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Folic Acid B6 & B12

Mason Natural
4.8
★ ★ ★ ★ ★
(2835 ratings)
Vitamin B6 50 mg
Vitamin B12 100 mcg
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Score81
An economical B6-led formula with straightforward dosing, but basic forms and long-term B6 exposure limit it.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
Heart Health
General Health
Cardiovascular Support

Score 81

An economical B6-led formula with straightforward dosing, but basic forms and long-term B6 exposure limit it.
How scoring works
$5.78($0.06 per serving)
Pure Formulas
$ 6.29
Vitacost
$ 6.59
iHerb
$ 5.78
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Analysis

The tablet delivers 50 mg of vitamin B6 with folate and a modest B12 amount. Its focus is clearly B6-led rather than balanced support across all three nutrients.

Pyridoxine hydrochloride requires conversion to P-5-P, while cyanocobalamin is a basic B12 form. No riboflavin cofactor or absorption-focused B12 delivery is provided.

Very low serving cost and one-tablet dosing make it accessible. The high B6 amount is not ideal for indefinite unsupervised use, especially alongside fortified foods or other supplements.

Who is it for
  • Adults seeking focused vitamin B6
  • Budget-conscious users
  • People comfortable with standard vitamin forms
Best for
  • B6 supplementation
  • Simple B-vitamin combination
  • Low-cost daily dosing

Pros

  • Meaningful B6 amount
  • Includes folate and B12
  • Very low serving cost

Cons

  • Uses pyridoxine rather than P-5-P
  • Low-potency cyanocobalamin
  • No riboflavin cofactor

Warnings

  • Long-term daily use of 50 mg vitamin B6 may cause tingling or numbness
  • Avoid stacking with other B6 products
  • Users needing reliable B12 repletion should not rely on the modest cyanocobalamin amount alone

Nutrient quality

72 High impact

Pyridoxine, folic acid or unspecified folate, and cyanocobalamin are conventional rather than metabolically direct forms. The main B vitamins and supporting nutrients are present at purposeful amounts.

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Ingredient transparency

83 Highest impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

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Customer satisfaction

76 High impact

The average rating is very strong. The large rating volume provides a reliable satisfaction signal.

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Value for money

91 Highest impact

The supply provides excellent value per effective serving. The formula is not inflated by low-value extras.

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Goals

Heart Health
Heart Health
Impact
High effect
B+ Goal FitB- Strength of SupportC CoverageA+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 50 mgFolate · 667 mcg DFE

Vitamin B6, folate, and vitamin B12 create a focused combination for homocysteine metabolism. Each nutrient is supplied at a useful amount.

Pyridoxine and cyanocobalamin are less preferred than active coenzyme forms, and the folate form is not stated. The product supports one cardiovascular pathway but does not address lipids, vascular tone, or cardiac energy.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
A- Goal FitD+ Strength of SupportC- CoverageB+ Formula Quality
Folate · 667 mcg DFEVitamin B12 · 100 mcg

Folate, Vitamin B6, and Vitamin B12 support red blood cell formation, methyl-group metabolism, and normal nerve function. Their roles are well established, so the combination has a reasonable foundational-health rationale.

Cyanocobalamin and conventional B6 limit form quality, while the B6 amount is high for open-ended daily use. The product is better matched to a defined B-vitamin need than comprehensive general wellness.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B- Goal FitC- Strength of SupportD CoverageA Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 50 mgFolate · 667 mcg DFE

B6, folate, and B12 form a focused homocysteine-support combination. The nutrient amounts are substantial, but their forms are less favorable than active B6, methylfolate, and methylcobalamin.

Clinical event benefits from routine homocysteine lowering are inconsistent and the formula covers no other cardiovascular pathway. Long-term daily use of the high vitamin B6 amount may increase peripheral-neuropathy risk.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 50 mg
Folate
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Calcium (Calcium Phosphate)
 44 mg
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxine Hydrochloride) · 50 mg OverallScore74
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The formula supplies a preferred-range amount of pyridoxine hydrochloride with folate and B12. A one-tablet serving and very low serving cost make it practical and economical. Active P-5-P and riboflavin are not listed, and excipient purity cannot be verified.

View ingredientView products
Vitamin B12 (Cyanocobalamin) · 100 mcg OverallScore27
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The formula relies on cyanocobalamin rather than a bioactive coenzyme form. Its low B12 dose is better suited to maintenance than targeted high-dose support. The standard swallowed format offers no special absorption advantage.

View ingredientView products
Loading alternative details
82 Performance

BioActive Vitamin B

Terry Naturally
<p>Active forms of vitamin B6, methylcobalamin, and methylfolate preserve the original product’s main nutrient coverage in a concise formula. Compared with the original, the provided B6, B12, and several goal analyses are strong, although products containing trimethylglycine provide broader homocysteine-focused support.</p>
89 Performance

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>Methylcobalamin, folate, and pyridoxal 5-phosphate retain all three core B nutrients with clear amounts. Compared with the original, the provided overall, B12, general-health, and energy analyses are strong, but the B6 amount is much lower than in the original formulas.</p>
89 Performance

P-5-P 50 mg

Country Life
<p>Pyridoxal 5-phosphate gives this single-nutrient option a clearly disclosed active B6 form. Compared with the original, the provided B6 analysis is stronger, but the formula does not supply vitamin B12, folate, or trimethylglycine.</p>
86 Budget

Vitamin B12 2000 mcg

Nutricost
<p>A 2000 mcg methylcobalamin serving provides a clearly disclosed active vitamin B12 form. It is not lower-cost than the original, but it is among the closest economical eligible options, although the single-nutrient formula omits vitamin B6 and folate.</p>
86 Budget

Quick Dissolve B-12 Methylcobalamin 2500 mcg

Nature's Bounty
<p>A 2500 mcg methylcobalamin serving provides a clearly disclosed active vitamin B12 form. It is not lower-cost than the original, but it is among the closest economical eligible options, although the single-nutrient formula omits vitamin B6 and folate.</p>
87 Budget

Vitamin B-6 50 mg

Nature's Way
<p>The label lists vitamin B6 as both pyridoxal 5-phosphate and pyridoxine hydrochloride. It is not lower-cost than the original, but it is among the closest economical eligible options, although the formula omits vitamin B12 and folate, and the supplied listing repeats the amount across two B6 forms.</p>
81 Value

Tri-B

Carlson
<p>Vitamin B6, folate, and vitamin B12 preserve all three core nutrients with a favorable serving cost. Compared with the original, the broad nutrient match supports value, although pyridoxine and cyanocobalamin are less active forms than P5P and methylcobalamin.</p>
84 Value

P-5-P 50 mg

Nutricost
<p>A 50 mg pyridoxal 5-phosphate serving provides active B6 with strong disclosed B6 alignment and favorable serving economics. Compared with the original, it is a useful value choice when B6 is the priority, but it omits vitamin B12, folate, and trimethylglycine.</p>
85 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
<p>A 1000 mcg methylcobalamin serving provides an active B12 form with strong disclosed B12 and goal alignment at a favorable serving cost. Compared with the original, it is a focused value option when B12 is the priority, but it omits vitamin B6, folate, and trimethylglycine.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  2. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  3. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  4. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  5. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  6. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  7. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  8. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  9. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  10. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  11. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  12. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  13. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  14. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  15. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  16. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  17. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  18. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  19. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  20. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  21. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  22. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  23. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  24. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  25. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  26. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  27. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  28. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  29. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  30. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  31. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  32. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  33. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  34. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  35. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  36. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  37. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6