Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
Non-randomized trial60 participantsflagSkin Health forscienceBiotin
- Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation.
Ali A; Iqbal S; Ilyas A; Khan H; Asad MHHB; Fatima N; Akhtar N · Drug delivery and translational research · 2020
Non-randomized trial15 participantsflagSkin Health forscienceBiotin
- Interventions for infantile seborrhoeic dermatitis (including cradle cap).
Victoire A; Magin P; Coughlan J; van Driel ML · The Cochrane database of systematic reviews · 2019
Systematic review35 participants2 studies pooledflagSkin Health forscienceBiotin
- Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
Meta-analysis967 participants14 studies pooledflagSkin Health forscienceCollagen
- Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
Meta-analysis646 participants10 studies pooledflagSkin Health forscienceCollagen
- Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study.
Guadanhim LRS; Miot HA; Soares JLM; Silva SAM; Leonardi GR; Lopes RD; Bagatin E · Dermatology and therapy · 2023
Randomized trial56 participantsflagSkin Health forscienceCollagen
- The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
Patel MN; Maheshvari J; Patel N · Cureus · 2025
Randomized trial105 participantsflagHair Health flagNail Health forscienceBiotin
- The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
Narrative reviewflagHair Health forscienceBiotin
- Vitamins A, B, C, and D: A Short Review for the Dermatologist.
Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
Narrative reviewflagHair Health forscienceBiotin
- Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
Randomized trial114 participantsflagHair Health forscienceCollagen
- Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
Randomized trialflagHair Health forscienceCollagen
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
Narrative reviewflagHair Health forscienceCollagen
- The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Clinical Study in Healthy Women.
Tursi F; Nobile V; Cestone E; De Ponti I; Lepoudere A; Sergheraert R; Soulard JP · Journal of cosmetic dermatology · 2025
Randomized trialflagHair Health flagNail Health forscienceKeratin
- Halloysite/Keratin Nanocomposite for Human Hair Photoprotection Coating.
Cavallaro G; Milioto S; Konnova S; Fakhrullina G; Akhatova F; Lazzara G; Fakhrullin R; Lvov Y · ACS applied materials & interfaces · 2021
In vitro / ex vivo studyflagHair Health forscienceKeratin
- A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.
Winter H; Labrèze C; Chapalain V; Surlève-Bazeille JE; Mercier M; Rogers MA; Taieb A; Schweizer J · The Journal of investigative dermatology · 1998
Case series3 participantsflagHair Health forscienceKeratin
- Biotin for the treatment of nail disease: what is the evidence?
Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
Narrative reviewflagNail Health forscienceBiotin
- Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
Other32 participantsflagNail Health forscienceBiotin
- Brittle nails: response to daily biotin supplementation.
Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
Case series35 participantsflagNail Health forscienceBiotin
- Comparative Analysis of Type I Keratin Expression By Nail Consistency: An Immunohistochemistry Study.
Mingorance Álvarez E; Rodríguez-León J; Pérez Pico AM; Mayordomo R · Applied immunohistochemistry & molecular morphology : AIMM · 2022
Cross-sectional study32 participantsflagNail Health forscienceKeratin
- Exposure to toxic agents alters organic elemental composition in human fingernails.
Schumacher E; Dindorf W; Dittmar M · The Science of the total environment · 2009
Cross-sectional study120 participantsflagNail Health forscienceKeratin
- Low serum biotinidase activity in children with valproic acid monotherapy.
Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
Clinical trial125 participantsflagHair Health forscienceBiotin
- Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial.
Tenore GC; Caruso D; Buonomo G; D'Avino M; Santamaria R; Irace C; Piccolo M; Maisto M; Novellino E · Journal of medicinal food · 2018
Randomized trialflagHair Health forscienceKeratin
- Keratin/alginate hybrid hydrogels filled with halloysite clay nanotubes for protective treatment of human hair.
Cavallaro G; Caruso MR; Milioto S; Fakhrullin R; Lazzara G · International journal of biological macromolecules · 2022
In vitro / ex vivo studyflagHair Health forscienceKeratin
- Patient Satisfaction and Adverse Effects Following the use of Topical Hair Fiber Fillers.
Babadjouni A; Juhasz M; Pham C; Csuka E; Hedayati B; Evron E; Mesinkovska NA · International journal of trichology · 2024
Cross-sectional study40 participantsflagHair Health forscienceKeratin
- Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
Narrative reviewflagHair Health forscienceVitamin C
- Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
Methods validation study201,019 participantsflagHair Health forscienceVitamin C
- Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
Observational studyflagHair Health forscienceVitamin C
- Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
Methods validation studyflagHair Health forscienceVitamin C
- A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
Case reportflagHair Health forscienceVitamin C
- The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
Randomized trial200 participantsflagHair Health forscienceZinc
- Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
Randomized trialflagHair Health forscienceZinc
- A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
Randomized trial40 participantsflagHair Health forscienceZinc
- BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
Case-control study216 participantsflagHair Health forscienceZinc
- Analysis of serum zinc and copper concentrations in hair loss.
Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
Case-control study342 participantsflagHair Health forscienceZinc
- Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
Randomized trial50 participantsflagNail Health forscienceBiotin
- Vitamins and minerals: their role in nail health and disease.
Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
Narrative reviewflagNail Health forscienceBiotin flagNail Health forscienceZinc
- Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
Single-arm trial25 participantsflagNail Health forscienceCollagen
- Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
Randomized trial85 participantsflagNail Health forscienceCollagen
- Nail Supplements: When, How, and Why?
Zaraa I; Richert B · Skin appendage disorders · 2026
Narrative reviewflagNail Health forscienceCollagen
- Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
Observational study41 participantsflagNail Health forscienceCollagen
- Human keratin diseases: hereditary fragility of specific epithelial tissues.
Corden LD; McLean WH · Experimental dermatology · 1997
Narrative reviewflagNail Health forscienceKeratin
- Phenotype and genotype features of Vietnamese children with pachyonychia congenita.
Chu HT; Dinh Duong TA; Le DH; Le TV; Nguyen BB; Dang CV; Vu QV · Pediatrics and neonatology · 2023
Case series7 participantsflagNail Health forscienceKeratin
- Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
Other20 participantsflagNail Health forscienceVitamin C
- Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
Randomized trial100 participantsflagSkin Health forscienceCollagen
- Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
Randomized trial64 participantsflagSkin Health forscienceCollagen
- Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
Meta-analysis1,125 participants19 studies pooledflagSkin Health forscienceCollagen
- Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging.
Du YM; Zeng J; Li M; Wang YB; Wu Y; Qi RQ; Gao XH; Chen HD · Journal of cosmetic dermatology · 2021
Non-randomized trial32 participantsflagSkin Health forscienceResveratrol
- Exploring resveratrol-enriched collagen dressings for diabetic foot ulcers: A retrospective study of wound healing outcomes.
Sezikli İ; Kendirci M · Journal of tissue viability · 2025
Cohort study41 participantsflagSkin Health forscienceResveratrol
- Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin.
Moyano-Mendez JR; Fabbrocini G; De Stefano D; Mazzella C; Mayol L; Scognamiglio I; Carnuccio R; Ayala F; La Rotonda MI; De Rosa G · Drug development and industrial pharmacy · 2016
Clinical trialflagSkin Health forscienceResveratrol
- Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
Randomized trial134 participantsflagSkin Health forscienceResveratrol
- Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.
Montenegro L; Parenti C; Turnaturi R; Pasquinucci L · Pharmaceutics · 2020
Clinical trial12 participantsflagSkin Health forscienceResveratrol
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C
- Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
Meta-analysis2,088 participants20 studies pooledflagSkin Health forscienceZinc
- Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
Cohort study23 participantsflagSkin Health forscienceZinc
- Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
Randomized trial30 participantsflagSkin Health forscienceZinc
- A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
Randomized trial90 participantsflagSkin Health forscienceZinc
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceZinc