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Optimized Resveratrol

Life Extension
4.7
★ ★ ★ ★ ★
(4341 ratings)
Resveratrol 250 mg
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Score78
Meaningful resveratrol and quercetin amounts anchor a broad polyphenol capsule. Missing source refinement and a small fisetin addition are the key limitations.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Anti-Inflammatory Support
Cardiovascular Support
Anti-Aging
Skin Health
Metabolism Boost

Score 78

Meaningful resveratrol and quercetin amounts anchor a broad polyphenol capsule. Missing source refinement and a small fisetin addition are the key limitations.
How scoring works
$26.25($0.43 per serving)
iHerb
$ 27.00
Amazon
$ 36.75
Pure Formulas
$ 27.00
Vitacost
$ 26.25
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Analysis

The formula supplies 250 mg trans-resveratrol with 150 mg quercetin, an 85 mg grape-blueberry blend, and 10 mg fisetin. These amounts provide more polyphenol breadth than a single-ingredient resveratrol capsule.

Japanese knotweed is named as the resveratrol source, but purity and emodin removal are not stated. The grape-blueberry blend also lacks an individual breakdown.

A one-capsule serving and broad consumer-use history improve practicality. Fisetin is a minor addition, so the formula's main value comes from resveratrol and quercetin.

Who is it for
  • Adults seeking broad polyphenol coverage
  • People wanting resveratrol with quercetin
  • Users who prefer a one-capsule formula
Best for
  • General antioxidant support
  • Skin and cardiovascular wellness routines
  • Combined berry and polyphenol intake

Pros

  • Provides 250 mg trans-resveratrol
  • Adds 150 mg quercetin
  • Includes grape and blueberry compounds
  • Good routine value

Cons

  • No enhanced absorption system
  • Emodin removal is unverified
  • Berry blend proportions are hidden
  • Fisetin amount is small

Warnings

  • Resveratrol and quercetin may increase bleeding tendency with anticoagulant or antiplatelet medicines
  • Knotweed-derived material may cause loose stools if residual emodin is present

Nutrient quality

77 High impact

Trans-resveratrol and quercetin dihydrate are useful forms, but the standard capsule lacks enhanced delivery. Resveratrol and quercetin are meaningful, while fisetin and the fruit blend are modest.

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Ingredient transparency

83 Highest impact

Every listed active ingredient has a specific amount. Usage and inactive-ingredient details remain incomplete.

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Customer satisfaction

72 High impact

The average rating is consistently strong. The very large feedback pool makes the average highly dependable.

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Value for money

79 High impact

The main active amounts reasonably support the price. Serving value is good for meaningful resveratrol and quercetin doses.

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Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitB Strength of SupportB CoverageB+ Formula Quality

Trans-resveratrol and quercetin provide complementary polyphenol support for inflammatory and oxidative-stress pathways. The main active amounts are meaningful and clearly stated.

A standard powder capsule may limit absorption, and the smaller botanical blend and fisetin amounts add less certain value. Japanese knotweed is not identified as emodin-free, so sensitive users could experience laxative effects.

Study evidence
Resveratrol Supportive 34 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C Goal FitB- Strength of SupportC CoverageB+ Formula Quality

Trans-resveratrol and quercetin provide a plausible endothelial and antioxidant rationale. The resveratrol amount is meaningful, but standard capsule delivery and missing purity details limit confidence in exposure.

The antioxidant blend is coherent and broader than a single active, though its evidence is less direct than fish oil or CoQ10 for major cardiovascular markers. Japanese knotweed without an emodin-free statement may cause loose stools in sensitive users.

Study evidence
Resveratrol Supportive 73 studies
Anti-Aging
Anti-Aging
Impact
High effect
B- Goal FitC Strength of SupportC+ CoverageB Formula Quality

Trans-resveratrol and quercetin provide relevant polyphenol support for oxidative and inflammatory aging pathways. Human evidence for extending healthspan remains limited despite strong mechanistic interest.

The resveratrol amount is meaningful, while fisetin and the fruit blend appear too small for dependable senolytic or broad longevity effects. Japanese knotweed is used without an emodin-free statement, so residual emodin may cause laxative effects in sensitive users.

Study evidence
Resveratrol No effect 7 studies
Skin Health
Skin Health
Impact
High effect
C+ Goal FitB+ Strength of SupportC- CoverageB- Formula Quality
Resveratrol · 250 mg

A substantial trans-resveratrol amount plus quercetin provides focused polyphenol support against environmental oxidative stress. The additional berry blend and fisetin broaden antioxidant variety, but they do not create structural or hydration support.

Standard capsule delivery and missing purity data limit confidence in absorption and exact active yield. Japanese knotweed is used without an emodin-free statement, so sensitive users may experience a laxative effect if residual emodin is present.

Study evidence
Resveratrol Supportive 7 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C Goal FitB Strength of SupportC CoverageB Formula Quality
Resveratrol · 250 mg

Meaningful resveratrol and quercetin amounts support cellular and metabolic signaling. Mixed human evidence and low minor-active doses limit confidence in a noticeable metabolism effect.

It is more aligned with healthy aging than thermogenic fat oxidation. Resveratrol and quercetin may interact with anticoagulant or antiplatelet medicines.

Study evidence
Resveratrol Supportive 21 studies

Ingredients

IngredientAmount per serving
Trans-Resveratrol (Japanese Knotweed)
 250 mg
Quercetin (Quercetin Dihydrate)
 150 mg
Grape and Wild Blueberry blend
85 mg
Fisetin (Wax Tree extract)
 10 mg
Gluten Free Adults 18–50
Report overview
Resveratrol (Japanese Knotweed) · 250 mg OverallScore69
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB Value

The stated trans-resveratrol amount reaches the preferred daily range, but the standard capsule lacks enhanced delivery technology. The label does not disclose purity standardization or distinguish knotweed extract weight from active yield. Japanese knotweed is used without an emodin-free statement, so residual emodin could cause mild laxative effects in sensitive users.

View ingredientView products
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83 Performance

High Potency Trans-Resveratrol 600 mg

Doctor's Best
<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. A high amount of clearly identified trans-resveratrol provides strong depth at a favorable cost. Basic capsule delivery and missing purity and emodin-removal details limit refinement, while the high dose may increase stomach upset or bleeding tendency with anticoagulant or antiplatelet medicines.</p>
81 Performance

Resveratrol 250 mg with Red Wine Extract

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<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. A meaningful trans-resveratrol amount in a fat-containing softgel offers better delivery potential than a plain powder capsule. The larger package improves serving value, although purity details remain incomplete and resveratrol may add bleeding risk with anticoagulant or antiplatelet medicines.</p>
80 Performance

TransMax TR

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<p>Its ingredient profile and goal alignment make it a stronger formulation-focused alternative. MicroActive delivery directly addresses resveratrol absorption while providing a substantial trans-resveratrol amount. The high price buys meaningful delivery technology, but missing purity and emodin-removal details leave tolerability uncertainty for the knotweed source.</p>
80 Budget

Resveratrol 100 mg

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<p>The lower serving cost makes this a more economical alternative. Trans-resveratrol from grape and knotweed plus quercetin creates a focused antioxidant combination at a low serving cost. Duplicate source entries make the total active amount unclear, and missing purity and emodin-removal details limit dose and tolerability confidence.</p>
80 Budget

Resveratrol Plus

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<p>The lower serving cost makes this a more economical alternative. A supportive trans-resveratrol dose is paired with grape and pine polyphenols for broader antioxidant coverage. The economical large format improves value, though incomplete standardization and knotweed without emodin-removal verification leave potency and tolerability uncertainty.</p>
79 Budget

Resveratrol

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<p>The lower serving cost makes this a more economical alternative. Clearly named trans-resveratrol and red-wine polyphenols form a focused antioxidant formula at useful amounts. Standard capsule delivery, incomplete purity details, and missing emodin-removal verification leave absorption and tolerance uncertainty.</p>
78 Value

Resveratrol 100 mg

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<p>The balance of ingredient quality and serving economy makes it a stronger value choice. A long supply of resveratrol and vitamin C offers economical, modest antioxidant support. Unconfirmed trans-isomer content, standard capsule delivery, and missing emodin-removal detail limit confidence in effective exposure.</p>
72 Value

Resveratrol With Pterostilbene 100 mg

Life Extension
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. Trans-resveratrol and quercetin provide useful antioxidant support, but the repeated resveratrol entries make the total active amount ambiguous. Trace pterostilbene adds little practical value, while knotweed without emodin-removal verification may cause loose stools in sensitive users.</p>
72 Value

Resveratrol

youtheory
<p>The balance of ingredient quality and serving economy makes it a stronger value choice. A useful trans-resveratrol amount provides meaningful antioxidant coverage at an efficient serving cost. Pressed-tablet delivery, missing emodin verification, and an opaque fruit blend are the main limitations.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.
    Witte AV; Kerti L; Margulies DS; Flöel A · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Randomized trial46 participantsAnti-Aging forResveratrol
  2. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.
    Huhn S; Beyer F; Zhang R; Lampe L; Grothe J; Kratzsch J; Willenberg A; Breitfeld J; Kovacs P; Stumvoll M; Trampel R; Bazin PL; Villringer A; Witte AV · NeuroImage · 2019
    Randomized trial60 participantsAnti-Aging forResveratrol
  3. Resveratrol levels and all-cause mortality in older community-dwelling adults.
    Semba RD; Ferrucci L; Bartali B; Urpí-Sarda M; Zamora-Ros R; Sun K; Cherubini A; Bandinelli S; Andres-Lacueva C · JAMA internal medicine · 2014
    Cohort study783 participantsAnti-Aging forResveratrol
  4. Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
    Mansouri F; Feliziani G; Bordoni L; Gabbianelli R · Journal of the Academy of Nutrition and Dietetics · 2025
    Meta-analysis11 studies pooledAnti-Aging forResveratrol
  5. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
    Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
    Randomized trial134 participantsAnti-Aging Skin Health forResveratrol
  6. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
    Mahjabeen W; Khan DA; Mirza SA · Complementary therapies in medicine · 2022
    Randomized trial110 participantsAnti-Inflammatory Support forResveratrol
  7. Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis.
    Zhang Q; Xu S; Xu W; Zhou Y; Luan H; Wang D · Medicine · 2022
    Randomized trial160 participantsAnti-Inflammatory Support forResveratrol
  8. Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial.
    Keramatzadeh S; Hosseini SA; Majdinasab N; Cheraghian B; Zilaee M · Nutritional neuroscience · 2025
    Randomized trial55 participantsAnti-Inflammatory Support forResveratrol
  9. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; Yáñez-Gascón MJ; García-Almagro FJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · The American journal of cardiology · 2012
    Randomized trial75 participantsAnti-Inflammatory Support forResveratrol
  10. Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.
    Guo XF; Li JM; Tang J; Li D · Critical reviews in food science and nutrition · 2019
    Meta-analysis1,069 participants29 studies pooledAnti-Inflammatory Support forResveratrol
  11. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; García-Almagro FJ; Avilés-Plaza F; Parra S; Yáñez-Gascón MJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · Molecular nutrition & food research · 2012
    Randomized trial75 participantsCardiovascular Support forResveratrol
  12. Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients.
    Ahmadi P; Akbarzadeh S; Alizadeh M; Mohammadi N; Mahmoodi M; Amini A; Netticadan T; Rezaei M; Movahed A · Molecular and cellular biochemistry · 2025
    Randomized trial60 participantsCardiovascular Support forResveratrol
  13. Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases.
    Shen CY; Li CP; Yu JT; Ho YJ; Tsai RY · In vivo (Athens, Greece) · 2026
    Meta-analysis2,551 participants40 studies pooledCardiovascular Support forResveratrol
  14. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.
    Wong RH; Berry NM; Coates AM; Buckley JD; Bryan J; Kunz I; Howe PR · Journal of hypertension · 2014
    Randomized trial28 participantsCardiovascular Support forResveratrol
  15. Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.
    Simental-Mendía LE; Guerrero-Romero F · Nutrition (Burbank, Los Angeles County, Calif.) · 2020
    Randomized trial71 participantsCardiovascular Support forResveratrol
  16. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis.
    Zhu X; Wu C; Qiu S; Yuan X; Li L · Nutrition & metabolism · 2022
    Meta-analysis283 participants9 studies pooledMetabolism Boost forResveratrol
  17. Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.
    Sun JN; Yang R; Fang L; Li YJ; Xing WY; Sun ML; Wu L; Wu QJ; Gong TT · Nutrition journal · 2026
    Meta-analysis45 studies pooledMetabolism Boost forResveratrol
  18. Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial.
    Chen S; Zhao X; Ran L; Wan J; Wang X; Qin Y; Shu F; Gao Y; Yuan L; Zhang Q; Mi M · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2015
    Randomized trial60 participantsMetabolism Boost forResveratrol
  19. Supplementation with resveratrol modified gut microbiota improving insulin sensitivity and lipid metabolism in subjects with obesity and insulin resistance.
    Guevara-Cruz M; Sánchez-Tapia M; Velazquez-Villegas LA; Torre-Villalvazo I; Guizar-Heredia R; Godínez-Salas E; López-Barradas A; Granados O; Torres-Villalobos G; Torres N; Tovar AR · European journal of nutrition · 2026
    Randomized trial32 participantsMetabolism Boost forResveratrol
  20. Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review.
    Zhou Q; Wang Y; Han X; Fu S; Zhu C; Chen Q · Frontiers in physiology · 2022
    Meta-analysis1,171 participants25 studies pooledMetabolism Boost forResveratrol
  21. Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging.
    Du YM; Zeng J; Li M; Wang YB; Wu Y; Qi RQ; Gao XH; Chen HD · Journal of cosmetic dermatology · 2021
    Non-randomized trial32 participantsSkin Health forResveratrol
  22. Exploring resveratrol-enriched collagen dressings for diabetic foot ulcers: A retrospective study of wound healing outcomes.
    Sezikli İ; Kendirci M · Journal of tissue viability · 2025
    Cohort study41 participantsSkin Health forResveratrol
  23. Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin.
    Moyano-Mendez JR; Fabbrocini G; De Stefano D; Mazzella C; Mayol L; Scognamiglio I; Carnuccio R; Ayala F; La Rotonda MI; De Rosa G · Drug development and industrial pharmacy · 2016
    Clinical trialSkin Health forResveratrol
  24. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.
    Montenegro L; Parenti C; Turnaturi R; Pasquinucci L · Pharmaceutics · 2020
    Clinical trial12 participantsSkin Health forResveratrol