SAMe 400 mg

SAMe 400 mg

Lake Avenue Nutrition4.6 (10,658 ratings)
Format:Tablet Quantity: 60 Tablet(s) · 60 servings
Goals
$46.66 $0.77 per serving
AmazonLowest$46.66iHerb$48.99iHerb$48.99

About this product

The tablet combines a full commonly used SAMe amount with a named stable salt and enteric coating. Those features support both shelf stability and passage through the stomach.

The label does not clarify whether the stated weight is net active SAMe or salt complex. Moisture-resistant blister packaging is also not identified.

The focused one-tablet formula offers favorable value for mood, joint, stress, or methylation support. Its interaction profile still requires careful use.

Who is it for
  • Adults seeking well-protected full-dose SAMe
  • Users targeting mood or joint support
  • People wanting one tablet per serving
Best for
  • Stable enteric SAMe delivery
  • Full-strength daily use
  • Strong balance of potency and value

Pros

  • Stable salt is named
  • Enteric-coated tablet
  • Full amount in one unit
  • Favorable practical value

Cons

  • Net active SAMe is unclear
  • Blister packaging is not identified
  • Single pathway may not fit every goal
  • Full strength may be too much for beginners

Warnings

  • SAMe may provoke mania in people with bipolar disorder
  • Do not combine with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonergic agents without medical supervision
  • SAMe may cause insomnia, anxiety, nausea, or diarrhea

Product analysis

85 out of 100
A strong full-dose SAMe option with stable salt and enteric delivery, limited mainly by active-yield and packaging uncertainty.

AI assessment of the formula, label and price. How scoring works

Nutrient quality93

A stabilized salt and enteric coating support both shelf stability and delivery beyond the stomach. A full commonly used amount provides strong active depth, although net SAMe yield remains unclear.

Ingredient transparency82

The active amount is disclosed without a hidden blend, and the stabilizing salt is named. Missing net active yield, complete directions, and non-active ingredients leave important gaps.

Customer satisfaction71

The supplied average rating is strong and the rating volume is substantial. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money92

Ingredient quality and serving economics support strong practical value. It compares favorably within the category despite remaining disclosure gaps.

Format
Tablet
Container
60 Tablet(s)
Per serving
$0.77
Customer rating
4.6 · 10,658 ratings
Report analysis

Goals

Joint Health
Joint Health
Impact
High effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
SAMe · 400 mg
Study evidence
SAMe Supportive 9 studies
Mood Support
Mood Support
Impact
Moderate effect
B- Ingredient FitF PathwaysC+ EvidenceA+ Formulation Logic
SAMe · 400 mg
Study evidence
SAMe Disputed 20 studies
Detoxification
Detoxification
Impact
Highest effect
A Ingredient FitC- PathwaysA- EvidenceA+ Formulation Logic
SAMe · 400 mg
Study evidence
SAMe Supportive 30 studies
Stress Relief
Stress Relief
Impact
High effect
B- Ingredient FitF PathwaysC+ EvidenceA+ Formulation Logic
SAMe · 400 mg
Study evidence
SAMe Not classified

No linked studies yet.

Ingredients

IngredientAmount per servingScore
SAMe (S-Adenosyl-L-Methionine Disulfate Tosylate)
 400 mg 68
Gluten Free Adults 18–50 Dairy Free
Report overview
SAMe (S-Adenosyl-L-Methionine Disulfate Tosylate) · 400 mg OverallScore68
B Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
It lists 400 mg of SAMe per serving, but the available details don't identify its salt form or clarify whether the amount is active SAMe or the salt complex. The label doesn't indicate blister, enteric, or delayed-release protection; the equivalent cost is moderate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

The available details don't identify the SAMe salt form or say whether the tablets are protected from moisture.
Stabilized Salt Form
The available details don't identify the SAMe salt form.
Packaging Integrity
The information doesn't say whether the tablets are sealed in protective blister packs.

Dose, Safety & Label Transparency72

The serving lists 400 mg of SAMe, but the label doesn't clarify the active SAMe yield.
Active Dosage Strength
The serving lists 400 mg of SAMe.
Net SAMe Yield Transparency
The label gives an amount without distinguishing active SAMe from the salt complex.

Value40

The equivalent cost is moderate, but neither enteric nor delayed-release protection is indicated.
Price Per 400mg Active Dose
The cost per equivalent 400 mg amount is moderate, but the label indicates neither enteric nor delayed-release protection.
View ingredientView products
Loading alternative details
84 Performance

SAMe 400 mg

Life Extension

Enteric coating protects a full SAMe amount from stomach acid and supports purposeful delivery. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. The stabilized salt, net active yield, and moisture protection are not identified.

84 Performance

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt supplies a full SAMe amount in one tablet. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Enteric and sealed moisture protection are not stated, and net active yield remains unclear.

79 Performance

SAMe 400 mg

Source Naturals

Enteric coating protects a full SAMe amount from stomach acid. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. The stabilized salt, net active yield, and moisture protection are not identified.

74 Budget

SAMe 200

Jarrow Formulas

A common starting SAMe amount provides a simple, low-cost option. It lowers routine cost versus the original. Neither a stabilized salt nor acid-resistant delivery is identified, so protected active yield is uncertain.

83 Budget

SAMe 200 mg

NOW

A stabilized disulfate tosylate salt provides a credible common starting amount at efficient routine value. It lowers routine cost versus the original. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

84 Budget

SAMe 400 mg

Nutricost

A stabilized salt provides a full SAMe amount with efficient dose value. It lowers routine cost versus the original. The two-capsule serving has no stated acid resistance, and moisture protection is unclear.

84 Value

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt provides a full SAMe amount with favorable dose value. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection and sealed moisture protection are not stated.

80 Value

SAMe 400 mg

Swanson

A stable disulfate tosylate form provides a full SAMe amount in one tablet. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

78 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension

Enteric coating protects a common starting SAMe amount from stomach acid. Compared with the original, its delivery design and routine economics offer a useful value trade-off. The salt form, net active yield, and moisture protection are not identified.

Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
    Noureddin M; Sander-Struckmeier S; Mato JM · World journal of hepatology · 2020
    Systematic review9 studies pooledDetoxification forSAMe
  2. Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
    Zhang L; Liu XH; Qi HB; Li Z; Fu XD; Chen L; Shao Y · European review for medical and pharmacological sciences · 2016
    Randomized trial120 participantsDetoxification forSAMe
  3. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
    Guo T; Chang L; Xiao Y; Liu Q · PloS one · 2015
    Meta-analysis705 participants11 studies pooledDetoxification forSAMe
  4. Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
    Liu GY; Wang W; Jia WD; Xu GL; Ma JL; Ge YS; Yu JH; Sun QK; Meng FL · World journal of surgical oncology · 2014
    Non-randomized trial81 participantsDetoxification forSAMe
  5. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
    Mato JM; Cámara J; Fernández de Paz J; Caballería L; Coll S; Caballero A; García-Buey L; Beltrán J; Benita V; Caballería J; Solà R; Moreno-Otero R; Barrao F; Martín-Duce A; Correa JA; Parés A; Barrao E; García-Magaz I; Puerta JL; Moreno J; Boissard G; Ortiz P; Rodés J · Journal of hepatology · 1999
    Randomized trial123 participantsDetoxification forSAMe
  6. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495].
    Najm WI; Reinsch S; Hoehler F; Tobis JS; Harvey PW · BMC musculoskeletal disorders · 2004
    Randomized trial61 participantsJoint Health forSAMe
  7. Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease.
    Caruso I; Pietrogrande V · The American journal of medicine · 1988
    Clinical trial734 participantsJoint Health forSAMe
  8. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis.
    Glorioso S; Todesco S; Mazzi A; Marcolongo R; Giordano M; Colombo B; Cherie-Ligniere G; Mattara L; Leardini G; Passeri M · International journal of clinical pharmacology research · 1985
    Randomized trial150 participantsJoint Health forSAMe
  9. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis.
    König B · The American journal of medicine · 1988
    Single-arm trial108 participantsJoint Health forSAMe
  10. Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis.
    Hosea Blewett HJ · Critical reviews in food science and nutrition · 2008
    Narrative reviewJoint Health forSAMe
  11. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies.
    Delle Chiaie R; Pancheri P; Scapicchio P · The American journal of clinical nutrition · 2002
    Randomized trial576 participantsMood Support forSAMe
  12. A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder.
    Pancheri P; Scapicchio P; Chiaie RD · The international journal of neuropsychopharmacology · 2004
    Randomized trial293 participantsMood Support forSAMe
  13. Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression.
    Di Pierro F; Settembre R · International journal of general medicine · 2015
    Randomized trial64 participantsMood Support forSAMe
  14. S-adenosylmethionine blood levels in major depression: changes with drug treatment.
    Bell KM; Potkin SG; Carreon D; Plon L · Acta neurologica Scandinavica. Supplementum · 1994
    Randomized trial26 participantsMood Support forSAMe
  15. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.
    Sarris J; Murphy J; Mischoulon D; Papakostas GI; Fava M; Berk M; Ng CH · The American journal of psychiatry · 2017
    Meta-analysisMood Support forSAMe