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Wild & Pure Resveratrol + 500 mg Trans-Resveratrol

Nature's Answer
4.7
★ ★ ★ ★ ★
(201 ratings)
Resveratrol 500 mg
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Score73

Two resveratrol sources offer substantial polyphenol exposure, but the actual active yield and knotweed purity are unclear.

How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Metabolism Boost
Cardiovascular Support
Anti-Inflammatory Support
Skin Health
Anti-Aging

Score 73

Two resveratrol sources offer substantial polyphenol exposure, but the actual active yield and knotweed purity are unclear.

How scoring works
$36.74($0.61 per serving)
iHerb
$ 52.49
Pure Formulas
$ 49.40
Amazon
$ 36.74
Vitacost
$ 52.49
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Analysis

The formula lists 500 mg resveratrol from Japanese knotweed and 500 mg from muscadine grape. It is unclear whether both entries represent active resveratrol amounts or source-extract quantities.

Using two botanical sources broadens the polyphenol profile. No enhanced-delivery feature, trans-isomer percentage, or emodin-removal statement is supplied.

One capsule and 60 servings are convenient for regular use. It fits users comfortable with a high-source blend, while dose-focused buyers should seek clearer active-yield labeling.

Who is it for
  • Adults wanting knotweed and grape resveratrol sources
  • Users comfortable with unclear active yield
  • People preferring one capsule daily
Best for
  • Broad polyphenol routines
  • Skin and vascular support
  • Users valuing two botanical sources

Pros

  • Uses knotweed and muscadine grape
  • Substantial source amounts
  • One-capsule serving
  • Sixty servings

Cons

  • Active trans-resveratrol yield is unclear
  • No enhanced delivery
  • Emodin removal is not verified
  • Purity details are missing

Warnings

  • Resveratrol may add to anticoagulant or antiplatelet effects
  • Unverified knotweed processing may leave laxative emodin
  • The unusually large listed source amounts warrant label verification before use

Nutrient quality

80 Highest impact

Substantial resveratrol exposure and complementary botanical sources provide good formula depth. Unclear source contributions, missing purity details, and basic delivery reduce confidence.

Ingredient transparency

64 Moderate impact

The label names the main actives and avoids a broad hidden blend. Repeated entries, missing active yields, absent directions, and undisclosed excipients reduce clarity.

Customer satisfaction

67 High impact

The supplied average rating is very strong and the rating volume is moderate. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money

81 Highest impact

The formula provides fair value for its cost. It remains moderately competitive but does not clearly lead the category.

Report analysis

Goals

Metabolism Boost
Metabolism Boost
Impact
High effect
C+ Goal FitA- Strength of SupportC+ CoverageB+ Formula Quality
Resveratrol · 500 mg

Trans-resveratrol may support mitochondrial signaling and insulin sensitivity without acting as a direct thermogenic. Human evidence for metabolic outcomes is mixed despite a plausible mechanism and supportive biomarker data.

The 500 mg resveratrol amount is high and provides substantial exposure. Japanese knotweed and muscadine grape sources are named, but repeated total amounts make their individual contributions unclear. Resveratrol may increase bleeding risk when combined with anticoagulant or antiplatelet medicines.

Study evidence
Resveratrol Supportive 21 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageA- Formula Quality

The substantial resveratrol formula may support endothelial signaling and antioxidant defenses. Human cardiovascular findings remain mixed, so it is less dependable than established lipid or mineral strategies.

Japanese knotweed and muscadine grape provide complementary sources, but the exact active yield and purity of each are unclear. Japanese knotweed can contain emodin, which may cause a mild laxative effect in sensitive users.

Study evidence
Resveratrol Supportive 73 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageA- Formula Quality

The stated trans-resveratrol amount is substantial and supports antioxidant and inflammatory-signaling pathways. Standard capsule delivery and unclear separation of extract weight from active yield limit confidence in exposure.

Japanese knotweed and muscadine grape provide related polyphenols rather than broad mechanistic coverage. The lack of an emodin-free statement may matter for sensitive users because residual emodin can have a laxative effect.

Study evidence
Resveratrol Supportive 34 studies
Skin Health
Skin Health
Impact
High effect
C+ Goal FitB Strength of SupportD+ CoverageA- Formula Quality
Resveratrol · 500 mg

Resveratrol offers antioxidant support against environmental and ultraviolet stress. Human evidence for oral resveratrol and visible skin outcomes remains limited compared with collagen or astaxanthin.

The label presents a substantial trans-resveratrol claim, but extract weights, active yield, and purity are not clearly separated. Japanese knotweed is included without emodin-removal verification, which may cause a mild laxative effect in sensitive users.

Study evidence
Resveratrol Supportive 7 studies
Anti-Aging
Anti-Aging
Impact
High effect
C Goal FitB Strength of SupportD+ CoverageB- Formula Quality

Resveratrol provides plausible metabolic, vascular, and antioxidant mechanisms relevant to healthy aging. The label lists substantial amounts from knotweed and grape, but it does not clearly state how much is the active trans isomer.

The focused formula gives reasonable depth for one polyphenol pathway without covering mitochondrial, structural, or neurological aging broadly. Resveratrol may add to the effects of anticoagulant or antiplatelet medicines, particularly when combined with other products that affect clotting.

Study evidence
Resveratrol No effect 7 studies

Ingredients

IngredientAmount per serving
Resveratrol (Japanese Knotweed (Polygonum cuspidatum) (root) extract, Muscadine Grape)
 500 mg
Adults 18–50
Report overview
Resveratrol (Japanese Knotweed (Polygonum cuspidatum) (root) extract, Muscadine Grape) · 500 mg OverallScore70
C Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA+ Value

The label identifies a substantial trans-resveratrol amount that fits the targeted daily range and offers favorable cost efficiency. Standard capsule delivery and missing purity percentages limit confidence in absorption and exact active yield. Japanese knotweed is included without an emodin-free statement, so sensitive users may face a mild laxative effect.

View ingredientView products
Loading alternative details
83 Performance

High Potency Trans-Resveratrol 600 mg

Doctor's Best
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. A high amount of clearly identified trans-resveratrol provides strong depth at a favorable cost. Basic capsule delivery and missing purity and emodin-removal details limit refinement, while the high dose may increase stomach upset or bleeding tendency with anticoagulant or antiplatelet medicines.</p>
81 Performance

Resveratrol 500 mg

Solgar
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. A substantial amount of clearly identified trans-resveratrol gives this focused formula meaningful depth. Standard capsule delivery and missing source and purity details limit refinement, while the dose remains economical for the category.</p>
80 Performance

TransMax TR

Biotivia
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. MicroActive delivery directly addresses resveratrol absorption while providing a substantial trans-resveratrol amount. The high price buys meaningful delivery technology, but missing purity and emodin-removal details leave tolerability uncertainty for the knotweed source.</p>
81 Budget

Resveratrol 250 mg with Red Wine Extract

Solgar
<p>The lower serving cost makes this a more economical alternative. A meaningful trans-resveratrol amount in a fat-containing softgel offers better delivery potential than a plain powder capsule. The larger package improves serving value, although purity details remain incomplete and resveratrol may add bleeding risk with anticoagulant or antiplatelet medicines.</p>
80 Budget

Resveratrol 100 mg

Life Extension
<p>The lower serving cost makes this a more economical alternative. Trans-resveratrol from grape and knotweed plus quercetin creates a focused antioxidant combination at a low serving cost. Duplicate source entries make the total active amount unclear, and missing purity and emodin-removal details limit dose and tolerability confidence.</p>
80 Budget

Resveratrol Plus

Country Life
<p>The lower serving cost makes this a more economical alternative. A supportive trans-resveratrol dose is paired with grape and pine polyphenols for broader antioxidant coverage. The economical large format improves value, though incomplete standardization and knotweed without emodin-removal verification leave potency and tolerability uncertainty.</p>
78 Value

Resveratrol 100 mg

Jarrow Formulas
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. A long supply of resveratrol and vitamin C offers economical, modest antioxidant support. Unconfirmed trans-isomer content, standard capsule delivery, and missing emodin-removal detail limit confidence in effective exposure.</p>
72 Value

Resveratrol With Pterostilbene 100 mg

Life Extension
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. Trans-resveratrol and quercetin provide useful antioxidant support, but the repeated resveratrol entries make the total active amount ambiguous. Trace pterostilbene adds little practical value, while knotweed without emodin-removal verification may cause loose stools in sensitive users.</p>
72 Value

Resveratrol

youtheory
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. A useful trans-resveratrol amount provides meaningful antioxidant coverage at an efficient serving cost. Pressed-tablet delivery, missing emodin verification, and an opaque fruit blend are the main limitations.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.
    Witte AV; Kerti L; Margulies DS; Flöel A · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Randomized trial46 participantsAnti-Aging forResveratrol
  2. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.
    Huhn S; Beyer F; Zhang R; Lampe L; Grothe J; Kratzsch J; Willenberg A; Breitfeld J; Kovacs P; Stumvoll M; Trampel R; Bazin PL; Villringer A; Witte AV · NeuroImage · 2019
    Randomized trial60 participantsAnti-Aging forResveratrol
  3. Resveratrol levels and all-cause mortality in older community-dwelling adults.
    Semba RD; Ferrucci L; Bartali B; Urpí-Sarda M; Zamora-Ros R; Sun K; Cherubini A; Bandinelli S; Andres-Lacueva C · JAMA internal medicine · 2014
    Cohort study783 participantsAnti-Aging forResveratrol
  4. Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
    Mansouri F; Feliziani G; Bordoni L; Gabbianelli R · Journal of the Academy of Nutrition and Dietetics · 2025
    Meta-analysis11 studies pooledAnti-Aging forResveratrol
  5. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
    Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
    Randomized trial134 participantsAnti-Aging Skin Health forResveratrol
  6. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
    Mahjabeen W; Khan DA; Mirza SA · Complementary therapies in medicine · 2022
    Randomized trial110 participantsAnti-Inflammatory Support forResveratrol
  7. Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis.
    Zhang Q; Xu S; Xu W; Zhou Y; Luan H; Wang D · Medicine · 2022
    Randomized trial160 participantsAnti-Inflammatory Support forResveratrol
  8. Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial.
    Keramatzadeh S; Hosseini SA; Majdinasab N; Cheraghian B; Zilaee M · Nutritional neuroscience · 2025
    Randomized trial55 participantsAnti-Inflammatory Support forResveratrol
  9. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; Yáñez-Gascón MJ; García-Almagro FJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · The American journal of cardiology · 2012
    Randomized trial75 participantsAnti-Inflammatory Support forResveratrol
  10. Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.
    Guo XF; Li JM; Tang J; Li D · Critical reviews in food science and nutrition · 2019
    Meta-analysis1,069 participants29 studies pooledAnti-Inflammatory Support forResveratrol
  11. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; García-Almagro FJ; Avilés-Plaza F; Parra S; Yáñez-Gascón MJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · Molecular nutrition & food research · 2012
    Randomized trial75 participantsCardiovascular Support forResveratrol
  12. Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients.
    Ahmadi P; Akbarzadeh S; Alizadeh M; Mohammadi N; Mahmoodi M; Amini A; Netticadan T; Rezaei M; Movahed A · Molecular and cellular biochemistry · 2025
    Randomized trial60 participantsCardiovascular Support forResveratrol
  13. Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases.
    Shen CY; Li CP; Yu JT; Ho YJ; Tsai RY · In vivo (Athens, Greece) · 2026
    Meta-analysis2,551 participants40 studies pooledCardiovascular Support forResveratrol
  14. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.
    Wong RH; Berry NM; Coates AM; Buckley JD; Bryan J; Kunz I; Howe PR · Journal of hypertension · 2014
    Randomized trial28 participantsCardiovascular Support forResveratrol
  15. Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.
    Simental-Mendía LE; Guerrero-Romero F · Nutrition (Burbank, Los Angeles County, Calif.) · 2020
    Randomized trial71 participantsCardiovascular Support forResveratrol
  16. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis.
    Zhu X; Wu C; Qiu S; Yuan X; Li L · Nutrition & metabolism · 2022
    Meta-analysis283 participants9 studies pooledMetabolism Boost forResveratrol
  17. Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.
    Sun JN; Yang R; Fang L; Li YJ; Xing WY; Sun ML; Wu L; Wu QJ; Gong TT · Nutrition journal · 2026
    Meta-analysis45 studies pooledMetabolism Boost forResveratrol
  18. Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial.
    Chen S; Zhao X; Ran L; Wan J; Wang X; Qin Y; Shu F; Gao Y; Yuan L; Zhang Q; Mi M · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2015
    Randomized trial60 participantsMetabolism Boost forResveratrol
  19. Supplementation with resveratrol modified gut microbiota improving insulin sensitivity and lipid metabolism in subjects with obesity and insulin resistance.
    Guevara-Cruz M; Sánchez-Tapia M; Velazquez-Villegas LA; Torre-Villalvazo I; Guizar-Heredia R; Godínez-Salas E; López-Barradas A; Granados O; Torres-Villalobos G; Torres N; Tovar AR · European journal of nutrition · 2026
    Randomized trial32 participantsMetabolism Boost forResveratrol
  20. Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review.
    Zhou Q; Wang Y; Han X; Fu S; Zhu C; Chen Q · Frontiers in physiology · 2022
    Meta-analysis1,171 participants25 studies pooledMetabolism Boost forResveratrol
  21. Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging.
    Du YM; Zeng J; Li M; Wang YB; Wu Y; Qi RQ; Gao XH; Chen HD · Journal of cosmetic dermatology · 2021
    Non-randomized trial32 participantsSkin Health forResveratrol
  22. Exploring resveratrol-enriched collagen dressings for diabetic foot ulcers: A retrospective study of wound healing outcomes.
    Sezikli İ; Kendirci M · Journal of tissue viability · 2025
    Cohort study41 participantsSkin Health forResveratrol
  23. Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin.
    Moyano-Mendez JR; Fabbrocini G; De Stefano D; Mazzella C; Mayol L; Scognamiglio I; Carnuccio R; Ayala F; La Rotonda MI; De Rosa G · Drug development and industrial pharmacy · 2016
    Clinical trialSkin Health forResveratrol
  24. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.
    Montenegro L; Parenti C; Turnaturi R; Pasquinucci L · Pharmaceutics · 2020
    Clinical trial12 participantsSkin Health forResveratrol