Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
Meta-analysis1,998 participants34 studies pooledflagSleep Support forscienceMelatonin
- Meta-analysis: melatonin for the treatment of primary sleep disorders.
Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
Meta-analysis1,683 participants19 studies pooledflagSleep Support forscienceMelatonin
- Melatonin treatment for age-related insomnia.
Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
Randomized trial30 participantsflagSleep Support forscienceMelatonin
- Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
Randomized trial116 participantsflagSleep Support forscienceMelatonin
- Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis.
Albalawi AA · Nutrition and health · 2025
Meta-analysis488 participants13 studies pooledflagStress Relief forscienceAshwagandha
- A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
Chandrasekhar K; Kapoor J; Anishetty S · Indian journal of psychological medicine · 2013
Randomized trial64 participantsflagStress Relief forscienceAshwagandha
- A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
Randomized trial54 participantsflagStress Relief forscienceAshwagandha
- Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.
Salve J; Pate S; Debnath K; Langade D · Cureus · 2020
Randomized trial60 participantsflagStress Relief forscienceAshwagandha
- Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review.
Della Porta M; Maier JA; Cazzola R · Nutrients · 2023
Systematic review9 studies pooledflagStress Relief forscienceAshwagandha
- A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
Deshpande A; Irani N; Balkrishnan R; Benny IR · Sleep medicine · 2021
Randomized trial150 participantsflagSleep Support forscienceAshwagandha
- Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial.
Thanawala S; Shah R; Alluri KV; Bhupathiraju K; Desomayanandanam P; Bhuvenendran A · Medicine · 2026
Randomized trial135 participantsflagSleep Support forscienceAshwagandha
- Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
Gopukumar K; Thanawala S; Somepalli V; Rao TSS; Thamatam VB; Chauhan S · Evidence-based complementary and alternative medicine : eCAM · 2022
Randomized trial130 participantsflagSleep Support flagStress Relief forscienceAshwagandha
- Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.
Langade D; Thakare V; Kanchi S; Kelgane S · Journal of ethnopharmacology · 2021
Randomized trial80 participantsflagSleep Support forscienceAshwagandha
- Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.
Langade D; Kanchi S; Salve J; Debnath K; Ambegaokar D · Cureus · 2020
Randomized trial60 participantsflagSleep Support forscienceAshwagandha
- The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
Meta-analysis409 participants8 studies pooledflagSleep Support forscienceMelatonin
- Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
Randomized trial791 participantsflagSleep Support forscienceMelatonin
- Effects of exogenous melatonin on sleep: a meta-analysis.
Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
Meta-analysis284 participants8 studies pooledflagSleep Support forscienceMelatonin
- An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
Lopresti AL; Smith SJ; Malvi H; Kodgule R · Medicine · 2019
Randomized trial60 participantsflagStress Relief forscienceAshwagandha
- Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels.
Mishra DN; Kumar M · Heliyon · 2024
Randomized trial60 participantsflagStress Relief forscienceAshwagandha
- Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
Randomized trial126 participantsflagStress Relief forscienceMagnesium
- Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
Randomized trial137 participantsflagStress Relief forscienceMagnesium
- Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
Non-randomized trial60 participantsflagStress Relief forscienceMagnesium
- Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
Randomized trial45 participantsflagStress Relief forscienceMagnesium
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
Randomized trialflagStress Relief forscienceMagnesium
- The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
Randomized trial202 participantsflagStress Relief forscienceMelatonin
- Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
Randomized trial90 participantsflagStress Relief forscienceMelatonin
- Melatonin for pre- and postoperative anxiety in adults.
Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
Meta-analysis774 participants12 studies pooledflagStress Relief forscienceMelatonin
- Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
Meta-analysis441 participants5 studies pooledflagStress Relief forscienceMelatonin
- Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
Randomized trial88 participantsflagStress Relief forscienceMelatonin