SAMe 400 mg
Life Extension
SAMe 400 mg
4.8
★ ★ ★ ★ ★
(3073 ratings)
SAMe 400 mg
Score 93.0
A premium 400mg SAMe from a highly reputable brand, offering excellent value and outstanding user satisfaction for comprehensive support.
Quantity: 60 Tablet(s)Servings size: 1 Tablet(s) (60 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 93.0
A premium 400mg SAMe from a highly reputable brand, offering excellent value and outstanding user satisfaction for comprehensive support.
insights Analysis
Life Extension is revered in the supplement industry for its scientifically-backed formulations and stringent quality control, and their SAMe 400 mg product lives up to this reputation. Providing a potent 400mg dose per tablet, it aligns with dosages often recommended by nutritionists for significant support in areas like mood, joint health, and liver function. The product's impressive review count of over 2800 signifies widespread consumer satisfaction and perceived efficacy. Life Extension SAMe products are typically enteric-coated to ensure the delicate SAMe molecule survives stomach acid and is properly absorbed in the small intestine, though this is implied rather than explicitly stated in the provided data. While it doesn't include additional B vitamin cofactors, its core offering of high-quality, high-dose SAMe at a competitive price makes it a standout choice for those prioritizing a standalone, trusted source.
- Provides a robust 400mg dose of SAMe, highly effective for various health goals.
- Life Extension is a highly reputable brand known for science-backed formulations and quality.
- Outstanding number of positive online reviews, indicating widespread consumer trust and effectiveness.
- Competitive price per serving for a 400mg dose in a 60-count, offering good value.
- Does not explicitly state the specific form of SAMe (e.g., Disulfate Tosylate), though Life Extension typically uses stable forms.
- Does not include additional B vitamin cofactors that could enhance SAMe metabolism for some individuals.
- SAMe may interact with certain medications, including antidepressants and blood thinners; consult a healthcare professional before use.
$49.50($0.82 per serving)
 Amazon | $ 49.50 | |
 iHerb | $ 49.50 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| S-Adenosyl-Methionine | 400 mg |
Categories
SAMe 95.0
This SAMe product's combination of effective dosage, top-tier brand reputation, and overwhelming positive consumer response places it among the elite options for SAMe supplementation.
Goals
Mood Support 95.0
The 400mg dose is very effective for mood support, and the product's high quality and strong user feedback make it an excellent choice for those seeking reliable mood benefits.
Joint Health 95.0
This product's 400mg dose is an optimal and highly effective dosage for supporting joint comfort and mobility, aligning well with its established benefits and user satisfaction.
Digestive Health 95.0
The 400mg dose is highly relevant for liver and digestive health, offering significant support. Its reputable brand and excellent value ensure consistent and effective daily supplementation.
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