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Circadian Sleep

Life Extension
4.5
★ ★ ★ ★ ★
(222 ratings)
Melatonin 1.5 mg
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Score77
A thoughtful low-dose gradual-release formula for overnight support, with nobiletin adding interest but also higher cost and some uncertainty.
How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Sleep Support
General Health

Score 77

A thoughtful low-dose gradual-release formula for overnight support, with nobiletin adding interest but also higher cost and some uncertainty.
How scoring works
$21.00($0.70 per serving)
Pure Formulas
$ 21.00
iHerb
$ 21.00
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Analysis

MicroActive melatonin provides a conservative 1.5 mg amount with gradual release, addressing both falling asleep and staying asleep more directly than an immediate capsule. That delivery choice is the formula’s clearest strength.

Nobiletin at 50 mg adds a citrus-derived circadian angle without crowding the formula. Its sleep contribution is less established, so the product should still be judged primarily on melatonin amount and release profile.

The capsule suits adults whose sleep problem extends beyond onset and who value controlled release. The specialized design carries a higher recurring cost and still may cause vivid dreams or morning drowsiness in sensitive users.

Who is it for
  • Adults seeking support for both sleep onset and maintenance
  • People who prefer a lower gradual-release melatonin amount
Best for
  • Overnight circadian support
  • A specialized controlled-release routine

Pros

  • Provides 1.5 mg of gradual-release melatonin
  • Includes 50 mg of nobiletin
  • Targets sleep onset and maintenance
  • Keeps the formula focused

Cons

  • Serving value is relatively weak
  • Nobiletin’s practical sleep contribution is less established
  • No supplied independent purity verification is identified

Warnings

  • Melatonin can cause drowsiness or next-day grogginess, so it should not be taken before driving or another task that requires alertness.
  • Gradual-release melatonin may still cause vivid dreams or next-morning drowsiness in sensitive users.

Nutrient quality

93 Highest impact

MicroActive gradual release adds useful support for overnight maintenance. The practical amount supports sleep without obvious excess.

Ingredient transparency

82 Highest impact

The shown active ingredients have clear amounts and no proprietary blend hides a key dose. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

64 Moderate impact

The supplied aggregate rating is favorable and supported by a useful review volume. Detailed feedback is unavailable, so repeated complaints and fit with the intended use cannot be judged.

Value for money

64 Moderate impact

The formula provides moderate practical value for its dose and delivery features. Secondary ingredients or delivery extras reduce category competitiveness.

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Goals

Sleep Support
Impact
Highest effect
A Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Melatonin · 1.5 mg

MicroActive melatonin at 1.5 mg directly supports circadian timing, while gradual release is suited to both sleep onset and overnight maintenance. Nobiletin adds a second circadian-focused mechanism without crowding the formula.

The specialized delivery is clearly identified, but independent purity verification is not supplied in the provided data. Melatonin may still cause vivid dreams or next-morning drowsiness in sensitive users.

Study evidence
Melatonin Supportive 181 studies
General Health
Impact
High effect
C- Goal FitA Strength of SupportC- CoverageA- Formula Quality

Controlled-release melatonin provides a clearly disclosed amount suited to sleep maintenance and circadian support. Nobiletin adds a distinct citrus-derived compound, though its general-health evidence is less established than melatonin's sleep role.

The combination may support daily well-being through better-aligned sleep rather than broad foundational nutrition. Its specialized delivery gives good depth for that purpose, but the formula covers few other health pathways.

Study evidence
Melatonin Supportive 69 studies

Ingredients

IngredientAmount per serving
Nobiletin (Citrus fruit)
50 mg
MicroActive Melatonin
1.5 mg
Adults 18–50
Report overview
Melatonin · 1.5 mg OverallScore71
D Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

The 1.5 mg dose is physiologically aligned and clearly provided in one liquid-filled capsule. MicroActive delivery supports gradual release, making it better suited to sleep maintenance than standard immediate-release capsules. The specialized technology raises the serving cost, and no independent purity certification is supplied.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
    Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
    Randomized trial116 participantsSleep Support forMelatonin
  3. Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
    Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
    Meta-analysis205 participants7 studies pooledSleep Support forMelatonin
  4. Melatonin for preventing and treating jet lag.
    Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
    Systematic review10 studies pooledGeneral Health forMelatonin
  5. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
    Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
    Randomized trial125 participantsGeneral Health forMelatonin
  6. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
    Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
    Meta-analysis23 studies pooledGeneral Health forMelatonin
  7. Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
    Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
    Meta-analysis24 studies pooledGeneral Health forMelatonin
  8. Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
    Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
    Randomized trial60 participantsGeneral Health forMelatonin
  9. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  10. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  11. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  12. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin