Product Image

Hair Skin and Nails

Dr. Mercola
4.6
★ ★ ★ ★ ★
(198 ratings)
Biotin 5000 mcg
Keratin 500 mg
Hyaluronic Acid 20 mg
Product Image
Score70
A focused biotin-and-keratin capsule for hair and nails, but unclear keratin processing, low hyaluronic acid, and high cost limit its appeal.
How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Hair Health
Nail Health
Skin Health

Score 70

A focused biotin-and-keratin capsule for hair and nails, but unclear keratin processing, low hyaluronic acid, and high cost limit its appeal.
How scoring works
$39.59($1.31 per serving)
iHerb
$ 39.59
Pure Formulas
$ 39.99
Vitacost
$ 43.55
Report prices

Analysis

Biotin and 500 mg of keratin give the formula a clear hair-and-nail focus. Biotin is most likely to help when intake or status is low, while the substantial keratin amount may provide structural support.

Keratin source, hydrolysis, and solubility are not disclosed, so absorption is difficult to judge. Sodium hyaluronate is a useful form, but 20 mg is below the amount commonly chosen for focused oral hydration support.

The one-capsule serving is easy to use, yet the serving cost is high for a three-ingredient formula with important quality gaps. High-dose biotin also requires planning around laboratory testing because it can distort some results.

Who is it for
  • Adults seeking a simple hair-and-nail supplement
  • People who specifically want biotin paired with keratin
Best for
  • Targeted hair nutrient support
  • Biotin and keratin supplementation

Pros

  • Provides a substantial 500 mg keratin amount
  • Biotin amount is clearly disclosed
  • Simple one-capsule serving

Cons

  • Keratin source and processing are not disclosed
  • Hyaluronic acid amount is too small for focused oral hydration support
  • Serving cost is high for the formula

Warnings

  • The 5,000 mcg biotin amount can interfere with thyroid, cardiac, and other laboratory tests, so tell the clinician or laboratory before testing

Nutrient quality

75 High impact

The focused formula provides meaningful keratin and biotin, but hyaluronic acid is lightly dosed and key form details are missing. High-dose biotin creates a practical laboratory-test interference concern.

Ingredient transparency

76 High impact

Active amounts are fully disclosed and no proprietary blend hides key doses. Missing keratin-processing details, daily directions, and a complete excipient list reduce clarity.

Customer satisfaction

68 High impact

The supplied aggregate satisfaction metric is strong and supported by meaningful feedback volume. No feedback excerpts or complaint themes are supplied, so specific experience patterns cannot be verified.

Value for money

57 Moderate impact

Meaningful keratin and biotin amounts provide some practical value, but the expensive serving lacks strong form assurance. The focused active list avoids filler, yet category competitiveness remains weak.

Report analysis

Goals

Hair Health
Hair Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Biotin · 5000 mcgKeratin · 500 mg

Keratin and biotin directly address hair-shaft structure and keratin production, while hyaluronic acid may support scalp moisture. The keratin amount is substantial compared with many beauty formulas, giving the blend meaningful structural focus.

Hair-growth evidence depends on the keratin’s processing and on whether biotin status is low, and neither point is fully resolved by the label. The high biotin amount can interfere with thyroid, cardiac, and other laboratory tests, so users should disclose it before testing.

Study evidence
Biotin Supportive 4 studies
Hyaluronic Acid Mixed 7 studies
Keratin Disputed 14 studies
Nail Health
Nail Health
Impact
High effect
C Goal FitC Strength of SupportB- CoverageA- Formula Quality
Biotin · 5000 mcgKeratin · 500 mg

Biotin provides a relevant route to nail health. The disclosed amount appears meaningful for that focused role.

Several complementary pathways broaden the formula. Hair Skin and Nails is best viewed as targeted support rather than proof of a clinical benefit.

Study evidence
Biotin Supportive 8 studies
Skin Health
Skin Health
Impact
High effect
C Goal FitC Strength of SupportC CoverageB+ Formula Quality
Hyaluronic Acid · 20 mg

Keratin offers structural relevance, while sodium hyaluronate may support hydration and biotin helps mainly in deficiency. The hyaluronic acid amount is too small for strong oral hydration support, and direct evidence for the full combination is limited.

All three actives are disclosed and the formula is reasonably focused. Biotin at 5,000 mcg can interfere with thyroid and cardiac blood tests, so users should notify the testing clinician or laboratory.

Study evidence
Biotin Supportive 10 studies
Hyaluronic Acid Supportive 96 studies

Ingredients

IngredientAmount per serving
Biotin
5000 mcg
Keratin
500 mg
Low density Hyaluronic Acid (Sodium Hyaluronate)
 20 mg
Adults 18–50
Report overview
Biotin · 5000 mcg OverallScore82
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

The exact biotin amount is well aligned with targeted hair, skin, and nail use. Keratin and hyaluronic acid add relevant co-factors, although the capsule label does not confirm d-biotin. High-dose biotin can interfere with some laboratory results, and the broader formula supports a neutral value assessment despite a costly serving.

View ingredientView products
Keratin · 500 mg OverallScore48
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The full daily amount matches the target for keratin supplementation and is clearly disclosed. However, the label gives no source, hydrolysis, solubilization, or branded-form details to support absorption. A high serving cost for generic keratin reduces value despite the substantial dose.

View ingredientView products
Hyaluronic Acid (Sodium Hyaluronate) · 20 mg OverallScore45
D+ Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value

Sodium hyaluronate offers a stable form, but the source and production method are not disclosed. The hyaluronic acid amount is clearly stated yet remains too low for a typical targeted oral dose, making the high serving cost difficult to justify for this ingredient. The high biotin dose may interfere with some thyroid and cardiac blood tests, so users should tell the testing clinician or laboratory before testing.

View ingredientView products
Loading alternative details
81 Performance

Hair Skin & Nails Collagen Plus Formula

Life Extension
<p>Substantial collagen peptides and keratin provide a strong structural base for hair, skin, and nails. The clearer ingredient focus improves on the original’s low hyaluronic acid, unclear keratin sourcing, weak serving value, and high-biotin laboratory interference, although basic mineral forms and a low silicon amount temper the otherwise focused formula.</p>
74 Performance

Type l ll & lll Collagen Keratin with Alpha Lipoic Acid & Hyaluronic Acid

Solaray
<p>Solubilized keratin with vitamin C and mineral cofactors creates a well-targeted hair and nail formula. The clearer ingredient focus improves on the original’s low hyaluronic acid, unclear keratin sourcing, weak serving value, and high-biotin laboratory interference, although collagen and hyaluronic acid are modest, and fish or chicken collagen may not suit people with the corresponding allergy.</p>
77 Performance

Hair Ultra Softgels

OLLY
<p>Keratin, biotin, vitamin D3, zinc, and silicon create a focused formula with fully disclosed doses. The clearer ingredient focus improves on the original’s low hyaluronic acid, unclear keratin sourcing, weak serving value, and high-biotin laboratory interference, although keratin and silicon are modest, while very high biotin may interfere with laboratory tests.</p>
73 Budget

Undeniable Beauty Grapefruit Glam

OLLY
<p>A higher serving cost makes this option more economical while high biotin provides direct hair and nail support in a narrow gummy formula. Keratin is modest, and biotin can distort some thyroid, hormone, and cardiac laboratory tests.</p>
68 Budget

Keratin Hair Booster

Reserveage Nutrition
<p>A higher serving cost makes this option more economical while meaningful keratin and high biotin provide direct hair and nail support. Zinc oxide and copper sulfate are basic forms, while a hidden longevity blend limits assessment.</p>
70 Budget

Hair Skin & Nails

Bluebonnet Beautiful Ally
<p>A higher serving cost makes this option more economical while biotin, zinc, vitamin C, collagen peptides, MSM, and soluble keratin create broad hair, skin, and nail coverage. Several structural and antioxidant ingredients are modest, while high biotin can interfere with laboratory tests.</p>
76 Value

Heavenly Hair Tropical Citrus

OLLY
<p>Biotin, zinc citrate, silica, horsetail, keratin, and amla align closely with hair and nail support at a higher serving cost. The quality-to-cost balance may improve on the original’s low hyaluronic acid, unclear keratin sourcing, weak serving value, and high-biotin laboratory interference, although keratin and botanical extracts are light, while high biotin can interfere with laboratory tests.</p>
65 Value

Keratin Hair Booster

Reserveage Nutrition
<p>Meaningful keratin and high biotin provide direct hair and nail support at a higher serving cost. The quality-to-cost balance may improve on the original’s low hyaluronic acid, unclear keratin sourcing, weak serving value, and high-biotin laboratory interference, although basic mineral forms and a premium serving cost weaken the formula’s value.</p>
52 Value

Hair

Codeage
<p>Active vitamins, chelated minerals, bamboo silica, and a hair-focused design provide useful breadth at a higher serving cost. The quality-to-cost balance may improve on the original’s low hyaluronic acid, unclear keratin sourcing, weak serving value, and high-biotin laboratory interference, although four opaque complexes, very high biotin, underdosed structural actives, and high serving cost sharply reduce clarity and value.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsSkin Health Hair Health Nail Health forBiotin
  2. Interventions for infantile seborrhoeic dermatitis (including cradle cap).
    Victoire A; Magin P; Coughlan J; van Driel ML · The Cochrane database of systematic reviews · 2019
    Systematic review35 participants2 studies pooledSkin Health forBiotin
  3. Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation.
    Ali A; Iqbal S; Ilyas A; Khan H; Asad MHHB; Fatima N; Akhtar N · Drug delivery and translational research · 2020
    Non-randomized trial15 participantsSkin Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  6. The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Clinical Study in Healthy Women.
    Tursi F; Nobile V; Cestone E; De Ponti I; Lepoudere A; Sergheraert R; Soulard JP · Journal of cosmetic dermatology · 2025
    Randomized trialHair Health Nail Health forKeratin
  7. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  8. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  9. Brittle nails: response to daily biotin supplementation.
    Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
    Case series35 participantsNail Health forBiotin
  10. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  11. Efficacy and safety of non-cross-linked hyaluronic acid compound in the treatment of keratosis pilaris: A split-body randomized clinical trial.
    Li Y; Wang SW; Liu YH; Zou MY; Wu JX; Luo SK; Hong WJ · Journal of cosmetic dermatology · 2024
    Randomized trialHair Health forHyaluronic Acid
  12. Intradermal Injections of 10% Glucose (Sihler G) for Scalp Hair Regrowth: A Randomized, Evaluator-Blinded Pilot Study.
    Yi KH; Sydorchuk O; Lee S; Sobchyshyn M; Kim TH; Lee SR; Park S; Chang-Il Y; Kyu-Eun L · Aesthetic plastic surgery · 2026
    Observational studyHair Health forHyaluronic Acid
  13. Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With PCOS: An Open-Label, Non-randomized, Prospective Study.
    Khare S · Cureus · 2023
    Randomized trialHair Health forHyaluronic Acid
  14. Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review.
    Bekkers VZ; Bik L; van Huijstee JC; Wolkerstorfer A; Prens EP; van Doorn MBA · Drug delivery and translational research · 2023
    Systematic reviewHair Health forHyaluronic Acid
  15. Revitalizing Effect on the Scalp After Injection with a Mechanically Stabilized Hyaluronic Acid Complex in Subjects with Androgenetic Alopecia.
    Siquier-Dameto G; Boisnic S; Verdú E · Journal of clinical medicine · 2024
    Clinical trial26 participantsHair Health forHyaluronic Acid
  16. Halloysite/Keratin Nanocomposite for Human Hair Photoprotection Coating.
    Cavallaro G; Milioto S; Konnova S; Fakhrullina G; Akhatova F; Lazzara G; Fakhrullin R; Lvov Y · ACS applied materials & interfaces · 2021
    In vitro / ex vivo studyHair Health forKeratin
  17. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial.
    Tenore GC; Caruso D; Buonomo G; D'Avino M; Santamaria R; Irace C; Piccolo M; Maisto M; Novellino E · Journal of medicinal food · 2018
    Randomized trialHair Health forKeratin
  18. Keratin/alginate hybrid hydrogels filled with halloysite clay nanotubes for protective treatment of human hair.
    Cavallaro G; Caruso MR; Milioto S; Fakhrullin R; Lazzara G · International journal of biological macromolecules · 2022
    In vitro / ex vivo studyHair Health forKeratin
  19. Patient Satisfaction and Adverse Effects Following the use of Topical Hair Fiber Fillers.
    Babadjouni A; Juhasz M; Pham C; Csuka E; Hedayati B; Evron E; Mesinkovska NA · International journal of trichology · 2024
    Cross-sectional study40 participantsHair Health forKeratin
  20. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  21. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin
  22. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  23. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  24. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  25. Efficacy and Safety of Sodium Hyaluronate Gel for Facial Skin Rejuvenation.
    Liao Z; Hong W; Wang S; Hou Y; Lu S; Chen R; Zhang Y; Chen J; Liu Y; Luo S · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
    Randomized trial420 participantsSkin Health forHyaluronic Acid
  26. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study.
    Hsu TF; Su ZR; Hsieh YH; Wang MF; Oe M; Matsuoka R; Masuda Y · Nutrients · 2021
    Randomized trial40 participantsSkin Health forHyaluronic Acid
  27. Safety and efficacy of hyaluronic acid injectable filler in the treatment of nasolabial fold wrinkle: a randomized, double-blind, self-controlled clinical trial.
    Li XZ; Chiang CF; Lin YH; Chen TM; Wang CH; Tzeng YS; Cui HY · The Journal of dermatological treatment · 2023
    Randomized trial95 participantsSkin Health forHyaluronic Acid
  28. A Split-Face Study of the Effects of a Stabilized Hyaluronic Acid-Based Gel of Nonanimal Origin for Facial Skin Rejuvenation Using a Stamp-Type Multineedle Injector: A Randomized Clinical Trial.
    Roh NK; Kim MJ; Lee YW; Choe YB; Ahn KJ · Plastic and reconstructive surgery · 2016
    Randomized trial25 participantsSkin Health forHyaluronic Acid
  29. Long-term Safety and Effectiveness of Cold-Crosslinked Hyaluronic Acid Fillers: Multicenter, Randomized, Controlled, Double-Blind Study.
    Kaminer MS; Avelar RL; Baumann L; Callender V; Dayan SH; Green JB; Grekin SK; Guyon S · Aesthetic surgery journal · 2025
    Randomized trial140 participantsSkin Health forHyaluronic Acid