Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
Randomized trial100 participantsflagAnti-Aging flagSkin Health forscienceCollagen
- Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
Meta-analysis1,125 participants19 studies pooledflagAnti-Aging flagSkin Health forscienceCollagen
- Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
Proksch E; Segger D; Degwert J; Schunck M; Zague V; Oesser S · Skin pharmacology and physiology · 2014
Randomized trial69 participantsflagAnti-Aging forscienceCollagen
- Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Lee E; Ahn DK; Kim JH; Lee S; Kim HJ; Lee HK; Shin JH · Journal of microbiology and biotechnology · 2025
Randomized trial70 participantsflagAnti-Aging forscienceCollagen
- Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
Proksch E; Schunck M; Zague V; Segger D; Degwert J; Oesser S · Skin pharmacology and physiology · 2014
Randomized trial114 participantsflagAnti-Aging forscienceCollagen
- Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
Zi Y; Liu J; Liu Q; Pan Y; Jiang X · Journal of cosmetic dermatology · 2026
Randomized trial66 participantsflagAnti-Aging forscienceVitamin C
- Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
Yokota M; Yahagi S · Journal of cosmetic dermatology · 2022
Randomized trial69 participantsflagAnti-Aging forscienceVitamin C
- The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach.
Crisan D; Roman I; Crisan M; Scharffetter-Kochanek K; Badea R · Clinical, cosmetic and investigational dermatology · 2015
Clinical trial60 participantsflagAnti-Aging forscienceVitamin C
- In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound.
Vergilio MM; Aiello LM; Furlan AS; Caritá AC; Azevedo JR; Bolzinger MA; Chevalier Y; Leonardi GR · Journal of cosmetic dermatology · 2022
Randomized trial25 participantsflagAnti-Aging forscienceVitamin C
- Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
Boghosian T; Mendez H; Boghosian N; Sayegh M; Beer J; Tosti A · The Journal of clinical and aesthetic dermatology · 2026
Systematic review44 studies pooledflagAnti-Aging forscienceVitamin C
- Undenatured type II collagen for knee osteoarthritis.
Gupta A; Maffulli N · Annals of medicine · 2025
Systematic review12 studies pooledflagAnti-Inflammatory Support forscienceCollagen
- Anti-inflammatory effect of collagen tripeptide in atopic dermatitis.
Hakuta A; Yamaguchi Y; Okawa T; Yamamoto S; Sakai Y; Aihara M · Journal of dermatological science · 2018
Randomized trial17 participantsflagAnti-Inflammatory Support forscienceCollagen
- [Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment].
Shavlovskaya OA; Gromova OA; Torshin IY · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
Narrative reviewflagAnti-Inflammatory Support forscienceCollagen
- Ultrasound Guided Injection of Collagen for Elbow Lateral Epicondylitis - A Pilot Study.
Porta F; Filippucci E; Barni X; Dinescu SC; Vreju FA · Current health sciences journal · 2026
Single-arm trial13 participantsflagAnti-Inflammatory Support forscienceCollagen
- Effects of porcine-derived collagen hydrolysates on 24 h blood pressure profiles, markers for endothelial dysfunction and low-grade inflammation and the retinal vasculature in adults with overweight/obesity: a randomized, controlled trial.
Chavez-Alfaro MA; Mensink RP; Joris PJ; Plat J · Food & function · 2025
Randomized trial56 participantsflagAnti-Inflammatory Support forscienceCollagen
- Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
Randomized trial107 participantsflagAnti-Inflammatory Support flagJoint Health forscienceVitamin C
- The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
Meta-analysis1,162 participants10 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
Meta-analysis852 participants8 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
Systematic review811 participants17 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
Randomized trial44 participantsflagAnti-Inflammatory Support forscienceVitamin C
- Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
Randomized trial51 participantsflagBone Health forscienceCollagen
- Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
Randomized trialflagBone Health forscienceCollagen
- A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
Randomized trial39 participantsflagBone Health forscienceCollagen
- Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
Methods validation study189 participantsflagBone Health forscienceCollagen
- Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
Randomized trial51 participantsflagBone Health forscienceCollagen
- Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
Meta-analysis19,484 participants17 studies pooledflagBone Health forscienceVitamin C
- Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
Meta-analysis6 studies pooledflagBone Health forscienceVitamin C
- Smoking, antioxidant vitamins, and the risk of hip fracture.
Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
Cohort study66,651 participantsflagBone Health forscienceVitamin C
- Micronutrients and the risk of hip fracture: Case-control study.
Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
Case-control study189 participantsflagBone Health forscienceVitamin C
- Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
Cross-sectional study1,196 participantsflagBone Health forscienceVitamin C
- A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
Kumar S; Sugihara F; Suzuki K; Inoue N; Venkateswarathirukumara S · Journal of the science of food and agriculture · 2015
Randomized trialflagGeneral Health forscienceCollagen
- Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
Randomized trial101 participantsflagGeneral Health flagJoint Health forscienceCollagen
- Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.
Mościcka P; Cwajda-Białasik J; Szewczyk MT; Jawień A · International journal of environmental research and public health · 2022
Randomized trial100 participantsflagGeneral Health forscienceCollagen
- Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
Shiojima Y; Takahashi M; Takahashi R; Maruyama K; Moriyama H; Bagchi D; Bagchi M; Akanuma M · Journal of the American Nutrition Association · 2023
Randomized trial64 participantsflagGeneral Health forscienceCollagen
- The use of a collagen matrix in hard-to-heal venous leg ulcers.
Romanelli M; Mulder G; Paggi B; Macchia M; Panduri S; Dini V · Journal of wound care · 2016
Randomized trial40 participantsflagGeneral Health forscienceCollagen
- Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
Meta-analysis69 studies pooledflagGeneral Health forscienceVitamin C
- Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagGeneral Health forscienceVitamin C
- Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
Cohort study598 participantsflagGeneral Health forscienceVitamin C
- Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
Cohort study12,530 participantsflagGeneral Health forscienceVitamin C
- Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
Cohort study19,496 participantsflagGeneral Health forscienceVitamin C
- Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
Randomized trial114 participantsflagHair Health forscienceCollagen
- Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
Randomized trialflagHair Health forscienceCollagen
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
Narrative reviewflagHair Health forscienceCollagen
- Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
Narrative reviewflagHair Health forscienceVitamin C
- Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
Methods validation study201,019 participantsflagHair Health forscienceVitamin C
- Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
Observational studyflagHair Health forscienceVitamin C
- Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
Methods validation studyflagHair Health forscienceVitamin C
- A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
Case reportflagHair Health forscienceVitamin C
- Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
Devasia S; Joseph JT; P S S; Koizumi S; Clarke L; V T S; Kailas AP; Madhavan S · Cartilage · 2024
Randomized trial100 participantsflagJoint Health forscienceCollagen
- Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
Randomized trial191 participantsflagJoint Health forscienceCollagen
- [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Mazurov VI; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LY · Terapevticheskii arkhiv · 2024
Randomized trial212 participantsflagJoint Health forscienceCollagen
- The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.
Zdzieblik D; Brame J; Oesser S; Gollhofer A; König D · Nutrients · 2021
Randomized trial180 participantsflagJoint Health forscienceCollagen
- Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.
Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
Randomized trial100 participantsflagJoint Health forscienceVitamin C
- Osteoarthritis prevalence and modifiable factors: a population study.
Plotnikoff R; Karunamuni N; Lytvyak E; Penfold C; Schopflocher D; Imayama I; Johnson ST; Raine K · BMC public health · 2016
Cross-sectional study4,733 participantsflagJoint Health forscienceVitamin C
- Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial.
Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
Randomized trial110 participantsflagJoint Health forscienceVitamin C
- Musculoskeletal manifestations of scurvy.
Fain O · Joint bone spine · 2005
Narrative reviewflagJoint Health forscienceVitamin C
- Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
Single-arm trial25 participantsflagNail Health forscienceCollagen
- Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
Randomized trial85 participantsflagNail Health forscienceCollagen
- Nail Supplements: When, How, and Why?
Zaraa I; Richert B · Skin appendage disorders · 2026
Narrative reviewflagNail Health forscienceCollagen
- Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
Observational study41 participantsflagNail Health forscienceCollagen
- Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
Other20 participantsflagNail Health forscienceVitamin C
- Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
Meta-analysis967 participants14 studies pooledflagSkin Health forscienceCollagen
- Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
Meta-analysis646 participants10 studies pooledflagSkin Health forscienceCollagen
- Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
Randomized trial64 participantsflagSkin Health forscienceCollagen
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C