amount alone does not demonstrate a routine toxin-clearance benefit.

Pathways19

SAMe supplies methyl groups, a normal metabolic role rather than a demonstrated routine toxin-removal effect.
Depth
SAMe supplies methyl groups, a normal metabolic role rather than a demonstrated routine toxin-removal effect.
Breadth
The connection is limited to methyl-group supply, without demonstrating broad toxin removal.

Evidence86

SAMe has a metabolic role, but a routine toxin-clearance benefit at this serving is unclear.
Evidence strength
SAMe has a metabolic role, but a routine toxin-clearance benefit at this serving is unclear.
Studied preparation
The declared SAMe amount identifies the ingredient, without resolving whether it improves routine toxin clearance.

Formulation logic100

No required companion ingredient or particular ingredient conflict is identified.
Partner coverage
No required companion ingredient is missing for the relevant ingredient roles.
Conflicts
No particular ingredient conflict is identified.
Effective doses
SAMe provides 200 mg per serving; the amount alone does not demonstrate a routine toxin-clearance benefit.
Study evidence
SAMe Supportive 30 studies

Ingredients

IngredientAmount per servingScore
Calcium (Calcium Citrate)
 20 mg
Magnesium (Magnesium Bisglycinate)
 20 mg
SAMe
200 mg 70
Gluten Free Adults 18–50 Dairy Free
Report overview
SAMe · 200 mg OverallScore70
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
SAMe 200 mg lists a named disulfate tosylate salt among its ingredients and records a 200 mg serving. The stored facts indicate the net SAMe amount is distinguished, but source proportions are not established. No individually sealed foil blister pack is recorded, and the cost for a 400 mg comparison amount is high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

A named stabilized salt appears in the nested ingredients, but individually sealed foil blisters are not recorded.
Stabilized Salt Form
The ingredients include S-adenosyl-L-methionine disulfate p-toluenesulfonate, a stabilized salt form; its proportion is unknown.
Packaging Integrity
The saved facts do not identify individually sealed foil blister packs.

Dose, Safety & Label Transparency88

The serving lists 200 mg of SAMe, and the saved facts indicate the net amount is distinguished from the salt complex.
Active Dosage Strength
It lists 200 mg of SAMe per serving.
Net SAMe Yield Transparency
The facts indicate the label separates net SAMe from the salt complex.

Value20

The cost for a 400 mg comparison amount is high; this is a price-normalization unit.
Price Per 400mg Active Dose
The cost is high when normalized to a 400 mg SAMe amount.
View ingredientView products
Loading alternative details
85 Performance

SAMe 400 mg

Lake Avenue Nutrition

A stabilized salt and enteric coating protect a full SAMe amount during storage and passage through the stomach. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Net active yield and moisture-resistant packaging remain unclear.

84 Performance

SAMe 400 mg

Life Extension

Enteric coating protects a full SAMe amount from stomach acid and supports purposeful delivery. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. The stabilized salt, net active yield, and moisture protection are not identified.

84 Performance

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt supplies a full SAMe amount in one tablet. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Enteric and sealed moisture protection are not stated, and net active yield remains unclear.

74 Budget

SAMe 200

Jarrow Formulas

A common starting SAMe amount provides a simple, low-cost option. It lowers routine cost versus the original. Neither a stabilized salt nor acid-resistant delivery is identified, so protected active yield is uncertain.

83 Budget

SAMe 200 mg

NOW

A stabilized disulfate tosylate salt provides a credible common starting amount at efficient routine value. It lowers routine cost versus the original. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

84 Budget

SAMe 400 mg

Nutricost

A stabilized salt provides a full SAMe amount with efficient dose value. It lowers routine cost versus the original. The two-capsule serving has no stated acid resistance, and moisture protection is unclear.

84 Value

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt provides a full SAMe amount with favorable dose value. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection and sealed moisture protection are not stated.

80 Value

SAMe 400 mg

Swanson

A stable disulfate tosylate form provides a full SAMe amount in one tablet. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

78 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension

Enteric coating protects a common starting SAMe amount from stomach acid. Compared with the original, its delivery design and routine economics offer a useful value trade-off. The salt form, net active yield, and moisture protection are not identified.

Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
    Noureddin M; Sander-Struckmeier S; Mato JM · World journal of hepatology · 2020
    Systematic review9 studies pooledDetoxification forSAMe
  2. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial.
    Medici V; Virata MC; Peerson JM; Stabler SP; French SW; Gregory JF; Albanese A; Bowlus CL; Devaraj S; Panacek EA; Richards JR; Halsted CH · Alcoholism, clinical and experimental research · 2012
    Randomized trial37 participantsDetoxification forSAMe
  3. Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
    Zhang L; Liu XH; Qi HB; Li Z; Fu XD; Chen L; Shao Y · European review for medical and pharmacological sciences · 2016
    Randomized trial120 participantsDetoxification forSAMe
  4. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
    Guo T; Chang L; Xiao Y; Liu Q · PloS one · 2015
    Meta-analysis705 participants11 studies pooledDetoxification forSAMe
  5. Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
    Liu GY; Wang W; Jia WD; Xu GL; Ma JL; Ge YS; Yu JH; Sun QK; Meng FL · World journal of surgical oncology · 2014
    Non-randomized trial81 participantsDetoxification forSAMe
  6. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
    Mato JM; Cámara J; Fernández de Paz J; Caballería L; Coll S; Caballero A; García-Buey L; Beltrán J; Benita V; Caballería J; Solà R; Moreno-Otero R; Barrao F; Martín-Duce A; Correa JA; Parés A; Barrao E; García-Magaz I; Puerta JL; Moreno J; Boissard G; Ortiz P; Rodés J · Journal of hepatology · 1999
    Randomized trial123 participantsDetoxification forSAMe