Lifestyle changes
Keep strength, balance, and comfortable movement part of your week. Stay socially connected, make time for enjoyable learning, and adapt activities as your needs change.
Longevity
Healthy aging is about maintaining the capacity to move comfortably, think clearly, and stay involved in the things you enjoy. Strength, mobility, skin and connective-tissue health, and everyday mental function all contribute to that capacity. An anti-aging routine is most useful when it focuses on these practical aspects of vitality and wellbeing. The body’s needs can change with age, activity, appetite, and health circumstances. Nutritional support may focus on maintaining muscle, covering essential nutrient needs, or supporting cellular energy and antioxidant systems. More targeted choices can address a particular priority, such as comfortable movement or the nutritional foundation for brain function. Meaningful progress is connected to daily life. Feeling capable during familiar activities, recovering well, and maintaining independence can each guide the choices you make. A clear set of priorities helps keep the routine manageable and allows it to evolve with your needs over time.
Warnings
- Check medicine interactions: Ask a pharmacist or clinician to review your exact products alongside your medicines. The ingredient, amount, and treatment determine which combinations are suitable.
- Track meaningful progress: Track outcomes that matter in daily life, such as strength, comfortable movement, and cognitive function. Interpret laboratory or other health measurements within their appropriate clinical context.
- Check herbal suitability: Check the specific extract before use, particularly during pregnancy or with liver or thyroid conditions. A pharmacist or clinician can review compatibility with your medicines.
- Avoid overlapping high doses: Count nutrients from multivitamins, individual supplements, and fortified products together. Keep the combined amounts within appropriate limits for your circumstances.
Ingredient overview
Goal guidance
Diet changes
Maintain enough food and protein, including when appetite becomes smaller. Varied plants, fiber-rich foods, and unsaturated fats help build a practical nutritional foundation.
Who this is for
Adults who want to maintain strength, mobility, mental sharpness, and quality of life as they grow older.
Who should be careful
Review supplements if you take several medicines or have kidney, liver, or cardiovascular conditions. Keep high-dose combinations under review, and arrange assessment for unexplained changes in weight, memory, or daily function.
Expected timeline
Follow practical outcomes such as strength, comfortable movement, and daily independence. These develop through consistent habits, while long-term wellbeing calls for an ongoing approach.
Common mistakes
A complex supplement routine can distract from food intake, activity, and recovery. Give each product a specific purpose and review it as your needs or medicines change.
Ingredients
Coenzyme Q-10 Other Nutrients
Impact
Highest effect
Typical dose100–400 mg / day
CoQ10 is essential for the function of high-energy organs like the heart, liver, and brain. Supplementing can help combat age-related declines in cellular energy, reduce oxidative stress, and support cardiovascular health. The ubiquinol form offers superior bioavailability.
- Focuses on
- Most relevant for
- Individuals interested in supporting cellular antioxidant defenses and cardiovascular biomarkers, particularly when combined with other nutrients like selenium.
Potential benefits
- Antioxidant Skin Protection.Unconfirmed. Topical CoQ10 has been shown to reduce wrinkle depth and protect against UV-induced oxidative stress; however, it is unconfirmed if oral supplements provide the same skin-specific anti-aging benefits.
- Cardiovascular Biomarker Support.Unconfirmed. Long-term use, especially when combined with selenium, may positively influence biomarkers related to inflammation and heart health in older adults, though evidence for CoQ10 alone is less certain.
- Cellular Energy Processes.Unconfirmed. As a key component of the mitochondrial electron transport chain, supplementation may help maintain cellular bioenergetics, though its ability to slow biological aging remains unproven.
Limitations
- Lack of Functional Improvement.In healthy older adults, 400mg daily increased blood CoQ10 levels but failed to improve muscle mitochondrial function, physical performance, or cognitive scores over 12 weeks.
- Dependency on Other Nutrients.Several significant anti-aging findings involve CoQ10 taken alongside selenium, making it difficult to determine if CoQ10 alone provides the same cardiovascular or longevity benefits.
- Uncertain Impact on Biological Age.Large-scale observational data linking CoQ10 to lower epigenetic biological age lost statistical significance after adjusting for health and lifestyle factors.
Things to consider
Supplementation effectively raises plasma levels, but this does not always translate into higher concentrations within muscle tissue or improved physical energy in robust individuals.
Study evidence
6 studiesCoenzyme Q-10 has promising findings for some age-related conditions and skin changes, but the available research does not establish that oral supplementation slows aging. Benefits from combinations or topical products cannot be assumed for Coenzyme Q-10 supplements alone.
Folate Vitamins
Impact
Highest effect
Typical dose400–800 mcg / day
Proper methylation is essential for turning genes on and off correctly, a process that can become dysregulated during aging. Folate, preferably in its active L-methylfolate form, is a primary methyl donor that supports this process. Maintaining adequate folate levels helps ensure genomic stability and reduces the risk of elevated homocysteine, a significant factor in vascular aging.
- Focuses on
- Most relevant for
- Older adults seeking to support long-term cognitive and vascular health, particularly in populations where dietary intake is low or food is not fortified.
Potential benefits
- Cellular and Epigenetic Support.Unconfirmed. Higher folate status is associated with laboratory markers of slower biological aging, such as maintained telomere length and reduced epigenetic age deviation. This is unconfirmed because changes in laboratory markers have not yet been proven to extend lifespan or improve health span in humans.
- Cognitive Longevity.Unconfirmed. Adequate blood folate levels are linked to slower cognitive decline in long-term observational studies of older adults. This is unconfirmed as clinical trials have not consistently demonstrated that supplementation prevents cognitive impairment in those with already sufficient levels.
- Vascular Health.Unconfirmed. High dietary folate intake is associated with a slower progression of arterial stiffness, a major factor in vascular aging. This is unconfirmed because it is unclear if supplements provide the same protection as naturally occurring dietary folate.
Limitations
- Confounding Factors.Many anti-aging associations are observational and may be influenced by smoking status, kidney function, or overall diet rather than folate alone.
- Limited Physical Impact.Research has found no significant link between folate levels and improvements in physical performance, such as grip strength, or changes in brain volume over time.
- Diminishing Returns.Evidence suggests a saturation point where folate intake above approximately 500 micrograms per day provides no additional benefit for cellular aging markers.
Things to consider
Clinical benefits for sensory functions like hearing have primarily been observed in older adults with high homocysteine living in regions without mandatory folic acid fortification.
Study evidence
16 studiesAdequate folate status is associated with healthier aging markers and, in some studies, less cognitive decline. These associations do not establish that folate supplements slow aging or extend life, and benefits beyond correcting inadequate status remain uncertain.
Magnesium Minerals
Impact
Highest effect
Typical dose200–500 mg / day
Magnesium plays a vital role in ATP synthesis, the body's primary energy currency. It also helps regulate blood pressure, supports nerve function, and promotes relaxation and sleep quality, which are often compromised with age. Bioavailable forms like glycinate or citrate are preferred.
- Focuses on
- Most relevant for
- Middle-aged and older adults seeking to maintain physical strength and cognitive function by supporting mineral balance during the aging process.
Potential benefits
- Musculoskeletal Maintenance.Higher dietary magnesium intake is associated with better grip strength, preserved muscle mass, and higher bone density in middle-aged and older adults.
- Frailty Risk Reduction.Increased magnesium intake is linked to a lower incidence of frailty and helps maintain physical performance, particularly walking speed, in seniors.
- Cognitive Support.Unconfirmed. Personalized supplementation may support cognitive function in seniors with high calcium-to-magnesium intake ratios, though a general anti-aging effect on the brain is unproven.
Limitations
- Observational Evidence.Most research relies on dietary associations, which can suggest health benefits during aging but do not prove that magnesium independently slows the biological aging process.
- Unproven Longevity.While magnesium supports functional health, there is no clinical evidence that supplementation extends lifespan or fundamentally alters the rate of aging.
- Deficiency Dependency.Some metabolic benefits associated with magnesium may only occur when correcting an existing deficiency rather than from increasing intake beyond adequate levels.
Things to consider
Standard serum magnesium tests may not accurately reflect cellular magnesium levels or overall deficiency status.
Study evidence
12 studiesMagnesium intake is associated with some favourable aspects of health during ageing, but supplementation has not been shown to slow ageing itself. Findings about physical or cognitive function do not establish longer life or a general anti-ageing effect.
Omega-3 Fatty Acids
Impact
Highest effect
Typical dose1000–3000 EPA+DHA mg / day
The omega-3 fatty acids EPA and DHA are potent anti-inflammatories that help balance the pro-inflammatory effects of omega-6s. They are integral components of cell membranes, particularly in the brain and retina, and are clinically shown to support cognitive health and reduce triglyceride levels.
- Focuses on
- Most relevant for
- Older adults seeking to support cellular and cognitive health through balanced nutrition.
Potential benefits
- Cellular Aging Markers.Unconfirmed. Higher blood levels of omega-3s are associated with slower shortening of telomeres, which protect chromosomes, though evidence that supplements directly slow biological aging remains emerging.
- Cognitive Preservation.Unconfirmed. Some research suggests a modest benefit in maintaining executive function and slowing mental decline, particularly in those with low baseline intake or specific genetic risks.
- Physical Resilience.Unconfirmed. High erythrocyte levels of EPA and DHA are linked to a lower incidence of frailty and may support muscle maintenance in older populations.
Limitations
- Inconsistent Clinical Results.Large-scale trials have frequently shown no significant changes in brain volume or cognitive performance compared to placebo, even when fatty acids reach the brain.
- Lifespan Impacts Unproven.While omega-3s may influence specific markers related to aging, there is no definitive evidence that supplementation extends the human lifespan or slows overall aging.
- Dietary Threshold Effect.Benefits are often only observed in individuals with low initial omega-3 levels; those already consuming enough through diet may not experience additional anti-aging effects.
Things to consider
Daily doses of 1g or more have been linked to a dose-dependent increase in atrial fibrillation risk, particularly in older individuals with cardiovascular risk factors.
Study evidence
56 studiesOmega-3s show promise for selected aspects of healthy aging, including some cellular markers and cognitive measures, but supplementation has not consistently improved these outcomes. The supplied evidence does not establish that omega-3 supplements slow overall aging or extend lifespan.
Vitamin B12 Vitamins
Impact
Highest effect
Typical dose10–1000 mcg / day
Vitamin B12 is vital for maintaining the myelin sheath that protects nerve cells and for metabolizing homocysteine, an amino acid linked to cardiovascular and cognitive issues when elevated. Age-related changes in stomach acid can impair B12 absorption from food, making supplementation a key strategy for older adults to maintain energy levels and brain function.
- Focuses on
- Most relevant for
- Older adults seeking to maintain physical function and brain health who may face age-related nutrient absorption challenges.
Potential benefits
- Frailty Support.Adequate vitamin B12 status is associated with a lower prevalence of physical frailty and better functional status in older populations.
- Biological Aging Markers.Unconfirmed. Observational research suggests adequate B12 levels correlate with slower biological aging as measured by DNA methylation clocks, though clinical proof for B12 alone is lacking.
- Neurological Preservation.Unconfirmed. Evidence in older women suggests a link between B12 supply and markers of brain structure aging, though long-term preventative effects are not firmly established.
Limitations
- Unproven Reversal.Research primarily links deficiency to accelerated aging markers; it does not confirm that supplementing above adequate levels slows or reverses the aging process.
- Complex Mortality Risks.Higher serum B12 concentrations have been associated with increased all-cause mortality in a J-shaped pattern in some elderly cohorts, suggesting excessive levels may be harmful.
- Indirect Evidence.Positive impacts on biological aging clocks have often been observed in multivitamin trials, making it difficult to isolate B12 as the sole cause of benefit.
Things to consider
Routine screening for B12 deficiency is often recommended for older adults because age-related changes in stomach acid and transport proteins can impair absorption regardless of dietary intake.
Study evidence
8 studiesVitamin B12 status is linked to frailty and some markers of aging, but these associations do not show that supplementation slows aging. The supplied evidence does not establish longer life or broad anti-aging benefits from extra B12 in people with adequate levels.
Vitamin D Vitamins
Impact
Highest effect
Typical dose1000–4000 IU / day
Vitamin D deficiency is linked to osteoporosis, a weakened immune system (immunosenescence), and cognitive decline. Supplementation is one of the most effective ways to maintain adequate levels, supporting calcium absorption for strong bones and modulating immune responses.
- Focuses on
- Most relevant for
- Older adults aiming to maintain functional independence and manage biological markers of aging, especially if they have low vitamin D status.
Potential benefits
- Biological Age Management.Clinical trial data indicates that supplementation, particularly when combined with omega-3 and exercise, can slow specific DNA methylation markers of biological aging like PhenoAge.
- Functional Independence.Maintaining adequate serum levels is associated with a lower risk of disability in daily activities and a reduced likelihood of rapid deterioration in physical capacity as adults age.
- Cognitive Preservation.Unconfirmed. Higher intake and serum levels are linked to a lower risk of dementia and cognitive impairment in observational studies. unconfirmed=true. Clinical trials have not yet consistently shown that supplementation improves cognitive function in non-demented adults.
Limitations
- No Effect on Skin Aging.Mendelian randomization studies indicate that there is no causal relationship between vitamin D concentrations and facial skin aging features like wrinkling or age spots.
- Baseline Status Dependency.Anti-aging benefits and physical performance gains are generally not observed in individuals who already have sufficient baseline vitamin D levels.
- Unproven Longevity Impact.While deficiency is a strong predictor of mortality, high-quality clinical evidence is lacking to prove that supplementation independently extends the human lifespan.
Things to consider
In populations with already sufficient levels, high-dose vitamin D supplementation does not prevent fractures and has been associated with an increased risk of fractures in some clinical research.
Study evidence
50 studiesLow Vitamin D levels are associated with several signs of less healthy aging, but these links do not prove that supplements slow aging. Preliminary findings on biological-age markers are encouraging, especially in deficiency, while clear benefits for longevity or broad age-related function remain unestablished.
Studies
Explore published research for this goal.
Sources
Up to five highest-ranked published examples per ingredient. Study counts and charts include all published studies for the connection.
- Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
- Coenzyme Q10 Supplementation in Aging and Disease.
- Coenzyme Q10, a cutaneous antioxidant and energizer.
- Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
- Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
- One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999-2002.
- Longitudinal associations of one-carbon metabolism biomarkers with biological and epigenetic aging in older adults in India.
- Associations between leukocyte telomere length and three measures of folate status: a cross-sectional analysis of NHANES 1999-2002.
- Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging.
- Blood folate is associated with asymptomatic or partially symptomatic Alzheimer's disease in the Nun study.
- Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
- Higher Magnesium Intake Is Associated with a Lower Risk of Frailty in Older Adults.
- Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial.
- The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES.
- Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging.
- Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
- Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary substudy of a randomized, controlled trial in midlife adults.
- Omega-3 Polyunsaturated Fatty Acids and Cognitive Decline in Adults with Non-Dementia or Mild Cognitive Impairment: An Overview of Systematic Reviews.
- Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.
- Long-chain omega-3 fatty acids improve brain function and structure in older adults.
- Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging.
- Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects.
- Homocysteine and the risk of nursing home admission and mortality in older persons.
- Dynamics and interactions of cobalamin and folate status during advanced aging - a longitudinal study in a community-dwelling cohort with multiple follow-ups.
- Association between serum vitamin B12 and risk of all-cause mortality in elderly adults: a prospective cohort study.
- Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
- Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
- Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
- Vitamin D deficit is associated with accelerated brain aging in the general population.
- Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
- Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
- Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
- Vitamin K status and cognitive function in healthy older adults.
- High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
- Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
- Markers of Hypoxia and Oxidative Stress in Aging Volunteers Ingesting Lycosomal Formulation of Dark Chocolate Containing Astaxanthin.
- The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
- Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
- Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.
- Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4.
- Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging.
- Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
- Nutritional Strategies Targeting Glucose Metabolism to Slow Cognitive Aging: A Scoping Review of Human Trials.
- Multinuclear MRS at 7T Uncovers Exercise Driven Differences in Skeletal Muscle Energy Metabolism Between Young and Seniors.
- Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
- Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
- Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
- Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
- Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
- Creatine supplementation during resistance training in older adults-a meta-analysis.
- Strategic creatine supplementation and resistance training in healthy older adults.
- Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.
- Changes in Fat Mass Following Creatine Supplementation and Resistance Training in Adults ≥50 Years of Age: A Meta-Analysis.
- Creatine supplementation improves muscular performance in older men.
- Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study.
- Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
- A novel phospholipid delivery system of curcumin (Meriva®) preserves muscular mass in healthy aging subjects.
- Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.
- Curcumin and arterial function in health and disease: impact on oxidative stress and inflammation.
- Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.
- Dietary protein and amino acid intakes for mitigating sarcopenia in humans.
- Age-Related Neurochemical Changes in the Vestibular Nuclei.
- SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.
- Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study.
- Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging.
- Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length.
- Can teatime increase one's lifetime?
- Influences of tea consumption on self-rated health and life satisfaction among older adults: Evidence from the CLHLS.
- Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin.
- Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women.
- Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70.
- Association of taurine intake with changes in physical fitness among community-dwelling middle-aged and older Japanese adults: an 8-year longitudinal study.
- Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
- Associations of dietary flavones, particularly apigenin and luteolin, with phenotypic age acceleration: A cross-sectional study using NHANES data.
- Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
- Association of dietary sulfur amino acid intake with mortality from diabetes and other causes.
- Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
- Effectiveness and Safety of a Cross-linked Hyaluronic Acid Plus Mannitol Filler for the Correction of Nasolabial Folds in Chinese Subjects: A Randomized, Blinded, Controlled Study.
- A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
- Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.
- Safety and Efficacy of Hyaluronic Acid-Based Filler for Neck Wrinkles: A Prospective, Multicenter, Randomized, Parallel-Controlled Non-Inferiority Trial.
- A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.
- Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women.
- Associations of different isomeric forms of serum lycopene with cardiovascular disease and all-cause mortality.
- Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009-2018.
- Biological Aging Mediates the Associations Between Multiple Serum Micronutrients and All-Cause Mortality Among U.S. Adults.
- Topical lycopene emulgel significantly improves biophysical parameters of human skin.
- Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.
- Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.
- Resveratrol levels and all-cause mortality in older community-dwelling adults.
- Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
- Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
- Selenium Concentrations and Mortality among Community-Dwelling Older Adults: Results from IlSIRENTE Study.
- Selenium and mortality in the elderly: results from the EVA study.
- Association of dietary selenium intake and all-cause mortality of Parkinson's disease and its interaction with blood cadmium level: a retrospective cohort study.
- Selenium alleviates cadmium-induced biological aging acceleration and the potential mediating role of inflammation.
- Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic Review.
- Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
- Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
- The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach.
- In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound.
- Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
- Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study.
- Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
- Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study.
- The L-shaped link between total antioxidant capacity and phenotypic age acceleration: evidence from NHANES 2003-2010.
- Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.
- The immune system and the impact of zinc during aging.
- Associations between serum trace elements and biological age acceleration in the Chinese elderly: A community-based study investigating the mediating role of inflammatory markers and the moderating effect of physical activity.
- Bidirectional associations of zinc supplement intake with biological ageing interacted by metabolic equivalent of task: A large-scale population-based Biobank study.
- Zinc, metallothioneins, longevity: effect of zinc supplementation on antioxidant response: a Zincage study.
- Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.
- Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review.
- Do glutathione levels decline in aging human brain?
- Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study.
- Changes in the intracellular homocysteine and glutathione content associated with aging.
- A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.
- Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis.
- Neurometabolite changes in cingulate cortex regions in healthy Indian population and effect of Bacopa monnieri intervention: a H1 MRS study.
- Efficacy of Integrated Yoga and Ayurveda Rasayana on cognitive functions in elderly with mild cognitive impairment: Non-randomized three-arm clinical trial.
- Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.
- Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
- Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial.
- Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age.
- Melatonin and healthy aging.
- Clinical Studies Using Topical Melatonin.